DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nej and BRDT

DIOPT Version :9

Sequence 1:	NP_001188575.1	Gene:	nej / 43856	FlyBaseID:	FBgn0261617	Length:	3282	Species:	Drosophila melanogaster
Sequence 2:	NP_001229735.2	Gene:	BRDT / 676	HGNCID:	1105	Length:	951	Species:	Homo sapiens

Alignment Length:	912	Identity:	167/912 - (18%)
Similarity:	282/912 - (30%)	Gaps:	333/912 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  1562 KLDSIKQDDD---IKKEFMDDSCGGNNDSSQMDCSTGGGKGKNVNNDGTSMIK-MEIKTEDGLDG 1622
            ||..:.|::.   :|:.......||    :|.:.:....|.|:..:....:.| .||.:
Human   129 KLSQMPQEEQVVGVKERIKKGKAGG----TQQNIAVSSAKEKSSPSATEKVFKQQEIPS------ 183

  Fly  1623 EVKIKTEAMDVDEAGGSTAGEHHGEGGGGSGVGGGKDNINGAHDGGA--TGGAVDIKPKTETKPL 1685
             |..||....::...|:                    ::|.:....|  |.|   :|.|.:|
Human   184 -VFPKTSISPLNVVQGA--------------------SVNSSSQTAAQVTKG---VKRKADT--- 221

  Fly  1686 VPEPLAPNAGDKKKKCQFNP--EELRTALLPTLEKLYRQEPESV--------------------- 1727
                ..|.....|...:|:|  .|...||.|..|.:    |::|
Human   222 ----TTPATSAVKASSEFSPTFTEKSVALPPIKENM----PKNVLPDSQQQYNVVKTVKVTEQLR 278

  Fly  1728 -------------------PFRYPVDPQALGIPDYFEIVKKPMDLGTIRTNIQNGKYSDPWEYVD 1773
                               ||..|||..|||:.:|:::||.|||||||:..:.|.:|.|.:::..
Human   279 HCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAA 343

  Fly  1774 DVWLMFDNAWLYNRKTSRVYRYCTKLSEVFEAE-----IDPVMQALGYCCGRKYTFNPQVLCCYG 1833
            ||.|||.|.:.||.....|......|.:|||..     |:||                     ..
Human   344 DVRLMFMNCYKYNPPDHEVVTMARMLQDVFETHFSKIPIEPV---------------------ES 387

  Fly  1834 KQLCTIPRDAKYYSYQNSLKEYGVASN-----------RYTYCQKCFNDIQGDTVTLGDDPLQSQ 1887
            ..||.|..|....:.:.:..|.....|           |....|:....:......|...|.:..
Human   388 MPLCYIKTDITETTGRENTNEASSEGNSSDDSEDERVKRLAKLQEQLKAVHQQLQVLSQVPFRKL 452

  Fly  1888 TQIKKDQFKEMKNDHLELEPFVNCQECGRKQHQICVLWLDSIWPGGFVCDNCLKKKNSKRKENK- 1951
            .:.|:...||.|.:.:.     |..|..||                 :|:....|:.|||.:.|
Human   453 NKKKEKSKKEKKKEKVN-----NSNENPRK-----------------MCEQMRLKEKSKRNQPKK 495

  Fly  1952 ----------------------------FNAKRLPTTKLGVYIETRVNNFLKKKEAGAG------ 1982
                                        .|..:||..|||     ||.:.::.:|....
Human   496 RKQQFIGLKSEDEDNAKPMNYDEKRQLSLNINKLPGDKLG-----RVVHIIQSREPSLSNSNPDE 555

  Fly  1983 -EVHIRVVSSS---------DKCVEVKP---------------------GMRRRFVEQGEMMNEF 2016
             |:....:.:|         ..|:..:|                     .:.:|.::....:|..
Human   556 IEIDFETLKASTLRELEKYVSACLRKRPLKPPAKKIMMSKEELHSQKKQELEKRLLDVNNQLNSR 620

  Fly  2017 PYRAKA----------------------------------LFAFEEVDGIDVCF----------- 2036
            ..:.|:                                  |.:.:..|.....|
Human   621 KRQTKSDKTQPSKAVENVSRLSESSSSSSSSSESESSSSDLSSSDSSDSESEMFPKFTEVKPNDS 685

  Fly  2037 -FGMHVQEYGSECPAPNTRR--VYIAYL--DS-------VHFFRPRQYRTAVYHEILLGYMDY-- 2087
             ...:|::..:||..|..|.  ..|.|.  |:       ||...|.......:|::...|.:.
Human   686 PSKENVKKMKNECIPPEGRTGVTQIGYCVQDTTSANTTLVHQTTPSHVMPPNHHQLAFNYQELEH 750

  Fly  2088 ---VKQL-----------------GYTMAHIWACPPSEGDDYIF--HCHPTDQKIPKPKRLQEWY 2130
               ||.:                 |.|:.|    |..:.|..:.  .|....||..|.|....|
Human   751 LQTVKNISPLQILPPSGDSEQLSNGITVMH----PSGDSDTTMLESECQAPVQKDIKIKNADSW- 810

  Fly  2131 KKMLDK-----GMIERIIQDYKDILKQAMEDKLGSAAELPYFEGDFWPNVLEESIKELDQEEEEK 2190
             |.|.|     |:::...:.:....|.|:|.::.:..:      :.....||::.|||...:|.:
Human   811 -KSLGKPVKPSGVMKSSDELFNQFRKAAIEKEVKARTQ------ELIRKHLEQNTKELKASQENQ 868

  Fly  2191 RKQAEAAEAAAAANLFSIEENEVSGDGKKKGQKKAKKSNKSK---------AAQRKNSKKSNEHQ 2246
            |.........:.:|..   :|:.||:.:|:.|:.::..:|||         |.|::..::..|..
Human   869 RDLGNGLTVESFSNKI---QNKCSGEEQKEHQQSSEAQDKSKLWLLKDRDLARQKEQERRRREAM 930

  Fly  2247 SG 2248
            .|
Human   931 VG 932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nej	NP_001188575.1	ZnF_TAZ	530..600	CDD:214717
		KIX	946..1024	CDD:280354
		Bromo_cbp_like	1705..1812	CDD:99927	45/153 (29%)
		RING_CBP-p300	1824..1906	CDD:276805	14/92 (15%)
		PHD_CBP_p300	1908..1939	CDD:277032	5/30 (17%)
		HAT_KAT11	1970..2283	CDD:285432	65/411 (16%)
		ZZ_CBP	2339..2379	CDD:239077
		ZnF_TAZ	2404..2476	CDD:214717
BRDT	NP_001229735.2	Bromo_Brdt_I_like	27..133	CDD:99929	2/3 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..232		8/35 (23%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:22971749	213..224		4/20 (20%)
		Bromo_Brdt_II_like	276..377	CDD:99930	34/100 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	399..424		2/24 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	448..515		15/88 (17%)
		BET	513..575	CDD:293640	11/66 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	614..702		8/87 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	886..928		10/41 (24%)
		BRD4_CDT	909..951	CDD:293710	4/24 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810