Protein Alignment nej and ep300b

DIOPT Version :10

• Sequence 1: NP_001188575.1
• Gene: nej / 43856
• FlyBaseID: FBgn0261617
• Length: 3282
• Species: Drosophila melanogaster
• Sequence 2: XP_009297682.1
• Gene: ep300b / 565612
• ZFINID: ZDB-GENE-080403-15
• Length: 2646
• Species: Danio rerio
• Alignment Length: 3337
• Identity: 1197/3337 - (35%)
• Similarity: 1487/3337 - (44%)
• Gaps: 949/3337 - (28%)

  Fly   170 SKSPNLQSP------NQGGMQQVVGTQMGMVNSMPMSISNNGN----NGMNAIPGMNTIAQGNLG 224
            :|.|.|.||      :.|   ...|:...:.:.:|..:.|:.:    |||:.
Zfish    13 AKRPKLSSPALSVSASDG---NDFGSLFDLEHDLPDELINSSDLGLPNGMDP------------- 61

  Fly   225 NMVLTNSVGGGMGGMV-----------NHLKQ--QPGGGGGGMINSVSVPGGPG--AGAGGVGAG 274
            :.:.|:..||||.|.:           .||.:  :||...    ::.:..|.||  |..|.:|..
Zfish    62 SQLHTSLGGGGMSGPLGVSGQDTAAKHKHLSELLRPGAPP----SASTATGSPGNAASLGMMGGL 122

  Fly   275 GGGAVAANQGMHMQNGPMMGR--MVGQQHMLRGPHLMGASGGAGGPGNGPGG----GGPRMQNPN 333
            .||.|....|...|...||.:  |||..:..    :||...|.|.|.:..||    |.|||...|
Zfish   123 SGGPVTQGMGGPQQQPSMMPQPGMVGGLNRA----MMGTQKGNGQPQSMMGGQMMNGAPRMGYAN 183

  Fly   334 MQMNFRPFAAQLNSLPYGVGQYGGPGGGNN-PQQQQQQQQQQLLAQQMAQRGGVVPGMPQGNRPV 397
            :.||                 .|..|.||. |...||..    ..||||| ..:.|..|
Zfish   184 VNMN-----------------AGMAGNGNMLPDSLQQPN----AGQQMAQ-AAMRPQQP------ 220

  Fly   398 GTVVPMSTLGGDG--SGPAGQLVSGNPQQQQMLAQQQTGAMGPRPPQPNQLLGHPGQQQQQQQQP 460
            |.|..|..:|..|  .|..||  .|...|.....|.:.|       |||.:     .|....::|
Zfish   221 GAVNKMGMMGAPGPYGGSYGQ--CGGQSQLGPQLQNKAG-------QPNSI-----NQFNMDKKP 271

  Fly   461 GTSQQQQQQQGVGIGGAGVVANAGTVAGVPAVAGGGAGGAVQSSGPGG-ANRDVPDDRKRQ-IQQ 523
            ...|.....||                  |.|.||       .||||| |.....|..||: |||
Zfish   272 QLGQNMGGMQG------------------PGVVGG-------VSGPGGTAAPPAADPEKRKLIQQ 311

  Fly   524 QLMLLLHAHKCNRRENLNPNREVCNVNYCKAMKSVLAHMGTCKQSKDCTMQHCASSRQILLHYKT 588
            ||:||||||||:|||..|.....||:.:|:.||:||.||..|:..|.|.:.||||||||:.|:|.
Zfish   312 QLVLLLHAHKCHRREQANGEVRQCNLPHCRTMKNVLNHMTHCQAGKSCQVAHCASSRQIISHWKN 376

  Fly   589 CQNSGCVICYPFRQNHSVFQNANVPPGGGPAGIGGAPPGGGGAGGGAAGAGGNLQQQQQQQQQQQ 653
            |....|.:|.|.:                                 :||              .:
Zfish   377 CTRHDCPVCLPLK---------------------------------SAG--------------DK 394

