DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nej and brdt

DIOPT Version :9

Sequence 1:	NP_001188575.1	Gene:	nej / 43856	FlyBaseID:	FBgn0261617	Length:	3282	Species:	Drosophila melanogaster
Sequence 2:	XP_002662470.2	Gene:	brdt / 333996	ZFINID:	ZDB-GENE-030131-5928	Length:	1093	Species:	Danio rerio

Alignment Length:	1066	Identity:	216/1066 - (20%)
Similarity:	358/1066 - (33%)	Gaps:	345/1066 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1675 DIKPKTETKPLVPE-------PLAPNAGDKKKKCQFNPEELRTALLPTLEK-----LYRQEPESV 1727
            |:||        |:       |..|...:.||     |..| |..|..:||     |::.. .|.
Zfish     3 DVKP--------PQHFTMNGNPPPPEFKNPKK-----PGRL-TNHLQYIEKVVIRALWKHH-FSW 52

  Fly  1728 PFRYPVDPQALGIPDYFEIVKKPMDLGTIRTNIQNGKYSDPWEYVDDVWLMFDNAWLYNRKTSRV 1792
            |||.|||...|.:|||:.|:|.||||.|||..::|..|....|.|:|...||.|.::|||....:
Zfish    53 PFRQPVDAVRLNLPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNRPGDDI 117

  Fly  1793 YRYCTKLSEVF----------EAEID------PVMQALGYCCG-RKYTFNPQVLCCYGKQLCTIP 1840
            ......|.::|          |.||.      ||..|.....| :|...:|.....:.:.:..||
Zfish   118 VLMAQVLEKLFLEKVAEMPEEEYEISALTTKGPVKGARKSTIGLKKRPPSPMSEVVFQQTVTVIP 182

  Fly  1841 RDAKYYSYQNSLKEYGVASNRYTYCQKCFNDIQGDTVTLGDDPLQSQTQIKKDQFKEMKNDHLEL 1905
            .||.:                                |:...||.:|...|      :||
Zfish   183 PDALH--------------------------------TIPSAPLSAQLTAK------LKN----- 204

  Fly  1906 EPFVNCQECGRKQHQICVLWLDSIWPGGFVCDNCLKKKNSKRKENKFNAKRLPTTKLGVYI-ETR 1969
                     |.|:.      .|:..|                     :|..:|:.:....: |.:
Zfish   205 ---------GVKRK------ADTTTP---------------------SASSIPSCESSSCVTEPK 233

  Fly  1970 VNNFLKKKEAGAGEVHIRVVSSSDKCVEVKP-----GMRRRFVEQGEMMNEFPYRAKALFAFEEV 2029
            |.....::.:|      |.:....|.:...|     |.|.:..|:.:..|..   .|.:|:
Zfish   234 VLKLFSRRGSG------RPIKPPCKDLPESPPQHQVGRRTKLSERLKYCNAI---LKEMFS---- 285

  Fly  2030 DGIDVCFFGMHVQEYGSECPAPNTRRVYIAYLDSVHFFRPRQYRT---AVYHEILLGYMDY---- 2087
                                     :.:.||  :..|::|....|   ..||||:...||.
Zfish   286 -------------------------KKHSAY--AWPFYKPVDAETLGLLDYHEIIHQPMDMSTIK 323

  Fly  2088 --VKQLGYTMAHIWACPPSEGDDYIF-HCH----PTDQKIPKPKRLQEWYK----KMLDKGMIER 2141
              ::...||.|..:|....    .:| :|:    |..:.:...::||:.::    |:.|:.....
Zfish   324 KKMEAREYTDALQFAADMR----LMFSNCYKYNPPGHEVVSMARKLQDVFEFRFSKIPDEPKNAN 384

  Fly  2142 IIQDYKDILKQ-----AMEDKLGSAAELPYFEGDFWPNVLEESIKELDQEEEEKRKQAEAAEAAA 2201
            .:..:..:.|:     :..:...|.:..|....|......||....|...||:.:...|..:...
Zfish   385 PVSSHNRVKKERARSPSSSESSDSESSSPENSSDTEEEDEEERAHRLASLEEQLKAVREQLQLLT 449

