DRSC/TRiP Functional Genomics Resources

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Protein Alignment nej and crebbpb

DIOPT Version :9

Sequence 1:NP_001188575.1 Gene:nej / 43856 FlyBaseID:FBgn0261617 Length:3282 Species:Drosophila melanogaster
Sequence 2:NP_001352115.1 Gene:crebbpb / 567111 ZFINID:ZDB-GENE-050302-102 Length:2431 Species:Danio rerio


Alignment Length:3419 Identity:1189/3419 - (34%)
Similarity:1458/3419 - (42%) Gaps:1126/3419 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 MADH-LDEPPQ--KRVKMD---------PTDISYF-LEENLPDELVSSNSGWSDQLTGGAGGGNG 53
            |||: ||..|.  ||.|::         |..:|.| ||.:|||||:.                ||
Zfish     1 MADNLLDMGPSAAKRPKLNSPALSSSDTPDFVSLFDLENDLPDELIP----------------NG 49

  Fly    54 GGGASGVTTNPTSGPNPGGGPNKPAAQGPGSGTGGVGVGVNVGVGGVVGVGVVPSQMNGAGGGNG 118
            ..|...:                     |.:|.||||..:...|..........||:..|  |:|
Zfish    50 DLGLMSM---------------------PSNGDGGVGSRMGGNVPDAAAKHKQLSQLLQA--GSG 91

  Fly   119 SGTGGDDGSGNGSGAGNRISQMQHQQLQHLLQQQQQGQKGAMVVPGMQQLGSKSP--NLQSPNQG 181
            ||.||:....:|.|                      ||.||:   |...:|..||  ..|:|   
Zfish    92 SGLGGNLSPQSGMG----------------------GQLGAL---GKSPMGQGSPGHQTQAP--- 128

  Fly   182 GMQQVVGTQMGMVNSMPMSISNNGNNGMNAIPGMNTIAQGNLG-NMVLTNSVGGGMGGMVNHLKQ 245
               :.|||..|..|:.|         ||    ||||      | |..:.|:.....|.|..::..
Zfish   129 ---KPVGTPTGQGNNSP---------GM----GMNT------GFNPAMLNNNNQAHGLMGQNMTP 171

  Fly   246 QPGGGGGGMINSVSVPGGPGAGAGGVGAGGGGAVAANQGMHMQNGPMMGRMVGQQHMLRGPHLMG 310
            |     |.|:|.|..|.|.|..|.|:         ..||..||..|:                  
Zfish   172 Q-----GQMMNGVMGPAGRGRTAPGM---------QYQGQGMQGAPV------------------ 204

  Fly   311 ASGGAGGPGNGPGGGGPRMQNPNMQMNFRPFAAQLNSLPYGVGQYGGPGGGNNPQQQQQQQQQQL 375
               |||| |.|.|..|               :....:|..|..|.    |.:|...||.....::
Zfish   205 ---GAGG-GQGVGVSG---------------SVLAETLTQGAPQM----GAHNAINQQAGNMNKM 246

  Fly   376 LAQQMAQRGGVVPGMPQGNRPVGTVVPMSTLGGDGSGPAGQLVSGNPQQQQ---MLAQQQTGAMG 437
                         |:...|.|.|.                |.|.|:.||..   :.||.|..|..
Zfish   247 -------------GLATANGPFGQ----------------QYVQGSVQQMSNAGLNAQMQNKAAL 282

  Fly   438 PRPPQPNQLLGHPGQQQQQQQQPGTSQQQQQQQGVGIGGAGVVANAGTVAGVPAVAGGGAGGAVQ 502
            |...||. |.|       ....|...|||....|: :.|.||                       
Zfish   283 PNSLQPT-LKG-------ASSVPNLLQQQVPSVGM-VPGQGV----------------------- 315

  Fly   503 SSGPGGANRDVPDDRKRQ-IQQQLMLLLHAHKCNRRENLNPNREVCNVNYCKAMKSVLAHMGTCK 566
            |:||      ..|..||: |||||:||||||||.|||..|.....|.:.:|:.||:||.||..|:
Zfish   316 SAGP------TADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACALPHCRTMKNVLNHMTHCQ 374

