DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nej and bptf

DIOPT Version :9

Sequence 1:	NP_001188575.1	Gene:	nej / 43856	FlyBaseID:	FBgn0261617	Length:	3282	Species:	Drosophila melanogaster
Sequence 2:	XP_009297692.1	Gene:	bptf / 324479	ZFINID:	ZDB-GENE-030131-3200	Length:	2900	Species:	Danio rerio

Alignment Length:	1535	Identity:	288/1535 - (18%)
Similarity:	448/1535 - (29%)	Gaps:	613/1535 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   365 QQQQQQQQQQLLAQQMAQRGGVVPGMPQGNRPVGTVVPMSTLGGDGSGPAGQLVSGNPQQQQMLA 429
            |.:.|.:||:|.|||...         :..:| .|....:||....:.|       ....|:::.
Zfish  1860 QLEAQLKQQRLAAQQKRL---------EQQKP-STTSNTTTLTSTPTTP-------GTTTQKVVV 1907

  Fly   430 QQQTGAMGPRPP-QPNQLLGHP--GQQQQQQQQPGTSQQQQQQQGVGIGGAGVV---ANAGTVAG 488
            ...:|.:...|. .....||.|  .||.:..||...|..:|.|||..:..:.||   |::.|.:|
Zfish  1908 GSISGQVTSTPKVVMTTKLGSPVTFQQNKNFQQSFASWVKQGQQGNSVSTSSVVTVAASSATTSG 1972

  Fly   489 ----VPAVAGGGAGGAVQSSGPGGANR-----DVPDDRKR--QIQQQLMLLLHAHKCNRRENLNP 542
                :.|..|..||..:.:..|..||.     :||..:..  |:||:::.::.:......::..|
Zfish  1973 QTFHIAAAPGSMAGSVIAAKLPVPANSKIVTVNVPTTQGGLVQVQQKVVGIIPSSTAGNAQSFPP 2037

  Fly   543 NREVCNVNYCKAMKSVLAHMGTCKQSKDCTM----QHCASSRQILLHYKTCQNSGCVICYPFRQN 603
                                   .|.:..|:    ....|::|:|....|.:....||..|.:|.
Zfish  2038 -----------------------FQPRTATINIRPNTTTSTQQVLTTGTTLRPGMTVIRSPLQQA 2079

  Fly   604 HSVFQNANVPPGGGPAGIGGAPPGGGGAGGGAAGAGGNLQQQQQQQQQQQQNQQPNLTGLVVDGK 668
            .::.:.....|                           |..||.|.|||.|.            .
Zfish  2080 TTLGKTIIRTP---------------------------LMVQQGQTQQQVQT------------S 2105

  Fly   669 QGQQVAPGGGQNTAIVLPQQQGAGGAPGAPKTPADMVQQLTQQQQQQQQQVHQQQVQQQELRRFD 733
            .|.||.   |....:..|.|      |..|:|||        ..:.||.||.....|..:|
Zfish  2106 SGTQVV---GTPPRLPTPNQ------PQTPQTPA--------SPRPQQGQVKLTLAQLTQL---- 2149

  Fly   734 GMSQQVVAGGMQQQQQQGLPPVIRIQGAQPA-VRVLGPGGPGGPSGPNVLPNDVNSLHQQQQQML 797
               .|...||     .|||..||:.||.... ::|:       |.|..|:|.       ..||::
Zfish  2150 ---TQGAQGG-----NQGLTVVIQGQGQTTGQLQVI-------PQGVTVIPG-------PGQQLM 2192

  Fly   798 QQQQQQGQNRRRGGLATMVEQQQQHQQQQQQPNPAQLGGNIPAPLSVNVGGFGNT--NFGGAAAG 860
            |.....||.:|  .|.|         .....|.||      |||:|........|  :...|||.
Zfish  2193 QAAMPNGQVQR--FLFT---------PMAPAPTPA------PAPVSAPAAPSNTTPSSVPPAAAP 2240

  Fly   861 GAVGANDKQQLK-VAQVHPQSHGVGAGGASAGAGASGGQVAAGSSVLMPADTTGSGNAGNPNQNA 924
            .||.:.....:: .|::.||.....:                    |.|
Zfish  2241 TAVTSTTPAPIQTAARLAPQPQPPPS--------------------LPP---------------- 2269

  Fly   925 GGVAGGAGGGNGGNTGPPGDNEKDWRESVTADLRNHLVHKLVQAIFPTSDPTTMQDKRMHNLVSY 989
                            ||.                          .|.|.|.
Zfish  2270 ----------------PPS--------------------------VPPSQPV------------- 2279

  Fly   990 AEKVEKDMYEMAKSRSEYYHLLAEKIYKIQKELEEKRLKRKEQHQQMLMQQQGVANPVAGGAAGG 1054
                                                      ||....:|...:..|.
Zfish  2280 ------------------------------------------QHTPAPIQTAVIPQPT------- 2295

  Fly  1055 AGSAAGVAGGVVLPQQQQQQQQQQQQQGQQPLQSCI-------HPSISPMGGVMPPQQL------ 1106
                         |..|.....|.:.|.|.|.|:.:       .|.|:.:....||||:
Zfish  2296 -------------PPIQPHPPVQLRPQPQLPPQNPVVPPTPVSTPQIAQVTATAPPQQITTLPVT 2347

  Fly  1107 -------RP--QGPPGILG-------------QQTAAGLGVGVGVTNNMVTMRSHSPGGNMLALQ 1149
                   :|  |.||.:|.             .|.||.:...||.|..|               .
Zfish  2348 QTTVTKVQPQIQLPPQLLSVPGLQQQVLSHIQSQVAAQIQAQVGTTAGM---------------P 2397

