DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nej and Lpt

DIOPT Version :9

Sequence 1:	NP_001188575.1	Gene:	nej / 43856	FlyBaseID:	FBgn0261617	Length:	3282	Species:	Drosophila melanogaster
Sequence 2:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster

Alignment Length:	1627	Identity:	276/1627 - (16%)
Similarity:	456/1627 - (28%)	Gaps:	645/1627 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly  1795 YCTK-LSEVFEAEIDPVMQALGYCCGRKYTFNPQVLC----------CYGKQLCTIPRDAKYYSY 1848
            :||: ||:|.....|..::.|.  |......:..::|          |.|  |..:| |.:
  Fly   187 FCTEHLSQVPVICSDNNVECLS--CSSLGDLSKLIMCSTCGDHFHSTCIG--LANLP-DTR---- 242

  Fly  1849 QNSLKEYGVASNRYTYCQKCFNDIQGDTVTLGDDPLQSQTQIKKDQFKEMKNDHLELEPFVNCQE 1913
                  .|....|.|.||.|......||                              .:|.|::
  Fly   243 ------SGWNCARCTKCQICRQQDSNDT------------------------------KYVKCEQ 271

  Fly  1914 CGRKQHQICVLWLDSIWPG-GFVCDNCLKKKNSKRKENKFNAKRLPTTKLGVYIETRVNNFLKKK 1977
            |.:..|..|:..:.|..|. |:.|:.|                             ||......:
  Fly   272 CQKTYHASCLRPVISAIPKYGWKCNRC-----------------------------RVCTDCGSR 307

  Fly  1978 EAGAGEVHIRVVSSS---------DKCVEVKPGMRRRFVEQGEMMNEFPYRAKALFAFEEVDGID 2033
            ..|.|       |||         |.|                    :..|.|
  Fly   308 TPGGG-------SSSRWHSHYTICDSC--------------------YQQRNK------------ 333

  Fly  2034 VCFFGMHVQEYGSECP--------APNTRRVYIAYLDS-VHFFRPRQYRTAVYHEILLGYMDYVK 2089
                       |..||        |.:...|..::.:. ||.....:.....||:
  Fly   334 -----------GFSCPICQKAYRAASHKEMVKCSWCNKFVHSTCDEEADLTAYHK---------- 377

  Fly  2090 QLGYTMAHIWACPPSEGDDYIFHCHPTDQKIPKPKRLQEWYKKMLDKGMIERIIQDYKDILKQAM 2154
                        ...:..||.:.|.........|...|                |....|:..||
  Fly   378 ------------KKEQNPDYDYVCPNCKSNSSGPGSSQ----------------QTIDSIVLSAM 414

  Fly  2155 EDKLGSAAELPYFEGDFWPNVLEESIKELDQEEEEKRKQAEAAEAAAAANLFSIEENEVSGDGKK 2219
            :    |::|             :.|:||::.:..|.:...:.          |.:|......|||
  Fly   415 D----SSSE-------------QLSLKEIELDPLEGKPTMDP----------SSDELHKLPTGKK 452

  Fly  2220 KGQKKAKKSNKSK------AAQRKNSKKSNEHQSGNDLSTKIYATMEKHKEVFFVIRLHSAQSAA 2278
            |....:.:....|      ....:.:||.:....|..|:                  |.:..|..
  Fly   453 KVCLTSVRGRSGKFVLHRMGVMSQINKKRSTRGKGRQLA------------------LPTISSDR 499

  Fly  2279 SLAPIQDPDPLLTCDLMDGRDAFLTLARDKHFEFSSLRRAQFSTLSMLYELHNQGQDKFVYTCNH 2343
            .|:...:.|  ||.|    :...|..||||..        |...:.::........|..:.||..
  Fly   500 CLSRSMETD--LTSD----KKLLLCSARDKFI--------QAQDICVMCGSLGIESDSVMITCAQ 550