  Fly   654 QNQQPNLTGLVVDGKQGQQVAPGGGQNTAIVLPQQQGAGGAPGAPKTPADMVQQLTQQQQQQQQQ 718
            :||| :|.|                           |||.|.|.|
Zfish   395 RNQQ-SLLG---------------------------GAGMAMGGP-------------------- 411

  Fly   719 VHQQQVQQQELRRFDGMSQQVVAGGMQQQQQQGLPPVIRIQGAQPAVRVLGPGGPGG-PSGPNVL 782
                                                             ||...||| ||.||:.
Zfish   412 -------------------------------------------------LGGSLPGGQPSAPNIN 427

  Fly   783 PN---DVNSLHQQQQQMLQQQQQQGQNRRRGGLATMVEQQQQHQQQQQQPNPAQLGGNIPAPLSV 844
            |.   |.:|:                .|....|....:..|...|.||...|.|     |...|:
Zfish   428 PPSQIDPSSI----------------ERAYAALGLTYQGNQASNQNQQTSVPGQ-----PGMRSL 471

  Fly   845 NVGGFGNTNFGGAAAGGAVGANDKQQLKVAQVHPQSHGVGAGGASAGAGASGGQVAAG------S 903
            |          ..|.|.::|.|......::..||                  |.:..|      :
Zfish   472 N----------NMAGGNSMGVNGGVGAPMSNQHP------------------GMLPDGMLHRNMT 508

  Fly   904 SVLMPADTTGSGNAGNPNQNAGGVAGGAGGGNGGNTGPPGDNEKDWRESVTADLRNHLVHKLVQA 968
            :..:..|::|.||.|:        |..|       |.|.....|.|.|.:|.|||||||||||||
Zfish   509 AQSLMNDSSGVGNMGS--------AATA-------TPPSAGMRKSWHEDITQDLRNHLVHKLVQA 558

  Fly   969 IFPTSDPTTMQDKRMHNLVSYAEKVEKDMYEMAKSRSEYYHLLAEKIYKIQKELEEKRLKRKEQH 1033
            ||||.||..::|:||.|||:||.|||.||||.|.||:|||||||||||||||||||||..|
Zfish   559 IFPTPDPAALKDRRMENLVAYARKVEGDMYESANSRAEYYHLLAEKIYKIQKELEEKRRTR---- 619

  Fly  1034 QQMLMQQQGVANPVAGGAAGGAGSAAGVAGGVVLPQQQQQQQQQQQQQGQQPLQSCIHPSISPMG 1098
               |.:|.|                         |...                    ||:....
Zfish   620 ---LQKQDG-------------------------PHSD--------------------PSLVQAT 636

  Fly  1099 GVMPPQQL--RPQGPPGILGQQTAAGLGVGVGVTNNMVTMRSHSPGGNMLALQQQQRMQFPQQQQ 1161
            |   |.|:  |.|.|.|:                       .||..|         ..||.|...
Zfish   637 G---PSQMVNRMQNPAGM-----------------------PHSLNG---------MNQFGQVGM 666

  Fly  1162 QQPPGSGAGKMLVGPPGPSPGGMVVNPALSPYQTTNVLTSPVPGQQQQQQFINANGGTGANPQLS 1226
            |||.|..|                              |.|:|              .|||
Zfish   667 QQPMGQRA------------------------------TPPLP--------------MGAN---- 683

  Fly  1227 EIMKQRHIHQQQQQQQQQQQQGMLLPQSPFSNSTPLQQQQQQQQQQQQQQQATSNSFSSPMQQQQ 1291
                          ..|...||           ||...|....|.|.|..|   |.|:.......
Zfish   684 --------------LNQMSMQG-----------TPRMAQPNVPQLQNQYMQ---NQFTGTGAGLG 720

  Fly  1292 QGQ--QQQQQKPGSVLNNMPPTPTSL----------EALNAGAGAPGTGGSASNVTVSAPSPSPG 1344
            ||.  ..|....|::..|..|||.||          .::.....|.|..|..||  ...|:|.||
Zfish   721 QGAVGLNQPAGQGAMPQNQMPTPPSLSVHSPVAQSQSSVPVSGAAAGPQGPPSN--HPPPAPQPG 783

