DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nej and Brd4

DIOPT Version :9

Sequence 1:	NP_001188575.1	Gene:	nej / 43856	FlyBaseID:	FBgn0261617	Length:	3282	Species:	Drosophila melanogaster
Sequence 2:	NP_001273559.1	Gene:	Brd4 / 57261	MGIID:	1888520	Length:	1401	Species:	Mus musculus

Alignment Length:	1701	Identity:	326/1701 - (19%)
Similarity:	499/1701 - (29%)	Gaps:	608/1701 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1652 SGVGGGKDNINGAHDG------GATGGAVDIKP--KTETKPLVPEPLAPNAGDKKKKCQFNPEEL 1708
            ||.|....|:....||      ..|......:|  ...|.|..||...||    |.|.|.|  :|
Mouse     5 SGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPN----KPKRQTN--QL 63

  Fly  1709 RTALLPTLEKLYRQEPESVPFRYPVDPQALGIPDYFEIVKKPMDLGTIRTNIQNGKYSDPWEYVD 1773
            :..|...|:.|::.: .:.||:.|||...|.:|||::|:|.|||:|||:..::|..|.:..|.:.
Mouse    64 QYLLRVVLKTLWKHQ-FAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQ 127

  Fly  1774 DVWLMFDNAWLYNRKTSRVYRYCTKLSEVF----------EAEIDPVMQALGYCCGRKYTFNPQV 1828
            |...||.|.::||:....:......|.::|          |.|| .::||.|...|||.|
Mouse   128 DFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEI-MIVQAKGRGRGRKET----- 186

  Fly  1829 LCCYGKQ----LCTIPRDAKYYSYQNSLKEYGVASNRYTYCQKCFNDIQGDT-----VT------ 1878
                |:.    :.|:|          :..:...:....|..|.....:|..|     ||
Mouse   187 ----GRAAKPGVSTVP----------NTTQASTSPQTQTPQQNPPPPVQATTHPFPAVTPDLIAQ 237

  Fly  1879 ------LGDDPLQSQTQIKKD------QFKEMKNDHLEL-----EPFVNCQECGRKQHQICVLWL 1926
                  :...|||:.:.:...      ...:....|..:     :|....:...||........:
Mouse   238 PPVMTMVPPQPLQTPSPVPPQPPPPPAPVPQPVQSHPPIIATTPQPVKTKKGVKRKADTTTPTTI 302

  Fly  1927 DSIWPGGFVCDNCLKKKNSKRKENKFNAKRLPTTKLGVYIETRVNNFLKKKEAGAGEVHIRVVSS 1991
            |.|           .:..|...|.|       |.|||...|:.......||:....:.|
Mouse   303 DPI-----------HEPPSLAPEPK-------TAKLGPRRESSRPVKPPKKDVPDSQQH------ 343

  Fly  1992 SDKCVEVKPGMRR--RFVEQ----GEMMNEFPYRAKALFAFEEVDGIDVCFFGMHVQEYGSECPA 2050
                    ||..:  :..||    ..::.|...:..|.:|:.....:||...|:|  :|......
Mouse   344 --------PGPEKSSKISEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLH--DYCDIIKH 398

  Fly  2051 PNTRRVYIAYLDSVHFFRPRQYRTAVYHEILLGYMDYVKQLGYTMAHIWACPPSEGDDYIFHCH- 2114
            |.......:.|:|      |:||.|             ::.|..:..:::           :|:
Mouse   399 PMDMSTIKSKLES------REYRDA-------------QEFGADVRLMFS-----------NCYK 433

  Fly  2115 ---PTDQKIPKPKRLQEWYKKMLDKGMIERIIQDYKDILKQAMEDKLGSAAELPYFEGDFWPNVL 2176
               |..:.:...::||:.::....| |.:...:....:...|:.......|  |....|...:..
Mouse   434 YNPPDHEVVAMARKLQDVFEMRFAK-MPDEPEEPVVTVSSPAVPPPTKVVA--PPSSSDSSSDSS 495

