DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atf3 and Atf7

DIOPT Version :9

Sequence 1:	NP_001259125.1	Gene:	Atf3 / 43867	FlyBaseID:	FBgn0028550	Length:	688	Species:	Drosophila melanogaster
Sequence 2:	NP_001296995.1	Gene:	Atf7 / 223922	MGIID:	2443472	Length:	483	Species:	Mus musculus

Alignment Length:	369	Identity:	85/369 - (23%)
Similarity:	136/369 - (36%)	Gaps:	115/369 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 PKTPEILNSLIAMTNPLENFSYSSAAAAAAAVSVASSSASCS-------------AASTPVVTV- 76
            |.||:|   .|....|:|..|....:.|         |:.||             ..|||..|:
Mouse    99 PSTPDI---KIKEEEPVEVDSSPPDSPA---------SSPCSPPLKEKEVTTKPVVISTPTPTIV 151

  Fly    77 ------RHFNG---HPNGQSHSQDSSHSSCSGSPLDSPAGTATTPSVQ-----QTCSRLIKEGLK 127
                  .|...   ||...|.:...:.:..|...:.||.|  :.|.|.     ||...|....::
Mouse   152 RPGSLPLHLGYDPLHPTLPSPTSVITQAPPSNRQIGSPTG--SLPLVMHLANGQTMPMLPGPPVQ 214

  Fly   128 LS--IQSKRKLSTCD----------SSSGSEQP-------------HSKYSRRSSNHNGHSGSSN 167
            :.  |...|.:|...          ::|||..|             .:..:.:.|:.||..|...
Mouse   215 MPSVISLARPVSMVPNIPGIPGPPVNNSGSISPSGHPMPSEAKMRLKATLTHQVSSINGGCGMVV 279

  Fly   168 NYSGSMSNANDLDDDCEES----SDDDSETKSQPKGLTP----------------EDEDRRRRR- 211
            ..:.:|..|..     |::    ...|:.:.:||: ::|                ||.|.||:|
Mouse   280 GTASTMVTARP-----EQNQILIQHPDAPSPAQPQ-VSPAQPTPSTGGRRRRTVDEDPDERRQRF 338

  Fly   212 RERNKIAATKCRMKKRERTQNLIKESEVLDTQNVELKNQVRQLETERQKLVDMLKSH-GCQRAGG 275
            .|||:.||::||.|::....:|.|::|.|.:||::|.|:|..|..|..:|..:|.:| .|
Mouse   339 LERNRAAASRCRQKRKLWVSSLEKKAEELTSQNIQLSNEVTLLRNEVAQLKQLLLAHKDC----- 398

  Fly   276 CQLPSQLLQSPAQKYLSELE------------LETVSIDGPNSG 307
               |...||...|.||...:            ::..|...|::|
Mouse   399 ---PVTALQKKTQGYLESPKESSEPTGSPAPVIQHSSASAPSNG 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atf3	NP_001259125.1	bZIP_ATF3	215..268	CDD:269870	19/52 (37%)
Atf3	NP_001259125.1	coiled coil	215..265	CDD:269870	18/49 (37%)
Atf7	NP_001296995.1	Transactivation domain. /evidence=ECO:0000250	1..285		40/199 (20%)
		C2H2 Zn finger	9..31	CDD:275370
		GCN4_cent	47..84	CDD:213399
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..140		12/52 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	299..337		9/38 (24%)
		bZIP_ATF2	334..394	CDD:269835	24/59 (41%)
		coiled coil	334..394	CDD:269835	24/59 (41%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	334..354		11/19 (58%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	360..388		11/27 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910