DRSC/TRiP Functional Genomics Resources

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Protein Alignment nej and PBRM1

DIOPT Version :9

Sequence 1:NP_001188575.1 Gene:nej / 43856 FlyBaseID:FBgn0261617 Length:3282 Species:Drosophila melanogaster
Sequence 2:XP_016862214.1 Gene:PBRM1 / 55193 HGNCID:30064 Length:1734 Species:Homo sapiens


Alignment Length:1618 Identity:299/1618 - (18%)
Similarity:487/1618 - (30%) Gaps:643/1618 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly  1657 GKDNINGAHDGGATGGAVDIKPKTETKPLVPEPLAPNAGDKKKKCQFNPEELRTALL----PT-- 1715
            |:||     .|..|.|.|...|..::.|...:.:.              |:|..|::    |:  
Human   187 GQDN-----QGTVTEGKVLFSPHYQSSPAYLKEIL--------------EQLLEAIVVATNPSGR 232

  Fly  1716 -LEKLYRQEPESVPFRYPVDPQALGIPDYFEIVKKPMDLGTIRTNIQNGKYSDPWEYVDDVWLMF 1779
             :.:|:::.|..|.:           |||:.|:|:|:||.||...||||.|........|:.|:.
Human   233 LISELFQKLPSKVQY-----------PDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLA 286

  Fly  1780 DNAWLYNRKTSRVYRYCTKLSEVF---EAEID-------------PVMQALGYCCG--------- 1819
            .||..||...|:|::....:.::|   :|||:             |...|.....|         
Human   287 KNAKTYNEPGSQVFKDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLG 351

  Fly  1820 ------RKYTFNPQVLCCYGKQLCTIPRDAKYYSYQNSLKEYGVASNRYTYCQK------CFNDI 1872
                  .||..|.:.:  .|.:|..|....:|.|  .|.::..:|:.||...:.      .|.|:
Human   352 EERNPTSKYYRNKRAV--QGGRLSAITMALQYGS--ESEEDAALAAARYEEGESEAESITSFMDV 412

  Fly  1873 QG------DTV--------TLGDDPL-----------------------QSQTQIKKDQFKEMKN 1900
            ..      |||        .|..:|.                       |.:|::|..:::.:  
Human   413 SNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETL-- 475

  Fly  1901 DHLELEPFVNCQECGRKQHQI-------CVLWL--------------DSIWPGGFVCDNCLKKKN 1944
            ||||.:  :|......|::.:       .||.|              |.|..|..:..:......
Human   476 DHLECD--LNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTG 538

  Fly  1945 S-KRKENKFNAKRLPTTKLGVYIETR-------VNNFLKKKEAGAGE--VHIRVVSSSDK----- 1994
            | |||.|..:::.|...:|......|       .|..|:.:|.|:|.  ..:.:|..|.|     
Human   539 SAKRKRNTHDSEMLGLRRLSSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDY 603

  Fly  1995 -CVEVKPGMRRRFVEQGEMMNEFPYRAKALFAFEE--VDGIDVCF-FGMHVQEYGSEC------- 2048
             .:.::| |..:.:|. .:.|:       .:|.||  ::.:.:.| ...|..|.||:.       
Human   604 YKIILEP-MDLKIIEH-NIRND-------KYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHIL 659

  Fly  2049 ------------PAPN-----------TRRVYIAYLDSVHFFRPRQYRTAVYHEILLGYMDYVKQ 2090
                        |.|:           :|:..|:...| .:..|.|.:....:|.:..|.|   :
Human   660 EKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKS-KYMTPMQQKLNEVYEAVKNYTD---K 720

  Fly  2091 LGYTMAHIWACPPSEGD--DYIFHCHPTDQKIPKPKRLQEWYKKMLDKGM--IERIIQD------ 2145
            .|..::.|:...||..:  ||..       .|.||..:::....|:....  |:.:::|      
Human   721 RGRRLSAIFLRLPSRSELPDYYL-------TIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFN 778

  Fly  2146 ------------YKD------ILKQAMEDKLG--------------------------------- 2159
                        |||      :|.:...|..|                                 
Human   779 NACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGR 843

  Fly  2160 ----SAAELPYFEGDFWPN-------VLEESIKE----------------LDQEEEEKRKQAEAA 2197
                |.||:|..:.:| ||       ::.::::.                |::.....|..:|..
Human   844 CYSDSLAEIPAVDPNF-PNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIY 907

  Fly  2198 EAAAAANLFSIE------------------------ENEVSGDGKKKGQKKAKKSNKSKAAQRKN 2238
            |.|.....|.|:                        .|:|..:.|:|..|:.:: :|.|..:.|.
Human   908 EDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHNDVEKERKEKLPKEIEE-DKLKREEEKR 971