  Fly  1345 FLSNGPSIGTPSNNNNNSSANNNPPSVSSLMQQPLSNRPGTPPYIPASPVPATSASGLAASSTPA 1409
            ..::.|.:           ..|:|....||...|..::  |||.:|.:..|        ...||
Zfish   784 LHTHCPPL-----------RQNSPSPARSLTPTPAPHQ--TPPQLPGNQTP--------QPHTP- 826

  Fly  1410 SAAATCASSGSGSNSSSGATAAGASSTSSSSSAGSGTPLS-SVSTPTSATMATSSGGGGGGGGNA 1473
                                   .|||:.:..|....|:: .|::..|:.:...|.|||..||..
Zfish   827 -----------------------NSSTTMAPPASQLPPMAQGVASEKSSQLQQQSHGGGATGGPQ 868

  Fly  1474 GGGSSTTPASN----------PLLLMSGGTAGGGTGATTTTSTSSSSRMMSSSSSLSSQMAALEA 1528
            .|.:|:.|:.|          ||...|..|..|......:.|::..|..::||...:...:..|.
Zfish   869 TGLASSVPSQNAHGLCTHPHSPLSQKSSATVDGQASTPASVSSADPSSQLTSSEPTAPLDSKTEV 933

  Fly  1529 AARDNDDETPSPSGENTNGSGGSGNAGGMASKGKLDSIKQDDDIKKEFMDDSCGGNNDSSQMDCS 1593
            ..:|.::|     .||......||....|.::     ||.::
Zfish   934 KQQDEEEE-----NENETEDKASGKMAAMQTE-----IKSEE----------------------- 965

  Fly  1594 TGGGKGKNVNNDGTSMIKMEIKTEDGLDGEVKIKTEAMDVDEAGGSTAGEHHGEGGGGSGVGGGK 1658
                             |.|||.|:....|  .|||.|:
Zfish   966 -----------------KPEIKKEEPAGDE--CKTEPME-------------------------- 985

  Fly  1659 DNINGAHDGGATGGAVDIKPKTETKPLVPEPLAPN---AGDKKKKCQFNPEELRTALLPTLEKLY 1720
                       |..|.|.||:.:|:|...|....|   |..:.||.:|.|:|||.||:||||.||
Zfish   986 -----------TSTAEDKKPEVKTEPKEEEVAGANSTPANTQSKKKEFKPDELRQALMPTLEALY 1039

  Fly  1721 RQEPESVPFRYPVDPQALGIP-----------DYFEIVKKPMDLGTIRTNIQNGKYSDPWEYVDD 1774
            ||:|||:|||.|||||.||||           |||:|||.|:||.||:..:..|:|.:||:||||
Zfish  1040 RQDPESLPFRQPVDPQLLGIPVRIRTSNKTNLDYFDIVKNPIDLSTIKRKLDTGQYQEPWQYVDD 1104

  Fly  1775 VWLMFDNAWLYNRKTSRVYRYCTKLSEVFEAEIDPVMQALGYCCGRKYTFNPQVLCCYGKQLCTI 1839
            |||||:|||||||||||||:||:||:||||.|||||||.||||||||..|:||.|||||||||||
Zfish  1105 VWLMFNNAWLYNRKTSRVYKYCSKLAEVFEQEIDPVMQELGYCCGRKLEFSPQTLCCYGKQLCTI 1169

  Fly  1840 PRDAKYYSYQNSLKEYGVASNRYTYCQKCFNDIQGDTVTLGDDPLQSQTQIKKDQFKEMKNDHLE 1904
            ||||.|:|||||..:||:.::||.:|:||||:|||:.|:|||||.|.||.|.||||:..|||.|:
Zfish  1170 PRDAAYFSYQNSSPKYGLLADRYHFCEKCFNEIQGENVSLGDDPTQPQTSINKDQFQRKKNDTLD 1234

