DRSC/TRiP Functional Genomics Resources

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Protein Alignment nej and polybromo

DIOPT Version :9

Sequence 1:NP_001188575.1 Gene:nej / 43856 FlyBaseID:FBgn0261617 Length:3282 Species:Drosophila melanogaster
Sequence 2:NP_651288.1 Gene:polybromo / 42954 FlyBaseID:FBgn0039227 Length:1654 Species:Drosophila melanogaster


Alignment Length:1763 Identity:307/1763 - (17%)
Similarity:525/1763 - (29%) Gaps:691/1763 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly  1509 SSRMMSSSSSLSSQMAALEAAARDNDDETPSPSGENT---------NGSGGSGNAG--------- 1555
            :.|:.|.|   |:.:|||:.....:|||..|..||..         |..|.|.:.|         
  Fly   305 AKRVKSLS---SAAIAALKEEVDSSDDEETSKKGEGPMWALFDHLYNAPGTSEHPGVTGPPLGNS 366

  Fly  1556 ---------------------GMA------SKG---KLDSIKQD-----DDIKKEFMDDSCGGNN 1585
                                 .|:      .||   .:..:..|     |:.||.|         
  Fly   367 LWKLPVRRFHPEYFELIKRPISMSQIHTKLKKGDYANISDLTADLYLMLDNAKKAF--------- 422

  Fly  1586 DSSQMDCSTGGGKGKNVNNDGTSMIKM------EIKTEDG--LDGEVKIKTEAMDVDEAGGSTAG 1642
                       ......:.|...|:|:      |...|:|  ||.|   ..|.||.:....||..
  Fly   423 -----------PTSHRTHKDALKMLKLMNAKLVEESLEEGSDLDDE---DAEEMDTEVFTVSTQP 473

  Fly  1643 EHHGEGGGGSGVGGGKDNINGAHDGGATGGAVDIKPKTETKPLVPEPLAPNAGDKKKKCQFNPEE 1707
            |....         |:..||...:..|:.     .|.....| ....:|.||..|||        
  Fly   474 EKRKP---------GRPRINSNSNSNASH-----TPNNSNSP-KSNRIAINAAIKKK-------- 515

  Fly  1708 LRTALLPTLEKLYRQEPESVPFRYPVD-----PQALGIPDYFEIVKKPMDLGTIRTNIQNGKYSD 1767
                 :.:::| |..: .|:..|.|::     |.....|||::|::.|:|:.||..||:..:|:.
  Fly   516 -----ILSIQK-YLVD-YSLGNRRPIEMFMEKPPRKIYPDYYDIIQNPIDMNTIEHNIRTDRYAA 573

  Fly  1768 PWEYVDDVWLMFDNAWLYNRKTSRVYRYCTKLSEVFEAEIDPVMQALGYCCGRKYTFNPQVLCCY 1832
            ..:.|.|..|||.|...||.:.|.:|.....|.....   :.:.:..|...|:|   :.|.....
  Fly   574 VEDVVSDYRLMFSNCRQYNEEGSNIYEDANILERALN---EKLKEFPGLTEGKK---SQQKYSKV 632

  Fly  1833 GKQLCTIPRDAKYYSYQNSLKEYGVASNRYTYCQKCFNDIQGDTVTLGDDPLQSQTQIK----KD 1893
            |::|.|.....:.:.:..::|||                         .:| :.:.|:.    |.
  Fly   633 GRKLKTAVITERLWQFYETVKEY-------------------------QEP-KGKRQLSLIFTKL 671

  Fly  1894 QFKEMKNDHLEL--EPFVNCQECGRKQHQICVLWLDSIWPGGFVCDNCLKKKNSKRKENKFNAKR 1956
            ..|....|:.::  || ::.....:|..|.....||.:     ..|..|..:|:    .|:|.  
  Fly   672 PSKSEYPDYYDIIREP-IDMDRIAQKLKQGAYDTLDDL-----AADFLLMLENA----CKYNE-- 724

  Fly  1957 LPTTKLGVYIETRVNNFLKKKEAGAGEVHIRVVSSSDKCVEVKPGMRRRFVEQGEMMNEFPYRAK 2021
             |.::  :|.:..|...|                    .:::|..:|    .:.:.:.:.|...:
  Fly   725 -PDSQ--IYKDALVLQQL--------------------TLQLKQQLR----TERDSLPDVPLAVQ 762

