DRSC/TRiP Functional Genomics Resources

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Protein Alignment HnRNP-K and HNRNPK

DIOPT Version :10

Sequence 1:NP_995906.1 Gene:HnRNP-K / 43862 FlyBaseID:FBgn0267791 Length:502 Species:Drosophila melanogaster
Sequence 2:NP_002131.2 Gene:HNRNPK / 3190 HGNCID:5044 Length:464 Species:Homo sapiens


Alignment Length:528 Identity:187/528 - (35%)
Similarity:239/528 - (45%) Gaps:129/528 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 RMKREMNDEGEGPQDQKRNRRNEETV--RILIPSSIAGAVIGKGGQHIQKMRTQYKATVSVDDSQ 68
            |...:|.:|    |..||:|..:|.|  |||:.|..|||||||||::|:.:||.|.|:|||.||.
Human    22 RPAEDMEEE----QAFKRSRNTDEMVELRILLQSKNAGAVIGKGGKNIKALRTDYNASVSVPDSS 82

  Fly    69 GPERTIQISADIESTLEII----------------------------TEMLKYFEERDEDFD--V 103
            ||||.:.||||||:..||:                            .|.|.|...:..|||  :
Human    83 GPERILSISADIETIGEILKKIIPTLEEGLQLPSPTATSQLPLESDAVECLNYQHYKGSDFDCEL 147

  Fly   104 RLLIHQSLAGCVIGKGGQKIKEIRDRIGCRFLKVFSNVAPQSTDRVVQTVGKQSQVIEAVREVIT 168
            ||||||||||.:||..|.||||:|:..... :|:|....|.||||||...||..:|:|.::.::.
Human   148 RLLIHQSLAGGIIGVKGAKIKELRENTQTT-IKLFQECCPHSTDRVVLIGGKPDRVVECIKIILD 211

  Fly   169 LTRDTPIKGAIHNYDPMNFDRVYADEYGGYGTGSGSTRPSQRGNNRNGGGAGGVAGGAAGGNGGG 233
            |..::||||....|||..:|..|  :|||:         :...::|.|...|             
Human   212 LISESPIKGRAQPYDPNFYDETY--DYGGF---------TMMFDDRRGRPVG------------- 252

  Fly   234 FNAGGARGNAGGRGGADRFGGAAGGAVAGAGMGQRDNPFINPWANGGGGDVDGFGNNAGGAGGFA 298
                   ....||||.||.....||.....  .:||...::| ..|......|    .||.||..
Human   253 -------FPMRGRGGFDRMPPGRGGRPMPP--SRRDYDDMSP-RRGPPPPPPG----RGGRGGSR 303

  Fly   299 GNSFGGGAGGPFGGGSFGNNGFGGGPSD-FGGNSGNFGQAQGTNSLPSLGSFSQNQGGTSSL--- 359
            ..:.......|..||........|.|.| :.|..|                ||.::...|::   
Human   304 ARNLPLPPPPPPRGGDLMAYDRRGRPGDRYDGMVG----------------FSADETWDSAIDTW 352

  Fly   360 -PSLGSFGQNPGGPGGLGNGLSGGANGGVGTLGGANGAGGFNAVGGANGGPNGSPNAATNVPQGH 423
             ||.......|.|..|.....:|| .|..|.|||                               
Human   353 SPSEWQMAYEPQGGSGYDYSYAGG-RGSYGDLGG------------------------------- 385

  Fly   424 DPNNSTQVTIPKELAGAIIGKGGGRIRRIRNESSAYITIDEPLPNSNDRIITISGTPKQIQMAQY 488
             |..:|||||||:|||:||||||.||::||:||.|.|.|||||..|.||||||:||..|||.|||
Human   386 -PIITTQVTIPKDLAGSIIGKGGQRIKQIRHESGASIKIDEPLEGSEDRIITITGTQDQIQNAQY 449

  Fly   489 LLQQSVHE 496
            |||.||.:
Human   450 LLQNSVKQ 457

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HnRNP-KNP_995906.1 KH-I_HNRNPK_rpt1 28..91 CDD:411860 38/92 (41%)
KH-I_HNRNPK_rpt2 100..170 CDD:411861 34/71 (48%)
KH-I_HNRNPK_rpt3 426..498 CDD:411862 49/71 (69%)
HNRNPKNP_002131.2 Necessary for interaction with DDX1. /evidence=ECO:0000269|PubMed:12183465 1..276 105/291 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37 6/18 (33%)
ROKNT 4..43 CDD:429813 8/24 (33%)
Interaction with ASFV p30 35..197 72/162 (44%)
KH-I_HNRNPK_rpt1 42..105 CDD:411860 36/62 (58%)
2 X 22 AA approximate repeats 54..421 148/454 (33%)
5 X 4 AA repeats of G-X-G-G 59..407 134/435 (31%)
KH-I_HNRNPK_rpt2 144..213 CDD:411861 32/69 (46%)
Interaction with ZIK1. /evidence=ECO:0000250 209..337 40/165 (24%)
RNA-binding RGG-box 236..273 14/65 (22%)
2 X 6 AA approximate repeats 245..329 24/110 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 250..329 22/105 (21%)
KH-I_HNRNPK_rpt3 387..460 CDD:411862 49/71 (69%)

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