DRSC/TRiP Functional Genomics Resources

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Protein Alignment nej and ep300b

DIOPT Version :9

Sequence 1:NP_001188575.1 Gene:nej / 43856 FlyBaseID:FBgn0261617 Length:3282 Species:Drosophila melanogaster
Sequence 2:XP_009297682.1 Gene:ep300b / 565612 ZFINID:ZDB-GENE-080403-15 Length:2646 Species:Danio rerio


Alignment Length:3337 Identity:1197/3337 - (35%)
Similarity:1487/3337 - (44%) Gaps:949/3337 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   170 SKSPNLQSP------NQGGMQQVVGTQMGMVNSMPMSISNNGN----NGMNAIPGMNTIAQGNLG 224
            :|.|.|.||      :.|   ...|:...:.:.:|..:.|:.:    |||:.             
Zfish    13 AKRPKLSSPALSVSASDG---NDFGSLFDLEHDLPDELINSSDLGLPNGMDP------------- 61

  Fly   225 NMVLTNSVGGGMGGMV-----------NHLKQ--QPGGGGGGMINSVSVPGGPG--AGAGGVGAG 274
            :.:.|:..||||.|.:           .||.:  :||...    ::.:..|.||  |..|.:|..
Zfish    62 SQLHTSLGGGGMSGPLGVSGQDTAAKHKHLSELLRPGAPP----SASTATGSPGNAASLGMMGGL 122

  Fly   275 GGGAVAANQGMHMQNGPMMGR--MVGQQHMLRGPHLMGASGGAGGPGNGPGG----GGPRMQNPN 333
            .||.|....|...|...||.:  |||..:..    :||...|.|.|.:..||    |.|||...|
Zfish   123 SGGPVTQGMGGPQQQPSMMPQPGMVGGLNRA----MMGTQKGNGQPQSMMGGQMMNGAPRMGYAN 183

  Fly   334 MQMNFRPFAAQLNSLPYGVGQYGGPGGGNN-PQQQQQQQQQQLLAQQMAQRGGVVPGMPQGNRPV 397
            :.||                 .|..|.||. |...||..    ..||||| ..:.|..|      
Zfish   184 VNMN-----------------AGMAGNGNMLPDSLQQPN----AGQQMAQ-AAMRPQQP------ 220

  Fly   398 GTVVPMSTLGGDG--SGPAGQLVSGNPQQQQMLAQQQTGAMGPRPPQPNQLLGHPGQQQQQQQQP 460
            |.|..|..:|..|  .|..||  .|...|.....|.:.|       |||.:     .|....::|
Zfish   221 GAVNKMGMMGAPGPYGGSYGQ--CGGQSQLGPQLQNKAG-------QPNSI-----NQFNMDKKP 271

  Fly   461 GTSQQQQQQQGVGIGGAGVVANAGTVAGVPAVAGGGAGGAVQSSGPGG-ANRDVPDDRKRQ-IQQ 523
            ...|.....||                  |.|.||       .||||| |.....|..||: |||
Zfish   272 QLGQNMGGMQG------------------PGVVGG-------VSGPGGTAAPPAADPEKRKLIQQ 311

  Fly   524 QLMLLLHAHKCNRRENLNPNREVCNVNYCKAMKSVLAHMGTCKQSKDCTMQHCASSRQILLHYKT 588
            ||:||||||||:|||..|.....||:.:|:.||:||.||..|:..|.|.:.||||||||:.|:|.
Zfish   312 QLVLLLHAHKCHRREQANGEVRQCNLPHCRTMKNVLNHMTHCQAGKSCQVAHCASSRQIISHWKN 376

  Fly   589 CQNSGCVICYPFRQNHSVFQNANVPPGGGPAGIGGAPPGGGGAGGGAAGAGGNLQQQQQQQQQQQ 653
            |....|.:|.|.:                                 :||              .:
Zfish   377 CTRHDCPVCLPLK---------------------------------SAG--------------DK 394

