DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nej and pbrm1l

DIOPT Version :9

Sequence 1:	NP_001188575.1	Gene:	nej / 43856	FlyBaseID:	FBgn0261617	Length:	3282	Species:	Drosophila melanogaster
Sequence 2:	XP_005168819.1	Gene:	pbrm1l / 445141	ZFINID:	ZDB-GENE-010501-3	Length:	1657	Species:	Danio rerio

Alignment Length:	1900	Identity:	348/1900 - (18%)
Similarity:	559/1900 - (29%)	Gaps:	758/1900 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly  1168 GAGKMLVGPPGPSPGGMVVNPALSPYQTTNVLTSPVPGQQQQQQFINANGGTGANPQLSEIMKQR 1232
            |:.:.....|..|..|...:.|.|        ::||.|.::::. .||       |.:.:|....
Zfish     2 GSKRRRATSPSSSASGGDFDDASS--------STPVSGWKRRRA-SNA-------PSVDQIAVCH 50

  Fly  1233 HIHQ--QQQQQQQQQQQGMLLPQSPFSNSTP--------------LQQQQQQQQQQQQQQ----- 1276
            .::.  :..:..|.:|...|..::|...:.|              :||:.:.::.|..:|
Zfish    51 ELYNTVRDYKDDQGRQICELFVRAPKRRNQPDYYEIVSQPIDMMKIQQKLRAEEYQDVEQFSADF 115

  Fly  1277 -----------QATS----------NSFSSPMQQQQQGQQQQQQKPGSVLNNMPPTPTSLE---- 1316
                       ||.|          |.|.|...:..||...::.:......:...|..|:|
Zfish   116 HLLINNTKAYYQADSAEHRAASKLLNVFLSAKNELLQGGDGEEAEDDEESEDAENTNASMEEERP 180

  Fly  1317 ----------ALNAGAGAPGTGGS-ASNVTVSAPS----PSPGFLSNGP----SIGTPSNNNNNS 1362
                      .|.|.|....:.|. .|.:....||    |....:...|    ::.......:..
Zfish   181 PSYLKAILEQLLEAIASCTDSSGRLVSELFQKLPSKLHYPDYYAVIKEPIDLRAVAQKIQGGHYK 245

  Fly  1363 SANNNPPSVSSLMQQPLS-NRPGTPPYIPASPVPATSASGL----AASSTPASAAATCASSGSGS 1422
            |.:.....:..|::...: |.||:..:..|:.:....|...    .|..|..|.......|..|.
Zfish   246 SISAMAKDIDLLVKNAKTYNEPGSQVFKDANTIKKVFAQRKIEIEQAEPTKTSLRIRNRRSAQGD 310

  Fly  1423 NSSSGATAAGASSTSSSSSAGSGTPLSSVSTPTSATMATSSGGGGGGGGNAGGGSSTTPASNPLL 1487
            ..|:...|..|.|.|...|..:||    |...|..|.|..       |.:||         :|:|
Zfish   311 RLSAITMALQAGSESDEDSILTGT----VRYDTGETEADC-------GLSAG---------DPIL 355

  Fly  1488 LMSGGTAGGGTGATTTTSTSSSSRMMS-----------------------SSSSLSSQMAALEAA 1529
            |:.....|         :.|....::|                       |...:..:|...:..
Zfish   356 LLYQAVRG---------ARSVQGLLLSEPFLQLPSRREYPDYYHQIKNPISLQQIREKMKNGDYE 411

  Fly  1530 ARDNDDETPSPSGENTNGSGGSGNAGGMASKGKLDSIKQDDDIKKEFMDDSCGGNNDSSQMDCST 1594
            |.:..:...|...||.. .....|:.......:|..|.|..  |:||.||..|   |.|..:...
Zfish   412 AVEQIEADLSVMFENAR-RYNMPNSTIYKRAQRLQLIMQQK--KREFRDDDEG---DVSTANSDV 470

  Fly  1595 GGGKGK-------------------NVNNDGTS-------MIKMEIK--------TEDGLDG--- 1622
            |..|.|                   :....|:.       |:|...|        .:|.:|.
Zfish   471 GSSKKKSHKKSAKKNRMKMLYAVLTDAREPGSGRRLCDLFMVKPLKKDYPDYYKIIQDPMDMRTI 535

  Fly  1623 EVKIKTEAMDVDEAGGSTA------GEHHGEGGGGSGVGGGKDNINGAHDGGATGGAVDIKPKTE 1681
            |..|:||..:.::|.....      ..|:.|        .|....|.|:       .::...|.:
Zfish   536 ENNIRTERYNNEDALMEDMKLMFRNARHYNE--------EGSQVYNDAN-------VLEKMVKDK 585

