DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nej and baz1a

DIOPT Version :9

Sequence 1:	NP_001188575.1	Gene:	nej / 43856	FlyBaseID:	FBgn0261617	Length:	3282	Species:	Drosophila melanogaster
Sequence 2:	NP_001352072.1	Gene:	baz1a / 334173	ZFINID:	ZDB-GENE-030131-6105	Length:	1470	Species:	Danio rerio

Alignment Length:	1371	Identity:	239/1371 - (17%)
Similarity:	409/1371 - (29%)	Gaps:	495/1371 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   762 QPAVRVLGPGGPGGPSGP-NVLPNDVN------SLHQQQQQML---------------QQQQQQG 804
            :|.|....|.|.|....| |....::|      .|.||::||:               ::::::.
Zfish   264 EPPVFTFSPPGKGRGRPPNNASSTEINYIEEKLKLMQQKEQMMSMEKFRKERDDLIEAKKKEKED 328

  Fly   805 QNRRRGGLATMVEQQQQHQQQQQQ----------------------------------------- 828
            :.:::..:..::|:::..::::::
Zfish   329 KEKKKEEMKRILEEEKLRRKEERERMKVEKEREREKLKEEKKKYAERLKLWSKPREDMECDDLKE 393

  Fly   829 -PNPAQLGGNIPAPLSVNVGGFGNTNFGGA--------AAG--------------------GAVG 864
             |.|..:...:|..|           ||.|        |.|                    ..||
Zfish   394 LPKPIPVKTRLPPEL-----------FGDALMVLEFLHAFGELFDLKDEFPDGVTLEVLEEAVVG 447

  Fly   865 AND--------------------KQQLKVAQ--------------VHPQSHGVGAGGASAGA--- 892
            ::.                    ::|.:||:              ..|....:.|..:.|.|
Zfish   448 SDPEGPLCELLFFFLSAIFQALAEEQEEVAKDQLAEDLSEALDDDADPTQSAISAVASLAAAWPQ 512

  Fly   893 ---GASGGQVAAGS---------SVLMPADTTGSGNAGNPNQNAGGVAGGAGGGNGGNTGPPGDN 945
               |.|..|:...|         .:|......|..||....|..||.         |:|..|
Zfish   513 LHQGCSLKQLDLDSCTLSEILRLHILSSGADCGFTNAKFRYQKQGGF---------GSTDDP--- 565

  Fly   946 EKDWRESVTADLRNH-LVHKLVQAIFPTSDPTTMQD-------KRMHN-------LVSYAEKVEK 995
                  .|...|.|| |:.||        ..|::.|       |.:|:       |||..:.:|.
Zfish   566 ------CVELRLSNHGLLKKL--------SCTSVYDLLPGEKLKILHSMCGKLLTLVSTRDFIED 616

  Fly   996 DMYEMAKSRSEYYHL-----------LAEKIYKIQKE-LEEKRLKRKEQHQQMLMQQQGVANPVA 1048
            :..|...::.|...|           .||::.|.::| |.|:.||.||:|:::..:
Zfish   617 NADEQRAAKQELRELKAEQHRREREEAAERVRKRKEEKLREQELKLKEKHERLKEE--------- 672

  Fly  1049 GGAAGGAGSAAGVAGGVVLPQQQQQQQQQQQQQGQQPLQSCIHPSISPMGGVMPPQQLRPQGPPG 1113
               |...|..||.........|:...:|..:.:.:||.:|   ..:....|.   .:.:|.|.
Zfish   673 ---AKNGGQLAGEEMDTSTESQEGHAEQHTEDEEEQPAKS---KKVKKTNGT---TKEKPSGE-- 726

  Fly  1114 ILGQQTAAGLGVGVGVTNNMVTMRSHSPGGNMLALQQQQRMQFPQQQQQQP-------------- 1164
                         |.:.:|:      ||  ..|.|||.:..:..::.||..
Zfish   727 -------------VEMKDNL------SP--EELQLQQLKERELLERIQQAMACTYILPLGRDRLY 770

  Fly  1165 ------PGSGA-----------GKMLVGPPGPSPGGMVVNPALSPYQTTNVL--------TSPVP 1204
                  |.:||           ..||...|.|.|....|..|.||.:|....        |||..
Zfish   771 RRYWIFPSAGALFVEDDFFGLTEDMLEPRPTPEPKIEEVLSAESPVKTDGATEELVLVQNTSPPV 835

  Fly  1205 GQQQQQQFINANGGTGANPQLSEIMKQRHIHQQQQQQ------------------QQQQQQGMLL 1251
            .:..|..|.:.   |....||.|.:..|.:.:...::                  |:....|..|
Zfish   836 NRPNQWYFYST---TEEVEQLIEALNPRGLRESSLKETLTLERGRIFQLMESNAAQRYHHSGESL 897

  Fly  1252 PQSPFS---------NSTPLQQQQQQQQQ------QQQQQQAT--------SNSFSSPMQQ---- 1289
            |::..|         ::.|.:...:.:.:      :.:..|.|        .||:.:.::.
Zfish   898 PETKGSSGKAKVGPQSTVPAECFMENRLRDLLLDIEDRIYQGTLGSIKVMERNSWRAALENGNYE 962