  Fly  2344 CKTAVETRYH---------------------CTVCDDFDLCIVCKEKVGHQHKMEKLGFDIDDGS 2387
            |...    ||                     ||||:            |...|.::....:.|..
  Fly   551 CGQC----YHPYCAGVKPSRGILQKGWRCLDCTVCE------------GCGKKNDEARLLLCDEC 599

  Fly  2388 ALADH-------KQANPQEARKQSI----QRCIQSLAHACQCRDAN-CRLPSCQKMKLVVQHTKN 2440
            .::.|       .:..|....|.|.    |:|.::.....:..|:| ...|||..
  Fly   600 DISYHIYCVNPPLETVPTGNWKCSFCTLCQKCGRNPTEKSEFGDSNMLECPSCTS---------- 654

  Fly  2441 CKRKPNGGCPICK------QLIALC--C-----YHAKNCEEQ-----------KCPVPFCPNIKH 2481
                 ...||:||      ::|..|  |     :|..:...|           ||   |......
  Fly   655 -----QSSCPVCKVSYSNGEMIIQCEHCELWAHFHCDSVNAQLTIDHYDNNVYKC---FKCRCST 711

  Fly  2482 KLKQQQSQQKFQQQQLLRRRVALMSRTAAP----AALQGPA--AVSG-----PTVVSGGVP---- 2531
            :.....:..||..:..|    |:..:.:.|    .|..||:  :.||     || :||.:|
  Fly   712 RSTNSLADAKFGNEDSL----AITPQGSKPFVHITASSGPSFDSKSGAERNHPT-LSGDMPESAP 771

  Fly  2532 --VVGMSGVAVSQQVIPGQAGILPPGAGGMSPSTVAVPSPVSGGAGAGGMGGMTSPHPHQPGIGM 2594
              :..:.||.:|:                               :|.|.:..:::....:..:..
  Fly   772 EALHWIDGVCLSE-------------------------------SGLGMIKSLSTEIKRKRKMRQ 805

  Fly  2595 KPGGGHSPSPNVLQVVKQVQEEAARQQVSH-------GGGFGKGVPMAPPVMNRPMGGAGPNQNV 2652
            ..|.|           |..|.|||.::...       ..|....:|....:.....|     .|:
  Fly   806 ALGNG-----------KDGQLEAAAEEALEKYKDGMVWDGTENAIPEGFTISINDEG-----VNI 854

  Fly  2653 VNQLGGMGVGVGGVGGVGVGGVG-------GVGVNQLNSGGGNTPGAPISGPGMNVNHLMSMDQ- 2709
            :.:.....:...|:||..|...|       ...|:|:||                   ||:||:
  Fly   855 LRKKRQRNLQKLGIGGFSVRNRGLKKDSEETTAVDQINS-------------------LMTMDKK 900

  Fly  2710 ------------------------WGGGGAGGGG--------------------ANPGGGNPQAR 2730
                                    :|.....||.                    ..|.|.:|
  Fly   901 KKIIRKKQKNKLIEAYPVYLQEAFFGKPLLEGGELVMADTDSSDEIDASMKVYFTRPEGKSP--- 962

  Fly  2731 YANNTGGMRQPTHVMQTNLIPPQQQQQMMGGLGGPNQ-LGGGQMPVGGQHGGMGMGMGAPP---- 2790
             ||      |.|  :..|..|.:..:::...|...|: :...|||:|.|:..     |..|
  Fly   963 -AN------QDT--LAVNKSPAKTVKKVKAELKTENKTVFIQQMPMGIQNKN-----GTTPVSNV 1013

  Fly  2791 -------MAGTVGGVR------PSPGAGGGGGSATGGGLNTQQLALIMQKIKNNPTNESNQHILA 2842
                   ::.||...|      .||              |..:|.: ...:...|:.|.   |..
  Fly  1014 FDPLQAEISNTVFANRHPLDALASP--------------NVPELDM-ANSVSTVPSAEV---IEK 1060