  Fly  1150 QQQRMQFPQQQQQQPPGSGAGKMLVGPPGPSPGGMVVNPALSPYQTTNVLTSPVPGQQQQQQFIN 1214
            ||.::|.|.|.|||    |.|:                  :..:|..|::|......|:|.|.|.
Zfish  2398 QQIKLQLPIQIQQQ----GGGQ------------------VQAHQIQNLVTIQTASVQEQLQRIQ 2440

  Fly  1215 ANGGTGANPQLSEIMKQRHIHQQQQQQQQQQ---QQGMLLPQSPFSNSTPLQQQQQQQ-----QQ 1271
                     ||.|..:|:...|:.:::|.||   |..::..|.....:..::|.:|::     ::
Zfish  2441 ---------QLCEQQQQKKKQQEAKREQAQQHVSQSDLIQKQVAQKQNVAIEQLKQKKTMTPAER 2496

  Fly  1272 QQQQQQATSNSF--------------SSPMQQQQQGQQQQQQKPGSVLNNMPPTPTSLEALNAGA 1322
            ::.|:....|..              ::..:::::..:|::.|..:         :.|.||..
Zfish  2497 EENQRMIVCNQVMKFILDKIDKDERQAAKKRKREESVEQKRSKQNA---------SKLSALLF-- 2550

  Fly  1323 GAPGTGGSASNVTVSAPSPSPGFLSNGPSIGTPSNNNNNSSANNNPPSVSSLMQQPLSNRPGTPP 1387
                                                .:......:.....:|:.:.|.
Zfish  2551 ------------------------------------KHKEQLKADILKKRALLDKELQ------- 2572

  Fly  1388 YIPASPVPATSASGLAASSTPASAAATCASSGSGSNSSSGATAAGASSTSSSSSAGSGTPLSSVS 1452
             :............|......|.|||        :.:::.|.||.|:||...|...|.|  .:|:
Zfish  2573 -LQVQEELKRDLIKLRREKEKAQAAA--------AQAAAAAAAAAAASTHVHSGLSSYT--GTVT 2626

  Fly  1453 TPTSATMATSSGGGGGGGGNAGGGSSTTPASNPLLLMSGGTAGGGTGATTTTSTSSSSRMMSSSS 1517
            :|||.              :.........|:.|                      ...:|:|::|
Zfish  2627 SPTST--------------HKRKREEERDAAKP----------------------KRKKMISTTS 2655

  Fly  1518 SLSSQMAALEAAARDNDDETPSPSGENTNGSGGSGNAGGMASKGKLDSIKQDDDIKKEFMDDSC- 1581
            ..|.:...|....:...||:....|.:...:...|...|:..|   ::.|.||.|..|     |
Zfish  2656 KDSKRDIKLYCICKTPYDESKFYIGCDLCSNWYHGECVGITEK---EAKKMDDYICSE-----CK 2712

  Fly  1582 ---GGNNDSSQMDCSTGGGKGKNVNNDGTSMIKMEIKTEDGLDGEVKIKTEAMDVDEAGGSTAGE 1643
               .||.:.....|.|                                     ..||
Zfish  2713 RAQEGNTEELYCICRT-------------------------------------PYDE-------- 2732

  Fly  1644 HHGEGGGGSGVGGGKDNINGAHDGGATGGAVDIKPKTETKPLVPEPLAPNAGDKKKKCQFNPEEL 1708
                    |....|.|.....:.|...|    |.....|.  :.|.:.|       :|| :.|:.
Zfish  2733 --------SQFYIGCDRCQNWYHGRCVG----ILQSEATH--IDEYVCP-------QCQ-STEDA 2775

  Fly  1709 RTALLPTLEKLY----------RQEPESVPFRYPVDPQALGIPDYFEIVKKPMDLGTIRTNIQNG 1763
            .|.|.|..:|.|          :....:.||..||||.  ..|||:.|:|:||||.|:...||..
Zfish  2776 MTVLTPLTDKDYEGLKRILRSLQSHKMAWPFLEPVDPN--DAPDYYGIIKEPMDLSTMEERIQKR 2838

  Fly  1764 KYSDPWEYVDDVWLMFDNAWLYNRKTSRVYRYCTKLSEVF 1803
            .||...|:|.|:..:|||...||...|..|: |.:..|.|
Zfish  2839 FYSKLTEFVADMTKIFDNCRYYNPSDSPFYQ-CAEFLESF 2877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nej	NP_001188575.1	ZnF_TAZ	530..600	CDD:214717	9/73 (12%)
		KIX	946..1024	CDD:280354	3/77 (4%)
		Bromo_cbp_like	1705..1812	CDD:99927	39/109 (36%)
		RING_CBP-p300	1824..1906	CDD:276805
		PHD_CBP_p300	1908..1939	CDD:277032
		HAT_KAT11	1970..2283	CDD:285432
		ZZ_CBP	2339..2379	CDD:239077
		ZnF_TAZ	2404..2476	CDD:214717
bptf	XP_009297692.1	DDT	198..254	CDD:280886
		WHIM1	296..345	CDD:292246
		PHD1_BPTF	349..391	CDD:277034
		WHIM2	414..439	CDD:292247
		PP28	<1833..1881	CDD:287254	8/29 (28%)
		PHD2_3_BPTF	2665..2711	CDD:277035	11/53 (21%)
		PHD2_3_BPTF	2723..2769	CDD:277035	13/111 (12%)
		Bromo_gcn5_like	2785..2885	CDD:99941	35/96 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810