Protein Alignment Ppn and lrig3

DIOPT Version :10

• Sequence 1: NP_788752.2
• Gene: Ppn / 43872
• FlyBaseID: FBgn0003137
• Length: 2898
• Species: Drosophila melanogaster
• Sequence 2: XP_002940426.3
• Gene: lrig3 / 100151727
• XenbaseID: XB-GENE-1219309
• Length: 1109
• Species: Xenopus tropicalis
• Alignment Length: 355
• Identity: 85/355 - (23%)
• Similarity: 139/355 - (39%)
• Gaps: 80/355 - (22%)

  Fly  2522 EPKEAHELDVQTAIGG--IAVLRCFATGNPAP-NITWSLKNLVINTNK-GRYV-LTANGD----- 2576
            :|:...:.:.|:||.|  :..:...|:.:.:| ...|...|.:::.:: ..|. |.|.|.
 Frog   493 KPQITVQPETQSAIKGSNVTFICSAASSSESPMTFAWKKDNELLHDSEIENYAHLRAQGGEVMEY 557

  Fly  2577 LTIVQVRQTD---DGTYVCVASNGLGEPVRREVALQVTEPVSQPAYIYGDKNVTQIVELNRPAVI 2638
            .||:::|..:   :|.|.||.||..|.....:..|.|.   ..|.:.....::|  :.....|.:
 Frog   558 TTILRLRNVEFINEGKYQCVISNHFGPTYSVKAKLTVN---MLPLFTKMPMDLT--IRAGSTARL 617

  Fly  2639 RCPAGGFPEPHVSWWRNGQMFGL--------KNNLMARDYSLVFNSIQLSDLGLYTCEVYNQRRP 2695
            .|.|.|.|.|.::|.:||   |.        :.::|..|......:::..|:|:|:|...|....
 Frog   618 ECAAVGHPTPQIAWQKNG---GTDFPAARERRMHVMPEDDVFFIVNVKTEDIGVYSCTAQNSAGS 679

  Fly  2696 VSLRVTLKAVGPVRPLSPEEEQYMQYVLNPATRPVTQRPSYPYRPTRPAYVPEPTVNVHAVLALE 2760
            :|...||..:        |...::        ||:..|.:
 Frog   680 ISANATLTVL--------ETPSFL--------RPLVDRTA------------------------- 703

  Fly  2761 PKNSYTPGSTIVMSCSVQGYPEPNVTWIKDDVPLYNNERVQITYQPHRLVLSDVTSADSGKYTCR 2825
                 :.|.|.|:.|...|.|.|.|.|.|||.||...||.........|::.|....|:|||||.
 Frog   704 -----SKGETTVLQCIAGGSPTPKVNWTKDDSPLVVTERHFFAAGNQHLIIVDTDLEDAGKYTCE 763

  Fly  2826 ASNAYTYANGEANVSIQSVVPVSPECVDNP 2855
            .||......|..::   ||:| :|.| |:|
 Frog   764 VSNILGTERGNIHL---SVLP-NPTC-DSP 788