  Fly  1290 ------QQQGQQQQQQKPGSVLNNMPPTPTSLEALNAGAGAPGTGGSASNVTVSAPSPSPGFLSN 1348
                  ::.|...::::|..:..| ......|:.|..      .|.||::.:||.|.|
Zfish   963 LLDPDFKEYGLTDREEEPMEIEEN-HRVKDRLQELKV------EGHSATSTSVSTPQP------- 1013

  Fly  1349 GPSIGTPSNNNNNSSANNNPPSVSSLMQQPLSNRPGTPPYIPASPVPATSASGLAASSTPASAAA 1413
                           .||....::..:.|.   ..|.......:|:....|.....:........
Zfish  1014 ---------------VNNVVHCLAHALAQV---EQGIERKFLKAPLGDEDAKKDQKAKKKDKKKD 1060

  Fly  1414 TCASSGSGSNSSSGATAAGASSTSSSSSAGSGTPLSSV----ST------------PTSATMATS 1462
            ...||.....|.||............|.... |.||.|    ||            .|...:...
Zfish  1061 DDQSSEKDDGSESGRQVKTVQERWRESLLAC-TSLSQVFLHLSTLERSVAWAKSILNTRCKVCRR 1124

  Fly  1463 SGGGGGGGGNAGGGSSTTPASNPLLLMSGGTAGGGTG-------------------ATTTTSTSS 1508
            .|                .|.|.||     ..|.|.|                   .........
Zfish  1125 KG----------------DAENMLL-----CDGCGRGYHIFCVRPKLKAVPSEDWFCPECRPKQR 1168

  Fly  1509 SSRMMS-SSSSLSSQMAALEAAARDNDDETPSPSGENT---------------------NGSGGS 1551
            .:|:.| ..||:.|:....:....:.:||..|...|.:                     |..||.
Zfish  1169 LNRINSRQRSSVDSEEEMEDEEESEEEDEEESEEEEESEEEQSEEEEVPKKAAVKLPLQNNKGGR 1233

  Fly  1552 GNAGGMASKGKLDSIKQDDDIKKEFMDDSCGGNNDSSQMDCSTGGGK-GKNVNNDGTSMIKME-I 1614
            .|:....::....:.:...:..|:....:.||:.:|.:.......|| .....|..::.:.:| |
Zfish  1234 SNSKSKQAESANSTSRSQQNTPKQSQPANKGGSKNSGKKATPVSNGKPPSRAGNRSSARLSLEVI 1298

  Fly  1615 KTEDGLDGEVKIKTEAMDVDEAGGSTAGEHHGEGGGGSGVGGGKDNINGAHDGGATGGAVDIKPK 1679
            .|.|                     |.|:..............|..|           ..::.||
Zfish  1299 STND---------------------TTGKSEQSSPAAGNAESRKRPI-----------TAEVSPK 1331

  Fly  1680 TETKPLVPEPLAPNAGDKKKKCQFNPEELRTALLPTLEKLYRQEPESVPFRYPVDPQALGIPDYF 1744
            ::   ::..|...::..:.........||....|.::: |.|.| :|.||...|  ....:|||:
Zfish  1332 SK---IILAPTTTSSSRRSSGRNLGVHELSACELLSVD-LVRHE-DSWPFMKLV--SRTQVPDYY 1389

  Fly  1745 EIVKKPMDLGTIRTNIQNGKYSDPWEYVDDVWLMFDNAWLYNRKTSRVYRYCTKLSEVFEAEIDP 1809
            :|:|||:.|.|||..:.|.:|....||::||.|||.|...||...:...:...:|...|.:|
Zfish  1390 DIIKKPIALSTIREKVNNCEYQTAAEYIEDVELMFSNCLEYNPHNTNEAKAGLRLQAFFHSE--- 1451

  Fly  1810 VMQALG 1815
             :|.||
Zfish  1452 -LQRLG 1456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nej	NP_001188575.1	ZnF_TAZ	530..600	CDD:214717
		KIX	946..1024	CDD:280354	23/104 (22%)
		Bromo_cbp_like	1705..1812	CDD:99927	36/106 (34%)
		RING_CBP-p300	1824..1906	CDD:276805
		PHD_CBP_p300	1908..1939	CDD:277032
		HAT_KAT11	1970..2283	CDD:285432
		ZZ_CBP	2339..2379	CDD:239077
		ZnF_TAZ	2404..2476	CDD:214717
baz1a	NP_001352072.1	WAC_Acf1_DNA_bd	23..122	CDD:313708
		DDT	406..467	CDD:214726	8/71 (11%)
		WHIM1	570..615	CDD:317926	13/52 (25%)
		Neuromodulin_N	<618..747	CDD:331332	34/169 (20%)
		WSD	759..875	CDD:317927	23/118 (19%)
		PHD_BAZ1A	1118..1163	CDD:277097	8/65 (12%)
		Bromodomain	1353..1457	CDD:321986	39/112 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900