DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nej and HAC12

DIOPT Version :9

Sequence 1:	NP_001188575.1	Gene:	nej / 43856	FlyBaseID:	FBgn0261617	Length:	3282	Species:	Drosophila melanogaster
Sequence 2:	NP_173115.1	Gene:	HAC12 / 838242	AraportID:	AT1G16710	Length:	1706	Species:	Arabidopsis thaliana

Alignment Length:	2064	Identity:	495/2064 - (23%)
Similarity:	746/2064 - (36%)	Gaps:	640/2064 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   735 MSQQVVAGGMQQQQ--QQGLPP----------VIRIQGAQPAVRVLGPGGPGGPSGPNVLP---- 783
            |:.|....|.:..|  .||..|          ::...||  |..|.|.|...| ||..|.|
plant     1 MNVQAHMSGQRSGQVPNQGTVPQNNGNSQMQNLVGSNGA--ATAVTGAGAATG-SGTGVRPSRNI 62

  Fly   784 -----NDVNSLHQQQQ----QMLQQQQ-------------------QQG-----------QNRR- 808
                 :|:..|.|..|    .||||:|                   ::|           .||.
plant    63 VGAMDHDIMKLRQYMQTLVFNMLQQRQPSPADAASKAKYMDVARRLEEGLFKMAVTKEDYMNRST 127

  Fly   809 -RGGLATMVEQQQQHQQQQQQPNPAQLGGNIPAP-LSVNVGG-------------FGNTNFGGAA 858
             ...:.::::.:|.:...|:..|.:.:|..||.| ||...|.             .||||....|
plant   128 LESRITSLIKGRQINNYNQRHANSSSVGTMIPTPGLSQTAGNPNLMVTSSVDATIVGNTNITSTA 192

  Fly   859 --------AGGAVGANDKQQLKVAQVHPQSHGVGAGGASAGAGASGGQVAAGSSVLMPADTTGSG 915
                    |||..|.|.....   |...::..:|:||:....||.     ..::.::|  |.|..
plant   193 LNTGNPLIAGGMHGGNMSNGY---QHSSRNFSLGSGGSMTSMGAQ-----RSTAQMIP--TPGFV 247

  Fly   916 NAGNPNQNAGGVAGGAGGGNGGNTGPPGDNEKDWRESVTADLRNHLVHKLVQAIFP--TSDPTTM 978
            |:.. |.|:||.:...       |..|...::..|:.......:.|.:.:...:.|  .|.|:..
plant   248 NSVT-NNNSGGFSAEP-------TIVPQSQQQQQRQHTGGQNSHMLSNHMAAGVRPDMQSKPSGA 304

  Fly   979 QDKRMHNLVSYAEKVEKDMYEMAKSRSEYYHLLAEKIYKIQKELEEKRLKR---------KEQHQ 1034
            .:..::..|...||:       ..|.|.|.:        ..|:|::.....         ..||.
plant   305 ANSSVNGDVGANEKI-------VDSGSSYTN--------ASKKLQQGNFSLLSFCPDDLISGQHI 354

  Fly  1035 QMLMQQQG----VANP-VAGGAAGGAGS---AAGVAGGVVLPQQQQQQQQQQQQQGQQPLQSCIH 1091
            :......|    ..|| ...||...||:   |..:......|..:.......|||.|||
plant   355 ESTFHISGEGYSTTNPDPFDGAITSAGTGTKAHNINTASFQPVSRVNSSLSHQQQFQQP------ 413

  Fly  1092 PSISPMGGVMPPQQLRPQGPPGILGQQTAAGLGVGVGVTNNMVTMRSHSPGGNMLALQQQQRMQF 1156
                |......|.|:                                           |||:.||
plant   414 ----PNRFQQQPNQI-------------------------------------------QQQQQQF 431

  Fly  1157 PQQQ--QQQPP-------GSGAGKMLVGPPGPSPGGMVVNPALSPYQTTNVLTSPVPGQQQQQQF 1212
            ..|:  :||.|       ..|.||..|      ...||......|.....   |..|..|..::|
plant   432 LNQRKLKQQTPQQHRLISNDGLGKTQV------DSDMVTKVKCEPGMENK---SQAPQSQASERF 487

  Fly  1213 INANGGTGANPQLSEIMKQRHIHQQQQQQQQQQQQGMLLP---QSPFSNSTPLQQQQ-QQQQQQQ 1273
                       |||::.     :|.|...:..|....|||   ||....|.|...|| ||....|
plant   488 -----------QLSQLQ-----NQYQNSGEDCQADAQLLPVESQSDICTSLPQNSQQIQQMMHPQ 536

  Fly  1274 QQQQATSNSFSS-----PMQQQQQGQQQQQQKPGSVLNNMPPTPTSLEALNAGAGAPG------T 1327
            .....:|||||:     ..:...|||...:.:..::::|         |:::|.....      |
plant   537 NIGSDSSNSFSNLAVGVKSESSPQGQWPSKSQENTLMSN---------AISSGKHIQEDFRQRIT 592

