Protein Alignment HnRNP-K and NOVA1

DIOPT Version :10

• Sequence 1: NP_995906.1
• Gene: HnRNP-K / 43862
• FlyBaseID: FBgn0267791
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_002506.2
• Gene: NOVA1 / 4857
• HGNCID: 7886
• Length: 507
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 127/570 - (22%)
• Similarity: 203/570 - (35%)
• Gaps: 186/570 - (32%)

  Fly    16 EGPQD---QKRNRRNEE---TVRILIPSSIAGAVIGKGGQHIQKMRTQYKATVSVDDSQG--PER 72
            |.|.:   .||....|:   .:::||||..||::||||||.|.:::.:..||:.:..|:.  |..
Human    31 EAPPEAGSTKRTNTGEDGQYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKDFYPGT 95

  Fly    73 TIQISADIESTLEIITEMLKYFEERDEDF------------------------------------ 101
            |.::.. |:.|:|.:..:..:..|:..:.
Human    96 TERVCL-IQGTVEALNAVHGFIAEKIREMPQNVAKTEPVSILQPQTTVNPDRIKQTLPSSPTTTK 159

  Fly   102 -------------DVRLLIHQSLAGCVIGKGGQKIKEIRDRIGCRFLKVFSNVAPQS---TDRVV 150
                         .|::::..|.||.:|||||..:|.:.::.|.   .|..:..|..   .:|||
Human   160 SSPSDPMTTSRANQVKIIVPNSTAGLIIGKGGATVKAVMEQSGA---WVQLSQKPDGINLQERVV 221

  Fly   151 QTVGKQSQVIEAVREVITLTRDTPIKGAIHNYDPMNFDRVYADEYGGYGTGSGSTRPSQRGNNRN 215
            ...|:..|..:||..:|...::.|..|:..|..       ||:
Human   222 TVSGEPEQNRKAVELIIQKIQEDPQSGSCLNIS-------YAN---------------------- 257

  Fly   216 GGGAGGVAGGAAGGNGGGFNAGGARGNAGGRGGADRFGGAAGGAVAGAGMGQRDNPFIN-----P 275
                  |.|..|..|..|                                    :|:.|     |
Human   258 ------VTGPVANSNPTG------------------------------------SPYANTAEVLP 280

  Fly   276 WANGGGGDVDGFGNNAGGA------GGFAGNSFGGGAGGPFGGGSFGNN----GFGGGPSDFGGN 330
            .|....| :.|..|.||.|      .||.||.............|:|.|    |.|
Human   281 TAAAAAG-LLGHANLAGVAAFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLG--------- 335

  Fly   331 SGNFGQAQGTNSLPSLGSFSQNQGGTSSLPSLGSFGQNPGGPGGLGNGLSGGANGGVGTLGGANG 395
               ..||..|.:|.:..:.:......::|  |.::.......|....|.:|  ...:|:|..|..
Human   336 ---LSQAAATGALAAAAASANPAAAAANL--LATYASEASASGSTAGGTAG--TFALGSLAAATA 393

  Fly   396 A--GGFNAVGGANGGPNGSPNAATNV---PQGHDPNNS-TQVTIPKELAGAIIGKGGGRIRRIRN 454
            |  |.|.|         .||.||:.:   .:..|.:.. .::.:|:.|.|||:||||..:...:.
Human   394 ATNGYFGA---------ASPLAASAILGTEKSTDGSKDVVEIAVPENLVGAILGKGGKTLVEYQE 449

  Fly   455 ESSAYITID---EPLPNSNDRIITISGTPKQIQMAQYLLQQSV-HENGRR 500
            .:.|.|.|.   |.:|.:.:|.:||:|||...|.||||:.|.: :|.|.|
Human   450 LTGARIQISKKGEFVPGTRNRKVTITGTPAATQAAQYLITQRITYEQGVR 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HnRNP-K	NP_995906.1	KH-I_HNRNPK_rpt1	28..91	CDD:411860	22/67 (33%)
		KH-I_HNRNPK_rpt2	100..170	CDD:411861	21/121 (17%)
		KH-I_HNRNPK_rpt3	426..498	CDD:411862	27/76 (36%)
NOVA1	NP_002506.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		4/12 (33%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	27..43		4/11 (36%)
		KH-I_NOVA_rpt1	49..121	CDD:411863	22/72 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	139..171		0/31 (0%)
		KH-I_NOVA_rpt2	172..241	CDD:411864	21/71 (30%)
		Required for RNA binding. /evidence=ECO:0000269|PubMed:10811881	419..503		29/81 (36%)
		KH-I_NOVA_rpt3	422..492	CDD:411807	26/69 (38%)