  Fly   654 QNQQPNLTGLVVDGKQGQQVAPGGGQNTAIVLPQQQGAGGAPGAPKTPADMVQQLTQQQQQQQQQ 718
            :||| :|.|                           |||.|.|.|                    
Zfish   395 RNQQ-SLLG---------------------------GAGMAMGGP-------------------- 411

  Fly   719 VHQQQVQQQELRRFDGMSQQVVAGGMQQQQQQGLPPVIRIQGAQPAVRVLGPGGPGG-PSGPNVL 782
                                                             ||...||| ||.||:.
Zfish   412 -------------------------------------------------LGGSLPGGQPSAPNIN 427

  Fly   783 PN---DVNSLHQQQQQMLQQQQQQGQNRRRGGLATMVEQQQQHQQQQQQPNPAQLGGNIPAPLSV 844
            |.   |.:|:                .|....|....:..|...|.||...|.|     |...|:
Zfish   428 PPSQIDPSSI----------------ERAYAALGLTYQGNQASNQNQQTSVPGQ-----PGMRSL 471

  Fly   845 NVGGFGNTNFGGAAAGGAVGANDKQQLKVAQVHPQSHGVGAGGASAGAGASGGQVAAG------S 903
            |          ..|.|.::|.|......::..||                  |.:..|      :
Zfish   472 N----------NMAGGNSMGVNGGVGAPMSNQHP------------------GMLPDGMLHRNMT 508

  Fly   904 SVLMPADTTGSGNAGNPNQNAGGVAGGAGGGNGGNTGPPGDNEKDWRESVTADLRNHLVHKLVQA 968
            :..:..|::|.||.|:        |..|       |.|.....|.|.|.:|.|||||||||||||
Zfish   509 AQSLMNDSSGVGNMGS--------AATA-------TPPSAGMRKSWHEDITQDLRNHLVHKLVQA 558

  Fly   969 IFPTSDPTTMQDKRMHNLVSYAEKVEKDMYEMAKSRSEYYHLLAEKIYKIQKELEEKRLKRKEQH 1033
            ||||.||..::|:||.|||:||.|||.||||.|.||:|||||||||||||||||||||..|    
Zfish   559 IFPTPDPAALKDRRMENLVAYARKVEGDMYESANSRAEYYHLLAEKIYKIQKELEEKRRTR---- 619

  Fly  1034 QQMLMQQQGVANPVAGGAAGGAGSAAGVAGGVVLPQQQQQQQQQQQQQGQQPLQSCIHPSISPMG 1098
               |.:|.|                         |...                    ||:....
Zfish   620 ---LQKQDG-------------------------PHSD--------------------PSLVQAT 636

  Fly  1099 GVMPPQQL--RPQGPPGILGQQTAAGLGVGVGVTNNMVTMRSHSPGGNMLALQQQQRMQFPQQQQ 1161
            |   |.|:  |.|.|.|:                       .||..|         ..||.|...
Zfish   637 G---PSQMVNRMQNPAGM-----------------------PHSLNG---------MNQFGQVGM 666

  Fly  1162 QQPPGSGAGKMLVGPPGPSPGGMVVNPALSPYQTTNVLTSPVPGQQQQQQFINANGGTGANPQLS 1226
            |||.|..|                              |.|:|              .|||    
Zfish   667 QQPMGQRA------------------------------TPPLP--------------MGAN---- 683

  Fly  1227 EIMKQRHIHQQQQQQQQQQQQGMLLPQSPFSNSTPLQQQQQQQQQQQQQQQATSNSFSSPMQQQQ 1291
                          ..|...||           ||...|....|.|.|..|   |.|:.......
Zfish   684 --------------LNQMSMQG-----------TPRMAQPNVPQLQNQYMQ---NQFTGTGAGLG 720

  Fly  1292 QGQ--QQQQQKPGSVLNNMPPTPTSL----------EALNAGAGAPGTGGSASNVTVSAPSPSPG 1344
            ||.  ..|....|::..|..|||.||          .::.....|.|..|..||  ...|:|.||
Zfish   721 QGAVGLNQPAGQGAMPQNQMPTPPSLSVHSPVAQSQSSVPVSGAAAGPQGPPSN--HPPPAPQPG 783

