DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HnRNP-K and Igf2bp3

DIOPT Version :9

Sequence 1:	NP_995906.1	Gene:	HnRNP-K / 43862	FlyBaseID:	FBgn0267791	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	XP_038963480.1	Gene:	Igf2bp3 / 312320	RGDID:	1306512	Length:	628	Species:	Rattus norvegicus

Alignment Length:	527	Identity:	106/527 - (20%)
Similarity:	183/527 - (34%)	Gaps:	127/527 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RLRMKREMNDEGE----GPQDQKRNRRNEETVRILIPSSIAGAVIGKGGQHIQKMRTQYKATVSV 64
            :||.:|.....|.    .|....:.:..:..:|:|:|:...||:|||.|..|:.:..|.::.:.|
  Rat   167 QLRGRRGPGQRGSSRQTSPGSVSKQKPCDLPLRLLVPTQFVGAIIGKEGATIRNITKQTQSKIDV 231

  Fly    65 ---DDSQGPERTIQI-------SADIESTLEII---TEMLKYFEERDEDFDVRLLIHQSLAGCVI 116
               :::...|::|.|       ||..:|.|||:   .:.:|:.||    ..:::|.|.:..|.:|
  Rat   232 HRKENTGAAEKSITILSTPEGTSAACKSILEIMHKEAQDIKFTEE----IPLKILAHNNFVGRLI 292

  Fly   117 GKGGQKIKEIRDRIGCRF-LKVFSNVAPQSTDRVVQTVGKQSQVIEAVREVITLTRDTPIKGAIH 180
            ||.|:.:|:|......:. :.....:...:.:|.:...|......:|..|::...|::      :
  Rat   293 GKEGRNLKKIEQDTDTKITISPLQELTLYNPERTITVKGNVETCAKAEEEIMKKIRES------Y 351

  Fly   181 NYDPMNFDRVYADEYGGYGTGSGSTRPSQRGNNRNGGGAGGVAGGAAGGNGGGFNAGGARGNAGG 245
            ..|..:.:.:|........||.......|
  Rat   352 ENDIASMNGLYHPLLASVSTGCTWRAAIQ------------------------------------ 380

  Fly   246 RGGADRFGGAAGGAVAGAGMGQRDNPFINPWANGG-------GGDVDGFGNNAGGAGGFAGNSFG 303
                     |.|.::   .|..||......:..|.       ...:.|...||.|.       |.
  Rat   381 ---------ATGTSI---HMYLRDKYTDTVFPRGSCILPKLQAHLIPGLNLNALGL-------FP 426

  Fly   304 GGAGGPFGGGSFGNNGFGGGPSDFGGNSGNFGQAQGTNSLPSLGSFSQNQGGTSSL--PSLGSFG 366
            ..:|.|              |...|..|.         ..|....|.|::..|..|  |:| |.|
  Rat   427 PTSGMP--------------PPTSGPPSA---------MTPPYPQFEQSETETVHLFIPAL-SVG 467

  Fly   367 QNPGGPGGLGNGLS--GGANGGVGTLGGANG-------AGGFNAVGGANGGPNGSPNAATNVPQG 422
            ...|..|.....||  .||:..:......:.       .|...|...|.|...|.......|...
  Rat   468 AIIGKQGQHIKQLSRFAGASIKIAPAEAPDAKVRMVIITGPPEAQFKAQGRIYGKIKEENFVSPK 532

  Fly   423 HDPNNSTQVTIPKELAGAIIGKGGGRIRRIRNESSAYITID-EPLPNSNDRIIT-ISGTPKQIQM 485
            .:......:.:|...||.:|||||..:..::|.|||.:.:. :..|:.||:::. |:|.....|:
  Rat   533 EEVKLEAHIRVPSFAAGRVIGKGGKTVNELQNLSSAEVVVPRDQTPDENDQVVVKITGHFYACQV 597

  Fly   486 AQYLLQQ 492
            ||..:|:
  Rat   598 AQRKIQE 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HnRNP-K	NP_995906.1	PCBP_like_KH	30..91	CDD:239089	21/73 (29%)
HnRNP-K	NP_995906.1	PCBP_like_KH	103..167	CDD:239089	13/64 (20%)
Igf2bp3	XP_038963480.1	RRM_SF	1..77	CDD:418427
		RRM2_IGF2BP3	81..156	CDD:410039
		KH-I_IGF2BP3_rpt1	197..272	CDD:411920	21/74 (28%)
		KH-I	275..359	CDD:412160	17/93 (18%)
		KH-I_IGF2BP3_rpt3	451..528	CDD:411926	18/77 (23%)
		KH-I_IGF2BP1_rpt4	536..611	CDD:411927	21/69 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D394765at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X348
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920