DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nej and KAT2B

DIOPT Version :9

Sequence 1:	NP_001188575.1	Gene:	nej / 43856	FlyBaseID:	FBgn0261617	Length:	3282	Species:	Drosophila melanogaster
Sequence 2:	NP_003875.3	Gene:	KAT2B / 8850	HGNCID:	8638	Length:	832	Species:	Homo sapiens

Alignment Length:	1070	Identity:	196/1070 - (18%)
Similarity:	315/1070 - (29%)	Gaps:	379/1070 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   859 AGGAVGANDKQQLKVAQVHPQSHGVGAGGASAGAGASGGQVAAGSSVLMPADTTGS-------GN 916
            ||||                   |.|..||.|||||..|.:....:.|.||...||       |:
Human     4 AGGA-------------------GPGGCGAGAGAGAGPGALPPQPAALPPAPPQGSPCAAAAGGS 49

  Fly   917 AGNPNQNAGGVAGGAGGGNGGNTGPPGDNEKDWRESVTADLRNHL-VHKLVQA---------IFP 971
            .......|...||.|.|..||.:......:...|.:..|.....| |:...:|         ..|
Human    50 GACGPATAVAAAGTAEGPGGGGSARIAVKKAQLRSAPRAKKLEKLGVYSACKAEESCKCNGWKNP 114

  Fly   972 TSDPTTMQDKRMHNLVSYAEKVEKDMYEMAKSRSEYYHLLAEKIYKIQKELEEKRLKRKEQHQQM 1036
            ...||..:......:||        :.|..:|.|   |.||..:..::...|       |:..::
Human   115 NPSPTPPRADLQQIIVS--------LTESCRSCS---HALAAHVSHLENVSE-------EEMNRL 161

  Fly  1037 LMQQQGVANPVAGGAAGGAGSAAGVAGGVVLPQQQ-----QQQQQQQQQQGQQPLQSCIHPSISP 1096
            |                          |:||..:.     .:::....:|....|...:..||..
Human   162 L--------------------------GIVLDVEYLFTCVHKEEDADTKQVYFYLFKLLRKSILQ 200

  Fly  1097 MGGVMPPQQLRPQGP---PGILGQQTAAGLGVGVGVTNNMVTMRSHSPGGNMLALQQQQRM---- 1154
            .|..:....|..:.|   |.|  :|         ||.|.:....||.|......:.:..:|
Human   201 RGKPVVEGSLEKKPPFEKPSI--EQ---------GVNNFVQYKFSHLPAKERQTIVELAKMFLNR 254

  Fly  1155 ------QFPQQQQQQPPGSGAGKMLVGPPGPSPGGMVVNPALSPYQTT--------NV--LTSPV 1203
                  :.|.|::.:.|                     |..:|.|:..        ||  ....:
Human   255 INYWHLEAPSQRRLRSP---------------------NDDISGYKENYTRWLCYCNVPQFCDSL 298

  Fly  1204 PGQQQQQQFINANGGTGANPQLSEIMKQRHIHQQQQQQQQ--QQQQGMLLPQSP----------F 1256
            |..:..|.|     |......:..:|:::.:.|.:|::.:  .:::.::|...|          :
Human   299 PRYETTQVF-----GRTLLRSVFTVMRRQLLEQARQEKDKLPLEKRTLILTHFPKFLSMLEEEVY 358

  Fly  1257 SNSTPLQQQQQQQQQQQQQQQATSNSFSSPMQQQQQGQQQQQQKP---GSVLNNMPPTPTSLEAL 1318
            |.::|:..|               :..|:..:..|.|.|.....|   |::..|  .|.:|||..
Human   359 SQNSPIWDQ---------------DFLSASSRTSQLGIQTVINPPPVAGTISYN--STSSSLEQP 406

  Fly  1319 NAGAGAPGTGGSASNVTVSAPSPSPGFLSNGPSIGTPSNNNNNSSAN----NNPPSVSSLMQQPL 1379
            |||:.:|            |...|.|..:|      |......:.::    ...|.|...:...|
Human   407 NAGSSSP------------ACKASSGLEAN------PGEKRKMTDSHVLEEAKKPRVMGDIPMEL 453

