DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atf3 and Fosl2

DIOPT Version :9

Sequence 1:	NP_001259125.1	Gene:	Atf3 / 43867	FlyBaseID:	FBgn0028550	Length:	688	Species:	Drosophila melanogaster
Sequence 2:	NP_032063.2	Gene:	Fosl2 / 14284	MGIID:	102858	Length:	326	Species:	Mus musculus

Alignment Length:	250	Identity:	68/250 - (27%)
Similarity:	113/250 - (45%)	Gaps:	50/250 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 LTPEDEDRRRRRRERNKIAATKCRMKKRERTQNLIKESEVLDTQNVELKNQVRQLETERQKLVDM 264
            |:||:|::||.||||||:||.|||.::||.|:.|..|:|.|:.:...|:.::.:|:.|::||..|
Mouse   119 LSPEEEEKRRIRRERNKLAAAKCRNRRRELTEKLQAETEELEEEKSGLQKEIAELQKEKEKLEFM 183

  Fly   265 LKSHGCQRAGGCQLPSQLLQSPAQKYLSELELETVSIDGPNSGNNNQRLQSIPSMATFKYGSKTA 329
            |.:||    ..|::..:..:||                 |.||     |||:...     ||...
Mouse   184 LVAHG----PVCKISPEERRSP-----------------PTSG-----LQSLRGT-----GSAVG 217

  Fly   330 AAMAQQLPNGYCKPSPSAQEFEHAGYQQQQQQQQQQQPQSLNPAGNNVIDQQHANPSPSLLSDYV 394
            ..:.:|.|.....||.||        ...:.|:...:|.|:  ||.....::     |......|
Mouse   218 PVVVKQEPPEEDSPSSSA--------GMDKTQRSVIKPISI--AGGGFYGEE-----PLHTPIVV 267

  Fly   395 PNCDGLTGSASN----HPSHNNNNNNNNSSGASSNTSNNNSNISSHSSNATSSTT 445
            .:...:|...||    :|:.....:.::.|.:.|.....:|:....||::.:|.|
Mouse   268 TSTPAITPGTSNLVFTYPNVLEQESPSSPSESCSKAHRRSSSSGDQSSDSLNSPT 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atf3	NP_001259125.1	bZIP_ATF3	215..268	CDD:269870	21/52 (40%)
Atf3	NP_001259125.1	coiled coil	215..265	CDD:269870	19/49 (39%)
Fosl2	NP_032063.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..131		6/11 (55%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	126..128		0/1 (0%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	129..136		5/6 (83%)
		bZIP_Fos	134..187	CDD:269869	21/52 (40%)
		coiled coil	134..186	CDD:269869	21/51 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	193..244		17/85 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	285..326		7/37 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833408
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1414
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740