  Fly  1905 LEPFVNCQECGRKQHQICVLWLDSIWPGGFVCDNCLKKKNSKRKENKFNAKRLPTTKLGVYIETR 1969
            .|..:.|.:||||.||||||..::|||.||:||.||||.||.|||||:.|||||.||||.::|||
Zfish  1235 PELLLECGDCGRKMHQICVLHNETIWPSGFICDGCLKKSNSTRKENKYAAKRLPQTKLGNFLETR 1299

  Fly  1970 VNNFLKKK-EAGAGEVHIRVVSSSDKCVEVKPGMRRRFVEQGEMMNEFPYRAKALFAFEEVDGID 2033
            ||::||:: ...:|||.||||..|||.|||||||:.|||:.|||...||||.||||||||:||.|
Zfish  1300 VNDYLKRQNHPESGEVTIRVVHISDKVVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGTD 1364

  Fly  2034 VCFFGMHVQEYGSECPAPNTRRVYIAYLDSVHFFRPRQYRTAVYHEILLGYMDYVKQLGYTMAHI 2098
            |||||||||||||:||.||.|||||:||||||||:||..||.||||||:||::|||::|:.|.||
Zfish  1365 VCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFQPRHLRTGVYHEILIGYLEYVKKMGFVMGHI 1429

  Fly  2099 WACPPSEGDDYIFHCHPTDQKIPKPKRLQEWYKKMLDKGMIERIIQDYKDILKQAMEDKLGSAAE 2163
            |||||||||||||||||:||||||||||||||||||||.:.|||:.|||||.|||.||:|.||.|
Zfish  1430 WACPPSEGDDYIFHCHPSDQKIPKPKRLQEWYKKMLDKAVTERIVHDYKDIFKQATEDRLTSAKE 1494

  Fly  2164 LPYFEGDFWPNVLEESIKELDQEEEEKRKQAE--AAEAAAAANLFSIEENEVSGDGKKKGQKKAK 2226
            ||||||||||||||||||||:|||||::::..  ::|:..|.|          ||.|...:|..|
Zfish  1495 LPYFEGDFWPNVLEESIKELEQEEEERKREENNTSSESIDATN----------GDSKNAKKKNNK 1549

  Fly  2227 KSNKSKAA-QRKNSKKSNEHQSGNDLSTKIYATMEKHKEVFFVIRLHSAQSAASLAPIQDPDPLL 2290
            |::|:|:: .|.|.||.......||||.|:|||||||||||||||..:..:|.||.||.|||.|:
Zfish  1550 KTSKNKSSLSRANKKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRFIAGPAANSLPPISDPDTLM 1614

  Fly  2291 TCDLMDGRDAFLTLARDKHFEFSSLRRAQFSTLSMLYELHNQGQDKFVYTCNHCKTAVETRYHCT 2355
            .||||||||||||||||||.||||||||::|::.||.|||||.||:||||||.||..||||:|||
Zfish  1615 ACDLMDGRDAFLTLARDKHLEFSSLRRAKWSSMCMLVELHNQTQDRFVYTCNECKHHVETRFHCT 1679

  Fly  2356 VCDDFDLCIVCKEKVGHQHKMEKLGFDIDDGSALADHKQA-----NPQEARKQSIQRCIQSLAHA 2415
            ||:|:||||.|....||:|||||||..:||.|    :.||     ||.::|:.|||||||||.||
Zfish  1680 VCEDYDLCITCYNVKGHEHKMEKLGLGLDDES----NNQAAASTQNPGDSRRLSIQRCIQSLVHA 1740

  Fly  2416 CQCRDANCRLPSCQKMKLVVQHTKNCKRKPNGGCPICKQLIALCCYHAKNCEEQKCPVPFCPNIK 2480
            ||||:|||.||||||||.||||||.||||.|||||||||||||||||||:|:|.|||||||.|||
Zfish  1741 CQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHCQETKCPVPFCLNIK 1805

