DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HnRNP-K and igf2bp3

DIOPT Version :9

Sequence 1:	NP_995906.1	Gene:	HnRNP-K / 43862	FlyBaseID:	FBgn0267791	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	XP_009292473.1	Gene:	igf2bp3 / 30967	ZFINID:	ZDB-GENE-000308-1	Length:	607	Species:	Danio rerio

Alignment Length:	540	Identity:	97/540 - (17%)
Similarity:	182/540 - (33%)	Gaps:	164/540 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KREMNDEGEGPQDQ-----KRNRRNEETVRILIPSSIAGAVIGKGGQHIQKMRTQYKATVSV--- 64
            :|..|..|...|..     :...:::..:|:|:|:...||:|||.|..|:.:..|..:.:.:
Zfish   169 RRGFNPRGPPRQGSPSLGARPKLQSDVPLRLLVPTQFVGAIIGKEGATIRNITKQTHSKIDIHRK 233

  Fly    65 DDSQGPERTIQISADIESTLEIITEMLKYFEER------DEDFDVRLLIHQSLAGCVIGKGGQKI 123
            :::...|:.|.:.:..|........:::..::.      .|:..:::|.|.:..|.:|||.|:.:
Zfish   234 ENAGAAEKPITVHSTPEGCSSACRNIMEIMQKEAIDTKITEEIPLKILAHNNFVGRLIGKEGRNL 298

  Fly   124 KEIRDRIGCRF-LKVFSNVAPQSTDRVVQTVGKQSQVIEAVREVITLTRDTPIKGAIHNYDPMNF 187
            |:|......:. :....::...:.:|.:...|......:|..|::...|::
Zfish   299 KKIEQDTDTKITISPLQDLTLYNPERTITVKGTLDACAKAEEEIMKKVRES-------------- 349

  Fly   188 DRVYADEYGGYGTGSGSTRPSQRGNNRNGGGAGGVAGGAAGGN---GGGFNAGGARGNAGGRGGA 249
               |.::                           ||......|   |...||.|.
Zfish   350 ---YEND---------------------------VAAMHLQSNLIPGLNLNALGL---------- 374

  Fly   250 DRFGGAAGGAVAGAGMGQRDNPFINPWANGGGGDVDGFGNNAGGAGGFAGNSFGGGAGGPFGGGS 314
              |.|||.|.::.:.:.                                    |...|...|..|
Zfish   375 --FPGAASGGISPSVVS------------------------------------GPPPGAQAGYQS 401

  Fly   315 FGNNGFGG----GPSDFGGNSGNFGQAQGTNS------LPSL--GSFSQNQGGTSSLPSLGSFGQ 367
            ||.:||.|    ..|....|||....:....|      :|:|  |:....||  ..:..|..|
Zfish   402 FGCSGFEGEVPFWASTLSSNSGCTAFSAQMESETVHLFIPALAVGAIIGKQG--QHIKQLSRF-- 462

  Fly   368 NPGGPGGLGNGLSGGANGGVGTLGGANGAGGFNAVGGANGGPNGSPNAATNVPQGH--------- 423
                         .||:..:....|.:.......:.|        |..|....||.
Zfish   463 -------------AGASIKIAPADGIDAKQRMVIISG--------PPEAQFKAQGRIFGKLKEEN 506

  Fly   424 --DPNNSTQ----VTIPKELAGAIIGKGGGRIRRIRNESSAYITID-EPLPNSNDRIIT-ISGTP 480
              .|....:    :.:|...||.:|||||..:..::|.:||.:.:. :..|:.||:::. |:|..
Zfish   507 FFGPKEEVKLEAHIKVPSFAAGRVIGKGGKTVNELQNLTSAEVVVPRDQTPDENDQVVVKITGHF 571

  Fly   481 KQIQMAQYLLQQSVHENGRR 500
            ...|:||..:|:.:.:..|:
Zfish   572 YASQLAQRKIQEIISQVRRQ 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HnRNP-K	NP_995906.1	PCBP_like_KH	30..91	CDD:239089	14/63 (22%)
HnRNP-K	NP_995906.1	PCBP_like_KH	103..167	CDD:239089	13/64 (20%)
igf2bp3	XP_009292473.1	RRM1_IGF2BP3	1..77	CDD:241071
		RRM2_IGF2BP3	81..156	CDD:241074
		KH-I	197..260	CDD:238053	14/62 (23%)
		KH-I	278..343	CDD:238053	13/64 (20%)
		KH-I	435..498	CDD:238053	15/87 (17%)
		KH-I	517..582	CDD:238053	19/64 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D394765at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X348
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920