  Fly  2022 ALF------AFEEVDGIDVCFFG--MHVQEYGSECPAPNTRRVYIAYLDSV--HFFRPRQYRTAV 2076
            .||      .:...|....|:..  ..:.||......|..|.:   .||.|  ...:....|..|
  Fly   763 ELFLTLFTTIYNHQDEEGRCYSDSLAELPEYDEIGEGPKVRGI---SLDLVKRRLDKGAYKRLDV 824

  Fly  2077 YHEILLGYMDYVKQLGYTMAHIWACPPSEGDDYIFHCHPTDQKIPKPKRLQEWYKKMLDK----- 2136
            |.|.:...::..::|..|.:.|:       .|.|              .||.::.:..|:     
  Fly   825 YQEDIFACLERARKLSRTDSDIF-------QDSI--------------ELQTYFIRKRDELCKDT 868

  Fly  2137 -------GMIERIIQDYKDILKQAMEDKLGSAAELPYFEGDFWPNVLEESIKELDQEEEEKRKQA 2194
                   ..:||::.|.:...:|.|:.                        :|.|||:::::.:.
  Fly   869 LSSSALNFSLERLMADVELCRQQKMQQ------------------------EEQDQEQDKEKDEF 909

  Fly  2195 EAAEAAAAANLFSIEENEVSGDGKKKGQKKAKKSNKSKAAQRKNSKKSNE-----------HQSG 2248
            .||:..:    .:|.:...|.......|....|.......:|..:..:||           |:: 
  Fly   910 NAAKGES----MTINQQVFSPGDYVYVQMPENKIPSICCIERLWTSPTNEKLMQASIFVRPHET- 969

  Fly  2249 NDLSTKIYATMEK--HKEVFFVIRLHSAQSAASLAPIQDPDPLLTCDLMDGRDAFLTLARDKHFE 2311
                  .:.|..|  .||||    ..|.....|:..:|.     .|.:|:.:|            
  Fly   970 ------YHVTTRKFLEKEVF----KSSLSQTISMDKVQG-----MCYVMNIKD------------ 1007

  Fly  2312 FSSLRRAQFSTLSMLYELHNQGQDKFVYTCNHCKTAVETRYHCTVCDDFDLCIVCKEKVGHQHKM 2376
            :..:|....             .:|.||.|       |:||:..               |...|.
  Fly  1008 YIKMRPENL-------------PEKDVYVC-------ESRYNIQ---------------GRWFKK 1037

  Fly  2377 EKLGFDIDDGSALADHKQANPQEAR------KQSIQRCIQSLAHACQCRDANCRLPSCQKMKLVV 2435
            .|....:.:||::....:..|.|.:      |:.:::      |..:..:            |.:
  Fly  1038 LKSWPPVREGSSVKFVPREQPLELKRVMSVFKERLEK------HKGELEE------------LKL 1084

  Fly  2436 QHTKNCKRKPNGGCPICKQLIALCCYHAKNCEEQKCPVPFCPNIKHKLKQQQSQQKFQQQQLLRR 2500
            |.|...|.|||..|.                     |.|         ..:.....:||..    
  Fly  1085 QETLVEKEKPNVSCD---------------------PPP---------NAEVGSTYYQQYN---- 1115

  Fly  2501 RVALMSRTAAPAALQGPAAVSGPTVVSGGVPV---------VGMSGVAVSQQVIPGQAG------ 2550
                                   |:.||.:..         .|...||..||:.. |.|      
  Fly  1116 -----------------------TICSGAIKTGDFVYVATQTGKQSVAQVQQIWE-QNGKSYFKG 1156

  Fly  2551 --ILP-----PGAG------GMSPSTVAVPSPVSGGAGAGGMGGMTSPHPHQPGIGMKPGGGHSP 2602
              :||     ||.|      .:..|||...|||.      |:.|..:...:...|..:|......
  Fly  1157 PWLLPPSETTPGLGKQFYRQELLLSTVEEVSPVV------GIVGRCAVLEYSEFISSRPTEISES 1215

  Fly  2603 SPNVLQVVKQVQEEAARQQVSHGGGFGKGVPMAPPV-------MNRPMGGAGPNQNVVNQLGGMG 2660
            ...:.:.|....::|.|:.|:   |..:....:|.|       ...|:..:...:|.:|:||.:.
  Fly  1216 DVYICESVYDELKKALRKLVT---GNMRKFQHSPSVTEDEIFYFKTPIKPSKDFKNELNELGMLE 1277

