DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nej and tou

DIOPT Version :9

Sequence 1:	NP_001188575.1	Gene:	nej / 43856	FlyBaseID:	FBgn0261617	Length:	3282	Species:	Drosophila melanogaster
Sequence 2:	NP_001097270.1	Gene:	tou / 36241	FlyBaseID:	FBgn0033636	Length:	3131	Species:	Drosophila melanogaster

Alignment Length:	3332	Identity:	604/3332 - (18%)
Similarity:	951/3332 - (28%)	Gaps:	1345/3332 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   470 QGVGIGGAGVVANAGTVAGVPAVAGGGAGGAVQSSG--------------PGGANRDVPDDRKRQ 520
            :..|.|..|..:|..:.||    .||||||....:|              |.||......:....
  Fly     3 KNAGDGSDGKNSNKNSNAG----GGGGAGGPHDPTGLLDAASLFAYWGRDPTGAAAAAASNPLFN 63

  Fly   521 IQ------QQLMLLLHAHKCNRRENLNPNREVCNVNYCKAMKSVLA-----HMGT----CKQSKD 570
            .|      ..|.||..|...:           .|..|..|..:..|     |..|    ..|:..
  Fly    64 SQFNAAAAAGLGLLPQAGGAS-----------ANDRYSMAAAAAAAAGAHHHQNTMAVAASQAAS 117

  Fly   571 CTMQHCA---SSRQILL--HYKTCQNSGCVICYPFRQNHSVFQNANVPPGGGPAGIG-GAPPGGG 629
            ....|.|   |..|:..  ::...|.||.          |.|.:.::....||||:| |...||.
  Fly   118 LAGLHPASWWSMAQLAAQDYFSRLQASGL----------SPFPHPDLAAAFGPAGMGMGGGAGGA 172

  Fly   630 GAGGGAAGAGGNLQQQQQQQQQQQQNQQPNLTGLVVDGKQGQQVAPGGGQNTAIVLPQQQGAGGA 694
            |||||.||..|                                                ||.||.
  Fly   173 GAGGGGAGVLG------------------------------------------------QGGGGN 189

  Fly   695 PGAPKTPADMVQQLTQQQQQQQQQVHQQQVQQQELRRFDGMSQQVVAGGMQQQQQQGLPPVIRIQ 759
            .|:
  Fly   190 GGS-------------------------------------------------------------- 192

  Fly   760 GAQPAVRVLGPGGPGGPSGPNVLPNDVNSLHQQQQQMLQQQQQQGQNRRRGGLATMVEQQQQHQQ 824
                     |.||.|..||                   ....:..::|:        |::...||
  Fly   193 ---------GNGGGGSSSG-------------------SSGSKSNKSRK--------EKRAAQQQ 221

  Fly   825 QQQQPNPAQLGGNIPAPLSVNVGGFGNTNFGGAAAGGAVGANDKQQLKVAQVHPQSHGV------ 883
            ||||.|.|.         |:|          .|||..|..|.:.....:|.:|....||
  Fly   222 QQQQQNLAN---------SLN----------AAAAAAAAAAANNPAAALASMHGFGVGVPGTSIP 267

  Fly   884 ----GAGGASAGAGASGGQVAAGSSVLMPADTTGSGNAGNPN---------------QNAGGVAG 929
                |:|..|..:|..|...:..|:...|:..|.|..|.||.               |.....|.
  Fly   268 SVSTGSGSISTNSGGHGSYKSTASAYGKPSTMTSSSMANNPGSAYDPVTLHKELLAMQAVAAAAS 332

  Fly   930 GAG--GGNGGNTGPPGDNEKDWRESVTADLRNHLVHKLVQAIFPTSDPTTMQDKRMHNLVSYAEK 992
            |:|  |.:|..:|..|.:...             :|.|...|..:..  .|...:....||.:..
  Fly   333 GSGSSGSSGKKSGGGGSSSSS-------------MHSLGMGIGGSGG--MMSSGKASTSVSASNS 382

  Fly   993 VEKDMYEMAKSRSEYYHLLAEKIYKIQKELEEKRLKRKEQHQQMLMQQQGVANPVAGGAAGGAGS 1057
            ....|:....|                                        :||:....||...|
  Fly   383 SLGGMHPSLTS----------------------------------------SNPLMSPHAGMGSS 407