  Fly  1682 TKPLVPEPLAPNAGDKKKKCQ-----FNPEELR---TALLPTLEKLYR----------QEPESVP 1728
            .|.|.|.|...:.|..|.|.:     .:|::.|   |.|...|.:||.          :...:|.
Zfish   586 QKELGPAPEEDDVGSPKLKLRRSGVAVSPKKARIQTTPLQQKLSELYEAVRNFTDNRGRRLSTVF 650

  Fly  1729 FRYPVDPQALGIPDYFEIVKKPMDLGTIRTNIQNGKYSDPWEYVDDVWLMFDNAWLYNRKTSRVY 1793
            .|.|...:   :|||:..:|:|:|:..||:.:..|:|.|.....:|..|||:||..||...|.:|
Zfish   651 LRLPSRSE---LPDYYAAIKRPIDMERIRSYMVQGRYQDVDSLAEDFILMFNNACTYNEPESLIY 712

  Fly  1794 RYCTKLSEVF-------EAEIDPVMQALGYCCGRKYTFNPQVLCCYGKQLCTIPRDA---KYYSY 1848
            |....|...|       |.|.:.....||                 |..:.::.|:.   .:.|.
Zfish   713 RDALLLHRAFLEARRRIEEEENGDEGGLG-----------------GLSVASLVRELIRNLFVSM 760

  Fly  1849 QNSLKEYGVASNRYTYCQKCFNDIQGDTVTLG----DDP----------LQSQTQIKKDQFKEMK 1899
            .....:.|          :|::|...:...:.    |||          :.|....:.|.|:|..
Zfish   761 MGHQDDEG----------RCYSDSLAEVPAIDPANPDDPPLTLEIIRNNVDSGRYRRLDVFQEHV 815

  Fly  1900 NDHLELEPFVNCQECGRKQHQICVLWLDSIWPGGF-------VCDNC------------------ 1939
            .:.||     ..:...|...:|   :.||:....|       :|.|.
Zfish   816 FEVLE-----KARRLNRTDSEI---FEDSVELQHFFVKIRDELCKNGEILLTPALSYTSKHLHSD 872

  Fly  1940 ------------LKKKNSKRKENKFNAKRLP-------------------------------TTK 1961
                        :::...||:|:|   |.||                               |..
Zfish   873 IDQEKREKLPQEIEEDQLKREEDK---KALPEGDKAEGPAEGGQWPSGSQSSYSQDCSFENNTYS 934

  Fly  1962 LG--VYIETRVNNF---------LKKKEAGAGEVHIRVVSSSDKCVEVKPG-----MRRRFVEQG 2010
            :|  ||::....|.         |.|.|:|...::        .|...:|.     ..|:|:|:.
Zfish   935 IGDYVYVQPAEANLQPHVVCIEKLWKDESGQQWMY--------GCWFYRPEETFHLATRKFLEKE 991

  Fly  2011 EMMNEFPYRAKALFAFEEVDGIDVCFFGMHVQEYGSECPAPNTRRVYIAYLDSVHFFRPRQYRTA 2075
            ...:::..|.    .|.::.|  .||. :.|::|....|               ..|:|...
Zfish   992 IFKSDYNNRV----PFSKILG--KCFV-LFVKDYFKLQP---------------EGFKPEDV--- 1031

  Fly  2076 VYHEILLGYMDYVKQLGYTM-------AHIWACPPSEGDDYIFHCHPTDQKIPKP-KRLQEWYKK 2132
                       ||.:..||:       ..||:.||:.       .....:::|.| .|:...:..
Zfish  1032 -----------YVCESRYTVRTKAFKKIKIWSMPPNS-------VKLLPREVPLPVVRVASMFVG 1078

  Fly  2133 MLDK----------GMIERIIQDYKDILKQAMEDKLGSAAELPYFE----GDFW----------- 2172
            ..||          |.||:   :.:|:..:....:||    ..|:|    .|.|
Zfish  1079 AKDKAADLPDGESGGFIEK---EREDVPVEVPNGELG----CQYYEQLRYNDMWLKLGDCVYIRS 1136

  Fly  2173 -----PNVLEESIKEL-----------------DQEEEEKRKQAEAAEAAAAANLFSIEEN---- 2211
                 |.|  ..|:::                 ::.|.|..|.....|..    |.|:|||
Zfish  1137 HGLVRPRV--GRIEKMWLRDGAAFFFGPIFIHPEETEHEPTKMFYKREVF----LSSLEENCPMT 1195