  Fly  2202 AANLFSIEENEVS--------------GDGKKKGQKKAKKSNKSKAAQRKNSKKSNEHQSGNDLS 2252
            ...|...::.|.|              |:..||..|..|:|:.||::.||.|:..:   |..:::
Zfish   450 QTPLLKPKKKEKSKKKKKKERESSKRKGEEMKKPAKILKRSSSSKSSGRKESRACD---SEEEMN 511

  Fly  2253 TKIYATMEKHKEVFFVIRLHSAQSAASLAPIQDPDPLLTCDLMDGRDAFLTLARDKHFEFSSLRR 2317
            |...:..||.:....:.:|...:....:..|:..:|||       ||   |...:...:|.:|:.
Zfish   512 TLPMSYEEKRQLSLDINKLPGDKLGKVVNIIKAREPLL-------RD---TDPEEIEIDFETLKP 566

  Fly  2318 AQFSTLSMLYELHNQGQDKFVYTCNHCKTAVETRYH-----CTVCD-DFDLCIVCKEKVGHQ--H 2374
               |||..|        :.:|..|...||. ||..:     ..:.: |.||    :...|.|  |
Zfish   567 ---STLRAL--------ECYVVGCLRKKTK-ETNKNKPPKKSKIKEKDKDL----QHATGEQNSH 615

  Fly  2375 KMEKLGFD-----------IDDGSALADHKQANPQEA---------------RKQSIQRCIQSLA 2413
            |..|:..|           :.|.|:.:....::..::               ||||     :...
Zfish   616 KKTKIETDGEIKDTTHPSRLSDSSSSSSSSDSSSSDSSSSDSCDSDSEQKTKRKQS-----KGPG 675

  Fly  2414 HACQ-----CRDANCRLPSCQKMKLVVQHTKNCKRKPNG-----GCPICKQLIALCCYHAKNCEE 2468
            ||.:     .|.||..:........|:     |:.:|:.     |   .|.|.|  ..|||:..|
Zfish   676 HANKIKKKALRQANAEVKDSSSASGVM-----CQSRPSSLVSETG---SKDLFA--SQHAKHPVE 730

  Fly  2469 QKCPVPFCPNIKHKLKQQQSQQKFQQQQLLRRRVALMSRTAAPAALQGPAAVSGPTVVSGGVPVV 2533
            .   :.....:..:|..|.|:...:...|.|:    :..|.:|.:|....|:|         |:.
Zfish   731 D---ITAITALHSRLPPQPSRPSGKAAALPRK----IWTTPSPLSLPPDQALS---------PLY 779

  Fly  2534 GMSGVAVSQQ--VIPGQAG----------------------ILPPGAGGMS----PSTVAVPSPV 2570
            ..|..:..:.  :||.::.                      :|||....:|    ||:||...|.
Zfish   780 NASATSPCKDHTIIPAKSSPESVTPDPPNSLPKDPLFPCSPLLPPPDMQVSQVGPPSSVAAKIPP 844

  Fly  2571 SGGAGAG---GMGGMTSPHPHQPGIG 2593
            ......|   .:..:|||....|..|
Zfish   845 QKSEKEGIPPLLSPLTSPSAAMPATG 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nej	NP_001188575.1	ZnF_TAZ	530..600	CDD:214717
		KIX	946..1024	CDD:280354
		Bromo_cbp_like	1705..1812	CDD:99927	45/127 (35%)
		RING_CBP-p300	1824..1906	CDD:276805	12/81 (15%)
		PHD_CBP_p300	1908..1939	CDD:277032	4/30 (13%)
		HAT_KAT11	1970..2283	CDD:285432	62/354 (18%)
		ZZ_CBP	2339..2379	CDD:239077	12/47 (26%)
		ZnF_TAZ	2404..2476	CDD:214717	17/81 (21%)
brdt	XP_002662470.2	Bromo_Brdt_I_like	29..135	CDD:99929	39/107 (36%)
		Bromo_Brdt_II_like	273..373	CDD:99930	23/137 (17%)
		BET	514..577	CDD:293640	16/83 (19%)
		BRD4_CDT	1050..1093	CDD:293710
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910