  Fly  2177 EESIKELDQEEEEK-RKQAEAAEAAAAAN--LFSIEENEVSGDGKKKGQKKAKKSNKSK----AA 2234
            .:|....|..|||: ::.||..|...|.:  |.::.:.:.:...||:..||.||..|.|    ..
Mouse   496 SDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKKKEEVE 560

  Fly  2235 QRKNS-------KKSNEHQSGND---------LSTKIYATMEKHKEVFFVIRLHSAQSAASLAPI 2283
            :.|.|       ||:.::.|.|.         ..||...|.|..:|.......:..:...||...
Mouse   561 ENKKSKTKELPPKKTKKNNSSNSNVSKKEPVPTKTKPPPTYESEEEDKCKPMSYEEKRQLSLDIN 625

  Fly  2284 QDPDPLLTCDLMDGRDAFLTLARDKHFEFSSLRRAQ--FSTL--SMLYELHNQGQDKFVYTCNHC 2344
            :.|...|      ||...:..:|:...:.|:....:  |.||  |.|.||     :::|.:|...
Mouse   626 KLPGEKL------GRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLREL-----ERYVTSCLRK 679

  Fly  2345 KTAVETRYHCTVCDDFDLCIVCKEKVGHQHKMEKLGFDIDDGSALADHKQANPQEARKQSIQRCI 2409
            |...:.                 |||           |:..||:......::..|:..:|
Mouse   680 KRKPQA-----------------EKV-----------DVIAGSSKMKGFSSSESESTSES----- 711

  Fly  2410 QSLAHACQCRDANCRLPSCQKMKLVVQHTKNCKRKPNGGCPICKQLIALCCYHAKNCEEQKCPVP 2474
                .:....|:...:....|.|   .||...::|.               :|..:.:.|..|.|
Mouse   712 ----SSSDSEDSETEMAPKSKKK---GHTGRDQKKH---------------HHHHHPQMQPAPAP 754

  Fly  2475 FCPNIKHKLKQQ----QSQQKFQQQQLLRRRVALMSRTAAPAALQGPAAVSGPTVVSGGVPVVGM 2535
             .|.......||    ...|:.|||.........|.:..|||....|     |..::..|||:
Mouse   755 -VPQQPPPPPQQPPPPPPPQQQQQQPPPPPPPPSMPQQTAPAMKSSP-----PPFITAQVPVL-- 811

  Fly  2536 SGVAVSQQVIPGQAGILPPGAGGMSPSTVAVPSPVSGGAGAGGMGGMTSPHPHQPGIGMKPGGGH 2600
                  :..:||  .:..| .|..:...:.:|.|            ...||..||       ..|
Mouse   812 ------EPQLPG--SVFDP-IGHFTQPILHLPQP------------ELPPHLPQP-------PEH 848

  Fly  2601 SPSPNVLQ---VVKQVQEEAARQQVSHGGGFGKGVPMAPPVMNRPMGGAGPNQNVVNQLGGMGVG 2662
            |..|::.|   |.......|..||.|........:|..|   .||
Mouse   849 STPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKP---TRP-------------------- 890

  Fly  2663 VGGVGGVGVGGVGGVGVNQLNSGGGNTPGAPISGPGMNVNHLMSMDQWGGGGAGGGGANPGGGNP 2727
                                          |...|.:....|:                     |
Mouse   891 ------------------------------PAVSPALAQPPLL---------------------P 904

  Fly  2728 QARYANNTGGMRQPTHVMQTNLIPPQQQQQMMGGLGGPNQLGGGQMPVGGQHGGMGMGMGAPPMA 2792
            |.       .|.||..|:..:..||                                   |||
Mouse   905 QP-------PMAQPPQVLLEDEEPP-----------------------------------APP-- 925

  Fly  2793 GTVGGVRPSPGAGGGGGSATGGGLNTQQLALIMQKIKNNPTNESNQHILAILKQNPQIMAAIIKQ 2857
                                   |.:.|:.|.:|:::.              .|.|..:...:|.
Mouse   926 -----------------------LTSMQMQLYLQQLQK--------------VQPPTPLLPSVKV 953