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559
		ADAMTS_CR_3	116..213	CDD:437068
		ADAMTS_spacer1	222..329	CDD:461796
		TSP1_ADAMTS	347..396	CDD:465950
		TSP1_ADAMTS	400..457	CDD:465950
		TSP1_ADAMTS	465..520	CDD:465950
		TSP1_ADAMTS	580..632	CDD:465950
		TSP1_ADAMTS	643..693	CDD:465950
		MSCRAMM_ClfA	<1049..1262	CDD:468110
		Kunitz_papilin_lacunin-like	1612..1663	CDD:438681
		Kunitz_BPTI	1670..1721	CDD:425421
		Kunitz-type	1730..1780	CDD:438633
		Kunitz_BPTI	1789..1840	CDD:425421
		Kunitz_papilin_mig6-like	1849..1899	CDD:438679
		Kunitz_papilin_mig6-like	1922..1972	CDD:438679
		Kunitz_papilin_mig6-like	2001..2051	CDD:438679
		Kunitz-type	2071..2121	CDD:438633
		Kunitz_BPTI	2127..2178	CDD:425421
		Kunitz_BPTI	2193..2245	CDD:425421
		Kunitz_BPTI	2252..2303	CDD:425421
		Kunitz_BPTI	2317..2372	CDD:425421
		WAP	2455..2497	CDD:459672
		Ig	2530..2610	CDD:472250	23/92 (25%)
		Ig strand B	2539..2543	CDD:409353	0/3 (0%)
		Ig strand C	2552..2556	CDD:409353	0/3 (0%)
		Ig strand E	2576..2579	CDD:409353	0/7 (0%)
		Ig strand F	2589..2594	CDD:409353	2/4 (50%)
		Ig strand G	2603..2606	CDD:409353	0/2 (0%)
		IG_like	2627..2703	CDD:214653	20/83 (24%)
		Ig strand B	2636..2640	CDD:409353	1/3 (33%)
		Ig strand C	2649..2653	CDD:409353	0/3 (0%)
		Ig strand E	2670..2674	CDD:409353	0/3 (0%)
		Ig strand F	2684..2689	CDD:409353	2/4 (50%)
		Ig strand G	2697..2700	CDD:409353	1/2 (50%)
		I-set	2766..2845	CDD:400151	28/78 (36%)
		Ig strand B	2771..2775	CDD:409353	1/3 (33%)
		Ig strand C	2784..2788	CDD:409353	1/3 (33%)
		Ig strand F	2821..2826	CDD:409353	4/4 (100%)
		PLAC	2851..2883	CDD:462560	3/5 (60%)
lrig3	XP_002940426.3	LRRNT	40..67	CDD:214470
		leucine-rich repeat	52..69	CDD:275380
		LRR	65..442	CDD:443914
		leucine-rich repeat	73..93	CDD:275380
		leucine-rich repeat	94..140	CDD:275380
		leucine-rich repeat	141..163	CDD:275380
		leucine-rich repeat	164..187	CDD:275380
		leucine-rich repeat	189..211	CDD:275380
		leucine-rich repeat	212..235	CDD:275380
		leucine-rich repeat	236..259	CDD:275380
		leucine-rich repeat	260..283	CDD:275380
		leucine-rich repeat	284..307	CDD:275380
		leucine-rich repeat	308..331	CDD:275380
		leucine-rich repeat	332..355	CDD:275380
		leucine-rich repeat	356..380	CDD:275380
		leucine-rich repeat	383..406	CDD:275380
		leucine-rich repeat	407..428	CDD:275380
		PCC	411..>489	CDD:188093
		Ig_3	493..580	CDD:464046	20/86 (23%)
		IgI_LRIG1-like	600..689	CDD:409420	21/93 (23%)
		Ig strand A'	606..610	CDD:409420	1/5 (20%)
		Ig strand B	613..622	CDD:409420	2/8 (25%)
		Ig strand C	628..633	CDD:409420	1/4 (25%)
		Ig strand C'	636..638	CDD:409420	1/1 (100%)
		Ig strand D	646..650	CDD:409420	0/3 (0%)
		Ig strand E	654..661	CDD:409420	0/6 (0%)
		Ig strand F	667..675	CDD:409420	3/7 (43%)
		Ig strand G	678..689	CDD:409420	3/10 (30%)
		I-set	692..779	CDD:400151	30/127 (24%)
		Ig strand B	709..713	CDD:409353	1/3 (33%)
		Ig strand C	722..726	CDD:409353	1/3 (33%)
		Ig strand E	743..749	CDD:409353	1/5 (20%)
		Ig strand F	759..764	CDD:409353	4/4 (100%)
		Ig strand G	772..775	CDD:409353	1/2 (50%)