DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nej and ITC1

DIOPT Version :9

Sequence 1:	NP_001188575.1	Gene:	nej / 43856	FlyBaseID:	FBgn0261617	Length:	3282	Species:	Drosophila melanogaster
Sequence 2:	NP_011382.1	Gene:	ITC1 / 852744	SGDID:	S000003101	Length:	1264	Species:	Saccharomyces cerevisiae

Alignment Length:	1072	Identity:	192/1072 - (17%)
Similarity:	347/1072 - (32%)	Gaps:	378/1072 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1556 GMASKGKLDSIK-QDDDIKKEFMDDSCGGNNDSSQMDCSTGGGKGK-NVNNDGTSMIKMEIKTED 1618
            |:..:...|.:| ::|:.......:|...::..|:.:.......|| |.:||.::
Yeast   258 GLTMEWPKDMLKYKEDEPVVARRSNSANVSSPESEKNKRQSKSSGKSNTSNDASN---------- 312

  Fly  1619 GLDGEVKIKTEAMDVDEAGGSTAGEHHGEGGGGSGVGGGKDNINGAHDGGATGGAVDIKPKTETK 1683
              ..|.|.|.:..:|:::..:::.|...:|          .|:.                 :||.
Yeast   313 --KKETKKKRKPTEVNDSENNSSEEDKKKG----------QNVT-----------------SETH 348

  Fly  1684 PLVPEPLAPNAGDKKKKCQFNPEELRTALLPTLEKLYRQEPESVPFRYPVDPQALGIPDYFEIVK 1748
                        .||:|.:.|.|       |..|.:     ||||.....:|||:.|....:
Yeast   349 ------------SKKRKKEANEE-------PNTENV-----ESVPTPANAEPQAVTITSIMD--- 386

  Fly  1749 KPMDLGTIRTNIQNGKYSDPWEYVDDVWLMFDNAWLYNRKTSRVYRYCTKLSEVFEAEIDPVMQA 1813
               ||..            |:::..::   |.|...||.|...:....||||..|:: ...::||
Yeast   387 ---DLAL------------PYQHPPNI---FPNLTYYNEKLECISLGSTKLSRPFDS-FGKLLQA 432

  Fly  1814 LGYCCGRKYTFNPQVLCCYGKQLCTIPRDAKYYSYQNSLKEYGVASNRYTYCQKCFN--DIQGDT 1876
            .            |.|..:|.::|              |..:.:  :::....||.:  :::|:.
Yeast   433 Y------------QFLNTFGSKIC--------------LSHFSL--DQFITSLKCTDPYELKGEV 469

  Fly  1877 VTLGDDPLQSQTQIKKDQFKEMKNDHLELEPFVNCQECGRKQHQICVLWLDSIWP-----GGFVC 1936
            |.     :..:||..|:|  |::|:.|   |..|..|...::        ||..|     ..|:.
Yeast   470 VL-----VNIRTQTSKEQ--EIENNGL---PMKNKAETTTEE--------DSENPSDWQRNSFIR 516

  Fly  1937 DNCLKKKNSKRKENKF----------------NAKRLP----TTKLGVYIETR-------VNNFL 1974
            | .:.|:||.:.|.|.                |...|.    |..|.::|...       |.|::
Yeast   517 D-MIMKRNSDKVEYKIVHDDPASDDILDNINHNGSALLIEVFTALLRLFINEEGDWSCIVVENWI 580

  Fly  1975 ---------KKKEAGAGE------VHIRVVSSSDKCVEVKPGMRRRFVE---QGEMMNEFPYR-- 2019
                     :|.|.|.||      .|...:...:|...:|..::....|   :.:..||....
Yeast   581 IDDKGVLMERKDERGEGEAKQKRNAHGYFLQDKEKIDNLKDTLKENATEVQKESDAKNETNSESD 645

  Fly  2020 AKALFAFEEVD-GIDVCFFGMHVQEYGSECPAPNTRRVYIAYLDSVHFFRPRQYRTAVYHEILLG 2083
            :|:....||.| .::.|.               |.|.|     :.:.....||:..:.:..||||
Yeast   646 SKSDSDSEERDPKLEKCL---------------NYRNV-----NWIERLTKRQFNNSYWLIILLG 690