  Fly  2212 --------------------EVSGDG----KKKGQKKAKKSNKSKAAQRKNSKKSNEHQSGNDLS 2252
                                |...:.    :.:..:..|:..|.||.:|.:            ||
Zfish  1196 CVLRKCVVSSFKDFLSCRPTECPEEDVLLFESRYIESEKQMKKFKALKRFS------------LS 1248

  Fly  2253 TKIYATMEKHKEVFFVIRLHSAQSAASLAPIQDPDPLLTCDLMDGRDAFLTLARDKHFEFSSLRR 2317
            .|:.     ..|:|:..:        .:.|.:.|.|||                ||..|....:.
Zfish  1249 AKVV-----DDEIFYFRK--------PIVPQKVPSPLL----------------DKKIEELEAKF 1284

  Fly  2318 AQFSTLSMLYELHNQGQDKFVYTCNHCKTAVETRYHCTVCDDFDLCIVCKEKVGHQHKMEKLGFD 2382
            |....|.                                 ||.|                  ..|
Zfish  1285 ADMEDLD---------------------------------DDMD------------------DLD 1298

  Fly  2383 IDDGSALA---------------DHKQANPQE-------ARKQSIQRCIQS---LAHACQCRD-A 2421
            .||..|.|               |.....||.       ::|:..:|.|..   :..:.:.|. .
Zfish  1299 DDDEEAAATPSMPPSQASTTSDMDMPYTPPQSTPKIKGMSKKEGAKRKINMSGYILFSSEVRSLI 1363

  Fly  2422 NCRLPSC---QKMKLV------VQHTKNCKRKPNGGCPICKQLIALCCYHAKNCEEQKCPVPFCP 2477
            ..|.|..   :..:||      ::.||..:.:...               ||..|:|:
Zfish  1364 KARHPDFSFGELSRLVGTEWRNLEATKKAEYEERA---------------AKLVEQQE------- 1406

  Fly  2478 NIKHKLKQQQSQQKFQQQQLLRRRVALMSRTAAPAALQGPAAVSGPTVVSGGVPVVGMSGVAVSQ 2542
              :.::.|||.||:.||||..:::       |:|.|               |.||..|.|
Zfish  1407 --RERVLQQQHQQQQQQQQQQQQQ-------ASPRA---------------GTPVGTMMG----- 1442

  Fly  2543 QVIPGQAGILPPGAGGM-SPSTVAVPS----------PVSGGAGAGGMGGMTSPH---------- 2586
             |:|      ||.|.|| :.:...||.          |:.|..|..|||| |.||
Zfish  1443 -VVP------PPSAMGMLNQAMPPVPGMMGNYGPPYMPMQGPEGMMGMGG-TPPHLMGVPQLPSQ 1499

  Fly  2587 -------------PHQPGIGMKPGGGHSPSPNVLQVVKQVQEEAARQQVSHGGGF-------GKG 2631
                         || ||: |.||...||.|.         .....|...:|.|.       |:|
Zfish  1500 HYLLPGMAGYPGMPH-PGV-MVPGMNGSPGPG---------NPYGMQMAGYGPGQQAPPPYPGQG 1553

  Fly  2632 VP----MAPPVMNRP 2642
            .|    .|||:...|
Zfish  1554 QPGHQQPAPPIFVAP 1568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nej	NP_001188575.1	ZnF_TAZ	530..600	CDD:214717
		KIX	946..1024	CDD:280354
		Bromo_cbp_like	1705..1812	CDD:99927	36/126 (29%)
		RING_CBP-p300	1824..1906	CDD:276805	15/98 (15%)
		PHD_CBP_p300	1908..1939	CDD:277032	6/37 (16%)
		HAT_KAT11	1970..2283	CDD:285432	66/409 (16%)
		ZZ_CBP	2339..2379	CDD:239077	3/39 (8%)
		ZnF_TAZ	2404..2476	CDD:214717	13/84 (15%)
pbrm1l	XP_005168819.1	Bromo_polybromo_I	43..152	CDD:99954	16/108 (15%)
		Bromo_polybromo_II	184..286	CDD:99948	16/101 (16%)
		Bromo_polybromo_III	352..452	CDD:99951	16/111 (14%)
		Bromo_polybromo_IV	485..585	CDD:99949	17/114 (15%)
		Bromo_polybromo_V	624..723	CDD:99946	30/101 (30%)
		Bromo_polybromo_VI	746..853	CDD:99956	20/124 (16%)
		BAH_polybromo	933..1049	CDD:240068	27/159 (17%)
		BAH_polybromo	1123..1241	CDD:240068	17/123 (14%)
		HMG-box	1346..1408	CDD:238037	12/85 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900