  Fly  2661 VGVGGVGGVGVGGVGGVGVNQLNSGGGNTPG-----APISGPGMNVNHL---------------- 2704
                                  :|..|:||.     |.:|.|..:||..                
  Fly  1278 ----------------------DSMDGDTPSLSSDIAAMSSPAPSVNSTPLTSKVKAAKSAKKCL 1320

  Fly  2705 -----------MSMDQWGGGGAGGGGANPGGGNPQARYAN------------------------- 2733
                       .|:.|               .||.|.:.:                         
  Fly  1321 TGYILYSSEVRKSICQ---------------SNPDATFGDISRMVGTEWKNLPSSVKQSWEDRAS 1370

  Fly  2734 ----NTGGMRQPTHVMQTNLIPPQQQQQMMGGLGGPNQLGGGQMPVGGQ---------------- 2778
                .|..:|:....:|.:..|..|..|                .|.||                
  Fly  1371 RQNEETAALRRELDDVQNSASPSSQVSQ----------------DVFGQVLTFECQWDKCDFQFE 1419

  Fly  2779 -------HGGMGMGMGAPPMAGTVGGVRPSPGAGGGGGSATGGGLNTQQLALIMQKIKNNPTNES 2836
                   |          .|:.:.|.::..|.|          |:.|:.:.|.....:...:.::
  Fly  1420 ELSDCTEH----------CMSDSTGHIQRHPQA----------GVETEYVCLWRNCPRVKKSVQA 1464

  Fly  2837 NQHILAILKQNPQI--------MAAIIKQRQ---QSQNNAAAGGGAPGPGGALQQQQAGNGPQNP 2890
            ..::|.::|...::        ::|..:.:.   :.|.:|......|.|....|..:|   |.|.
  Fly  1465 FPNVLRLIKHVREVHLSKCGKTISAADRSKNFVPRRQKHAQLATTVPIPPSLAQSPRA---PSNL 1526

  Fly  2891 QQQQQQQQQQQVMQQQQMQHMMNQQQGGGGPQQMNPNQQQQQQQVNLMQQQQQGGPGGPGSGL-- 2953
            :..|.||||.                    ||| |.:|.||||.:.|         |.|...|  
  Fly  1527 EAVQLQQQQH--------------------PQQ-NMHQLQQQQTIVL---------GPPPEPLFV 1561

  Fly  2954 -----PTRMPNMPNALGMLQSLPPNMSPGVSTQGGMVPNQNWNK-MRYMQMSQY--PPPYPQRQR 3010
                 .||:.:....:..::||.......|.|     .|.||.: :.::..:|.  ....|::..
  Fly  1562 TVPPRTTRVIHSEAYIKYIESLQTGSHLNVVT-----CNNNWRRALTHITPAQVVAKTALPEKWI 1621

  Fly  3011 GPHMGGAG 3018
            ||::...|
  Fly  1622 GPNLRDQG 1629

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nejNP_001188575.1 ZnF_TAZ 530..600 CDD:214717
KIX 946..1024 CDD:280354
Bromo_cbp_like 1705..1812 CDD:99927 28/111 (25%)
RING_CBP-p300 1824..1906 CDD:276805 12/87 (14%)
PHD_CBP_p300 1908..1939 CDD:277032 5/30 (17%)
HAT_KAT11 1970..2283 CDD:285432 55/347 (16%)
ZZ_CBP 2339..2379 CDD:239077 7/39 (18%)
ZnF_TAZ 2404..2476 CDD:214717 11/71 (15%)
polybromoNP_651288.1 Bromodomain 46..158 CDD:295360
Bromo_polybromo_II 191..294 CDD:99948
Bromo_polybromo_III 335..443 CDD:99951 17/127 (13%)
Bromo_polybromo_IV 512..613 CDD:99949 31/118 (26%)
Bromo_polybromo_V 641..733 CDD:99946 21/132 (16%)
Bromo_polybromo_VI 758..867 CDD:99956 24/132 (18%)
BAH_polybromo 921..1040 CDD:240068 29/181 (16%)
BAH_polybromo 1120..1234 CDD:240068 26/120 (22%)
HMG-box 1320..1375 CDD:238037 5/69 (7%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5076
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.810

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