  Fly  2858 RQQSQNNAAAGGGAPGPGGALQQQQAGNGPQNPQQQQQQQQQQQVMQQQQMQHMMNQQQGGGGPQ 2922
            :.|..        .|.|           .|.:|..||||.|.|                    |.
Mouse   954 QSQPP--------PPLP-----------PPPHPSVQQQQLQPQ--------------------PP 979

  Fly  2923 QMNPNQQQQQQQVNLMQQQQQGGPGGPGSGLPTRMPNMPNALGMLQSLPPNMSPGVSTQGGMVPN 2987
            ...|.|.|...     |||.|..|      .|..:|:||.:..:.|..||   ||
Mouse   980 PPPPPQPQPPP-----QQQHQPPP------RPVHLPSMPFSAHIQQPPPP---PG---------- 1020

  Fly  2988 QNWNKMRYMQMSQYPPPYPQRQRGPHMGGAGPGPGQQQFPGGGGGAGNFNAGGAGGAGGVVGVGG 3052
               .:..:....|.||| ||..:...:....|.|...:
Mouse  1021 ---QQPTHPPPGQQPPP-PQPAKPQQVIQHHPSPRHHK--------------------------- 1054

  Fly  3053 VPGGAGTVPGGDQYSMANAAAASNMLQQQQGQVGVGVGVGVKPGPGQQQQQMGVGMPPGMQQQQQ 3117
                      .|.||..:...|.:.|.....|:                        |..|....
Mouse  1055 ----------SDPYSAGHLREAPSPLMIHSPQM------------------------PQFQSLTH 1085

  Fly  3118 QQQPLQQQQMMQVAMPNANAQNPSAVVGGPNAQVMG-PPTPHSLQQQLMQSARSSPPIRSPQP-- 3179
            |..|.|..|..:.....|..|.|..|:|    |..| ||...:....|.|..| .|.:..|||
Mouse  1086 QSPPQQNVQPKKQVKGRAEPQPPGPVMG----QGQGCPPASPAAVPMLSQELR-PPSVVQPQPLV 1145

  Fly  3180 --------TPSPRSAP---SPRAAPSASPRAQPSPHHVMSSHSPAPQG-------PPHDGMHNHG 3226
                    :|..||.|   |.|..|...|....:|.|:.......|..       ||
Mouse  1146 VVKEEKIHSPIIRSEPFSTSLRPEPPKHPENIKAPVHLPQRPEMKPVDIGRPVIRPP-------- 1202

  Fly  3227 MHHQSPLPGVP 3237
             ...:|.||.|
Mouse  1203 -EQSAPPPGAP 1212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nej	NP_001188575.1	ZnF_TAZ	530..600	CDD:214717
		KIX	946..1024	CDD:280354
		Bromo_cbp_like	1705..1812	CDD:99927	35/116 (30%)
		RING_CBP-p300	1824..1906	CDD:276805	13/113 (12%)
		PHD_CBP_p300	1908..1939	CDD:277032	4/30 (13%)
		HAT_KAT11	1970..2283	CDD:285432	64/345 (19%)
		ZZ_CBP	2339..2379	CDD:239077	5/39 (13%)
		ZnF_TAZ	2404..2476	CDD:214717	11/71 (15%)
Brd4	NP_001273559.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		15/56 (27%)
		Bromo_Brdt_I_like	58..164	CDD:99929	34/108 (31%)
		Bromo_Brdt_II_like	355..456	CDD:99930	21/132 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	462..617		33/156 (21%)
		NPS region. /evidence=ECO:0000250	486..505		3/18 (17%)
		BID region. /evidence=ECO:0000250	526..581		13/54 (24%)
		BET	611..675	CDD:407211	16/74 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	676..1126		138/827 (17%)
		PHA03247	<793..1231	CDD:223021	134/752 (18%)
		C-terminal (CTD) region. /evidence=ECO:0000250	1051..1401		45/237 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1156..1378		16/66 (24%)
		TPH	<1267..1308	CDD:404709
		BRD4_CDT	1359..1401	CDD:407248
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810