DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nej and HAC4

DIOPT Version :9

Sequence 1:	NP_001188575.1	Gene:	nej / 43856	FlyBaseID:	FBgn0261617	Length:	3282	Species:	Drosophila melanogaster
Sequence 2:	NP_001319247.1	Gene:	HAC4 / 842048	AraportID:	AT1G55970	Length:	1470	Species:	Arabidopsis thaliana

Alignment Length:	1637	Identity:	367/1637 - (22%)
Similarity:	594/1637 - (36%)	Gaps:	529/1637 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1206 QQQQQQFINANGGTGANPQLSEIMKQRHIHQQQQQQ------QQQQQQGMLLPQSPFSNSTPLQQ 1264
            ||....||... .|....::..|::    |:|:|.|      .|||||.:    ...:....|::
plant    28 QQDANNFIKKR-RTALRNRIYAIVR----HKQKQHQIFLDKKNQQQQQRV----DDATQRALLEK 83

  Fly  1265 QQQQ----QQQQQQQQQATSNSFSS------------PMQQQQQGQQQQQQKPGSVLNN-MPPTP 1312
            |.||    .:..:::...:|.||..            .:.||......|::...:.:|| .....
plant    84 QDQQCIAATRMIEEELLKSSRSFEEYFDLRTFDARVRTILQQLGTMLSQRRAAAAAMNNGEAQCI 148

  Fly  1313 TSLEALNAGAGAPGTGGSASN--------VTVSAPSPSPGFLSNGPSIGT-PSNNNNNSSANNNP 1368
            ||..|::       |..|.||        |.::..:.:.|..|.||.:.| .|...|:.....|.
plant   149 TSTRAVH-------TSISVSNSFQCGRSLVPINCTTATAGAFSIGPDMQTHHSTGANHQMVEVNR 206

  Fly  1369 PSVSSL---MQQPLSNRPGTPPYIPASPVPATSASGLAASSTPASAAATCASSGSGSNSSSGATA 1430
            |:::.:   :..||                   .:|...:..|.||.....|... .|::..:|.
plant   207 PNMNQITCGISSPL-------------------ITGFNGNCVPVSANIPMTSQDL-FNATHFSTL 251

  Fly  1431 -------------AGASSTSSSSSAGSGTPLSSVSTPTSATMATSSGGGGGGGGNAGGGSSTTPA 1482
                         ....|.|:.:|.|...|.......:|.:||.:              .::.|.
plant   252 PQPFLQPPPDQSHMHRYSMSNVASFGQSNPYPCGVVMSSGSMAVA--------------QNSIPW 302

  Fly  1483 SNPLLLMSGGTAGGGTGATTTTSTSSSSRMMSS------------SSSLSSQMAALEAAARDNDD 1535
            :||..:.       |...|.|:..|:...|..:            :::..|        |.:|.|
plant   303 NNPNPMQ-------GLDPTVTSYHSNLQPMQQTPLPKRQLHHPLWNTNFQS--------APNNRD 352

  Fly  1536 ETPSPSGENTNGSGGSGNAGGMASKGKLDSIKQDDD-------------------IKKEFMDDSC 1581
            ..|..|.:.:|  .||....|..|:.......|:.|                   :..:.:::.|
plant   353 NLPQVSQQLSN--HGSRQHRGQHSQNLYPGQLQNQDRLLPNLTQQAMALAAPVMHVPSKQVNEDC 415

  Fly  1582 GGNNDSS----------------------------------QMDC-------------------- 1592
            |..:.::                                  .:||
plant   416 GQTSSNTVLRWIPFMFHARHCKAKKDKCASKFCFQARKIVKHIDCCKVPNCKYRYCLGTRMWLDH 480

  Fly  1593 -----------------------------------------------------STGGGKGKNVNN 1604
                                                                 ..||.:..:|:.
plant   481 FKQCKSISCRTCVAVREYMEKNKYTIVPLRRAKCSSASSKCQPKKSSKSRQAYKKGGAEAPSVDA 545

