DRSC/TRiP Functional Genomics Resources

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Protein Alignment nej and Crebbp

DIOPT Version :9

Sequence 1:NP_001188575.1 Gene:nej / 43856 FlyBaseID:FBgn0261617 Length:3282 Species:Drosophila melanogaster
Sequence 2:XP_038942595.1 Gene:Crebbp / 54244 RGDID:2401 Length:2454 Species:Rattus norvegicus


Alignment Length:3461 Identity:1190/3461 - (34%)
Similarity:1470/3461 - (42%) Gaps:1187/3461 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 MADH-LDEPPQ-KRVKM--------DPTDIS--YFLEENLPDELVSSNSGWSDQLTGGAGGGNGG 54
            ||:: ||.||. ||.|:        |.||..  :.||.:|||||:                    
  Rat     1 MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDELI-------------------- 45

  Fly    55 GGASGVTTNPTSGPNPGGGPNKPAAQGPGSGTGGVGVGVNVGVGGVVGVGVVPSQMNGAGGGNGS 119
                               ||           |.:.: :|.|       .:||.           
  Rat    46 -------------------PN-----------GELSL-LNSG-------NLVPD----------- 61

  Fly   120 GTGGDDGSGNGSGAGNRISQMQHQQLQHLLQQQQQGQKGAMVVPGMQQLGSKSPNLQSPNQGGMQ 184
                              :..:|:||..||    :|..|:.:.||:..:.:.||..|........
  Rat    62 ------------------AASKHKQLSELL----RGGSGSSITPGIGNVSASSPVQQGLGGQAQG 104

  Fly   185 QVVGTQMGMVNSMPMSISNNGNNGMNAIP---------------GMNTIAQGNLG---NMVLTNS 231
            |...|.|..:.:|..|..|.|::...::|               .:|..||..:|   :...|:.
  Rat   105 QPNSTSMASLGAMGKSPLNPGDSSTPSLPKQAASTSGPTPPASQALNPQAQKQVGLVTSSPATSQ 169

  Fly   232 VGGGMGGMVNHLKQQPGGGGGGMINSVSVPGGPGAGAGGVGAGGGGAVAANQGMHMQNGPMMGRM 296
            .|.|:....|..:..|     |::||                        |.|..:.|....|: 
  Rat   170 TGPGICMNANFNQTHP-----GLLNS------------------------NSGHSLMNQAQQGQ- 204

  Fly   297 VGQQHMLRGPHLMGASGGAGGPGNGPGGGGPRMQNPNMQMNFRPFAAQLNSLPYGVGQYGGPGGG 361
                     ..:|..|.||.|.|.|.|     |..|...|.....:....:|.....|..|..|.
  Rat   205 ---------AQVMNGSLGAAGRGRGAG-----MPYPAPAMQGATSSVLAETLTQVSPQMAGHAGL 255

  Fly   362 NNPQQQQQQQQQQLLAQQMAQRGGVVP-GMPQGNRPVGTVVPMSTLGGDGSGPAGQLVSGNPQQQ 425
            |.                 ||.||:.. ||.....|.|.  |.|..||...|..|.    |||  
  Rat   256 NT-----------------AQAGGMTKMGMTGNTSPFGQ--PFSQTGGQPMGATGV----NPQ-- 295

  Fly   426 QMLAQQQTGAMGPRPPQPNQLLGHPGQQQQQQQQPGTSQQQQQQQGVGIGGAGVVANAGTVAGVP 490
              ||.:|: .:...|..|..:     :.......|..||.|.        ..|:|...|...|..
  Rat   296 --LASKQS-MVNSLPAFPTDI-----KNTSVTTVPNMSQLQT--------SVGIVPAQGIATGPT 344

  Fly   491 AVAGGGAGGAVQSSGPGGANRDVPDDRKRQ-IQQQLMLLLHAHKCNRRENLNPNREVCNVNYCKA 554
            |                       |..||: |||||:||||||||.|||..|.....|::.:|:.
  Rat   345 A-----------------------DPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRT 386

  Fly   555 MKSVLAHMGTCKQSKDCTMQHCASSRQILLHYKTCQNSGCVICYPFRQNHSVFQNANVPPGGGPA 619
            ||:||.||..|:..|.|.:.||||||||:.|:|.|....|.:|.|.: |.|..:|...       
  Rat   387 MKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLK-NASDKRNQQT------- 443