  Fly  1345 FLSNGPSIGTPSNNNNNSSANNNPPSVSSLMQQPLSNRPGTPPYIPASPVPATSASGLAASSTPA 1409
            ..::.|.:           ..|:|....||...|..::  |||.:|.:..|        ...|| 
Zfish   784 LHTHCPPL-----------RQNSPSPARSLTPTPAPHQ--TPPQLPGNQTP--------QPHTP- 826

  Fly  1410 SAAATCASSGSGSNSSSGATAAGASSTSSSSSAGSGTPLS-SVSTPTSATMATSSGGGGGGGGNA 1473
                                   .|||:.:..|....|:: .|::..|:.:...|.|||..||..
Zfish   827 -----------------------NSSTTMAPPASQLPPMAQGVASEKSSQLQQQSHGGGATGGPQ 868

  Fly  1474 GGGSSTTPASN----------PLLLMSGGTAGGGTGATTTTSTSSSSRMMSSSSSLSSQMAALEA 1528
            .|.:|:.|:.|          ||...|..|..|......:.|::..|..::||...:...:..|.
Zfish   869 TGLASSVPSQNAHGLCTHPHSPLSQKSSATVDGQASTPASVSSADPSSQLTSSEPTAPLDSKTEV 933

  Fly  1529 AARDNDDETPSPSGENTNGSGGSGNAGGMASKGKLDSIKQDDDIKKEFMDDSCGGNNDSSQMDCS 1593
            ..:|.::|     .||......||....|.::     ||.::                       
Zfish   934 KQQDEEEE-----NENETEDKASGKMAAMQTE-----IKSEE----------------------- 965

  Fly  1594 TGGGKGKNVNNDGTSMIKMEIKTEDGLDGEVKIKTEAMDVDEAGGSTAGEHHGEGGGGSGVGGGK 1658
                             |.|||.|:....|  .|||.|:                          
Zfish   966 -----------------KPEIKKEEPAGDE--CKTEPME-------------------------- 985

  Fly  1659 DNINGAHDGGATGGAVDIKPKTETKPLVPEPLAPN---AGDKKKKCQFNPEELRTALLPTLEKLY 1720
                       |..|.|.||:.:|:|...|....|   |..:.||.:|.|:|||.||:||||.||
Zfish   986 -----------TSTAEDKKPEVKTEPKEEEVAGANSTPANTQSKKKEFKPDELRQALMPTLEALY 1039

  Fly  1721 RQEPESVPFRYPVDPQALGIP-----------DYFEIVKKPMDLGTIRTNIQNGKYSDPWEYVDD 1774
            ||:|||:|||.|||||.||||           |||:|||.|:||.||:..:..|:|.:||:||||
Zfish  1040 RQDPESLPFRQPVDPQLLGIPVRIRTSNKTNLDYFDIVKNPIDLSTIKRKLDTGQYQEPWQYVDD 1104

  Fly  1775 VWLMFDNAWLYNRKTSRVYRYCTKLSEVFEAEIDPVMQALGYCCGRKYTFNPQVLCCYGKQLCTI 1839
            |||||:|||||||||||||:||:||:||||.|||||||.||||||||..|:||.|||||||||||
Zfish  1105 VWLMFNNAWLYNRKTSRVYKYCSKLAEVFEQEIDPVMQELGYCCGRKLEFSPQTLCCYGKQLCTI 1169

  Fly  1840 PRDAKYYSYQNSLKEYGVASNRYTYCQKCFNDIQGDTVTLGDDPLQSQTQIKKDQFKEMKNDHLE 1904
            ||||.|:|||||..:||:.::||.:|:||||:|||:.|:|||||.|.||.|.||||:..|||.|:
Zfish  1170 PRDAAYFSYQNSSPKYGLLADRYHFCEKCFNEIQGENVSLGDDPTQPQTSINKDQFQRKKNDTLD 1234

