DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nej and HAC2

DIOPT Version :9

Sequence 1:	NP_001188575.1	Gene:	nej / 43856	FlyBaseID:	FBgn0261617	Length:	3282	Species:	Drosophila melanogaster
Sequence 2:	NP_564891.4	Gene:	HAC2 / 843042	AraportID:	AT1G67220	Length:	1367	Species:	Arabidopsis thaliana

Alignment Length:	1416	Identity:	320/1416 - (22%)
Similarity:	540/1416 - (38%)	Gaps:	340/1416 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1343 PGFLSNGPSIGTPSNNNNNSSANNNPPSVSSLM--------------QQPLSNRPGTPPYIPASP 1393
            |.|| |..|....:...||..|.:|..|.....              ::||.....:|..:..||
plant    13 PKFL-NTESFDEFNQRLNNLPAESNVTSDEDAQFLESRKCQSKRWRKEEPLKLNLRSPWNVLCSP 76

  Fly  1394 VPATSASGLAASS---------TPASAAATC-------ASSGSGSNSSSGA----------TAAG 1432
            ...:||..:...:         ..|:.|..|       .||||.|.::||:          :.:.
plant    77 ESISSAKFIVEKTCLIPVPSFEEAATNARRCLNTSSIPGSSGSASETNSGSDITKQDFKNDSPSD 141

  Fly  1433 ASSTSSSSSAGSGTP--------LSSVSTPTSATMATSSGGGG-----------------GGGGN 1472
            :.....||::.|..|        :..|:|.....:.|......                 .....
plant   142 SKKVQGSSTSKSAKPKVIKVYSFVDLVTTTKKGNIQTEESSLNHEKKLGTVVDIVEPMKCDERSK 206

  Fly  1473 AGGGSSTTPASNPLLLMSGGTAGGGTGATTT------TSTSS----------------------S 1509
            ...||||:.::.|.::.....|   ...|||      |..||                      |
plant   207 EVQGSSTSKSAKPKVIKVYSFA---DVVTTTKKGNIQTEESSLNHEKKLGTVVDIIEPMKCDERS 268

  Fly  1510 SRMMSSSSSLSSQMAALE--------AAARDNDDETPSPSGENTNGSGG---------------- 1550
            ..:..||:|.|:::..::        ...:..:.:|...|..:....|.
plant   269 KEVQGSSTSKSAKLKVIKVYSFADVVTTTKKGNIQTEESSLNHEKKLGTVVDIVEPMKCDERSKE 333

  Fly  1551 -SGNAGGMASKGKLDSIKQDDDI-----KKEFMDDSCGGNNDS---------SQMDCSTGGGKGK 1600
             .|::...:.|.|:..:....|:     |.....:....|::.         ..|.|..|
plant   334 VQGSSTSKSEKPKVIKVYSFADVVTTTKKGNIQTEESSLNHEKKLGTVVDIVEPMKCDEG----- 393

  Fly  1601 NVNNDGTSMIKMEIKTED-GLDGEVKIKT-----EAMDVDEAG---------GSTAGEHHG---E 1647
             ...:.|:..|.:|.||: .|:.|.|:.|     |.|..||..         |:|..|...   |
plant   394 -TKCEVTTTNKGKIHTEERSLNHEKKLGTVVDIVEPMKCDEGSKCEVTTTNKGNTQTEERSLNHE 457

  Fly  1648 GGGGSGVG---------GGKDNINGAHDGGATGGAVDIKPKTETKPLVPEP--------LAPNAG 1695
            ...|.||.         |.|..:...:.|         |.:||.:.|..|.        :.|...
plant   458 KKLGIGVDIVEPMKCDEGTKCEVTTTNKG---------KIQTEERSLNYEKKLGIGVDIVEPMKC 513

  Fly  1696 DKKKKCQFNPEELRTALLPTLE--KLYRQEPESVPFRYPVDPQALGIPDYF---EIVKKPMDLGT 1755
            |::.||:.|.:.....::..::  |:.:.|..       ||...:.|.:..   |:.|..:::.|
plant   514 DEENKCEVNADTFDVVIVEPMKCNKVTKCEVN-------VDTTGVNIVEPMKCNEVTKCEVNVDT 571

  Fly  1756 IRTNIQNGKYSDPWEYVDDVWLMFDNAWLYNRKTSRVYRYCTKLSEVFEAEIDPVMQAL------ 1814
            |..:|     .:|.:..::.....:...:..:|.|:  |..:.:....|.||...:.:|
plant   572 IGVDI-----VEPMKCNEESKCEVNADTMSLQKRSK--RAVSLVERFTEEEIKLHIMSLKKPSTQ 629

  Fly  1815 ----GYCCGRK------------YTFNPQVLCCYGKQLCTIPRDAKYYSYQNSLKEYGVASNRYT 1863
                |.|..::            ..|.||.|.|.   ||:...|.:.:.|....:|  :::.::.
plant   630 SAVEGMCDLKEEEESCQLCDDGTLLFPPQPLYCL---LCSRRIDDRSFYYTPGEEE--LSNAQHQ 689

  Fly  1864 YCQKCFNDIQGDTVTLGDDPLQSQTQIKKDQFKEMKNDHLELEPFVNCQECGRKQHQICVLW--- 1925
            .|..|.:..:......|.. :.....:|:..|     |:.:.|.:|.|:.|.:.|||||.|:
plant   690 ICSPCHSRCKTKFPLCGVF-IDKHKMLKRSNF-----DNADTEEWVQCESCEKWQHQICGLYNKL 748