  Fly  1058 AAGVAGGVVLPQQQQQQQQQQQQQGQQPLQSCIHPSISPMGGV-MPPQQLRPQGPPGILGQQTAA 1121
            ::               ...:.:....|..:.:: |:|..|.: |.|||       .:.....|.
  Fly   408 SS---------------SSSKDRDKNNPSLNALN-SLSQFGALGMTPQQ-------SMQAAMNAF 449

  Fly  1122 GLGVGVGVTNNMVTMRSHSPGGNMLALQQQQRMQFPQQQQQQPPG----SGAGK-------MLVG 1175
            ....||..:..:.:...||                 .|||||..|    ||:||       |..|
  Fly   450 AASTGVSPSATVTSSPHHS-----------------SQQQQQMGGNSSTSGSGKSSSKDYMMGTG 497

  Fly  1176 PPGPSPGGMVVNPALSPYQTTNVLTSP-VPGQQQQQQFINANGGTGANPQLSEIMKQRHIHQQQQ 1239
            ...||..|:.:.|.....:.|:.:..| :||...:          |....:||..:|  ..||||
  Fly   498 SEHPSLLGVRLPPDTEIIKYTSSIVGPKIPGTTSR----------GRKKTISETEQQ--TTQQQQ 550

  Fly  1240 QQQQQQQQGMLLPQSPFSNSTPLQQQQQQQQQQQQQQQATSNSFSS------------------- 1285
            :||.|.:|.:|                |||||.|::..:|.|:.||
  Fly   551 KQQHQAEQHLL----------------QQQQQAQKELDSTKNAISSLLAFPGLSPAKRARLEMEY 599

  Fly  1286 ------PMQQQQQGQQQQQQKPGSVLNNMPPTPTSLEALNAGAGAPGTGGSASNVTVSAPSPSPG 1344
                  ..||.||.|||.|.:            ..|..:...||.||..|     .|..|..|..
  Fly   600 AAMAAAAQQQHQQAQQQHQAQ------------QQLHGMLGAAGIPGMAG-----LVGLPGMSGN 647

  Fly  1345 FL-----SNGPSIGTPSNNNNNSSANNN---------------PPSVSSLMQQPLSNRPGTPPYI 1389
            .|     |...|...|:.:.::|||.:|               ||:::|.....||:: |...:.
  Fly   648 PLDQLSVSKASSSTAPTTSTSSSSAGSNLLNQSNSDRVEVIKLPPTITSNGAYNLSSK-GKEVHD 711

  Fly  1390 PASPVPATSASGL-------AASS--TPASAAATCAS----------------SGSGSNSSSGAT 1429
            ..:.: ||::.|:       |.||  ||:.|..:.::                ....|||||...
  Fly   712 LTTDM-ATNSGGVNLSLKSNAGSSALTPSGAVGSASNPITIDDFDAPLNLSMKPSDKSNSSSSNA 775

  Fly  1430 AAGASSTSS------------SSSAGSGTPLSSVSTPTSATMATSSGGGGGGGGNAGGGSSTTPA 1482
            |||.||:||            :||..||..|.|:|:.|:|.    .|.||..||:..|...|:||
  Fly   776 AAGGSSSSSAALANLASDYQAASSGQSGNSLQSLSSITAAL----GGTGGMPGGSISGSGGTSPA 836

  Fly  1483 SNPLLLMSGGTAGGGTGATTTTSTSSSSRMMSSSSSLSSQMAALEAAARDNDDETPSPSGENTNG 1547
                      .||.|:|||                                      ..|..:.|
  Fly   837 ----------PAGAGSGAT--------------------------------------GGGSGSGG 853

  Fly  1548 SGGSG---------NAGGMASKGKLDSI----------------------KQDDDIKK------- 1574
            |||..         |.|...||.|.:::                      :|..||:|
  Fly   854 SGGGSSSYKEGRPRNLGRGVSKPKKNTVASLLAQSRAVGLKPMLATQQLLQQGADIEKIRLALSE 918

  Fly  1575 --EFMDDSCGGNNDSSQMDCSTGGGKGKNVNNDGTSMIKMEIKTEDGLDGEVKIKTEAMDVDEAG 1637
              ..|:.|    .||..:...:|..:.::.:.:..::.::.:..|.|...|..|:         |
  Fly   919 ANAHMETS----TDSESVAAESGLSESESEDANILNVAELRVPLELGWKRETVIR---------G 970

  Fly  1638 GSTAGEHHGEGGGGSGVGGGKDNINGAHDGGATGGAVDIKPKTETKPLVPEPLAPNAGDKKKKCQ 1702
            .:..|:..||                               .|...|....||..|.
  Fly   971 LTKQGQIRGE-------------------------------VTYYAPGSTTPLKSNG-------- 996

