DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nej and BDF2

DIOPT Version :9

Sequence 1:	NP_001188575.1	Gene:	nej / 43856	FlyBaseID:	FBgn0261617	Length:	3282	Species:	Drosophila melanogaster
Sequence 2:	NP_010213.1	Gene:	BDF2 / 851488	SGDID:	S000002228	Length:	638	Species:	Saccharomyces cerevisiae

Alignment Length:	680	Identity:	143/680 - (21%)
Similarity:	232/680 - (34%)	Gaps:	198/680 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1423 NSSSGATAAGASSTSSSSSAGSGTPLSSVSTPTSATMATSSGGGGGGGGNAGGGSSTTPASNPL- 1486
            ::.|...||..|:|::|.|:.|.:..||.....:.          |.|.::|..|:.:....|.
Yeast    10 HAHSALLAAPQSATANSRSSNSSSESSSNKNNINV----------GVGDDSGNVSAVSIDDGPHF 64

  Fly  1487 --LLMSGGTAGGGTGATTTTSTSSSSRMMSSSSSLSSQMA-------------------ALEAAA 1530
              :...|........::..|:.:|||....:.|.:|...|                   ||||..
Yeast    65 RDIFHYGHEENYKLASSGITNLNSSSHAHQTLSPISISNASTPESFPEHPLGLERETEPALEAEM 129

  Fly  1531 RDNDDETPSPSGENTNGSGGSGNAGGMASKGKLDSIKQDDDIKK--------------------- 1574
              ..:|.|...                 ||..|.|||....:|.
Yeast   130 --EAEELPPHQ-----------------SKYLLSSIKATKRLKDARPFLKPVDPIALNIPHYFNY 175

  Fly  1575 -------EFMDDSCGGN---------NDSSQM--DCSTGGGKGKNVNNDGTSMIKMEIKTEDGLD 1621
                   ..::....||         :|...|  :|....|...::::....:.|...|....:.
Yeast   176 VQTPMDLSLIETKLQGNVYHSVEQVTSDFKTMVDNCLNFNGPESSISSMAKRIQKYFEKKLSAMP 240

  Fly  1622 GEV------------KIKTEAMD---VDEAGGSTAGEHHGEGGGGSGVGGGKDNINGAHDGGATG 1671
            ..|            :.|.|.||   |.....||..::.||.|...||.||
Yeast   241 PRVLPASALKKTSRNRKKNEDMDSPLVIRRSVSTTNDNIGESGNREGVSGG-------------- 291

  Fly  1672 GAVDIKPKTETKPLVPEPLAPNAGDKKKKCQFNPEELRTALLPTLEKLYRQEPESV--PFRYPVD 1734
                 :||....|...:.|.....:.|.|.:...::.||. |..|:.|..::...:  ||..|||
Yeast   292 -----RPKRTIHPPKSKDLFDIYENSKPKSKTLQKKFRTC-LKILKVLMSKKNSDINFPFLQPVD 350

  Fly  1735 PQALGIPDYFEIVKKPMDLGTIRTNIQNGKYSDPWEYVDDVWLMFDNAWLYNRKTSRVYRYCTKL 1799
            |.||.:|:||::||.|||||||..|:.|.||....::|||:.|:|.|.:.:|.:.:.|:....||
Yeast   351 PIALNLPNYFDVVKNPMDLGTISNNLMNWKYKTIDQFVDDLNLVFYNCFQFNPEGNEVHSMGKKL 415

  Fly  1800 SEVF------------EAEIDPVMQ----ALGYCCGRKY---------TFNPQVLCCYGK----- 1834
            .|:|            |.|.|..::    :..|....:|         ..||.:.....|
Yeast   416 KELFNFHWLENQDILNEIETDSDLEEDNYSSSYSSDDEYDDEDINENDITNPAIQYLEQKLKKME 480

  Fly  1835 -QLCTIPR-DAKYYSYQNSLKEYGVASNRYTYCQKCFNDIQGDTVT-----LGDDPLQSQTQIKK 1892
             :|..:.| :....|.:...|..|....|....:...:|:: .::|     |.|..:....:|.|
Yeast   481 VELQQLKRQELSKLSKERKRKHLGKTLLRRKAMKHSVDDLK-KSITDKINELSDLEMNGMIRIIK 544

  Fly  1893 -----DQFKEMKNDHLELEPFVNCQECGRKQHQICVLWLDSIWPGGF--VCDNCLKKKNSKRKEN 1950
                 |:......|.:|::                   ||.:.....  :.:...:|||:...:.
Yeast   545 NSLPADEILTSNEDEIEID-------------------LDILDEATIARIYERYFEKKNNNNSKR 590

  Fly  1951 KF--NAKRLPTTKLGVYIETRVNNFLKKKE 1978
            |.  |....||.|     :.:...||:|.|
Yeast   591 KLSGNYSTAPTNK-----KKKTLKFLEKDE 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nej	NP_001188575.1	ZnF_TAZ	530..600	CDD:214717
		KIX	946..1024	CDD:280354
		Bromo_cbp_like	1705..1812	CDD:99927	44/120 (37%)
		RING_CBP-p300	1824..1906	CDD:276805	18/98 (18%)
		PHD_CBP_p300	1908..1939	CDD:277032	2/32 (6%)
		HAT_KAT11	1970..2283	CDD:285432	4/9 (44%)
		ZZ_CBP	2339..2379	CDD:239077
		ZnF_TAZ	2404..2476	CDD:214717
BDF2	NP_010213.1	COG5076	55..378	CDD:227408	77/361 (21%)
		Bromodomain	<344..419	CDD:413371	35/74 (47%)
		Lebercilin	<472..>537	CDD:406132	11/65 (17%)
		BET	521..576	CDD:407211	10/74 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810