  Fly  2239 SKKSNEHQSG------------NDLSTK---------IY-----ATMEKH--------------- 2262
            ..:.:|..||            .|.|.|         :|     |.::.|               
Human   972 EAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGEK 1036

  Fly  2263 -----------------------KEVF-------------------------------------- 2266
                                   ||||                                      
Human  1037 WLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDV 1101

  Fly  2267 FVIR-LHSAQ--------------SAASLAPIQDPDPLLTCDLMDGRDAFLTLARDKHFEFSSLR 2316
            ||.. .:||:              |:....|...|.|::       |.|.:....||..:..:..
Human  1102 FVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVV-------RVASVFANADKGDDEKNTD 1159

  Fly  2317 RAQFSTLSMLYELHNQGQDKFVYTCN---HCKTAVETRYHCTVCDDFDL----CIVCKE------ 2368
            .::.|.....:.|..:.:|..|...|   .|....:..|     :|..|    |:..|.      
Human  1160 NSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHY-----NDMWLKVGDCVFIKSHGLVRP 1219

  Fly  2369 KVGHQHKMEKLGFDIDDGSA-----LADHKQANPQEARKQSIQR--CIQSLAHAC--QCRDANCR 2424
            :||   ::||:.  :.||:|     :..|.:....|..|...::  .:.:|...|  .|....|.
Human  1220 RVG---RIEKVW--VRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCA 1279

  Fly  2425 L------PSCQKMKLVVQHTKNCKRKPNGGCPICKQLIAL-------------CCYHAKNCEEQK 2470
            :      .||:..::.......|:.:.|......|:...|             ..|..|....||
Human  1280 VLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQK 1344

  Fly  2471 CPVPFCPNIKHKLKQQQSQQKFQQQQLLRRRVALMSRTAAPAALQGPAAVSGPTVVSGGVPVVGM 2535
            .|.|                      ||.:::.|:....|.              :.||...:..
Human  1345 EPSP----------------------LLEKKIQLLEAKFAE--------------LEGGDDDIEE 1373

  Fly  2536 SGVAVSQQVIPGQAGILP----PGAG--GMSPST--VAVPSPVSGGAGAGG------MGG----- 2581
            .|...|:.:.|..   ||    |.|.  .:.|.|  .:.|....|.|...|      |.|     
Human  1374 MGEEDSEVIEPPS---LPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFS 1435

  Fly  2582 ------MTSPHP-HQPG-----IG-----MKPGGGHSPSPNVLQVVKQVQEEAARQQVSHGGGFG 2629
                  :.:.|| :..|     :|     ::............:|.:|.:.|.|.||..      
Human  1436 SEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEERAAKVAEQQERERAAQQQQ------ 1494

  Fly  2630 KGVPMAPPVMNRPMG---GAGPNQNVVNQLGGMGVGVGGVGGVGVGGVGGVGVNQLNSGGGNTPG 2691
               |.|.|....|:|   |..|....:..|......|.|:                  .||..||
Human  1495 ---PSASPRAGTPVGALMGVVPPPTPMGMLNQQLTPVAGM------------------MGGYPPG 1538

  Fly  2692 -APISGPGMNVNHLMSMDQWGGGGAGGGGANP--GGGNPQARYANNTGGMR--QPTHVMQTNLIP 2751
             .|:.||   |:.|:||          |...|  .||.|.........|:.  .|..||...:.|
Human  1539 LPPLQGP---VDGLVSM----------GSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMNQGVAP 1590

  Fly  2752 PQQQQQMMGGLGGPNQLGGGQMPVGGQHGGMG-MGMGAPPMAGTVGGVRPSPGAGGGG 2808
                   |.|...|     |..|.|.|.|.:| .|..|||         |.||....|
Human  1591 -------MVGTPAP-----GGSPYGQQVGVLGPPGQQAPP---------PYPGPHPAG 1627

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nejNP_001188575.1 ZnF_TAZ 530..600 CDD:214717
KIX 946..1024 CDD:280354
Bromo_cbp_like 1705..1812 CDD:99927 35/129 (27%)
RING_CBP-p300 1824..1906 CDD:276805 24/124 (19%)
PHD_CBP_p300 1908..1939 CDD:277032 8/51 (16%)
HAT_KAT11 1970..2283 CDD:285432 88/582 (15%)
ZZ_CBP 2339..2379 CDD:239077 10/52 (19%)
ZnF_TAZ 2404..2476 CDD:214717 16/94 (17%)
PBRM1XP_016862214.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5076
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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