  Fly   567 QSKDCTMQHCASSRQILLHYKTCQNSGCVICYPFRQNHSVFQNANVPPGGGPAGIGGAPPGGGGA 631
            ..|.|.:.||||||||:.|:|.|....|.:|.|.:       ||:                    
Zfish   375 AGKSCQVAHCASSRQIISHWKNCTRHDCPVCLPLK-------NAS-------------------- 412

  Fly   632 GGGAAGAGGNLQQQQQQQQQQQQNQQPNLTGLVVDGKQGQQVAPGGGQNTAIVLPQQQGAGGAPG 696
                                .::||||.|:            :|..|..:    |..|.....|.
Zfish   413 --------------------DKRNQQPMLS------------SPNPGMQS----PLGQVGTSQPA 441

  Fly   697 APKTPADMVQQLTQQQQQQQQQVHQQQVQQQELRRFDGMSQQVVAGGMQQQQQQGLPPVIRIQGA 761
            ||...:.                          ...|..|.|.....:      |||     .|.
Zfish   442 APAISSG--------------------------THIDPSSMQRAYAAL------GLP-----YGN 469

  Fly   762 QPAVRVLGPGGPGGPSGPNVLPNDVNSLHQQQQQMLQQQQQQGQNRRRGGLATMVEQQQQHQQQQ 826
            |||.                                 |.|..|               ||..|.|
Zfish   470 QPAA---------------------------------QTQVAG---------------QQPTQTQ 486

  Fly   827 QQPNPAQLGGNIPAPLSVNVGGFGNTNFGGAAAGGAVGANDKQQLKVAQVHPQSHGVGAGGASAG 891
            |..:.|.||.|     .:|:||.|..              |:..|......|.|           
Zfish   487 QMRSMAALGSN-----QMNIGGNGMA--------------DQTNLHTDSSLPSS----------- 521

  Fly   892 AGASGGQVAAGSSVLMPADTTGSGNAGN-PNQNAGGVAGGAGGGNGGNTGPPGDNEKDWRESVTA 955
                     ..|:.:|| |.:..|.||| |              .......|| .:|.|.|.||.
Zfish   522 ---------LSSNQMMP-DGSNMGGAGNLP--------------TAAPLSMPG-MKKPWHEHVTQ 561

  Fly   956 DLRNHLVHKLVQAIFPTSDPTTMQDKRMHNLVSYAEKVEKDMYEMAKSRSEYYHLLAEKIYKIQK 1020
            |||||||||||||||||.||..::|:||.|||:||.|||.||||.|.||.||||.||||||||||
Zfish   562 DLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANSRDEYYHFLAEKIYKIQK 626

  Fly  1021 ELEEKRLKRKEQHQQMLMQQQGVANPVAGGAAGGAGSAAGVAGGVVLPQQQQQQQQQQQQQGQQP 1085
            ||||||..|..:.|.              ||.|                        .||.|.  
Zfish   627 ELEEKRKSRLSKPQM--------------GAQG------------------------PQQPGL-- 651

  Fly  1086 LQSCIHPSISPMGGVMPPQQLRPQGPPGILGQQTAAGLGVGVGVTN--NMVTMRSHSPGG----N 1144
                  |..:|||   |.|.:||...|              |.::|  |.:..|...|.|    |
Zfish   652 ------PQPNPMG---PAQAIRPPNGP--------------VSMSNVPNQLMARMQVPQGMGQFN 693

  Fly  1145 MLALQQQQRMQFPQQQQQQP---------PGSGAGKMLVGPPGPSPGGMVVNPALSPYQTTNVLT 1200
            .:.:   |.:|..|.|...|         |..|.|.:   ||      ||::|:..|        
Zfish   694 PVTM---QNVQMSQSQVGAPRAASPMTHNPQMGMGNV---PP------MVMSPSRMP-------- 738

