DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nej and YPL216W

DIOPT Version :9

Sequence 1:	NP_001188575.1	Gene:	nej / 43856	FlyBaseID:	FBgn0261617	Length:	3282	Species:	Drosophila melanogaster
Sequence 2:	NP_015108.1	Gene:	YPL216W / 855885	SGDID:	S000006137	Length:	1102	Species:	Saccharomyces cerevisiae

Alignment Length:	796	Identity:	152/796 - (19%)
Similarity:	250/796 - (31%)	Gaps:	316/796 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly  1675 DIKPKTETKPLVPEPLAPNAGDKKKKCQFNPEELRTALLPTLEKLYRQEPESVPFRYPVDPQALG 1739
            |:.||          .:||..|      :.|:.:.:    :..:||  .|.::|....|:|
Yeast   248 DVNPK----------CSPNMID------YLPDRMNS----SSSELY--TPLTIPPESDVEP---- 286

  Fly  1740 IPDYFEIVK------------KPMD------LGTIRTNIQNGKYSDPWEYVDDVWLMF------- 1779
             .|:.|..:            |.:|      ...|..|:.:..|:|....|||..|.|
Yeast   287 -ADWKETSETSETSETSLSKIKAIDDEISVSFDHIYDNVNSLAYNDLKGTVDDKELPFTGPSIPF 350

  Fly  1780 ------DNAWLYNRKTSRVYRYCTKLSEVFEAE-IDPVMQALGYCCGR-----KYTFNPQVLCCY 1832
                  |::..|.....:.::.|::    |..| :..|.|.|.: .||     .:.|: |.|...
Yeast   351 ENISYLDSSLEYKNIDQKWFKECSQ----FPTERLLVVYQFLSF-FGRFIGLSHFNFD-QFLTTI 409

  Fly  1833 GKQLCTIPRD-AKYYSYQNSLKEYG-----------------VASNRYTYCQKC--FNDIQGDTV 1877
               .||.|.. ...|...|.||.|.                 |.|:..:..:|.  ||..:...:
Yeast   410 ---KCTSPEALVDEYVKINFLKTYNSKGSFTNEKPRNEIYNQVTSSNVSQREKANVFNADESQRI 471

  Fly  1878 TLGDDPLQSQTQI---KKDQF--------KEMKNDHLELEPFVNCQECGRKQHQICVLWLDSIWP 1931
            .......|...:.   |..:|        |.:|||.:|.:.:          .::.:|::|
Yeast   472 PSNFTRNQKMRKFITDKSTEFVMYSIFKGKPLKNDDMEFQSY----------EKVNILYID---- 522

  Fly  1932 GGFVCD------------NCLKKKN---SKRKE--NKFNAKRLPTTKLGVYIETRVN-------N 1972
              .||.            ||....|   .||||  ||        |::.:.||..:|       .
Yeast   523 --IVCSLMCLMTDNEPDWNCNLMDNWTEEKRKEEGNK--------TEIDIAIEKCLNYGDTSWVK 577

  Fly  1973 FLKKKEAGAG------------EVHIRVVSSSDKCV--EVKPGMRRRFVEQG-EMMNEFPYRAKA 2022
            .|..|....|            ..|:...|...||:  ::.| :...||..| |:.:.|..|...
Yeast   578 LLHNKNFSNGNWLICLLGILQQNTHMIAYSDVAKCITKKILP-LSMNFVNLGDELWDNFRKRLSI 641

  Fly  2023 LFAFEEVDGIDVCF--------FGMHVQE------------------------------------ 2043
                  .|.|||.:        |..:::|
Yeast   642 ------KDKIDVLWVLVDFASNFSSYIKELVDKVPKLCNGIRLKLDSAKKEYIKLKRQLKTLTKN 700

  Fly  2044 ------------YGS-ECPAP-NTRRVYIAYL-DSVHFFRPRQYRTAVYHEILLG---------Y 2084
                        ||| ||... |..:|.|||| :.:.|...:..::.:....:||         :
Yeast   701 RVKLHSNVSMNRYGSDECKGKVNALKVKIAYLMEDIAFLEAKLIQSDIKRLEILGKDRNGNRYYW 765

  Fly  2085 MD------YVKQLG---YTMAHIWACPPSEGDDYIFHCHPTDQKIPKPKRLQEWYKKMLDK---- 2136
            ||      .:.:..   |....:|...|||.|  |..|...|     .:.|::|  ::|.|
Yeast   766 MDSNGSSSAISEKNEELYNCCFLWVQGPSEAD--INFCLDVD-----VESLKKW--ELLAKAKGT 821

  Fly  2137 ---------------GMIERIIQDY---------------------KDILKQAMEDKLGSAAELP 2165
                           |...:|.|..                     |.|:.:..|..|.|..:..
Yeast   822 AYATKEVFSIFRSTDGSYYQIAQGENFMIINSNGILMRPTIPAFIDKKIISETPEKLLLSHHQWA 886

  Fly  2166 YFEGDFWPNVLEESIKELDQEEEEKRKQAEAAEAAAAANLFSIEENEVSGDGKKKGQKKAKKSNK 2230
            :|      |.:|:....:|:.::.:..:.:..:|..:    .::..|||    .|.|.|.|:..:
Yeast   887 FF------NDIEDIHMLVDRLDDLRENEGQLKKALTS----KMDRIEVS----YKQQFKIKRRIE 937

  Fly  2231 SKAAQRKNSK--KSNE 2244
            .....:||.|  |:||
Yeast   938 CDETFKKNHKLLKNNE 953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nej	NP_001188575.1	ZnF_TAZ	530..600	CDD:214717
		KIX	946..1024	CDD:280354
		Bromo_cbp_like	1705..1812	CDD:99927	26/138 (19%)
		RING_CBP-p300	1824..1906	CDD:276805	24/112 (21%)
		PHD_CBP_p300	1908..1939	CDD:277032	4/42 (10%)
		HAT_KAT11	1970..2283	CDD:285432	76/416 (18%)
		ZZ_CBP	2339..2379	CDD:239077
		ZnF_TAZ	2404..2476	CDD:214717
YPL216W	NP_015108.1	WAC_Acf1_DNA_bd	26..124	CDD:287503
		DDT	375..435	CDD:214726	18/68 (26%)
		WHIM1	626..667	CDD:292246	10/46 (22%)
		WHIM2	750..793	CDD:292247	6/42 (14%)
		WHIM3	885..923	CDD:292248	5/47 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900