  Fly  2084 YMDYVKQLGYTMAHIWACPPSEGDDYIFHCHPTDQKIPK-------PKRLQEWYKKML---DK-- 2136
            .::..:.|......|        |.:|      ::.|||       ||:|...:.:.|   ||
Yeast   691 VLEDCRHLPMYTEFI--------DSFI------EKIIPKDISATQLPKQLWRNFCRKLSFSDKVN 741

  Fly  2137 --GMIERIIQDYKDILKQAMEDKL------------------GSAAELPYFEGDFWPNVLEESIK 2181
              .::..::..:...:|.|::|.:                  ..||.|...:||.  ..::|.:.
Yeast   742 ALWILVDLVSHFSPDIKAAVDDSMELCGQIRSERFKVARELKTEAAVLSNLQGDL--QAIQEKLN 804

  Fly  2182 ELDQ---------------------------------EEEEKRKQAEAAEAAAAAN--------- 2204
            :.|:                                 ||::|:.||..::.....|
Yeast   805 KTDENTPSADGADKKDDSESNSEPIDLIIIEKKQKLIEEQDKKVQALQSDKNFLDNCLFENDLQR 869

  Fly  2205 ------------LFSIEENEVSGDGKKKGQKKAKKSNKS-------------KAAQRKNSKKSNE 2244
                        .|.::.|.|.......|..:..|||.|             ||:..|.....::
Yeast   870 LKPLGLDRYGNRYFWLDHNGVPFPQYPAGMNETPKSNNSLSYHSGRLLIQGPKASSAKFFLNVSD 934

  Fly  2245 HQSGN---------------------DLSTKIYATMEKHKEVFFVIRLHSAQSAASLAPIQDPDP 2288
            .|..|                     ..|:..|..:|...||..:...........|.|||.
Yeast   935 EQLSNWQKIRNSEGISEATREVFGISKTSSGSYNYVENGIEVELLDSNDRVNPLIELTPIQK--- 996

  Fly  2289 LLTCDLMDGRDAFLTLARDKHFEFSSLRRAQFSTLSMLYE-LHNQGQDKFVY------TCNHCKT 2346
                .:||...:.|.|:.|:.:....|     ..||.:.: |.|.|:.:...      .....|:
Yeast   997 ----KIMDETPSRLLLSPDQWYCIDKL-----EDLSRIMDWLDNWGRKEHDLLRQIRPIMERIKS 1052

  Fly  2347 AVETRYHCTVCDDF--DLCIVCKEKVGHQHKMEKL---GFDIDDGSALADHK---QANPQEARKQ 2403
            ::..|.|......|  :...:.||...::....:|   ..|:||.::....:   |.:.:|.|:.
Yeast  1053 SLSLRDHALSLTAFTKNEEKLLKELENNEFTENELNVDSMDVDDKNSGVKSEVDVQVDAEEKREA 1117

  Fly  2404 SIQRCIQSLAHACQCRDANCRLPSCQKMKLVV 2435
            .|...::.:|      |...:|....|.:.|:
Yeast  1118 VIDEKLEVIA------DELMKLDDSSKTRNVL 1143

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nej	NP_001188575.1	ZnF_TAZ	530..600	CDD:214717
		KIX	946..1024	CDD:280354
		Bromo_cbp_like	1705..1812	CDD:99927	24/106 (23%)
		RING_CBP-p300	1824..1906	CDD:276805	16/83 (19%)
		PHD_CBP_p300	1908..1939	CDD:277032	7/35 (20%)
		HAT_KAT11	1970..2283	CDD:285432	75/453 (17%)
		ZZ_CBP	2339..2379	CDD:239077	6/47 (13%)
		ZnF_TAZ	2404..2476	CDD:214717	6/32 (19%)
ITC1	NP_011382.1	WAC_Acf1_DNA_bd	24..124	CDD:402251
		DDT	423..483	CDD:214726	16/95 (17%)
		WSD	869..952	CDD:406128	13/82 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900