  Fly  1703 FNPEELRTALLPTLEKLYRQEPESVP-FRYPVDPQALGIPDYFEIVKKPMDLGTIRTNIQNGKYS 1766
                    .:...||    |:|.::. ..:....:|: :..:.:....|              |:
  Fly   997 --------QVFAILE----QQPSNLSRENFSFSARAI-VGSFLQPAPPP--------------YA 1034

  Fly  1767 DPWEYV----DDVWLMFDNAWLYNRKTSRVYRYCTKLSEVFEAEIDPVMQALGYCCGRKYTFNPQ 1827
            :..||:    :||....::..::.|:|..|.:         ..||....||:
  Fly  1035 NDGEYIRMTDEDVAKRLEDLKVFTRQTLNVEQ---------RIEIAKQQQAM------------- 1077

  Fly  1828 VLCCYGKQLCTIPRDAKYYSYQNSLKEYGVASNRYTYCQKCFNDIQGDTVTLGDDPLQSQTQIKK 1892
                         ||||      .|::..:|.|:....|:..:.::...   .|..|::|..:::
  Fly  1078 -------------RDAK------KLQKEELARNKEKARQEKNSKLEQQR---KDKELKNQQAVEE 1120

  Fly  1893 DQFKEMKNDHLELEPFVNCQECGRKQHQICVLWLDSIWPGGFVCDNCLKKKNSKRKENKFNA--- 1954
            .:.::.:.|.|:.|..:..|:...|:.|..:|              ..:::..|:||....|
  Fly  1121 RKKRQEELDRLKQEELLKKQQEKEKRRQEAIL--------------AKEQELQKQKEMLLAAEME 1171

  Fly  1955 --KRLPTTKLGVYIETRVNNFLKKKEAGAGEVHIRVVSSSDKCVEVKPG-----MRRRFVEQGEM 2012
              :|.....|...:|.| ..|..:::.....|..|::....:..|.|..     :.||..|..||
  Fly  1172 RERRRQHMSLIRMLELR-RKFEDREKKKHQLVLDRLLLRERRMAERKRDAEILQLIRRPNEDSEM 1235

  Fly  2013 M-------------NEFPYRAKA--LFAFEEVDGIDVCFFGMHVQEYGSECPA-PNTRRVYIAYL 2061
            .             |..|.:|.|  |..||.:..     ||   :..|.:..: |:.:.::.|.:
  Fly  1236 PQELVIPELDRIAGNRLPGQAMADLLMVFEFLHN-----FG---ETLGFDMESLPSLQNLHDALM 1292

  Fly  2062 DSVHFFRPRQYRTAVYHEILLGYMD--------YVKQLGYTMAH-------------IWACPPSE 2105
            ...:.....:..:.:.|.::....|        :...||.::.:             |:....:.
  Fly  1293 SDSNADAEEELLSVMTHLLVCAIEDPGVPNPGRHTTLLGQSLRNADITNSNVSEILRIYLYATAT 1357

  Fly  2106 GDDYIFHCHPTD----QKIPKPKRL-------------QEWYKKMLDKGMIERIIQDYKD----- 2148
            |:....|....|    :::|...:|             ||:| |:|.:....::.|..||
  Fly  1358 GEVRQMHGITVDRERERRVPDHHQLDSDTTTHSHSVKNQEYY-KLLHENDTWKLSQSLKDRPFVA 1421

  Fly  2149 --------ILKQAMEDKLGSAAELPYFEGD-----------FWPNVLEESIK------------- 2181
                    :|.....|.|.:.|.|...:|.           :..::.....|
  Fly  1422 LNPTRKAQMLAHLCNDLLMNKAVLRQIDGSLETCAQMRKEKYMTDMKVRKYKALHMRKARIEAYE 1486

  Fly  2182 -----------------ELDQEE---EEKRKQAEAAEAAAAANLFSIEENEVSGDGKKKGQKKAK 2226
                             :||.|.   ||:.|.|.|.||||||.        ..|:..|.|....:
  Fly  1487 RAQAEREAAMQALMAQQKLDAERLKAEEEAKAAAAEEAAAAAG--------TDGEATKGGSPNGE 1543

  Fly  2227 KSNKSKAAQRKNSKKSNEHQSGNDLSTKIYATMEKHKEVFFVIRLHSAQSAA--------SLAPI 2283
            |.......:...:|:..:.|             ::..||..|:...|..|.|        ||.|.
  Fly  1544 KPEDGDQNEEGAAKEPQQQQ-------------QQPMEVDGVVDEASLVSPAKTIIQTDNSLTPS 1595