  Fly   620 GIGGAPPGGGGAGGGAAGAGGNLQQQQQQQQQQQQNQQPNLTGLVVDGKQGQQVAPGGGQNTAIV 684
             |.|:|..|.....|:.|||       ||......|..|              :.|.        
  Rat   444 -ILGSPASGIQNTIGSVGAG-------QQNATSLSNPNP--------------IDPS-------- 478

  Fly   685 LPQQQGAGGAPGAPKTPADMVQQLTQQQQQQQQQVHQQQVQQQELRRFDGMSQQVVAGGMQQQQQ 749
              ..|.|..|.|.|        .:.|.|.|.|.||..||..|                       
  Rat   479 --SMQRAYAALGLP--------YMNQPQTQLQPQVPGQQPAQ----------------------- 510

  Fly   750 QGLPPVIRIQGAQPAVRVLGPGGPGGPSGPNVLPNDVNSLHQQQQQMLQQQQQQGQNRRRGGLAT 814
               ||      |...:|.|           |.|.|:..|:                  ..||:.|
  Rat   511 ---PP------AHQQMRTL-----------NALGNNPMSI------------------PAGGITT 537

  Fly   815 MVEQQQQHQQQQQQPN-------PAQLGGNIPAPLSVNVGGFGNTNFGGAAAGGAVGANDKQQLK 872
                      .||.||       |..||...|.                        .||     
  Rat   538 ----------DQQPPNLISESALPTSLGATNPL------------------------MND----- 563

  Fly   873 VAQVHPQSHGVGAGGASAGAGASGGQVAAGSSV--LMPADTTGSGNAGNPNQNAGGVAGGAGGGN 935
                                |::.|.:.:.|::  ..|..:||.                     
  Rat   564 --------------------GSNSGSIGSLSTIPTAAPPSSTGV--------------------- 587

  Fly   936 GGNTGPPGDNEKDWRESVTADLRNHLVHKLVQAIFPTSDPTTMQDKRMHNLVSYAEKVEKDMYEM 1000
                      .|.|.|.||.|||:|||||||||||||.||..::|:||.|||:||:|||.||||.
  Rat   588 ----------RKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYES 642

  Fly  1001 AKSRSEYYHLLAEKIYKIQKELEEKRLKRKEQHQQMLMQQQGVANPVAGGAAGGAGSAAGVAGGV 1065
            |.||.|||||||||||||||||||||  |...|:|                        |:.|  
  Rat   643 ANSRDEYYHLLAEKIYKIQKELEEKR--RSRLHKQ------------------------GILG-- 679

  Fly  1066 VLPQQQQQQQQQQQQQGQQPLQSCIHPSISPMGGVMPPQQLRPQGPPGILGQQTAAGLGVGVGVT 1130
                    .|......|.||      |.|.|...|.|     |.||..:...:.....|      
  Rat   680 --------NQPALPAPGAQP------PVIPPTQSVRP-----PNGPLSLPVNRVQVSQG------ 719

  Fly  1131 NNMVTMRSHSPGGNMLALQQQQRMQFPQQQQQQPPGSGAGKMLVGPPGPSP-------------G 1182
                 |.|.:|            |.....|..|.|        :||...||             .
  Rat   720 -----MNSFNP------------MSLGNVQLPQAP--------MGPRAASPMNHSVQMNSMASVP 759

  Fly  1183 GMVVNPALSPYQTTNVLTSPVPGQQQQQQFINANGGTGANPQLSEIMKQRHIHQQQQQQQQQQQQ 1247
            ||.::|:..| |..|::                  ||.||    .||            .|...|
  Rat   760 GMAISPSRMP-QPPNMM------------------GTHAN----NIM------------AQAPTQ 789

  Fly  1248 GMLLPQSPFSNSTPLQQQQQQQQQQQQQQQATSNSFSSPMQQQQQGQQQQQQKPGSVLNNMPPTP 1312
            ...|||:.|.:|:...........|...|...|                |.|.||..|      |
  Rat   790 NQFLPQNQFPSSSGAMSVNSVGMGQPATQAGVS----------------QGQVPGGTL------P 832

  Fly  1313 TSLEALNAGAGAPGTGG-SASNVTVSA--PSPSPGFLSNG-PSIGTPSNNNNNSSANNNPPSVSS 1373
            ..|..|     ||.|.. ....||.|.  |:|.|...:.| ||:..|:           ||.:  
  Rat   833 NPLNML-----APQTSQLPCPPVTQSPLHPTPPPASTAAGMPSLQHPT-----------PPGM-- 879

