DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nej and Brd3

DIOPT Version :9

Sequence 1:	NP_001188575.1	Gene:	nej / 43856	FlyBaseID:	FBgn0261617	Length:	3282	Species:	Drosophila melanogaster
Sequence 2:	XP_006233887.1	Gene:	Brd3 / 362092	RGDID:	1308925	Length:	742	Species:	Rattus norvegicus

Alignment Length:	994	Identity:	165/994 - (16%)
Similarity:	269/994 - (27%)	Gaps:	435/994 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly  1295 QQQQQKPGSVLNNMPPTPTSLEALNAGAGAPGTGGSASNVTVSAPSPSPGFLSNGPSIGTPSNNN 1359
            |:..|.|...:..:||.|.. :.....|||...|..... .||:.||:|.|
  Rat   135 QKVAQMPQEEVELLPPAPKG-KGRKPAAGAQNAGAQQMG-AVSSVSPAPPF-------------- 183

  Fly  1360 NNSSANNNPPSVSSLMQQPLSNRPGTPPYIPASPVPATSASGLAASSTPASAAATCASSGSGSNS 1424
                 .|.||:||.            .|.|.|:|||..:|:..:....|.:|....|
  Rat   184 -----QNIPPTVSQ------------TPVIAATPVPTITANVTSVPVPPPAAPPPPA-------- 223

  Fly  1425 SSGATAAGASSTSSSSSAGSGTPLSSVSTPTSATMATSSGGGGGGGGNAGGGSSTTPASNPLLLM 1489
                                 ||:..|..||                             |.::.
  Rat   224 ---------------------TPIVPVVPPT-----------------------------PPVVK 238

  Fly  1490 SGGTAGGGTGATTTTSTSSSSRMMSSSSSLSSQMAALEAAARDNDDETPSPSGENTNGSGGSGNA 1554
            ..|........|.|||..::|| ..|...||....|...|.|::......|..::........:|
  Rat   239 KKGVKRKADTTTPTTSAITASR-SESPPPLSEPKQAKVVARRESGGRPIKPPKKDLEDGEVPQHA 302

  Fly  1555 GGMASKGKL-DSIKQDDDIKKEFMDDSCGGNNDSSQMDCSTGGGKGKNVNNDGTSMIKMEIKTED 1618
            |   .|||| :.::..|.|.:|.:
  Rat   303 G---KKGKLSEHLRHCDSILREML----------------------------------------- 323

  Fly  1619 GLDGEVKIKTEAMDVDEAGGSTAGEHHGEGGGGSGVGGGKDNINGAHDGGATGGAVDIKPKTETK 1683

  Rat   324 ----------------------------------------------------------------- 323

  Fly  1684 PLVPEPLAPNAGDKKKKCQFNPEELRTALLPTLEKLYRQEPESVPFRYPVDPQALGIPDYFEIVK 1748
                         .||...:                      :.||..|||.:||.:.||.:|:|
  Rat   324 -------------SKKHAAY----------------------AWPFYKPVDAEALELHDYHDIIK 353

  Fly  1749 KPMDLGTIRTNIQNGKYSDPWEYVDDVWLMFDNAWLYNRKTSRVYRYCTKLSEVFEAEI----DP 1809
            .||||.|::..:.:.:|.|...:..|:.|||.|.:.||.....|.....||.:|||...    |.
  Rat   354 HPMDLSTVKRKMDSREYPDAQGFAADIRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDE 418

  Fly  1810 VMQALGYCCGRKYTFNPQVLCCYGKQLCTIPRDAKYYSYQNSLKEYGVAS--------------- 1859
            .|:.            |.:      ...|.|..:|......|.:|....|
  Rat   419 PMEV------------PAL------PAPTAPIVSKGAESSRSSEESSSDSGSSDSEEERATRLAE 465

  Fly  1860 -NRYTYCQKCFND------------IQGDTVTLGDDPLQSQTQIKKDQFKEMKNDHLELEPFVNC 1911
             ...|.| ..|.|            :......|...|:....:.|:.:.||.|....|.|
  Rat   466 LQEQTGC-GAFQDQLLNVSSVQLKAVHEQLAALSQAPVNKPKKKKEKKEKEKKKKDKEKE----- 524

  Fly  1912 QECGRKQHQICVLWLDSIWPGGFVCDNCLKKKNSKRKENKFNAKRLPTTKLGVYIETRVNNFLKK 1976
                                         |:|:..:.|.:..||..|..|..           ::
  Rat   525 -----------------------------KEKHKAKSEEEKKAKAAPAAKQA-----------QQ 549

  Fly  1977 KEAGAGEVHIRVVSSSDKCVEVKPGMRRRFVEQGEMMNEFPYRAKALFAFEEVDGIDVCF----- 2036
            |:|...:.:....:|             |.:::|.......|.::     ||.:|:.:.:
  Rat   550 KKAPTKKANSTTTAS-------------RQLKKGGKQASASYDSE-----EEEEGLPMSYDEKRQ 596

  Fly  2037 FGMHVQEYGSECPAPNTRRVYIAYLDSVHFFRPRQYRTAVYHEILLGYMDYVKQLGYTMAHIWAC 2101
            ..:.:    :..|.....||       ||..:.|:
  Rat   597 LSLDI----NRLPGEKLGRV-------VHIIQSRE------------------------------ 620

  Fly  2102 PPSEGDDYIFHCHPTDQKIP----KPKRLQEWYKKMLDKGMIERIIQDYKDILKQAMEDKLGSAA 2162
             ||..|.     :|.:.:|.    ||..|:|          :||.:   |..|::.....|.::.
  Rat   621 -PSLRDS-----NPDEIEIDFETLKPTTLRE----------LERYV---KSCLQKKQRKPLSTSG 666

  Fly  2163 ELPYFEGDFWPNVLEESIKELDQEEEEKRKQAE--AAEAAAAANLFSIEENEVSGDGKKKGQKKA 2225
            :             :::.|..::..:||:|:.|  ..:.:...|.....:.|.||.....|..:.
  Rat   667 K-------------KQAAKSKEELAQEKKKELEKRLQDVSGQLNSKKPTKKEKSGSAPSGGPSRL 718

  Fly  2226 KKSNKSKAAQRKNSKKSNE 2244
            ..|:.|::|...:|..|::
  Rat   719 SSSSSSESASSSSSGSSSD 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nej	NP_001188575.1	ZnF_TAZ	530..600	CDD:214717
		KIX	946..1024	CDD:280354
		Bromo_cbp_like	1705..1812	CDD:99927	32/110 (29%)
		RING_CBP-p300	1824..1906	CDD:276805	18/109 (17%)
		PHD_CBP_p300	1908..1939	CDD:277032	0/30 (0%)
		HAT_KAT11	1970..2283	CDD:285432	44/286 (15%)
		ZZ_CBP	2339..2379	CDD:239077
		ZnF_TAZ	2404..2476	CDD:214717
Brd3	XP_006233887.1	Bromo_Brdt_I_like	34..140	CDD:99929	1/4 (25%)
		Bromo_Brdt_II_like	311..412	CDD:99930	36/241 (15%)
		BET	588..652	CDD:407211	17/123 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900