  Fly  1605 DGTSMIK--------------------------------MEIKTEDGLDGEVKIKTEAMDVDEAG 1637
            |....||                                |.::.:|||. .:|::...||:|..|
plant   546 DLQRSIKRPKLHRPSQNITPETKSISVTGCGVVCKPHSLMNMQEKDGLQ-SLKVEAMPMDIDVPG 609

  Fly  1638 GSTAG------EHHGEGGGGSGVGGGKDNINGAHDGGATGGAVDIKPKTETKPLVPEPLAPNAGD 1696
            .|...      :|..|           |...|.:.||..               :.|..:.....
plant   610 ASEIPVTRELVKHVAE-----------DTPKGNNCGGFA---------------MVEKTSCLLAQ 648

  Fly  1697 KKKKCQFNPEELRTALLPTLEKLYRQEPESVPFRYPVDPQALGIPDYFEIVKKPMDLGTIRTNIQ 1761
            .|.||.       ..:....|:..:|..|      .||...:.|....|:.........||:..|
plant   649 GKSKCM-------NEMSAPKEENVKQSVE------VVDASKMEISSLVELFTPEQVKEHIRSLRQ 700

  Fly  1762 NGKYSDPWEYVDDVWLMFDNAWLYNRKTSRVYRYCTKLSEVFEAEIDPVM------QALGYCCGR 1820
                                 |:...||              :||.:..|      .:...|...
plant   701 ---------------------WVGQSKT--------------KAEKNKAMGCSMSVNSCQLCAVE 730

  Fly  1821 KYTFNPQVLCCYGKQLC--TIPRDAKYYSYQNSLKEYGVASNRYTYCQKCFNDIQGDTVTLGDDP 1883
            ...|.|..:.|   ..|  .|.::|.:||       ..|..:|:..|..|:|:.:...|.|
plant   731 WLVFEPVPIYC---SPCGIRIKKNALHYS-------IAVGESRHYVCAPCYNEAREKLVFL---- 781

  Fly  1884 LQSQTQIKKDQFKEMKNDHLELEPFVNCQECGRKQHQICVLWLDSIWPG---GFVCDNCLKKKNS 1945
              ..|.|.|.:.::.|||....|.:|.|.:|...||.||.|:......|   .:.|.:|..::..
plant   782 --DGTSIPKTRLQKKKNDEQVPEGWVQCDKCEAWQHIICALFNSRRNHGESTKYTCPSCYIQEVE 844

  Fly  1946 KRKENKF------NAKRLPTTKLGVYIETRVNNFLKKKE----------------AGAGEVHIRV 1988
            :|:....      .|..||.|.|..::|.|:  |.|.||                .||..:.:||
plant   845 QRERRPLPLSAVPGATSLPVTSLSKHLEERL--FKKLKEERQERARLQGKTYEEVPGAESLTVRV 907

  Fly  1989 VSSSDKCVEVKPGMRRRFVE---QGEMMNEFPYRAKALFAFEEVDGIDVCFFGMHVQEYGSECPA 2050
            |:|.||.:|||    .||:|   :....:||||::||:|.|::::.::||.|||.|||:|::...
plant   908 VASVDKVLEVK----ERFLELFREENYPSEFPYKSKAIFLFQKIENVEVCLFGMFVQEFGTDSGP 968

  Fly  2051 PNTRRVYIAYLDSVHFFRP------RQY-RTAVYHEILLGYMDYVKQLGYTMAHIWACPPSEGDD 2108
            ||.||||::|||||.:|||      .:| :..:...:.:||:||.|:.|:|..:||||||.:|||
plant   969 PNERRVYLSYLDSVKYFRPLFRVLLHEYMKLIIVTNLQIGYLDYCKKRGFTSCYIWACPPLKGDD 1033