  Fly  1201 SPVPGQQQQQQFINANGGTGANPQLSEIMKQRHIHQQQQQQQQQQQQGMLLPQSPFSNS------ 1259
                 |.|.....:||...|..|..::.|.                      |:||..|      
Zfish   739 -----QAQAMMGGHANNMVGQTPNQNQFMN----------------------QTPFPASAGGMNV 776

  Fly  1260 -TPLQQQQQQQQQQQQQQQA--TSNSFSSPMQQQQQGQQQQQQKPGSVLNNMPPTPTSLEALNAG 1321
             ..|.||..|..||||||.|  |.|:..|             ..|.|.|.:.||.|:        
Zfish   777 NVNLAQQSGQTVQQQQQQNANLTLNAVGS-------------LGPPSALCSTPPPPS-------- 820

  Fly  1322 AGAPGTGGSASNVTVSAPSPSPGFLSNGPSIGTPSNNNNNSSANNNPPSVSSLMQQPLSNRPGTP 1386
            |..|....|..::.....:|:        |:|......:..|....||||  |...|..::|.||
Zfish   821 ASTPSAAASLQSLQTQPSTPA--------SVGGHVTPTHIPSGLPRPPSV--LGSSPAPSQPHTP 875

  Fly  1387 PYIPASPVPATSASGLAASSTPASAAATCASSGSGSNSSSGATAAGASSTSSSSSAGSGTPLSSV 1451
              :.:.|.|...      ...|.|..|...|                            ||||.:
Zfish   876 --LQSQPEPPMQ------MQQPTSVQAQQPS----------------------------TPLSQM 904

  Fly  1452 S------TPTSATMATSSGGGGGGGGNAGGGSSTTPASNPLLLMSGGTAGGGTGATTTTSTSSSS 1510
            :      .||.|::|.:                                                
Zfish   905 APSVDNRVPTPASVAET------------------------------------------------ 921

  Fly  1511 RMMSSSSSLSSQMAALEAAARDNDDETPSPSGENTNGSGGSGNAGGMASKGKLDSIKQDDDIKKE 1575
               .|..:|....|| |......:||....||                 |.:.|...:|:|:|  
Zfish   922 ---HSQQALPDYPAA-EPKIEHQEDEQEVESG-----------------KKRPDIKMEDEDVK-- 963

  Fly  1576 FMDDSCGGNNDSSQMDCSTGGGKGKNVNNDGTSMIKMEIKTEDGLDGEVKIKTEAMDVDEAGGST 1640
                                           ...:|.:.:|       |:.|.|.|:.:      
Zfish   964 -------------------------------PPQVKEQPET-------VEPKQEPMETE------ 984

  Fly  1641 AGEHHGEGGGGSGVGGGKDNINGAHDGGATGGAVDIKPKTETKPLVPEPLAPNAGD------KKK 1699
                                              |.||:|:|:|...|..:.|:..      :.:
Zfish   985 ----------------------------------DKKPETKTEPKEEEVSSTNSSTPANQSAQSR 1015

  Fly  1700 KCQFNPEELRTALLPTLEKLYRQEPESVPFRYPVDPQALGIPDYFEIVKKPMDLGTIRTNIQNGK 1764
            |..|.|||||.||:||||.||||:|||:|||.||||..|||||||:|||.|:||.||:..:..|:
Zfish  1016 KKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPNLLGIPDYFDIVKNPIDLSTIKRKLDTGQ 1080

  Fly  1765 YSDPWEYVDDVWLMFDNAWLYNRKTSRVYRYCTKLSEVFEAEIDPVMQALGYCCGRKYTFNPQVL 1829
            |.:||:||||:||||:|||||||||||||:||:||:||||.|||||||.|||||||||.|:||.|
Zfish  1081 YQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLAEVFEQEIDPVMQGLGYCCGRKYEFSPQTL 1145