  Fly  2843 ILKQNPQIMAAI------IKQRQQSQNNAAAGGGA-PGPGGALQ-QQQAGNGPQNPQQQQQQQQQ 2899
            .::::|.::...      :.|.|:..|....||.. ..|...|| :|||   |||..:|..|...
  Fly  1061 PMRESPAVLVDSFMVPNQLPQEQKFHNQLYLGGNTLVNPAQQLQFRQQA---PQNANKQNMQTIM 1122

  Fly  2900 QQVMQQQQMQHMMNQQQGGGGPQQMNPNQQQQQQQVNLMQQQQQGGPGGPGSGL---PTRMPNM- 2960
            .||:.|.:.:....|:......:.:|...|:..::   |::.:..|.....|.:   .|..||:
  Fly  1123 SQVVLQTEKRPEEEQKVVEPVTETLNAGTQKTAEK---MRKDEDLGLMATISAVLYANTEHPNLK 1184

  Fly  2961 ----------PNALGMLQSL-----PPNMSPGVSTQGGMVPNQNWNKMRYMQMSQYPPPYPQRQR 3010
                      ...|...:||     .|.:......:..:...:..||:..       ||.||:|.
  Fly  1185 ELFPIWNDRCKQILKRWRSLCNEKKAPFLQKAKDNRSALRQRREQNKIPM-------PPKPQKQE 1242

  Fly  3011 GPHMGGAGPGPGQQQ---------FPGGGGGAGNFNAGGAGGAGGVVGVGGVPGGAGTVPGGD-- 3064
              .||.....|.:.:         :.|.....||:..|.|..|      ...|.....:|..:
  Fly  1243 --EMGRVWKQPPKLKEDQPNMFVTYNGNAYDMGNYVGGSAQAA------SNNPNPHHVMPNVNDN 1299

  Fly  3065 -------QYSMANAAAASNM-LQQQQGQVGVGVGV-GVKPGPGQQQQQMGVGMPPGMQQQQQQQQ 3120
                   |.:..:..|||.: :.....::.:...| |.:|...::.:.:         .|:...:
  Fly  1300 LVIKATMQRTQVHTTAASTLKMTTVDNRLELNTAVYGTEPIGDKKLRNL---------LQKNSTE 1355

  Fly  3121 PLQQ---------QQMMQVAMPNANAQNPSAVVGGPNAQVMGPPTP---HSLQQQLM----QSAR 3169
            |:..         ..:|::.|    .||.......|...:.|...|   .||:|.:.    |.|.
  Fly  1356 PMLMGANSDLFLGNDVMRLGM----MQNTPITQNNPMLSISGKSQPSEGRSLEQDVKLGEPQEAT 1416

  Fly  3170 SS 3171
            ||
  Fly  1417 SS 1418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nej	NP_001188575.1	ZnF_TAZ	530..600	CDD:214717
		KIX	946..1024	CDD:280354
		Bromo_cbp_like	1705..1812	CDD:99927	6/17 (35%)
		RING_CBP-p300	1824..1906	CDD:276805	14/91 (15%)
		PHD_CBP_p300	1908..1939	CDD:277032	9/31 (29%)
		HAT_KAT11	1970..2283	CDD:285432	48/336 (14%)
		ZZ_CBP	2339..2379	CDD:239077	11/60 (18%)
		ZnF_TAZ	2404..2476	CDD:214717	19/100 (19%)
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135	2/3 (67%)
		PHD1_KMT2C_like	205..250	CDD:276984	9/59 (15%)
		PHD2_KMT2C_like	252..298	CDD:276985	14/75 (19%)
		PHD_SF	337..392	CDD:304600	11/76 (14%)
		PHD4_KMT2C_like	530..578	CDD:276987	6/51 (12%)
		PHD5_KMT2C_like	580..625	CDD:276988	9/56 (16%)
		PHD6_KMT2C_like	657..707	CDD:276989	12/52 (23%)
		NHP6B	1101..>1237	CDD:227935	29/148 (20%)
		HMG	1173..1231	CDD:197700	7/57 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900