  Fly  2481 HKLKQQQSQQKFQQQQLLRRRVALMSRTAAPAALQGPAAVSGPTVVSGGVPVVGMSG-VAVSQQV 2544
            |||:|||.|.:.||.|:||||:|.|.|...|     |....||   .||:|..|.:| ...|...
Zfish  1806 HKLRQQQLQHRLQQAQMLRRRMATMQRVGQP-----PPCGGGP---PGGLPSPGNNGATGPSTPT 1862

  Fly  2545 IPGQAGILPPGAGGMSPSTVAVPSPVSGGAGAG------------------GMGGMTS------- 2584
            ..|.....|.....::|:.:::|.|.:||..||                  |.|||.:
Zfish  1863 SVGTQPATPQTPTQLTPNLISLPQPGAGGVPAGAPQQSPQHPVHHQFQQMPGAGGMMNSQQQQMV 1927

  Fly  2585 --------PHPHQPGIGMKPGGGHSPSPNVLQVVKQVQEEAARQQVSHGGGFGKGVPMA------ 2635
                    ||||.. .|..|.|   ||||.....|.....|...|:....|   .||||
Zfish  1928 PQQSLGQVPHPHNQ-YGPHPTG---PSPNTQSQGKPGLGPATPPQLPSNPG---TVPMAQQQQPT 1985

  Fly  2636 -PP------------------------VMNRPMGGAG--PNQNVVNQLGGMGVGVGGVGGVGVGG 2673
             ||                        ::.|....||  |..:...| |.:||...|:|.||..|
Zfish  1986 GPPAAAVEIAMKIQQVADAQRKMAQVQLLQRQAAQAGMMPQHHQQPQ-GQIGVAHPGIGMVGPQG 2049

  Fly  2674 VGGVGVNQLNSGGGNTPGAPISGPGMNVNHLMSMDQWGGGGAGGGGANPGGGNPQARYANNTGGM 2738
            :.                   |....:.|.:....|.|..|..|.|...   ..|.:.....|.|
Zfish  2050 LA-------------------SQAQTSANRVQMEQQQGPQGMMGAGPMQ---QQQPQQVAVQGQM 2092

  Fly  2739 RQPTHVMQTNLIPP-QQQQQMMGGLGGPNQLGGGQMPVGGQHGGMGMGMGAPP------------ 2790
            ....|..|..:.|| |.|||...|.|.|.|.....|   .|.|.:.|.....|
Zfish  2093 PPQMHPQQPRMNPPLQPQQQQWPGQGMPTQQRPAMM---SQQGMVSMQPQPQPQQPSQQTQQQQA 2154

  Fly  2791 ---------MAGTVGGVRPSPGAGGGGGSATGGGLNTQQLALIMQKIKNNPTNESNQHILAILKQ 2846
                     |:....|::....:|....:...|.|  |||   ::.:::..:.:..|.:|.||:.
Zfish  2155 PQMPNRNALMSMVQAGLQSGVASGAAASNLPQGAL--QQL---LRTLRSPSSPQQQQQVLNILRS 2214

  Fly  2847 NPQIMAAIIKQRQQSQNNAAAGGGAP--GPG----------------------GALQQQQAGNGP 2887
            :|.:|||.||||.........|...|  |||                      |...|.|..:..
Zfish  2215 SPLLMAAFIKQRVHKYKGGTGGPSGPQGGPGPMGGQPVGVNTGVPQPGMHLGQGVNMQSQLLSQQ 2279

  Fly  2888 QNPQQQQQQQ----QQQQV--MQQQQMQHMMNQQQGGGGPQQMNPNQQQQQQQVNLMQQQQQGGP 2946
            |:.||||.||    |||||  :||||.|....|||     ||...:|||||||.:..|||||.|.
Zfish  2280 QSQQQQQMQQRPLLQQQQVAALQQQQQQQQQQQQQ-----QQQQQHQQQQQQQQHQQQQQQQQGI 2339

  Fly  2947 GGPGSGLPTRMPNMPNALGMLQSLPPNMSPGVSTQGGMVPNQNWNKMRYMQMSQYPPPYPQRQRG 3011
            .|.|:      |||.|         |:....|.        :...::::.|..|......|:|..
Zfish  2340 QGQGT------PNMAN---------PHFRELVM--------RRQQQLQFQQQQQQQQQQQQQQMS 2381