  Fly  1830 CCYGKQLCTIPRDAKYYSYQNSLKEYGVASNRYTYCQKCFNDIQGDTVTLGDDPLQSQT------ 1888
            ||||||||||.||..|||||          |||.:|:||||:||||:|||||||.||||      
Zfish  1146 CCYGKQLCTISRDGTYYSYQ----------NRYHFCEKCFNEIQGDSVTLGDDPTQSQTYVSSAA 1200

  Fly  1889 -----QIKKDQFKEMKNDHLELEPFVNCQECGRKQHQICVLWLDSIWPGGFVCDNCLKKKNSKRK 1948
                 .|.|:||::.|||.|:.||||.|::||||.||||||..|.|||.||:|||||||....||
Zfish  1201 QKSLSMISKEQFEKKKNDTLDSEPFVECKDCGRKMHQICVLHYDVIWPSGFICDNCLKKSGKSRK 1265

  Fly  1949 ENKFNAKRLPTTKLGVYIETRVNNFLKKK-EAGAGEVHIRVVSSSDKCVEVKPGMRRRFVEQGEM 2012
            ||||:||:|..|:||.|||.|||.:||:: ...||||.:|||:||||.|||||||:.|||:.|||
Zfish  1266 ENKFSAKKLQCTRLGSYIEDRVNKYLKRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEM 1330

  Fly  2013 MNEFPYRAKALFAFEEVDGIDVCFFGMHVQEYGSECPAPNTRRVYIAYLDSVHFFRPRQYRTAVY 2077
            ...||||.||||||||:||:||||||||||||||:||.||||||||:||||:|||:||..|||||
Zfish  1331 SESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPFPNTRRVYISYLDSIHFFKPRLLRTAVY 1395

  Fly  2078 HEILLGYMDYVKQLGYTMAHIWACPPSEGDDYIFHCHPTDQKIPKPKRLQEWYKKMLDKGMIERI 2142
            ||||:||::|||:|||...|||||||||||||||||||.||||||||||||||:|||||...|||
Zfish  1396 HEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYRKMLDKAFAERI 1460

  Fly  2143 IQDYKDILKQAMEDKLGSAAELPYFEGDFWPNVLEESIKELDQEEEEKRKQAEAAEAAAAANLFS 2207
            |.|||||.|||.||:|.||.|||||||||||||||||||||:|||||::|:...|         |
Zfish  1461 IHDYKDIFKQATEDRLTSAYELPYFEGDFWPNVLEESIKELEQEEEERKKEENTA---------S 1516

  Fly  2208 IEENE-VSGDGKKKGQKKAKKSNKSKAA-QRKNSKKSNEHQSGNDLSTKIYATMEKHKEVFFVIR 2270
            .|..| ...|.|...:|..||:||:|:: .|.|.||.......||||.|:||||||||||||||.
Zfish  1517 SETTEGAQADSKNAKKKNNKKTNKNKSSVSRANKKKPGMPNVANDLSQKLYATMEKHKEVFFVIH 1581

  Fly  2271 LHSAQSAASLAPIQDPDPLLTCDLMDGRDAFLTLARDKHFEFSSLRRAQFSTLSMLYELHNQGQD 2335
            ||:.....:|.||.|||||||||||||||||||||||||:|||||||.::||:.||.||||||||
Zfish  1582 LHAGPVVNTLPPIMDPDPLLTCDLMDGRDAFLTLARDKHWEFSSLRRCKWSTMCMLVELHNQGQD 1646

  Fly  2336 KFVYTCNHCKTAVETRYHCTVCDDFDLCIVCKEKVGHQHKMEKLGFDIDDGS-ALADHKQANPQE 2399
            :||||||.||..||||:|||||:||||||.|....||:|:|.|.|..:||.| ........:|||
Zfish  1647 RFVYTCNECKHHVETRWHCTVCEDFDLCINCYNSKGHEHQMVKWGLGLDDDSNNQGGEANKSPQE 1711

