DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nej and fs(1)h

DIOPT Version :9

Sequence 1:	NP_001188575.1	Gene:	nej / 43856	FlyBaseID:	FBgn0261617	Length:	3282	Species:	Drosophila melanogaster
Sequence 2:	NP_001259321.1	Gene:	fs(1)h / 31722	FlyBaseID:	FBgn0004656	Length:	2046	Species:	Drosophila melanogaster

Alignment Length:	2259	Identity:	455/2259 - (20%)
Similarity:	637/2259 - (28%)	Gaps:	1037/2259 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DEPPQKRVKMDPTDISYFLE--ENLP-DEL----VSSNSGWSDQ--------LTGGAGGGNGGGG 56
            ::|.:..|.|..|....||:  |::| :||    |::..|...|        .:||||...|.|.
  Fly   116 NKPGEDVVVMAQTLEKVFLQKIESMPKEELELEPVTAKGGKKKQRAPATPKSSSGGAGASTGSGT 180

  Fly    57 ASGVTTNPTSGPNPGGGPNKPAAQGPGSGTGGVGVGVNVGVGGVVGVGVVPSQMNGAGGGNGSGT 121
            :|...|:                 |||||:..|.|..:            .:|.:|..|..|:|.
  Fly   181 SSAAVTS-----------------GPGSGSTKVSVAAS------------SAQQSGLQGATGAGG 216

  Fly   122 GGDD--GSGNGSGAGNRISQMQHQQLQHLLQQQQQGQKGAMVVPGMQQLGSKSPNLQSPNQGGMQ 184
            |...  |:..|||||                       ||:....:..:|    ...|...||..
  Fly   217 GSSSTPGTQPGSGAG-----------------------GAIAARPVSAMG----GTVSSTAGGAP 254

  Fly   185 QVVGTQMGMVNSMPMSISNNGNNGMNAIPG-MNTIAQGNLGNMVLTNSVGGGMGG---------- 238
            .:     ..:::||          .:.:|| .||          .|.::.||:||
  Fly   255 SI-----PPISTMP----------PHTVPGSTNT----------TTTAMAGGVGGPGAAGANPNA 294

  Fly   239 ---MVNHLK-----QQPGGGGGGMINSVSVPGGPGAGAGGVGAGGGGAVAANQGMHMQNGPMMGR 295
               |.:.|.     ..||..|...:||.|:..|..|......|....|.||
  Fly   295 AALMASLLNAGQTGAYPGAPGQTAVNSSSLLDGSTAAVAAAAAAAAAAAAA-------------- 345

  Fly   296 MVGQQHMLRGPHLMGASGGAGGPGNGPGGGGPRMQNPNMQMNFRPFAAQLNSLPYGVGQYGGPGG 360
             .|           ||:|.|||.|..|                   |..:|:..
  Fly   346 -AG-----------GAAGAAGGAGTIP-------------------AVAVNAAN----------- 368

  Fly   361 GNNPQQQQQQQQQQLLAQQMAQRGGVVPGMPQGNRPVGTVVPMSTLGGDGSGPAGQLVSGNPQQQ 425
                            |.|.....||..|       |..|:|                   |||.
  Fly   369 ----------------AVQAYVNAGVSVG-------VDAVIP-------------------PQQP 391

  Fly   426 QMLAQQQTGAMGPRPPQPNQLLGHPGQQQQQQQQPGTSQQQQQQQGVGIGGAGVVANAGTVAGVP 490
            ..:.:..........|..| ....|..|...:.....::::..:|.:|..|:|...:...|:|||
  Fly   392 AKIKKGVKRKADTTTPTAN-AFESPYTQMDSKSAKIATRRESNRQVIGKKGSGYNMSPLGVSGVP 455

  Fly   491 A----VAGGGAGGAVQSSGPGGANRDVPDDRKR---QIQQQLMLLLHA------HKCNRRENLNP 542
            .    ||||.||.||      ..|::...|..:   :|.::|....|:      :|....|.|..
  Fly   456 GLGGLVAGGVAGVAV------AKNKEKLSDALKSCNEILKELFSKKHSGYAWPFYKPVDAEMLGL 514

  Fly   543 NREVCNVNYCKAMKSVLAHMGTCKQSKDCTMQHCASSRQILLHYKTCQNSGCVI------CYPF- 600
            :      :|...:|..: .:||.|:..|        :|:    ||:.......:      ||.:
  Fly   515 H------DYHDIIKKPM-DLGTVKRKMD--------NRE----YKSAPEFAADVRLIFTNCYKYN 560

  Fly   601 ----------RQNHSVFQ--NANVPP------------GGGPAGIGGAPPGGGGAGGGAAGAGG- 640
                      |:...||:  .||:|.            |.|.....|...|.|...|...|.||
  Fly   561 PPDHDVVAMGRKLQDVFEMRYANIPDEPVANAAHHHGHGHGHGHGHGHGHGHGHGHGHGHGYGGS 625

  Fly   641 -------------------NLQQQQQQQQQQQQNQQPNLTGL----------------------- 663
                               |.....:::..:.:..:..|.||
  Fly   626 SSLKHDASDSSSEDSSDTENESNSDEERSARLKMLESKLLGLQEEIRKLSEEASAKKKAKKKLKE 690

  Fly   664 ---VVDGKQGQQV------APGGGQNTAIVLPQQQGAGGAPGAPKTPADMVQQLTQQQQQQQQQV 719
               .:.|..|...      |.|||.|..       |||| ||:
  Fly   691 KKKSIGGGSGSGSASHHCHATGGGANAG-------GAGG-PGS---------------------- 725