  Fly  1328 GGSASNVTVSAPSPSPGFLSNGPSIGTPSNNNNNSSANNNPPSVSSLMQQPLSNRPGTPPYIPAS 1392
            |         .....|..|:.|..||  .|:.:..|.::|           |.|..||
plant   593 G---------MDEAQPNNLTEGSVIG--QNHTSTISESHN-----------LQNSIGT------- 628

  Fly  1393 PVPATSASGLAASSTP-----------ASAAATCASSGSGSNSSSGATAAGASSTSSSSSAGSGT 1446
                |...| ..|..|           ...|.:|...|......:..|.  ....|...:.....
plant   629 ----TCRYG-NVSHDPKFKNQQRWLLFLRHARSCKPPGGRCQDQNCVTV--QKLWSHMDNCADPQ 686

  Fly  1447 PLSSVSTPTSATMATSSGGGGGGGGNAGGGSSTTPASNPLLLMSGGTAGGGTGATTTTSTSSSSR 1511
            .|......|.|.:          |..........|...|:               .|....::.|
plant   687 CLYPRCRHTKALI----------GHYKNCKDPRCPVCVPV---------------KTYQQQANVR 726

  Fly  1512 MMSSSSSLSSQMAALEAAARDNDDETPSPSGENTNGSGGSGNAGGMASKGK----LDSIK---QD 1569
            .::...:.||.:.::..:...||..              |.|||.::...:    ||:::   :.
plant   727 ALARLKNESSAVGSVNRSVVSNDSL--------------SANAGAVSGTPRCADTLDNLQPSLKR 777

  Fly  1570 DDIKKEFM-----DDSCGGNNDSSQMDCSTGGGKGKNVNNDGTSMIKMEIKTEDGLDGEVKIKTE 1629
            ..:::.|.     .:||     .|.:..:|.....::........:|.|..       |||::..
plant   778 LKVEQSFQPVVPKTESC-----KSSIVSTTEADLSQDAERKDHRPLKSETM-------EVKVEIP 830

  Fly  1630 AMDVDEAGG------------------STAGEHHGEGGGGSGVGGGKDNINGAHDGGATGGAVDI 1676
            ...|....|                  |..|:|     |.||....::||
plant   831 DNSVQAGFGIKETKSEPFENVPKPKPVSEPGKH-----GLSGDSPKQENI--------------- 875

  Fly  1677 KPKTETKPLVP--EPLAPNAGDKKKKCQFNPEELRTALLPTLEKLYRQE---PESVPFRYPVDPQ 1736
              |.:.:|..|  ||..|    ||::...:||....:..|.::.:...|   ||.|
plant   876 --KMKKEPGWPKKEPGCP----KKEELVESPELTSKSRKPKIKGVSLTELFTPEQV--------- 925

  Fly  1737 ALGIPDYFEIVKKPMDLGTIRTNIQNGKYSDPWEYVDDVWLMFDNAWLYNRKTSRVYRYCTKLSE 1801
                                |.:|:..:                 .|:...|.
plant   926 --------------------REHIRGLR-----------------QWVGQSKA------------ 941

  Fly  1802 VFEAEIDPVMQ------ALGYCCGRKYTFNPQVLCCYGKQLC--TIPRDAKYYSYQNSLKEYGVA 1858
              :||.:..|:      :...|...|.||.|..:.|   ..|  .|.|:|.||:       .|..
plant   942 --KAEKNQAMENSMSENSCQLCAVEKLTFEPPPIYC---TPCGARIKRNAMYYT-------VGGG 994

  Fly  1859 SNRYTYCQKCFNDIQGDTVTLGDDPLQSQTQIKKDQFKEMKNDHLELEPFVNCQECGRKQHQICV 1923
            ..|:.:|..|:|:.:|||:      |...|.:.|.:.::.|||....|.:|.|.:|...|||||.
plant   995 ETRHYFCIPCYNESRGDTI------LAEGTSMPKAKLEKKKNDEEIEESWVQCDKCQAWQHQICA 1053

  Fly  1924 LWLDSIWPGG---FVCDNC--LKKKNSKRK----ENKFNAKRLPTTKLGVYIETRVNNFLKKKEA 1979
            |:......||   :.|..|  :..:.::||    .....||.||.|.|..:||.|:...||::..
plant  1054 LFNGRRNDGGQAEYTCPYCYVIDVEQNERKPLLQSAVLGAKDLPRTILSDHIEQRLFKRLKQERT 1118

  Fly  1980 GAGEVH--------------IRVVSSSDKCVEVKPGMRRRFVE---QGEMMNEFPYRAKALFAFE 2027
            ....|.              :|||||.||.:|||    .||:|   :.....||||::|.:..|:
plant  1119 ERARVQGTSYDEIPTVESLVVRVVSSVDKKLEVK----SRFLEIFREDNFPTEFPYKSKVVLLFQ 1179

  Fly  2028 EVDGIDVCFFGMHVQEYGSECPAPNTRRVYIAYLDSVHFFRP-------RQYRTAVYHEILLGYM 2085
            :::|::||.|||:|||:||||..||.||||::|||||.:|||       ...||.||||||:||:
plant  1180 KIEGVEVCLFGMYVQEFGSECSNPNQRRVYLSYLDSVKYFRPDIKSANGEALRTFVYHEILIGYL 1244