  Fly  1374 LMQQPLSNRPGTPPYIPASPV-PATSASGLAASSTPASAAATCASSGSGSNSSSGATAAGASSTS 1437
                       |||. ||:|. |:|..|   :..||.....:..|:....::.:...||.|..|.
  Rat   880 -----------TPPQ-PAAPTQPSTPVS---SGQTPTPTPGSVPSAAQTQSTPTVQAAAQAQVTP 929

  Fly  1438 SSSSAGSGTPLS--SVSTPTSATMATSSGGGGGGGGNAGGGSSTTPASNPLLLMSGGTAGGGTGA 1500
            ...     ||:.  ||:||.|:....:.             ..|.|...||   |...|......
  Rat   930 QPQ-----TPVQPPSVATPQSSQQQPTP-------------VHTQPPGTPL---SQAAASIDNRV 973

  Fly  1501 TTTTSTSSSSRMMSSSSSLSSQMAALEAAAR-DNDDETPSPSGENTNGSGGSGNAGGMASKGKLD 1564
            .|.:|.:|:.   :||......:..||.... ..||..|.|:                .|||:..
  Rat   974 PTPSSVTSAE---TSSQQPGPDVPMLEMKTEVQTDDAEPDPA----------------ESKGEPR 1019

  Fly  1565 SIKQDDDIKKEFMDDSCGGNNDSSQMDCSTGGGKGKNVNNDGTSMIKMEIKTEDGLDGEVKIKTE 1629
            |...::|::                                |:|.:|.|..|.:.       |:|
  Rat  1020 SEMMEEDLQ--------------------------------GSSQVKEETDTTEQ-------KSE 1045

  Fly  1630 AMDVDEAGGSTAGEHHGEGGGGSGVGGGKDNINGAHDGGATGGAVDIKPKTETKPLVPEPLAPNA 1694
            .|:|:|.......|...|                 .:..|.|.|     ...|.|..|       
  Rat  1046 PMEVEEKKPEVKVEAKEE-----------------EENSANGTA-----SQSTSPSQP------- 1081

  Fly  1695 GDKKKKCQFNPEELRTALLPTLEKLYRQEPESVPFRYPVDPQALGIPDYFEIVKKPMDLGTIRTN 1759
               :||. |.|||||.||:||||.||||:|||:|||.|||||.|||||||:|||.||||.||:..
  Rat  1082 ---RKKI-FKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRK 1142

  Fly  1760 IQNGKYSDPWEYVDDVWLMFDNAWLYNRKTSRVYRYCTKLSEVFEAEIDPVMQALGYCCGRKYTF 1824
            :..|:|.:||:|||||||||:|||||||||||||::|:||:||||.|||||||:|||||||||.|
  Rat  1143 LDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEF 1207

  Fly  1825 NPQVLCCYGKQLCTIPRDAKYYSYQNSLKEYGVASNRYTYCQKCFNDIQGDTVTLGDDPLQSQTQ 1889
            :||.|||||||||||||||.|||||||..:||:.::||.:|:|||.:|||:.|||||||.|.||.
  Rat  1208 SPQTLCCYGKQLCTIPRDAAYYSYQNSSPKYGLLADRYHFCEKCFTEIQGENVTLGDDPSQPQTT 1272

  Fly  1890 IKKDQFKEMKNDHLELEPFVNCQECGRKQHQICVLWLDSIWPGGFVCDNCLKKKNSKRKENKFNA 1954
            |.||||::.|||.|:.||||:|:|||||.||||||..|.|||.||||||||||....||||||:|
  Rat  1273 ISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSA 1337

  Fly  1955 KRLPTTKLGVYIETRVNNFLKKK-EAGAGEVHIRVVSSSDKCVEVKPGMRRRFVEQGEMMNEFPY 2018
            |||.||:||.::|.|||.||::: ...||||.:|||:||||.|||||||:.|||:.|||...|||
  Rat  1338 KRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPY 1402

  Fly  2019 RAKALFAFEEVDGIDVCFFGMHVQEYGSECPAPNTRRVYIAYLDSVHFFRPRQYRTAVYHEILLG 2083
            |.||||||||:||:||||||||||||||:||.||||||||:||||:||||||..|||||||||:|
  Rat  1403 RTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIG 1467

  Fly  2084 YMDYVKQLGYTMAHIWACPPSEGDDYIFHCHPTDQKIPKPKRLQEWYKKMLDKGMIERIIQDYKD 2148
            |::|||:|||...|||||||||||||||||||.||||||||||||||||||||...||||.||||
  Rat  1468 YLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIINDYKD 1532