  Fly  1926 LDSIWPGGFVCDNCLKKKNSKRKE------NKFNAKRLPTTKLGVYIETRVNNFLKKKEAGAGE- 1983
            .|......::|..||.::......      ....||.||.|.|..::|.|:...||::.....:
plant   749 KDEDKTAEYICPTCLLEECQSINNMALVDYTDSGAKDLPETVLSYFLEQRLFKRLKEERYQTAKA 813

  Fly  1984 -------------VHIRVVSSSDKCVEVKPGMRRRF---VEQGEMMNEFPYRAKALFAFEEVDGI 2032
                         :.:|||.|:|:.:.|    .::|   :.:....:|||||:|.:..|::|.|:
plant   814 TGKSINDVPEPEGLTLRVVFSADRTLTV----NKQFASLLHKENFPSEFPYRSKVILLFQKVHGV 874

  Fly  2033 DVCFFGMHVQEYGSECPAPNTRRVYIAYLDSVHFFRPRQ-------YRTAVYHEILLGYMDYVKQ 2090
            |:|.|.:.|||:||||..||.|..||.|||||.:|:|.:       .||.||||:|:||::|.|.
plant   875 DICIFALFVQEFGSECSQPNQRSTYIFYLDSVKYFKPERVTFAGEALRTFVYHEVLIGYLEYCKL 939

  Fly  2091 LGYTMAHIWACPPSEGDDYIFHCHPTDQKIPKPKRLQEWYKKMLDKGMIERIIQDYKDILKQAME 2155
            .|:|.::||||||..|.|||.:.||..|:.|..|:|::||..||.|...:|::.:..::..:..:
plant   940 RGFTTSYIWACPPKIGQDYIMYSHPKTQQTPDTKKLRKWYVSMLQKAAEQRVVMNVTNLYDRFFD 1004

  Fly  2156 --DKLGSAAELPYFEGDFWPNVLEESIKELDQE-EEEKRKQAEAAEAAAAANLFSIEENEVSGDG 2217
              ::..:||.||||||.||.|..|..|:::::| ..|.:|:.:.........:......:|..|.
plant  1005 STEEYMTAARLPYFEGSFWSNRAEIMIQDIEREGNNELQKKVKLLSRRKVKTMSYKTTGDVDVDD 1069

  Fly  2218 KK------KGQKKAKKSNKSKAAQRKN------------------SKKSNEH------QSGNDL- 2251
            .|      |.:|:...:.|.......|                  .|..|.|      .:|.:|
plant  1070 VKNILLMEKLEKEVFPNKKDLMVVELNYSCTRCSKAVLSGLRWFCEKCKNLHLCESCYDAGQELP 1134

  Fly  2252 STKIYATMEKHKEVFFVIRLHSAQSAASLAPIQDPDPLLTCDLMDGRDAFLTLARDKHFEFSSLR 2316
            ...||..|:|.|.....::::....:.:    :|.|.:...|:.:.|.|||..::..::.|.:||
plant  1135 GEHIYKRMDKEKHQLSKVQVNGVLFSTT----EDNDIIQENDMFESRQAFLAFSQKHNYNFHTLR 1195

  Fly  2317 RAQFSTLSMLYELHNQ-----GQDKFVYTCNHCKTAVETR--YHCTVCDDFDLCIVCKEK---VG 2371
            .|:.|::.:|:.||..     .|:....||..||..|.|.  :.|.:|.|:..|..|..|   :.
plant  1196 HAKHSSMMILHHLHTSNKHHCSQNSSSLTCTACKKDVSTTIYFPCLLCPDYRACTGCYTKNRTLR 1260

  Fly  2372 HQHKMEKLGFDIDDGSALADHKQANPQEARKQSIQRCIQSLAHACQCR---DANCRLPSCQKMKL 2433
            |.|....|             ..||...:|...:...:.:::||..|:   ..:|..|.|.::|.
plant  1261 HLHIFPTL-------------PSANRAPSRTVMVLEILNAISHALLCQHKTTKSCSYPKCHEVKA 1312

  Fly  2434 VVQHTKNCK-RKPNGGCPICKQLIALCCYHAKNCEEQKCPVPFCPNIKHKL 2483
            :..|...|| ||....|..|.:|......|..:|::..||||.|.:.|..|
plant  1313 LFTHNVQCKIRKKGTRCNTCYKLWQTIRIHVYHCQDLNCPVPQCRDRKEVL 1363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nej	NP_001188575.1	ZnF_TAZ	530..600	CDD:214717
		KIX	946..1024	CDD:280354
		Bromo_cbp_like	1705..1812	CDD:99927	17/111 (15%)
		RING_CBP-p300	1824..1906	CDD:276805	16/81 (20%)
		PHD_CBP_p300	1908..1939	CDD:277032	11/33 (33%)
		HAT_KAT11	1970..2283	CDD:285432	108/370 (29%)
		ZZ_CBP	2339..2379	CDD:239077	14/44 (32%)
		ZnF_TAZ	2404..2476	CDD:214717	21/75 (28%)
HAC2	NP_564891.4	PHD_HAC_like	690..762	CDD:277086	18/77 (23%)
		HAT_KAT11	822..>1025	CDD:413203	83/206 (40%)
		ZZ	1099..>1128	CDD:412288	3/28 (11%)
		ZZ_dah	1223..1268	CDD:239085	14/44 (32%)
		ZnF_TAZ	1275..1357	CDD:214717	22/81 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	206	1.000	Domainoid score	I822
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2820
orthoMCL	1	0.900	-	-		OOG6_101987
Panther	1	1.100	-	-	O	PTHR13808
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X719
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.900