  Fly  1905 LEPFVNCQECGRKQHQICVLWLDSIWPGGFVCDNCLKKKNSKRKENKFNAKRLPTTKLGVYIETR 1969
            .|..:.|.:||||.||||||..::|||.||:||.||||.||.|||||:.|||||.||||.::|||
Zfish  1235 PELLLECGDCGRKMHQICVLHNETIWPSGFICDGCLKKSNSTRKENKYAAKRLPQTKLGNFLETR 1299

  Fly  1970 VNNFLKKK-EAGAGEVHIRVVSSSDKCVEVKPGMRRRFVEQGEMMNEFPYRAKALFAFEEVDGID 2033
            ||::||:: ...:|||.||||..|||.|||||||:.|||:.|||...||||.||||||||:||.|
Zfish  1300 VNDYLKRQNHPESGEVTIRVVHISDKVVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGTD 1364

  Fly  2034 VCFFGMHVQEYGSECPAPNTRRVYIAYLDSVHFFRPRQYRTAVYHEILLGYMDYVKQLGYTMAHI 2098
            |||||||||||||:||.||.|||||:||||||||:||..||.||||||:||::|||::|:.|.||
Zfish  1365 VCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFQPRHLRTGVYHEILIGYLEYVKKMGFVMGHI 1429

  Fly  2099 WACPPSEGDDYIFHCHPTDQKIPKPKRLQEWYKKMLDKGMIERIIQDYKDILKQAMEDKLGSAAE 2163
            |||||||||||||||||:||||||||||||||||||||.:.|||:.|||||.|||.||:|.||.|
Zfish  1430 WACPPSEGDDYIFHCHPSDQKIPKPKRLQEWYKKMLDKAVTERIVHDYKDIFKQATEDRLTSAKE 1494

  Fly  2164 LPYFEGDFWPNVLEESIKELDQEEEEKRKQAE--AAEAAAAANLFSIEENEVSGDGKKKGQKKAK 2226
            ||||||||||||||||||||:|||||::::..  ::|:..|.|          ||.|...:|..|
Zfish  1495 LPYFEGDFWPNVLEESIKELEQEEEERKREENNTSSESIDATN----------GDSKNAKKKNNK 1549

  Fly  2227 KSNKSKAA-QRKNSKKSNEHQSGNDLSTKIYATMEKHKEVFFVIRLHSAQSAASLAPIQDPDPLL 2290
            |::|:|:: .|.|.||.......||||.|:|||||||||||||||..:..:|.||.||.|||.|:
Zfish  1550 KTSKNKSSLSRANKKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRFIAGPAANSLPPISDPDTLM 1614

  Fly  2291 TCDLMDGRDAFLTLARDKHFEFSSLRRAQFSTLSMLYELHNQGQDKFVYTCNHCKTAVETRYHCT 2355
            .||||||||||||||||||.||||||||::|::.||.|||||.||:||||||.||..||||:|||
Zfish  1615 ACDLMDGRDAFLTLARDKHLEFSSLRRAKWSSMCMLVELHNQTQDRFVYTCNECKHHVETRFHCT 1679

  Fly  2356 VCDDFDLCIVCKEKVGHQHKMEKLGFDIDDGSALADHKQA-----NPQEARKQSIQRCIQSLAHA 2415
            ||:|:||||.|....||:|||||||..:||.|    :.||     ||.::|:.|||||||||.||
Zfish  1680 VCEDYDLCITCYNVKGHEHKMEKLGLGLDDES----NNQAAASTQNPGDSRRLSIQRCIQSLVHA 1740

  Fly  2416 CQCRDANCRLPSCQKMKLVVQHTKNCKRKPNGGCPICKQLIALCCYHAKNCEEQKCPVPFCPNIK 2480
            ||||:|||.||||||||.||||||.||||.|||||||||||||||||||:|:|.|||||||.|||
Zfish  1741 CQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHCQETKCPVPFCLNIK 1805

  Fly  2481 HKLKQQQSQQKFQQQQLLRRRVALMSRTAAPAALQGPAAVSGPTVVSGGVPVVGMSG-VAVSQQV 2544
            |||:|||.|.:.||.|:||||:|.|.|...|     |....||   .||:|..|.:| ...|...
Zfish  1806 HKLRQQQLQHRLQQAQMLRRRMATMQRVGQP-----PPCGGGP---PGGLPSPGNNGATGPSTPT 1862

  Fly  2545 IPGQAGILPPGAGGMSPSTVAVPSPVSGGAGAG------------------GMGGMTS------- 2584
            ..|.....|.....::|:.:::|.|.:||..||                  |.|||.:       
Zfish  1863 SVGTQPATPQTPTQLTPNLISLPQPGAGGVPAGAPQQSPQHPVHHQFQQMPGAGGMMNSQQQQMV 1927

  Fly  2585 --------PHPHQPGIGMKPGGGHSPSPNVLQVVKQVQEEAARQQVSHGGGFGKGVPMA------ 2635
                    ||||.. .|..|.|   ||||.....|.....|...|:....|   .||||      
Zfish  1928 PQQSLGQVPHPHNQ-YGPHPTG---PSPNTQSQGKPGLGPATPPQLPSNPG---TVPMAQQQQPT 1985

  Fly  2636 -PP------------------------VMNRPMGGAG--PNQNVVNQLGGMGVGVGGVGGVGVGG 2673
             ||                        ::.|....||  |..:...| |.:||...|:|.||..|
Zfish  1986 GPPAAAVEIAMKIQQVADAQRKMAQVQLLQRQAAQAGMMPQHHQQPQ-GQIGVAHPGIGMVGPQG 2049

  Fly  2674 VGGVGVNQLNSGGGNTPGAPISGPGMNVNHLMSMDQWGGGGAGGGGANPGGGNPQARYANNTGGM 2738
            :.                   |....:.|.:....|.|..|..|.|...   ..|.:.....|.|
Zfish  2050 LA-------------------SQAQTSANRVQMEQQQGPQGMMGAGPMQ---QQQPQQVAVQGQM 2092

  Fly  2739 RQPTHVMQTNLIPP-QQQQQMMGGLGGPNQLGGGQMPVGGQHGGMGMGMGAPP------------ 2790
            ....|..|..:.|| |.|||...|.|.|.|.....|   .|.|.:.|.....|            
Zfish  2093 PPQMHPQQPRMNPPLQPQQQQWPGQGMPTQQRPAMM---SQQGMVSMQPQPQPQQPSQQTQQQQA 2154

  Fly  2791 ---------MAGTVGGVRPSPGAGGGGGSATGGGLNTQQLALIMQKIKNNPTNESNQHILAILKQ 2846
                     |:....|::....:|....:...|.|  |||   ::.:::..:.:..|.:|.||:.
Zfish  2155 PQMPNRNALMSMVQAGLQSGVASGAAASNLPQGAL--QQL---LRTLRSPSSPQQQQQVLNILRS 2214

  Fly  2847 NPQIMAAIIKQRQQSQNNAAAGGGAP--GPG----------------------GALQQQQAGNGP 2887
            :|.:|||.||||.........|...|  |||                      |...|.|..:..
Zfish  2215 SPLLMAAFIKQRVHKYKGGTGGPSGPQGGPGPMGGQPVGVNTGVPQPGMHLGQGVNMQSQLLSQQ 2279

  Fly  2888 QNPQQQQQQQ----QQQQV--MQQQQMQHMMNQQQGGGGPQQMNPNQQQQQQQVNLMQQQQQGGP 2946
            |:.||||.||    |||||  :||||.|....|||     ||...:|||||||.:..|||||.|.
Zfish  2280 QSQQQQQMQQRPLLQQQQVAALQQQQQQQQQQQQQ-----QQQQQHQQQQQQQQHQQQQQQQQGI 2339

  Fly  2947 GGPGSGLPTRMPNMPNALGMLQSLPPNMSPGVSTQGGMVPNQNWNKMRYMQMSQYPPPYPQRQRG 3011
            .|.|:      |||.|         |:....|.        :...::::.|..|......|:|..
Zfish  2340 QGQGT------PNMAN---------PHFRELVM--------RRQQQLQFQQQQQQQQQQQQQQMS 2381