  Fly  2149 ILKQAMEDKLGSAAELPYFEGDFWPNVLEESIKELDQEEEEKRKQAEAAEAAAAANLFSIEENEV 2213
            |.|||.||:|.||.|||||||||||||||||||||:|||||::|:    |:.||:     |..|.
  Rat  1533 IFKQANEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKE----ESTAAS-----ETPEG 1588

  Fly  2214 S-GDGKKKGQKKAKKSNKSKAA-QRKNSKKSNEHQSGNDLSTKIYATMEKHKEVFFVIRLHSAQS 2276
            | ||.|...:|..||:||:|:: .|.|.||.:.....||||.|:||||||||||||||.||:...
  Rat  1589 SQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPV 1653

  Fly  2277 AASLAPIQDPDPLLTCDLMDGRDAFLTLARDKHFEFSSLRRAQFSTLSMLYELHNQGQDKFVYTC 2341
            .::..||.||||||:||||||||||||||||||:|||||||:::|||.||.|||.||||:|||||
  Rat  1654 ISTQPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTC 1718

  Fly  2342 NHCKTAVETRYHCTVCDDFDLCIVCKEKVGHQHKMEKLGFDIDD-GSALADHKQANPQEARKQSI 2405
            |.||..||||:|||||:|:||||.|.....|.|||.|.|..:|| ||:..:.:..:|||:|:.||
  Rat  1719 NECKHHVETRWHCTVCEDYDLCINCYNTKSHTHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSI 1783

  Fly  2406 QRCIQSLAHACQCRDANCRLPSCQKMKLVVQHTKNCKRKPNGGCPICKQLIALCCYHAKNCEEQK 2470
            |||||||.||||||:|||.||||||||.||||||.||||.|||||:|||||||||||||:|:|.|
  Rat  1784 QRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENK 1848

  Fly  2471 CPVPFCPNIKHKLKQQQSQQKFQQQQLLRRRVALMSRTAAPAALQGPAAVSGPTVVSGGVPVVGM 2535
            ||||||.||||||:|||.|.:.||.||:|||:|.|:....|                        
  Rat  1849 CPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVP------------------------ 1889

  Fly  2536 SGVAVSQQVIPGQAGILPPGAGGMSPSTVAVPSPVSGGAGAGGMGGMTSPHPHQPG-IGMKPGGG 2599
                  ||.:|.... .|||.....|||...|.|               |...||. :.|.|.|.
  Rat  1890 ------QQSLPSPTS-APPGTPTQQPSTPQTPQP---------------PAQPQPSPVNMSPAGF 1932

  Fly  2600 HS---------------------------PSPNVLQVVKQVQEEAARQQ------VSHG---GGF 2628
            .|                           |.|..::..:|::.||.:||      :::|   |..
  Rat  1933 PSVARTQPPTIVSAGKPTNQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRANINNGMPPGRA 1997

  Fly  2629 GKGVP---MAPPVMNRPMGGAGPNQNVVNQLGGMGVGVGGVGGVGVGGVGGVGVNQLNSGGGNTP 2690
            |.|.|   |||..:|.|.    |||                                        
  Rat  1998 GMGTPGSQMAPVGLNVPR----PNQ---------------------------------------- 2018

  Fly  2691 GAPISGPGMNVNHLMSMDQWGGGGAGGGGANPGGGNPQARYANNTGGMRQPTHVMQTNLIPPQQQ 2755
               :|||.|:   .|...||                .||                      |..|
  Rat  2019 ---VSGPVMS---SMPPGQW----------------QQA----------------------PIPQ 2039

  Fly  2756 QQMMGGLGGPNQLGGGQMPVGGQHGGMGMGMGAPPMAGTVGGVRP----SPGAGGGGGSATGGGL 2816
            ||.|.|:..|......|..|.|           |.|.    .|:|    ||.|            
  Rat  2040 QQPMPGMPRPVMSMQAQAAVAG-----------PRMP----NVQPPRSISPSA------------ 2077

  Fly  2817 NTQQLALIMQKIKNNPTNESNQHILAILKQNPQIMAAIIKQR----------------------- 2858
                |..:::.:|:..:.:..|.:|.|||.|||:|||.||||                       
  Rat  2078 ----LQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGM 2138

  Fly  2859 -------QQS--QNNAAAGGGAPGPG-GALQQQQAGNGPQ-----------NPQQQQQQQQQQQV 2902
                   ||.  ||..|...|.|.|| ...||...|..||           ||.......|.:::
  Rat  2139 QPQPGMHQQPSLQNLNAMQAGVPRPGVPPPQQAMGGLNPQGQALNIMNPGHNPNMANMNPQYREM 2203