  Fly  2400 ARKQSIQRCIQSLAHACQCRDANCRLPSCQKMKLVVQHTKNCKRKPNGGCPICKQLIALCCYHAK 2464
            :|:.|||||||||.||||||:|||.||||||||.||||||.||||.|||||:|||||||||||||
Zfish  1712 SRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAK 1776

  Fly  2465 NCEEQKCPVPFCPNIKHKLKQQQSQQKFQQQQLLRRRVALMSRTAAPAALQGPAAVSGPTVVSG- 2528
            :|:|.|||||||.||||||:|||.||:.||.|::|||:|||.....|.:|..|....||...:. 
Zfish  1777 HCQENKCPVPFCLNIKHKLRQQQIQQRLQQAQMMRRRMALMQGRGMPPSLPSPTTSGGPGTPNSQ 1841

  Fly  2529 -----GVPVVGMSGVAVSQQVIPGQAGIL------PPGAGGMSPSTVAVPSPVSGGAGAGGMGGM 2582
                 ..|....:.....||..|..|.::      ||     :|.:...|.|.|           
Zfish  1842 QLQQPNTPQTSQALANQPQQTHPNVAAMVQAFPNQPP-----TPGSQGKPGPQS----------- 1890

  Fly  2583 TSPHPHQPG-IGMKPGGGHSPSP--NVLQVVKQV-----------------QEEAARQQVSHGGG 2627
             ||.|.|.. :.|.|.....|||  ..|:|.||:                 |::..:||......
Zfish  1891 -SPLPQQQSPLPMPPQQQPQPSPQQQALKVAKQIEMMTKVKQQQQQQQQQQQQQQQQQQQQQQQD 1954

  Fly  2628 FG---KGVPMAPPVMNRPMGGAGPNQNVVNQLGGMGVGVGGVGGVGVGGVGGVGVNQLNSGGGNT 2689
            :.   .|:||..|.|...|...||.                                        
Zfish  1955 YRMSMNGMPMNQPRMMTSMQMMGPR---------------------------------------- 1979

  Fly  2690 PGAPISGPGMNVNHLMSMDQWGGGGAGGGGANPGGGNPQ---------ARYANNTGGMRQPTHVM 2745
                  ||.|..|  |...||..|.|   ..||.|..||         |:..:......|...::
Zfish  1980 ------GPQMVQN--MQQGQWAPGMA---MQNPQGPPPQQVPQQQMAMAQQQSQVAQTPQQAQMI 2033

  Fly  2746 QTNLIPPQQQQQMMGGLGGPNQLGGGQ-----MPVGGQHGGMGMGMGAPPMAGTVGGVRPSPGAG 2805
            |..|:..|||||..     |.|:....     .|...|..||       ...|....:  :||| 
Zfish  2034 QRALMQQQQQQQQQ-----PRQIQAVMPPQQVQPQAPQQQGM-------QQRGVTSNI--TPGA- 2083

  Fly  2806 GGGGSATGGGLNTQQLALIMQKIKNNPTNESNQHILAILKQNPQIMAAIIKQRQQSQNNAAAGGG 2870
                           |..:::.:|:..:.:..|.:|.|||.||.:|||.||||....        
Zfish  2084 ---------------LQDLLRTLKSPSSPQQQQQVLNILKSNPHLMAAFIKQRTAKY-------- 2125

  Fly  2871 APGPGGALQQQQAGNGPQNPQQQQQQQQQQQVMQQQQMQHMMNQQQGGGGPQQMNPNQQQQQQQV 2935
                             |..|.||||..|..:..||.||:|...|.|......|.|.||.|.|  
Zfish  2126 -----------------QANQPQQQQNPQAMLASQQGMQNMAAMQPGSVQRPVMPPQQQPQPQ-- 2171

  Fly  2936 NLMQQQQQGGPGGPGSGLPTRMPNMPNALGMLQSLPPNMSPGVSTQGGMV-----PNQNWNKMRY 2995
                                  |....|:..|.|           ||.|:     .||...:.:.
Zfish  2172 ----------------------PAATQAMAALGS-----------QGQMMNAAHNGNQQLFRRQL 2203