  Fly  2284 QDPDPLLTCDL----------MDGRDAFLTL------AR----DKHFEFSSLRRAQFSTLSMLYE 2328
            :...|..|..:          :.|.|..:.|      ||    |:|....|:.....|.|..  |
  Fly  1596 KQDMPTPTYQINGSSTPTTSGVTGGDMNVLLQAKKSGARNSINDEHHHDVSIIDDDLSDLDS--E 1658

  Fly  2329 LHNQGQ---------------DKFVYTCNHCKTAVE-----TRYHCTVCDDFDLCIVCKEKVG-- 2371
            :.|..:               ||.|....:||.|:|     .|..|...|.|........|.|
  Fly  1659 ITNVEEDEDNRLSADELQKKLDKIVRASLNCKEALEKSTNQLRAACFGQDRFWRRYWKLPKAGGI 1723

  Fly  2372 HQHKMEKLGFDIDDG----SALADHKQANPQEARKQS--------------IQRCIQSLAHACQC 2418
            ....:|....||.|.    .|:.|.|.||.::...::              :...|..|......
  Fly  1724 FIEALESAQNDICDYHEALEAMDDKKDANDEKENSENEKDVAAESSEQPMEVDESITKLEDGVPA 1788

  Fly  2419 RDANCRLPSCQKMKLVVQH----------TKNCKRKP----------NGGCPICK---------- 2453
            .|..  :|...:..   .|          |:..|.:|          :...|:.|
  Fly  1789 SDVG--MPESNQQN---AHQDEEDDDDDVTEINKVEPEIVDLGDDDDDAAPPLPKIEPPRPEIKV 1848

  Fly  2454 ----QLIA---LCCYHAKNCEEQKCPVPF--------------------------CPNIKHKLKQ 2485
                :|:.   ......|...|.:..:|.                          |..::..|..
  Fly  1849 KSEMELMGPPPTTMISTKTDFEAEIKIPSMPGILMPPTLNNNNTNNNNNNNGSDNCDKLETGLGL 1913

  Fly  2486 QQSQQKFQQQ----------------------------QLLRRRVALMSRTAAPAALQGPAAVSG 2522
            .|.||.|.|.                            .::||.|.|:|...|.
  Fly  1914 GQQQQNFSQSVIKTEDVKKEDDCIIVSTSSVDDTPKWFSIVRREVPLISELPAE----------- 1967

  Fly  2523 PTVVSGGVPVVGMS-GVAVSQQVIPGQAGI---------------LPP----------------G 2555
                .||  |||.. .::.:.|....|..:               :|.                .
  Fly  1968 ----EGG--VVGQELQISYANQNCSAQLQLQGHPWDLINNMQYYSIPMDECKVDTSKLGNECIFS 2026

  Fly  2556 AGGMSPSTVAVPSPVSGGAGAGGMGGMTSPHPH-------------------------------- 2588
            ..|:....:................|:.|||.|
  Fly  2027 LSGLDEKQMLAKVEEYKAHKVESKNGLGSPHRHHETKDDEEQAKLKLDKEIDTEMETDADDLAGK 2091

  Fly  2589 ------QPGIGMKPGGGHSPSPNVLQVVKQVQEEAARQQVSHG------GGFGKGVPMAPPVMNR 2641
                  :..:....|||.|...:|...::...:||..|...|.      ......:|:..|:
  Fly  2092 EKFFRLRSDVPPDTGGGVSEGTDVKPKIELRLDEALSQAYYHNIANMSLSSVQTYIPIDIPL--- 2153

  Fly  2642 PMGGAGPNQNVVNQLGGMGVGVGG----VGGVGVGGVGGVGVNQLNSGGG--------NTPGAPI 2694
            |:........::.|     |.:.|    |.||.|......|..||:....        |..|...
  Fly  2154 PLSMTPDEHRLLEQ-----VKLAGFPERVHGVYVPRRQRYGWWQLDDEQKLRQLLKTLNPSGLRE 2213

  Fly  2695 SGPGMNVNHLMSMDQWGGGGAGGGGANPGGGN---------PQARYANNTGGMRQPTHVMQTNLI 2750
            .....|:...:.::|            |.|.|         |:.....:..|...|....:..|.
  Fly  2214 RELQENLQRFLGLEQ------------PLGVNYKLKSDIDFPEEFLMPDKKGDWNPKVAKRVELA 2266