  Fly  2903 MQQQQMQHMMNQQQGGGGPQQMNPNQQQQQQQVNLMQQQQQGGPGGPGSGLPTRMPNMPNALGML 2967
            :::|.:||...|||           |||||||    |||||.                       
  Rat  2204 VRRQLLQHQQQQQQ-----------QQQQQQQ----QQQQQS----------------------- 2230

  Fly  2968 QSLPPNMSPGVSTQGGMVPNQNWNKMRYMQMSQYPPPYPQRQRGPHMGGAGPGPGQQQ----FPG 3028
                     ..|..|||..:           ||:     |:.:||  ||..|...||:    .|.
  Rat  2231 ---------SASLAGGMAGH-----------SQF-----QQPQGP--GGYAPAMQQQRMQQHLPI 2268

  Fly  3029 GGGGAGNFNAGGAGGAGGVVGVGGVPG-GAGTVPGGDQYSMANAAAASNMLQQQQGQVGVGVGVG 3092
            .|...|...|     ..|.:|..|.|| ||.:.|...|      |....:||||           
  Rat  2269 QGSSMGQMAA-----PMGQLGQMGQPGLGADSTPNIQQ------ALQQRILQQQ----------- 2311

  Fly  3093 VKPGPGQQQQQMGVGMPPGMQQQQQQQQPLQQQQMMQVAMPNANAQNPSAVVGGPNAQVMGPPTP 3157
                  |.:||:|   .||      |..|:..||.|....|.|             :.:.|....
  Rat  2312 ------QMKQQIG---SPG------QPNPMSPQQHMLSGQPQA-------------SHLPGQQIA 2348

  Fly  3158 HSLQQQLMQSARSSPPIRSPQP-TPSPRSAPSPRAAPSASPRAQPSPHHVMSSHSPAPQ-GPPHD 3220
            .||..|:    ||..|::||:| :..|.|:||||..|      |||||||      :|| |.||.
  Rat  2349 TSLSNQV----RSPAPVQSPRPQSQPPHSSPSPRIQP------QPSPHHV------SPQTGSPHP 2397

  Fly  3221 GMHNHGMHHQSPLPGVPQDVGVGVGVGVGVGVNVNVGNVGVGNAGGALPD--------------- 3270
            |:                        .|.:..:::.|::|.......||.               
  Rat  2398 GL------------------------AVTMASSMDQGHLGNPEQSAMLPQLNTPNRSALSSELSL 2438

  Fly  3271 ----ASDQLTKFVERL 3282
                ..|.|.||||.|
  Rat  2439 VGDTTGDTLEKFVEGL 2454

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nejNP_001188575.1 ZnF_TAZ 530..600 CDD:214717 33/69 (48%)
KIX 946..1024 CDD:280354 58/77 (75%)
Bromo_cbp_like 1705..1812 CDD:99927 80/106 (75%)
RING_CBP-p300 1824..1906 CDD:276805 55/81 (68%)
PHD_CBP_p300 1908..1939 CDD:277032 23/30 (77%)
HAT_KAT11 1970..2283 CDD:285432 216/315 (69%)
ZZ_CBP 2339..2379 CDD:239077 25/39 (64%)
ZnF_TAZ 2404..2476 CDD:214717 61/71 (86%)
CrebbpXP_038942595.1 zf-TAZ 362..429 CDD:396624 32/66 (48%)
KIX 586..666 CDD:366953 59/110 (54%)
PHA03247 <682..1098 CDD:223021 141/659 (21%)
COG5076 942..>1194 CDD:227408 125/358 (35%)
Bromo_cbp_like 1088..1195 CDD:99927 80/106 (75%)
RING_CBP-p300 1207..1289 CDD:276805 55/81 (68%)
PHD_CBP_p300 1291..1322 CDD:277032 23/30 (77%)
HAT_KAT11 1353..1660 CDD:400497 216/315 (69%)
ZZ_CBP 1716..1756 CDD:239077 25/39 (64%)
zf-TAZ 1783..1851 CDD:396624 57/67 (85%)
Med15 1971..>2425 CDD:312941 176/727 (24%)
Creb_binding 2045..2123 CDD:401102 29/108 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166338622
Domainoid 1 1.000 437 1.000 Domainoid score I544
eggNOG 1 0.900 - - E1_COG5076
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1304 1.000 Inparanoid score I142
OMA 1 1.010 - - QHG47779
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001062
OrthoInspector 1 1.000 - - oto97166
orthoMCL 1 0.900 - - OOG6_101987
Panther 1 1.100 - - O PTHR13808
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X719
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.760

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