DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and adamts12

DIOPT Version :9

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:XP_021332071.1 Gene:adamts12 / 100003937 ZFINID:ZDB-GENE-070705-471 Length:1500 Species:Danio rerio


Alignment Length:963 Identity:249/963 - (25%)
Similarity:349/963 - (36%) Gaps:360/963 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 LPESSVTPGGEGNDPDEWTPWSSPSDCSRTCGGGVSYQTRECLR-RDDRGEAVCSGGSRRYFSCN 106
            |||:  ..||       |.||||.|.||||||.||....|||.: :.:.|...|:|..:||..||
Zfish   550 LPET--VHGG-------WGPWSSWSHCSRTCGAGVQTADRECNQPKPEFGGKYCTGERKRYRVCN 605

  Fly   107 TQDCPEEESDFRAQQCSRFDRQQFDGVFYEWVPYTNAPNPCELNCMPKGERFYYRQREKVVDGTR 171
            |:.|..:...||..|||.|:...:....|:|:|.::...||||:|.|..|.|..:..:.|.|||.
Zfish   606 TKLCVRKHPSFREMQCSEFNTVPYHNELYQWIPVSSPSRPCELHCKPVDENFSEKMLDAVTDGTP 670

  Fly   172 C--NDKDLDVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYNDLLL 234
            |  |:...::||||.|..||||..:.|:||||.|..|.||||||:|::.....:| ..||.||:|
Zfish   671 CFMNNNSRNICVNGVCKEVGCDFGINSNAKEDSCGVCLGDGSTCETVKENFVEQD-GFGYMDLVL 734

  Fly   235 LPEGATNIRIEETVPSSNYLACR-NHSGHYYLNGDWRIDFPRPMFFANSWWNYQRKPMGFAAPDQ 298
            :|.||.:|.|:|...:.|:||.| :.|..|||||::.|.:........:.:||:|.    ...:.
Zfish   735 IPAGARDIYIQEVEEAGNFLAMRASDSDEYYLNGNYIIQWNGEYEAGGTKFNYERS----GNIEN 795

  Fly   299 LTCSGPISESLFIVMLVQEKNISLDYEYSI------------PESLSHSQQDTHTWTHHQFNACS 351
            ||.:||.:|.:.|.:|.||.|..:.|||:|            ||         :.|.|..:..||
Zfish   796 LTSAGPTTEPVMIQLLFQELNPGVKYEYTIKRRRPLGNEILEPE---------YIWKHGAWTDCS 851

  Fly   352 ASCGGGSQSRKVTC-NNRITLAEVNPSLCDQKSKPVEE-QACGTEPCAPHWVEGEWSKCSKGCGS 414
            .:||.|.|.:.|.| ...:.:.|.|  |||..::|.:: :.|.:..|...|..|.|..||..|||
Zfish   852 TTCGLGEQHQPVRCFEPEVGVVEEN--LCDPSTRPDDKHRKCKSRDCPARWWVGGWQTCSSTCGS 914

  Fly   415 DGFQNRSITCERISSSGEHTVEEDAVCLKEVGNKPATKQECNRDVKNCPKYHLGPWTPCDKLCGD 479
            .|.:.|:|.|.| :.:||..|.....|.:.:..|||.  .|||||....::.:|.|:.|.:.|..
Zfish   915 TGVKKRTILCVR-TVAGEERVLHPGDCKQLLKPKPAV--PCNRDVPCGSEWTVGNWSECSQSCDG 976

  Fly   480 GKQTRKVTC-------------------------------------------------------- 488
            |.::|.|.|                                                        
Zfish   977 GIKSRMVKCVAKQPSRCNPATRPRSTILCNLQSCSSTNRWTGPRFRPRKIPTQPPGTQTTQYSPT 1041

  Fly   489 -----------------------------FI--------------EENGHKRVLP---------- 500
                                         ||              :|.|...:.|          
Zfish  1042 ITPPNTSTPITTQSNTSPTSDIIHEDDKDFILVKKNNVAVPTITEDEEGSTDLQPPDKSYTPGYD 1106

