DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atf3 and FOSL1

DIOPT Version :9

Sequence 1:	NP_001259125.1	Gene:	Atf3 / 43867	FlyBaseID:	FBgn0028550	Length:	688	Species:	Drosophila melanogaster
Sequence 2:	NP_005429.1	Gene:	FOSL1 / 8061	HGNCID:	13718	Length:	271	Species:	Homo sapiens

Alignment Length:	232	Identity:	50/232 - (21%)
Similarity:	96/232 - (41%)	Gaps:	77/232 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 LTPEDEDRRRRRRERNKIAATKCRMKKRERTQNLIKESEVLDTQNVELKNQVRQLETERQKLVDM 264
            ::||:|:|||.||||||:||.|||.:::|.|..|..|::.|:.:...|:.::.:|:.::::|..:
Human   100 ISPEEEERRRVRRERNKLAAAKCRNRRKELTDFLQAETDKLEDEKSGLQREIEELQKQKERLELV 164

  Fly   265 LKSHGCQRAGGCQLPSQLLQSPAQKYLSELELETVSIDGPNSGNNNQRLQSIPSMATFKYGSKTA 329
            |::|    ...|::|                      :|...|:                   |.
Human   165 LEAH----RPICKIP----------------------EGAKEGD-------------------TG 184

  Fly   330 AAMAQQLPNGYCKPSPSAQEFEHAGYQQQQQQQQQQQPQSLNPAGNNVIDQQHANPSPSLLSDYV 394
            :......|...|:|.|..                     ||:|   ..:.:..|..:|:|::  .
Human   185 STSGTSSPPAPCRPVPCI---------------------SLSP---GPVLEPEALHTPTLMT--T 223

  Fly   395 PNCDGLTGS------ASNHPSHNNNNNNNNSSGASSN 425
            |:....|.|      ::..|..:.:..:::|||..|:
Human   224 PSLTPFTPSLVFTYPSTPEPCASAHRKSSSSSGDPSS 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atf3	NP_001259125.1	bZIP_ATF3	215..268	CDD:269870	16/52 (31%)
Atf3	NP_001259125.1	coiled coil	215..265	CDD:269870	15/49 (31%)
FOSL1	NP_005429.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	68..112		6/11 (55%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	107..127		14/19 (74%)
		bZIP_Fos	115..168	CDD:269869	16/52 (31%)
		coiled coil	115..167	CDD:269869	16/51 (31%)
		PRK13729	129..>250	CDD:184281	28/191 (15%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	133..161		5/27 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	173..202		8/69 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	237..271		5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143229
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1414
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740