DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atf3 and ATF7-NPFF

DIOPT Version :9

Sequence 1:	NP_001259125.1	Gene:	Atf3 / 43867	FlyBaseID:	FBgn0028550	Length:	688	Species:	Drosophila melanogaster
Sequence 2:	NP_001353488.1	Gene:	ATF7-NPFF / 114108587	HGNCID:	55073	Length:	463	Species:	Homo sapiens

Alignment Length:	334	Identity:	77/334 - (23%)
Similarity:	122/334 - (36%)	Gaps:	100/334 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PASSLLSIDSGGLLMGGHTPKTPEILNSLIAMTNPLENFSYSSAAAAAAAVSVASSSASCSAAST 71
            |.|.:.........||..|...|.:::.....|.|:   .........:.:|:|          .
Human   172 PTSVITQAPPSNRQMGSPTGSLPLVMHLANGQTMPV---LPGPPVQMPSVISLA----------R 223

  Fly    72 PVVTVRHFNGHPNGQSHSQDSSHSSCSGSPLDSPAGTATTPSVQQTCSRLIKEGLKLSIQSKRKL 136
            ||..|.:..|.|....:|  |...|.||.|:.|.|                |..||.::
Human   224 PVSMVPNIPGIPGPPVNS--SGSISPSGHPIPSEA----------------KMRLKATL------ 264

  Fly   137 STCDSSSGSEQPHSKYSRRSSNHNGHSGSSNNYSGSMSNANDLDDDCEES----SDDDSETKSQP 197
                            :.:.|:.||..|.....:.:|..|..     |:|    ...|:.:.:||
Human   265 ----------------THQVSSINGGCGMVVGTASTMVTARP-----EQSQILIQHPDAPSPAQP 308

  Fly   198 KGLTP----------------EDEDRRRRR-RERNKIAATKCRMKKRERTQNLIKESEVLDTQNV 245
            : ::|                ||.|.||:| .|||:.||::||.|::....:|.|::|.|.:||:
Human   309 Q-VSPAQPTPSTGGRRRRTVDEDPDERRQRFLERNRAAASRCRQKRKLWVSSLEKKAEELTSQNI 372

  Fly   246 ELKNQVRQLETERQKLVDMLKSH-GCQRAGGCQLPSQLLQSPAQKYLSELELE-----------T 298
            :|.|:|..|..|..:|..:|.:| .|        |...||...|.||...:..           |
Human   373 QLSNEVTLLRNEVAQLKQLLLAHKDC--------PVTALQKKTQGYLGGRQRTPPTTGCPDLWVT 429

  Fly   299 VSIDGPNSG 307
            |::..|.:|
Human   430 VALPAPGNG 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atf3	NP_001259125.1	bZIP_ATF3	215..268	CDD:269870	19/52 (37%)
Atf3	NP_001259125.1	coiled coil	215..265	CDD:269870	18/49 (37%)
ATF7-NPFF	NP_001353488.1	zf-C2H2	7..31	CDD:306579
		C2H2 Zn finger	9..31	CDD:275370
		GCN4_cent	47..84	CDD:213399
		bZIP_ATF2	334..394	CDD:269835	24/59 (41%)
		coiled coil	334..394	CDD:269835	24/59 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1414
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900