  Fly  2996 MQMSQYPPPYPQRQRGPHMGGAGPGPGQQQFPGGGGGAGNFNAGGAGGAGGVVGVGGVPGGAGTV 3060
            ::..|....:.|:|      ||.| |||.:||...|.|.....       .|.....:.||||  
Zfish  2204 LRQMQQQQQHQQQQ------GAMP-PGQGRFPQPQGAASYSQI-------RVQQQMAMQGGAG-- 2252

  Fly  3061 PGGDQYSMANAAAASNMLQQQQGQVGVGVGVGVKPGPGQQQQQMGVGMPPGMQQQQQQQQPLQQQ 3125
            |.|....||           |.||.|:|:         ..|||..:.....:||||||||.:.:|
Zfish  2253 PMGQMPPMA-----------QMGQPGMGL---------DAQQQQNLMQQRMLQQQQQQQQQMMKQ 2297

  Fly  3126 QMMQVAMPNANAQNPSAVVGGP-NAQVMGPPTPHSLQQQLMQSARSSPPIRSPQPTPS---PRSA 3186
            ||...|...:.:..|..:.|.| .|.:.|....::|..|:    ||..|::||:| ||   |.|:
Zfish  2298 QMGSPAQAASMSPQPHMLGGQPQGAHMPGQAMANALGNQV----RSPAPVQSPRP-PSQQPPHSS 2357

  Fly  3187 PSPRAAPSASPRAQPSPHHVMSSHSPAPQGP---PHDGMHNHGMHHQSPLPGVPQDVGVGVGVGV 3248
            ||||..|      ||||.|..||| |:..||   |.|..|.......:.||              
Zfish  2358 PSPRMQP------QPSPLHPGSSH-PSLAGPMPGPMDQAHMCTAEQSAMLP-------------- 2401

  Fly  3249 GVGVNVNVGNVGVGNAGGALPD-----ASDQLTKFVERL 3282
                     .:...|.||...|     ..|.|.||||.|
Zfish  2402 ---------QLNTPNRGGLTNDLNMDTTGDTLEKFVEGL 2431

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nejNP_001188575.1 ZnF_TAZ 530..600 CDD:214717 33/69 (48%)
KIX 946..1024 CDD:280354 58/77 (75%)
Bromo_cbp_like 1705..1812 CDD:99927 78/106 (74%)
RING_CBP-p300 1824..1906 CDD:276805 52/92 (57%)
PHD_CBP_p300 1908..1939 CDD:277032 21/30 (70%)
HAT_KAT11 1970..2283 CDD:285432 212/315 (67%)
ZZ_CBP 2339..2379 CDD:239077 26/39 (67%)
ZnF_TAZ 2404..2476 CDD:214717 61/71 (86%)
crebbpbNP_001352115.1 Med15 79..>505 CDD:312941 181/752 (24%)
zf-TAZ 338..405 CDD:307990 32/66 (48%)
KIX 550..630 CDD:280354 59/80 (74%)
Med15 596..>906 CDD:312941 126/486 (26%)
DNA_pol3_gamma3 <858..>982 CDD:331207 42/270 (16%)
Bromo_cbp_like 1021..1128 CDD:99927 78/106 (74%)
RING_CBP-p300 1140..1223 CDD:276805 52/92 (57%)
PHD_CBP 1224..1258 CDD:277117 24/33 (73%)
HAT_KAT11 1287..1594 CDD:311917 212/315 (67%)
ZZ_CBP 1650..1690 CDD:239077 26/39 (67%)
zf-TAZ 1717..1785 CDD:307990 57/67 (85%)
Creb_binding 2028..2125 CDD:312539 34/126 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170578149
Domainoid 1 1.000 438 1.000 Domainoid score I536
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1444 1.000 Inparanoid score I113
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001062
OrthoInspector 1 1.000 - - otm25856
orthoMCL 1 0.900 - - OOG6_101987
Panther 1 1.100 - - O PTHR13808
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X719
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
109.890

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