  Fly  2109 YIFHCHPTDQKIPKPKRLQEWYKKMLDKGMIERIIQD----YKDILKQAMEDKLG-SAAELPYFE 2168
            ||.:|||..||.||..:|:|||..||.|...|.::.:    |.....|:.|.:.. :||.||||:
plant  1034 YILYCHPEIQKTPKTDKLREWYLAMLRKASKEDVVVECTNLYNHFFVQSGECRANVTAARLPYFD 1098

  Fly  2169 GDFWPNVLEESIKELDQEEEEKRKQAEAAEAAAAANLFSIEENEVSGDGKKKGQKKAKKS----- 2228
            ||:||:..|:.:::::||::.:.|...                  .|..||...|:|.|:
plant  1099 GDYWPSAAEDLLRQMNQEDDGETKLHR------------------KGLTKKVISKRALKAVGQLD 1145

  Fly  2229 ---NKSKAAQRKNSKKSNE-------------------H-----QSGN----------DLSTKIY 2256
               |.||  .|...:|..|                   |     .|||          .:..|.|
plant  1146 LSLNASK--DRLMMQKLGETICPMKEDFIMVHLQHCCKHCTTLMVSGNRWVCNHCKNFQICDKCY 1208

  Fly  2257 ------ATMEKH------KEVFFVIRLHSAQSAASLAPIQDPDPLLTCDLMDGRDAFLTLARDKH 2309
                  ..:|:|      |...|.:.:....:     .|:|.|..|..:....|.|||.|.:..:
plant  1209 EVEQNRINIERHPINQKEKHALFPVAIKDVPT-----KIEDKDNNLESEFFHNRQAFLNLCQGNN 1268

  Fly  2310 FEFSSLRRAQFSTLSMLYELHNQGQDKFVYTCNHCKTAVETR--YHCTVCDDFDLCIVC--KEKV 2370
            :::.:||||:.|::.:||.|||.....|...|..|:..||..  :||.||..:|:|..|  |:.:
plant  1269 YQYETLRRAKHSSMMILYHLHNPTAPAFATVCTICQQEVENSQGWHCEVCPGYDVCSACYSKDSI 1333

  Fly  2371 GHQHKMEKLGFDIDDGSALADHKQANPQEARKQSIQRCIQSLAHACQCRDANCRLPSCQKMKLVV 2435
            .|.||:.... ...|.:.:..:.||:  ::.:..:::..:.|.||..||...|:...|:|.|::.
plant  1334 NHSHKLTSRS-SSTDSTVVQQNGQAS--QSYQVKLEKLKKLLVHAATCRSTQCQYQGCRKSKMLF 1395

  Fly  2436 QHTKNCKRKPNGGCPICKQLIALCCYHAKNCEEQKCPVPFCPNIK--HKLKQQQSQQKFQQ--QQ 2496
            :|..:|   ..|.|||||.|.:|...||:||.:.||.||.|..::  .:.||||:.::.:.  .:
plant  1396 RHCIDC---TTGDCPICKGLWSLLKLHARNCRDSKCTVPKCSGLRAISRRKQQQADKRRRAAVME 1457

  Fly  2497 LLRRRVALMSRT 2508
            ::|.|.|..:||
plant  1458 MMRERAAEATRT 1469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nej	NP_001188575.1	ZnF_TAZ	530..600	CDD:214717
		KIX	946..1024	CDD:280354
		Bromo_cbp_like	1705..1812	CDD:99927	16/112 (14%)
		RING_CBP-p300	1824..1906	CDD:276805	21/83 (25%)
		PHD_CBP_p300	1908..1939	CDD:277032	10/33 (30%)
		HAT_KAT11	1970..2283	CDD:285432	122/397 (31%)
		ZZ_CBP	2339..2379	CDD:239077	15/43 (35%)
		ZnF_TAZ	2404..2476	CDD:214717	27/71 (38%)
HAC4	NP_001319247.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	206	1.000	Domainoid score	I822
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	450	1.000	Inparanoid score	I385
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001062
OrthoInspector	1	1.000	-	-		otm2820
orthoMCL	1	0.900	-	-		OOG6_101987
Panther	1	1.100	-	-	O	PTHR13808
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X719
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.950