  Fly  2751 PPQQQQQMMGGLGGPN-QLGGGQMPVGGQHGGMGMGMGAPPMAGTVGGVRPSPGAGGGGGSATGG 2814
            ..:|.:.:...:...: ||...|:|...:                              ...|
  Fly  2267 LIEQLESLEDKVASASMQLKNWQLPNRVE------------------------------SELT-- 2299

  Fly  2815 GLNTQQ----------LALIMQKIKNNPTNESNQHILAIL-KQNPQIMAAIIKQRQ----QSQNN 2864
             |::|:          :.:|.::|.:...|...:::...| .|......|:|.|.|    |:||:
  Fly  2300 -LDSQEDVTEEDFVSIIPMIRERIIDLEANIERRYLKPPLGSQTGDAHLAVIAQNQHTTTQTQNS 2363

  Fly  2865 AAAGGGAPGPGGALQQQQAGNGPQNPQQQQQQQQQQQVMQQQQMQHMMNQQQGGGGPQQMNPNQQ 2929
            |:|....                   .|.||||||||:.||||     .||||.|....:||:..
  Fly  2364 ASAAAYL-------------------LQMQQQQQQQQLAQQQQ-----QQQQGSGAGNSLNPSSF 2404

  Fly  2930 QQQQQVNLMQQQQQGGPGGPGSGLPTRMPNMPNALGMLQSLPPNMSPGVSTQGGMVPNQNWNKMR 2994
            .::    .|.........|||           ||.|:..|         :...|..|.::
  Fly  2405 NER----TMALAAAAAASGPG-----------NATGVANS---------AVVAGATPCES----- 2440

  Fly  2995 YMQMSQYPPPYPQRQRGPHMGGAGPGPGQQQFPGGGGGAGNFNAGGAGGAGGVVG-----VGGVP 3054
                                                 |:|..|:|.|..|.....     |..:|
  Fly  2441 -------------------------------------GSGEPNSGNASPASNCDSDRDEKVEQIP 2468

  Fly  3055 GGAGTVPGGDQYSMANAAAASNM-LQQQQGQV----GVGVGVGVKPGPGQQQQQMGVGMPPGMQQ 3114
              .|.|...|..|.::..|...| |...:..|    .:......|....:::........|..:|
  Fly  2469 --KGLVQWRDAVSRSHTTAQLAMALYVLESCVAWDKSIMKAYATKNKSSKKKSSAKKQATPSKKQ 2531

  Fly  3115 QQQQQQPLQQQQMMQVAMPNANAQNPSAVVGGPNAQVMGPPTPHSLQQQLMQSARS--------S 3171
            ||::.:  ::||:    .||.......:.:..|..|     .|.|::..|...|::        :
  Fly  2532 QQKKNK--KEQQL----TPNGKESKSKSAINKPENQ-----APLSIKINLKALAQNGQCLLKTKT 2585

  Fly  3172 PPIRSPQPTPSPRSAPS 3188
            |||.:..||.||.|.|:
  Fly  2586 PPILTKSPTASPSSHPN 2602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nej	NP_001188575.1	ZnF_TAZ	530..600	CDD:214717	15/83 (18%)
		KIX	946..1024	CDD:280354	8/77 (10%)
		Bromo_cbp_like	1705..1812	CDD:99927	16/111 (14%)
		RING_CBP-p300	1824..1906	CDD:276805	13/81 (16%)
		PHD_CBP_p300	1908..1939	CDD:277032	4/30 (13%)
		HAT_KAT11	1970..2283	CDD:285432	75/436 (17%)
		ZZ_CBP	2339..2379	CDD:239077	11/46 (24%)
		ZnF_TAZ	2404..2476	CDD:214717	14/148 (9%)
tou	NP_001097270.1	HAT_MBD	953..1027	CDD:238691	18/134 (13%)
		ZapA	1021..1127	CDD:294720	24/164 (15%)
		MAP7	1043..1198	CDD:283355	36/213 (17%)
		RILP-like	1085..>1179	CDD:304877	18/110 (16%)
		DDT	1255..1317	CDD:280886	11/69 (16%)
		WHIM1	1406..1455	CDD:292246	9/48 (19%)
		WHIM3	2190..2224	CDD:292248	5/33 (15%)
		PHD_BAZ2A_like	2640..2685	CDD:277020
		RanBP2-type Zn finger	2640..2659	CDD:275375
		RanBP2-type Zn finger	2680..2698	CDD:275376
		PHD	2695..2744	CDD:279022
		Bromo_BAZ2A_B_like	3027..3123	CDD:99935
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900