  Fly  3012 PHMG-----GAGPGPGQQQFPGGGGGAGNFNAGGAGGAGGVVGVGGV-PGGAGTVPGGDQYSMAN 3070
            .|..     |.....|..|.|.||                 ..:.|| ||.....||......|.
Zfish  2382 NHAAFQQQQGYMSQQGNMQVPPGG-----------------QPLQGVQPGQQQNFPGNPAQQQAA 2429

  Fly  3071 AAAASNM------LQQQQGQVGVGVGVGVKPGPGQQQQQMGVGM--PPGMQQQQQQQQPLQQQQM 3127
            ||....:      ||.||.|.....|..:.||.|.|..|:|.|:  |..:.||...|:...|||.
Zfish  2430 AALQQRLAQQQHQLQMQQQQNAATQGPDMGPGGGPQPTQLGPGLQSPQALLQQALHQRLFPQQQH 2494

  Fly  3128 MQVAMPNANAQNPSAVVGGPNAQVMGPPTPHSLQQQLMQSARSSPPIRSPQPTPSPRSAPSPRAA 3192
            :....| |...||.:    |..|.:. .:||...|||..|.  |..:.||||:|.|:|.| |.::
Zfish  2495 LSGTSP-AQQNNPMS----PQQQQIS-QSPHLQGQQLPSSL--SNQVCSPQPSPRPQSQP-PHSS 2550

  Fly  3193 PSASPRAQPSPHHVMSSHSPAPQ-GPPHDG---MHNHGMHHQSPLPGVPQDVGVGVGVGVGVGVN 3253
            ||...:.||||||:    ||..| |.||..   .|:.||....|....||....... |.|...|
Zfish  2551 PSPRLQPQPSPHHI----SPQTQTGSPHPSHLQQHHSGMAPPPPPHQQPQHNSKDPS-GFGADQN 2610

  Fly  3254 VNVGNVGVGNAGGALPDASDQL 3275
            ..:..:. |.||...|.|:|.|
Zfish  2611 AMLSQLS-GMAGLHGPGANDML 2631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nej	NP_001188575.1	zf-TAZ	530..597	CDD:460457	33/66 (50%)
		KIX	944..1024	CDD:366953	58/79 (73%)
		Bromo_cbp_like	1705..1812	CDD:99927	79/117 (68%)
		RING_CBP-p300	1824..1906	CDD:276805	54/81 (67%)
		PHD_CBP_p300	1908..1939	CDD:277032	18/30 (60%)
		HAT_KAT11	1970..2284	CDD:400497	209/317 (66%)
		ZZ_CBP	2339..2379	CDD:239077	27/39 (69%)
		zf-TAZ	2405..2473	CDD:460457	58/67 (87%)
		NCBD_CREBBP-p300_like	2820..2862	CDD:411021	14/41 (34%)
		PLN02983	<3147..>3218	CDD:215533	30/71 (42%)
ep300b	XP_009297682.1	Med15	126..>276	CDD:312941	53/195 (27%)
		zf-TAZ	318..385	CDD:460457	33/66 (50%)
		KIX	534..614	CDD:366953	58/79 (73%)
		PABP-1234	<659..760	CDD:130689	36/176 (20%)
		PHA03247	<729..932	CDD:223021	55/249 (22%)
		Bromo_cbp_like	1024..1142	CDD:99927	79/117 (68%)
		RING_CBP-p300	1154..1236	CDD:276805	54/81 (67%)
		PHD_SF	1237..1271	CDD:473978	19/33 (58%)
		HAT_KAT11	1300..1608	CDD:400497	209/317 (66%)
		ZZ_CBP	1663..1703	CDD:239077	27/39 (69%)
		zf-TAZ	1730..1798	CDD:460457	58/67 (87%)
		PAT1	<1870..>2020	CDD:401645	34/156 (22%)
		PAT1	<1954..>2100	CDD:401645	34/171 (20%)
		Creb_binding	<2168..2231	CDD:462659	19/67 (28%)