DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HnRNP-K and ps

DIOPT Version :9

Sequence 1:	NP_995906.1	Gene:	HnRNP-K / 43862	FlyBaseID:	FBgn0267791	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001262415.1	Gene:	ps / 44258	FlyBaseID:	FBgn0261552	Length:	780	Species:	Drosophila melanogaster

Alignment Length:	549	Identity:	131/549 - (23%)
Similarity:	207/549 - (37%)	Gaps:	118/549 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 KRNRRNE----ET---VRILIPSSIAGAVIGKGGQHIQKMRTQYKATVSVDDSQG-----PERTI 74
            :.|..|.    ||   ::||:|:..:||:|||||:.|..::....|.|.:..|..     .||..
  Fly   260 ENNNNNHIHHGETTYHMKILVPAVASGAIIGKGGETIASLQKDTGARVKMSKSHDFYPGTTERVC 324

  Fly    75 QISADIES---TLEIITEML---------------KYFEERDEDFDVRLLIHQSLAGCVIGKGGQ 121
            .|:...|:   .:|.|.:.:               |..:|||:  .|::|:..|.||.:|||||.
  Fly   325 LITGSTEAIMVVMEFIMDKIREKPDLTNKIVDTDSKQTQERDK--QVKILVPNSTAGMIIGKGGA 387

  Fly   122 KIKEIRDRIGCRFLKVFSNVAPQSTD-----RVVQTVGKQSQVIEAVREVITLTRDTP------- 174
            .||:|::..|.     :..::.:.||     |.:..:|.:.....|.:.:::...:.|
  Fly   388 FIKQIKEESGS-----YVQISQKPTDVSLQERCITIIGDKENNKNACKMILSKIVEDPQSGTCLN 447

  Fly   175 -----IKGAIHNYDPMNFDRVYADEYGGYGTGSGSTRPSQRGNNRNGGGAGGVAGGAAG--GNGG 232
                 :.|.:.|::|..         ..|.|...:...|....|...|...|.|..||.  .||.
  Fly   448 VSYADVSGPVANFNPTG---------SPYATNQNAINSSTASLNSTLGTTIGGANSAASLLVNGT 503

  Fly   233 GFNAG---GARGNAGGRGGADRFGGAAGGAVAGAGMGQR-DNPFINPWANGGGGDVDGFG---NN 290
            |.|..   |:...|.....|.:.......|:.|:|..:. .|..:...:......|.|.|   ::
  Fly   504 GINLSINLGSPNPAPNLAVATQLLEHIKVAMRGSGYSETVTNEVVAALSVLAKYGVLGMGVGVSH 568

  Fly   291 AGGAGGFAGNSFG---------GGAGGPFGGGSFGNNGFGGGPSDFGGNSGNFGQ-AQGTNSLPS 345
            ..||....||..|         ..|........||..|           ..|..| |....|..:
  Fly   569 TNGAHSTLGNFLGVTTLDQQTAAAASAATASNVFGAVG-----------QVNLEQYAAAVASAAA 622

  Fly   346 LGSFSQNQGGTSSLP-----SLGSFGQNPGGPGGLGNGLSGGANGGVGTLGGANGAGGFNAVGGA 405
            ....:|:|...:::.     .|||.......|..|.|. |.|.....||           |....
  Fly   623 ASRPTQSQLDAAAVQFDPFRHLGSATAPAATPVSLNNN-SFGLTATTGT-----------ATTAQ 675

  Fly   406 NGGPNGSPNAATNVPQGHDPNNSTQVTIPKELAGAIIGKGGGRIRRIRNESSAYITIDEP---LP 467
            .||.:.||     .|......:|..|.:|:.:.|||:|..|..:..|::.|.|.:.|.:.   .|
  Fly   676 LGGLSKSP-----TPGDLSSKDSKNVEVPEVIIGAILGPSGRSLVEIQHVSGANVQISKKGIFAP 735

  Fly   468 NSNDRIITISGTPKQIQMAQYLLQQSVHE 496
            .:.:||:||:|.|..|..||||::|.::|
  Fly   736 GTRNRIVTITGQPSAIAKAQYLIEQKINE 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HnRNP-K	NP_995906.1	PCBP_like_KH	30..91	CDD:239089	21/71 (30%)
HnRNP-K	NP_995906.1	PCBP_like_KH	103..167	CDD:239089	19/68 (28%)
ps	NP_001262415.1	PCBP_like_KH	275..340	CDD:239089	19/64 (30%)
		PCBP_like_KH	368..433	CDD:239089	19/69 (28%)
		KH-I	696..759	CDD:238053	23/62 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439332
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10288
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940