  Fly  2086 DYVKQLGYTMAHIWACPPSEGDDYIFHCHPTDQKIPKPKRLQEWYKKMLDKGMIERIIQD----Y 2146
            :|.|..|:|..:||||||.:|:|||.:|||..||.||..:|:|||..||.|...|.|:.:    |
plant  1245 EYCKLRGFTSCYIWACPPLKGEDYILYCHPEIQKTPKSDKLREWYLAMLRKAAKEGIVAETTNLY 1309

  Fly  2147 KDILKQAMEDKLG-SAAELPYFEGDFWPNVLEESIKELDQEEEEKRKQAEAAEAAAAANLFSIEE 2210
            .....|..|.:.. :||.||||:||:||...|:.|.::.||:
plant  1310 DHFFLQTGECRAKVTAARLPYFDGDYWPGAAEDIISQMSQED----------------------- 1351

  Fly  2211 NEVSGDGKKKGQKKAKKSNKSKAAQRKNSKKSNEHQSGND--LSTKIYATMEKHKEVFFVIRL-H 2272
                 ||:|..:|...|...:|.|.:.:.:......:..|  |..|:..|:...||.|.::.| |
plant  1352 -----DGRKGNKKGILKKPITKRALKASGQSDFSGNASKDLLLMHKLGETIHPMKEDFIMVHLQH 1411

  Fly  2273 SAQSAASLA--------------------------------------------PIQ--------- 2284
            |.....:|.                                            |::
plant  1412 SCTHCCTLMVTGNRWVCSQCKDFQLCDGCYEAEQKREDRERHPVNQKDKHNIFPVEIADIPTDTK 1476

  Fly  2285 DPDPLLTCDLMDGRDAFLTLARDKHFEFSSLRRAQFSTLSMLYELHNQGQDKFVYTCNHCKTAVE 2349
            |.|.:|..:..|.|.|||:|.:..|:::.:||||:.|::.:||.|||.....||.|||.|...:|
plant  1477 DRDEILESEFFDTRQAFLSLCQGNHYQYDTLRRAKHSSMMVLYHLHNPTAPAFVTTCNVCHLDIE 1541

  Fly  2350 T--RYHCTVCDDFDLCIVCKEKVG---HQHKMEKLGFDIDDGSALADHKQANPQEARK---QSIQ 2406
            :  .:.|.||.|:|:|..|.:|.|   |.||       :....:|||....| :|||:   ..::
plant  1542 SGLGWRCEVCPDYDVCNACYKKEGCINHPHK-------LTTHPSLADQNAQN-KEARQLRVLQLR 1598

  Fly  2407 RCIQSLAHACQCRDANCRLPSCQKMKLVVQHTKNCKRKPNGGCPICKQLIALCCYHAKNCEEQKC 2471
            :.:..|.||.|||...|..|:|:|:|.:.:|...||.:.:|||.:||::..|...||:.|:|.:|
plant  1599 KMLDLLVHASQCRSPVCLYPNCRKVKGLFRHGLRCKVRASGGCVLCKKMWYLLQLHARACKESEC 1663

  Fly  2472 PVPFCPNIKHKLKQQQSQQKFQQQQLLRRRVALM----SRTAAPAALQG 2516
            .||.|.::|..|:      :.|||...|||.|:|    .|.|..|...|
plant  1664 DVPRCGDLKEHLR------RLQQQSDSRRRAAVMEMMRQRAAEVAGTSG 1706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nej	NP_001188575.1	ZnF_TAZ	530..600	CDD:214717
		KIX	946..1024	CDD:280354	13/79 (16%)
		Bromo_cbp_like	1705..1812	CDD:99927	13/109 (12%)
		RING_CBP-p300	1824..1906	CDD:276805	23/83 (28%)
		PHD_CBP_p300	1908..1939	CDD:277032	12/33 (36%)
		HAT_KAT11	1970..2283	CDD:285432	124/388 (32%)
		ZZ_CBP	2339..2379	CDD:239077	17/44 (39%)
		ZnF_TAZ	2404..2476	CDD:214717	27/71 (38%)
HAC12	NP_173115.1	ZnF_TAZ	638..716	CDD:214717	11/89 (12%)
		PHD_HAC_like	1000..1072	CDD:277086	25/77 (32%)
		HAT_KAT11	1146..>1344	CDD:295182	95/201 (47%)
		ZZ	1407..>1441	CDD:294208	4/33 (12%)
		ZZ	1531..1576	CDD:294208	17/51 (33%)
		ZnF_TAZ	1591..1668	CDD:214717	27/76 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	206	1.000	Domainoid score	I822
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	450	1.000	Inparanoid score	I385
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001062
OrthoInspector	1	1.000	-	-		otm2820
orthoMCL	1	0.900	-	-		OOG6_101987
Panther	1	1.100	-	-	LDO	PTHR13808
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X719
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.860