  Fly   501 ---------EEDCVEEKPE-----------------TEKSCLLT-------------PC------ 520
                     |:|....|||                 |.|..:.|             .|      
Zfish  1107 YIEDPERIREDDLFTSKPEEVLISSVQPITMSAPVSTTKPAITTTIRTQYDGHLATHACAKTSLY 1171

  Fly   521 ----------------------------------------------------------------- 520
                                                                             
Zfish  1172 EFNSTPKPTLSHLNTLSSQVTVPTVKILRKALQTLKVPNKSNVLKAARLKLQMTTITDDDDGNLN 1236

  Fly   521 -----EGVDWIISQWSGCN-ACGQNTETRTAICGNKEGKVYPEEFC------EPEVPTLSRPC-- 571
                 :...|.:..||.|: :||.....|:..|.:|:     ||.|      ||......|||  
Zfish  1237 AQIVSKNAFWKVGNWSDCSTSCGLGAVWRSVSCSSKQ-----EEDCASVKKPEPARRCNLRPCAV 1296

  Fly   572 -------KSPK--------------------------CEA-----------------QWFSSEWS 586
                   |.|:                          |:|                 ||..|.|.
Zfish  1297 WKTGNWSKCPEGCVTDMKYREVQCIDTQNRRPLRPFHCQALSHKPPSSLPCNTLPCLQWMHSPWG 1361

  Fly   587 KCSAPCGKGVKSRIVICGEFDGKTVTPADDDSKCNKETKPESEQDCEGEEKVCPGEWFTGPWGKC 651
            :||..||.|||.|:|.|.|           :..||...||.|.:.|..:.  |.| |.|..|.:|
Zfish  1362 ECSKSCGHGVKERLVYCPE-----------NQHCNVTLKPNSTESCHLQP--CAG-WATEAWSQC 1412

  Fly   652 SKPCGGGERVREVLCLSNGTKSVNCDEEKV-------EPLS-EKCNSEACTED 696
            |:.||||.:.|.|.|::..:.    :|||.       :|.| :.|::|.|..|
Zfish  1413 SRSCGGGVQKRAVRCINEESG----EEEKASMCAIINKPDSVQNCSTEDCKTD 1461

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559 25/51 (49%)
ADAM_spacer1 214..329 CDD:283607 41/127 (32%)
TSP1 468..521 CDD:214559 22/276 (8%)
TSP_1 645..693 CDD:278517 18/55 (33%)
Kunitz_BPTI 1611..1663 CDD:278443
Kunitz_BPTI 1670..1721 CDD:278443
Kunitz_BPTI 1729..1781 CDD:278443
Kunitz_BPTI 1789..1840 CDD:278443
Kunitz_BPTI 1848..1899 CDD:278443
KU 1920..1973 CDD:238057
Kunitz_BPTI 2001..2051 CDD:278443
KU 2071..2121 CDD:238057
Kunitz_BPTI 2127..2178 CDD:278443
KU 2192..2245 CDD:238057
KU 2251..2304 CDD:238057
KU 2316..2372 CDD:238057
WAP 2457..2497 CDD:278522
Ig 2521..2610 CDD:299845
IG_like 2530..2610 CDD:214653
IG_like 2627..2703 CDD:214653
Ig 2636..2701 CDD:143165
IG_like 2766..2841 CDD:214653
Ig 2768..2830 CDD:299845
PLAC 2851..2883 CDD:285849
adamts12XP_021332071.1 Pep_M12B_propep 51..190 CDD:307618
ZnMc_ADAMTS_like 259..466 CDD:239801
ADAM_CR 529..689 CDD:326582 59/147 (40%)
TSP1 558..609 CDD:214559 25/50 (50%)
ADAM_spacer1 715..825 CDD:310520 40/114 (35%)
TSP1 960..1011 CDD:214559 8/50 (16%)
TSP_1 1358..1401 CDD:326556 19/55 (35%)
TSP1 1404..1458 CDD:214559 19/57 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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