  Fly  3012 PHMG-----GAGPGPGQQQFPGGGGGAGNFNAGGAGGAGGVVGVGGV-PGGAGTVPGGDQYSMAN 3070
            .|..     |.....|..|.|.||                 ..:.|| ||.....||......|.
Zfish  2382 NHAAFQQQQGYMSQQGNMQVPPGG-----------------QPLQGVQPGQQQNFPGNPAQQQAA 2429

  Fly  3071 AAAASNM------LQQQQGQVGVGVGVGVKPGPGQQQQQMGVGM--PPGMQQQQQQQQPLQQQQM 3127
            ||....:      ||.||.|.....|..:.||.|.|..|:|.|:  |..:.||...|:...|||.
Zfish  2430 AALQQRLAQQQHQLQMQQQQNAATQGPDMGPGGGPQPTQLGPGLQSPQALLQQALHQRLFPQQQH 2494

  Fly  3128 MQVAMPNANAQNPSAVVGGPNAQVMGPPTPHSLQQQLMQSARSSPPIRSPQPTPSPRSAPSPRAA 3192
            :....| |...||.:    |..|.:. .:||...|||..|.  |..:.||||:|.|:|.| |.::
Zfish  2495 LSGTSP-AQQNNPMS----PQQQQIS-QSPHLQGQQLPSSL--SNQVCSPQPSPRPQSQP-PHSS 2550

  Fly  3193 PSASPRAQPSPHHVMSSHSPAPQ-GPPHDG---MHNHGMHHQSPLPGVPQDVGVGVGVGVGVGVN 3253
            ||...:.||||||:    ||..| |.||..   .|:.||....|....||....... |.|...|
Zfish  2551 PSPRLQPQPSPHHI----SPQTQTGSPHPSHLQQHHSGMAPPPPPHQQPQHNSKDPS-GFGADQN 2610

  Fly  3254 VNVGNVGVGNAGGALPDASDQL 3275
            ..:..:. |.||...|.|:|.|
Zfish  2611 AMLSQLS-GMAGLHGPGANDML 2631

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nejNP_001188575.1 ZnF_TAZ 530..600 CDD:214717 34/69 (49%)
KIX 946..1024 CDD:280354 58/77 (75%)
Bromo_cbp_like 1705..1812 CDD:99927 79/117 (68%)
RING_CBP-p300 1824..1906 CDD:276805 54/81 (67%)
PHD_CBP_p300 1908..1939 CDD:277032 18/30 (60%)
HAT_KAT11 1970..2283 CDD:285432 208/316 (66%)
ZZ_CBP 2339..2379 CDD:239077 27/39 (69%)
ZnF_TAZ 2404..2476 CDD:214717 62/71 (87%)
ep300bXP_009297682.1 zf-TAZ 318..385 CDD:280324 33/66 (50%)
KIX 534..614 CDD:280354 58/79 (73%)
Bromo_cbp_like 1024..1142 CDD:99927 79/117 (68%)
RING_CBP-p300 1154..1236 CDD:276805 54/81 (67%)
PHD_SF 1237..1271 CDD:304600 19/33 (58%)
HAT_KAT11 1300..1607 CDD:285432 208/316 (66%)
ZZ_CBP 1663..1703 CDD:239077 27/39 (69%)
ZnF_TAZ 1724..1802 CDD:214717 64/77 (83%)
Creb_binding <2164..2231 CDD:286163 20/71 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170578152
Domainoid 1 1.000 438 1.000 Domainoid score I536
eggNOG 1 0.900 - - E1_COG5076
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1444 1.000 Inparanoid score I113
OMA 1 1.010 - - QHG47779
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001062
OrthoInspector 1 1.000 - - otm25856
orthoMCL 1 0.900 - - OOG6_101987
Panther 1 1.100 - - LDO PTHR13808
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X719
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1211.890

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