  Fly  1380 SNRPGTPPYIPASPV-PATSASGLAASSTPASAA------------ATCASSGSGSNSSSGATAA 1431
            .|...:....||:.: |.|:.  |:|.|....||            ....|.....|........
Human   454 INEVMSTITDPAAMLGPETNF--LSAHSARDEAARLEERRGVIEFHVVGNSLNQKPNKKILMWLV 516

  Fly  1432 GASSTSSSSSAGSGTPLSS--VSTPTSATMATSSGGGGGGGGNAGGGSSTTPASNPLLLMSGGTA 1494
            |..:..|...........:  |..|...|:|                          |:..|...
Human   517 GLQNVFSHQLPRMPKEYITRLVFDPKHKTLA--------------------------LIKDGRVI 555

  Fly  1495 GGGTGATTTTSTSSSSRMMSSSSSLSSQMAALEAAARDNDDETPSPSGENTNGSGGSGNAGGMAS 1559
            ||           ...||..|.........|:             .|.|...|.|..     :.:
Human   556 GG-----------ICFRMFPSQGFTEIVFCAV-------------TSNEQVKGYGTH-----LMN 591

  Fly  1560 KGKLDSIKQDDDIKKEFMDDSCGGNNDSSQMDCSTGGGKGKNVNNDGTSMIKMEIKTEDGLDGEV 1624
            ..|...||.|......:.|:...|                              ...:.|...|:
Human   592 HLKEYHIKHDILNFLTYADEYAIG------------------------------YFKKQGFSKEI 626

  Fly  1625 KI-KTEAMDVDEAGGSTAGEHHGEGGGGSGVGGGKDNINGAHDGGATGG------------AVDI 1676
            || ||:.                       ||..||     ::|....|            :|.|
Human   627 KIPKTKY-----------------------VGYIKD-----YEGATLMGCELNPRIPYTEFSVII 663

  Fly  1677 KPKTE-TKPL------------------------VPEPLAPN--------AGDKKKKCQFNPEEL 1708
            |.:.| .|.|                        :|....|.        :|.:|.|...:|::|
Human   664 KKQKEIIKKLIERKQAQIRKVYPGLSCFKDGVRQIPIESIPGIRETGWKPSGKEKSKEPRDPDQL 728

  Fly  1709 RTALLPTLEKLYRQEPESVPFRYPVDPQALGIPDYFEIVKKPMDLGTIRTNIQNGKYSDPWEYVD 1773
            .:.|...|::: :....:.||..||  :....|.|:|:::.||||.|:...::|..|.....::.
Human   729 YSTLKSILQQV-KSHQSAWPFMEPV--KRTEAPGYYEVIRFPMDLKTMSERLKNRYYVSKKLFMA 790

  Fly  1774 DVWLMFDNAWLYNRKTSRVYRYCTKLSEVF 1803
            |:..:|.|...||...|..|: |..:.|.|
Human   791 DLQRVFTNCKEYNPPESEYYK-CANILEKF 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nej	NP_001188575.1	ZnF_TAZ	530..600	CDD:214717
		KIX	946..1024	CDD:280354	16/87 (18%)
		Bromo_cbp_like	1705..1812	CDD:99927	28/99 (28%)
		RING_CBP-p300	1824..1906	CDD:276805
		PHD_CBP_p300	1908..1939	CDD:277032
		HAT_KAT11	1970..2283	CDD:285432
		ZZ_CBP	2339..2379	CDD:239077
		ZnF_TAZ	2404..2476	CDD:214717
KAT2B	NP_003875.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..54		20/68 (29%)
		PCAF_N	75..325	CDD:368925	52/330 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	395..436		14/60 (23%)
		COG5076	487..826	CDD:227408	77/450 (17%)
		Acetyl-CoA binding. /evidence=ECO:0000269\|PubMed:10393169	574..576		0/1 (0%)
		Acetyl-CoA binding. /evidence=ECO:0000269\|PubMed:10393169	581..587		1/5 (20%)
		Acetyl-CoA binding. /evidence=ECO:0000269\|PubMed:10393169	612..615		0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	706..725		3/18 (17%)
		Bromo_gcn5_like	727..826	CDD:99941	27/97 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900