  Fly   720 HQQQVQQQELRRFDGMSQQVVAGGMQQQQQQGLPPVIRIQGAQPAVRVLGPGGPGGPS------- 777
                         .|.....|.||                     |..|||||.||.:
  Fly   726 -------------GGHGSVSVPGG---------------------VGSLGPGGAGGANLNALLGG 756

  Fly   778 ------GPNV---LPNDVNSLHQQQQQMLQQQQQQGQNRRRGGLATMVEQQQQHQQQQQQPNPAQ 833
                  |..|   :|| |.:||.|...:.....|..    .||.|.                .|.
  Fly   757 SLVGHGGAAVAGGVPN-VGALHSQVHDVAMAFSQMA----GGGAAA----------------GAG 800

  Fly   834 LGGNIPAPLSVNVGGFGNTNFGGAAAGGAVGANDKQQLKVAQVHPQSHG---------------- 882
            .|..:.| ...:.||...|..|..|||.|.||........:....:|.|
  Fly   801 FGAGVTA-AGASSGGKAGTLAGALAAGAAAGAGGTTAGSGSSKGAKSKGGRGAKGSGAGGVGASN 864

  Fly   883 --------VGAGGASAGAGASGGQVAAGSSVLMPADTTGSGNA-----GNPNQNAGGVAGGAGGG 934
                    .||.||:||||:.||...||::        |.|||     |:.:..|||..|||...
  Fly   865 NAAAGNAAGGAAGAAAGAGSVGGVGGAGAA--------GGGNASKRAKGSSSAGAGGGVGGANAS 921

  Fly   935 NGGNTGPPGDNEK--------DWRESVTA--------------------DLRNHLVHKL------ 965
            .|| .|..|.::|        |..|..||                    |....:||.:
  Fly   922 AGG-AGARGSSKKKPSQVMNFDSEEEDTAKPMSYDEKRQLSLDINKLPGDKLGRVVHIIQNREPS 985

  Fly   966 --------VQAIFPTSDPTTMQDKRMHNLVSYAEKVEKDMYEMAKSRSEYYHLLAEKIYKIQKEL 1022
                    ::..|.|..|:|:::...:......:|..|.  ...||:.|.   :|||..:::|.|
  Fly   986 LRDSNPDEIEIDFETLKPSTLRELESYVASCLRKKTHKK--PSGKSKDEQ---MAEKKQELEKRL 1045

  Fly  1023 EE--------KRLKRKEQHQQMLMQQQGVANPVA------------------------------- 1048
            ::        |:..:|::.....::....||||:
  Fly  1046 QDVTGQLGASKKTAKKDESASSKVEAVQPANPVSSSSSSSDSSSSSSSDSSSSDSSDSEAVLVIP 1110

  Fly  1049 ----------------------------------------------------------------- 1048

  Fly  1111 APTGDGDERPPRKKKSRDSNGSNVNNPSINVVMGGNLPSGALSPTTMLMGLDHVVNSNTPTSQMS 1175

  Fly  1049 ----------------------------GGA-AGG----AGSAAGVAGGVVLPQQQQQQQQQQQQ 1080
                                        ||| |.|    ||:...|||..|    .....||..:
  Fly  1176 NMLGNANPLTAAAMLNNNNKTSLPGSNFGGAPAPGNMMHAGAGVPVAGAAV----SASTGQQHNK 1236

  Fly  1081 QGQQPLQSCIHPSISPMGGVMPPQQL-----------------------RPQG-PPGILGQQTAA 1121
            .|...| |.:.|. .|:...:||...                       :|.| ..|.||:..||
  Fly  1237 NGPNDL-SKVQPG-GPINAALPPHSFAGGTATVATSQSSGGIRIASNLHKPSGLGGGDLGEHHAA 1299

  Fly  1122 -------GLG----VGVGVTNN-----------------MVT----------------------- 1135
                   |:.    .|.|:.||                 ||.
  Fly  1300 LAAALTSGINSTGTAGGGINNNGGSNNNANPLGGSHGDAMVNASLASLASGLKQIPQFDDPVEQS 1364

  Fly  1136 ---------------------MRSH--SPGGNMLALQQQQRMQF---------PQQQQQQPPGSG 1168
                                 |:.|  .|.|.....||||:..|         .||||||.....
  Fly  1365 LASLEFSAGSTGKSGLTDNFLMQQHLMQPAGPQQQQQQQQQQPFGHQQQQQQQQQQQQQQQQHMD 1429

  Fly  1169 AGKMLVGPPGPSPGGMVVNPAL-------SPYQTTNVLTSPVPGQQQQQQFINA--------NGG 1218
            ....|:.....:.|||..|..|       :.||..:      |.|||||...|.        .|.
  Fly  1430 YVTELLSKGAENVGGMNGNHLLNFNLDMAAAYQQKH------PQQQQQQAHNNGFNVADFGMAGF 1488

  Fly  1219 TGAN---------------PQLSEIMKQRHIHQQQQQQQQQQQQGMLLPQSPFSNSTPLQQQQQQ 1268
            .|.|               .|:.::..|:..|||||||..|||                ||.|||
  Fly  1489 DGLNMTAASFLDLEPSLQQQQMQQMQLQQQHHQQQQQQTHQQQ----------------QQHQQQ 1537

  Fly  1269 QQQQQQQQQATSNSFSSPMQQQQQGQQQQQQ-----------------KPGSVLNNMPPTPTSLE 1316
            ..|||||||.|........|||||.|..|||                 ||   :.:|.|:|...:
  Fly  1538 HHQQQQQQQLTQQQLQQQQQQQQQQQHLQQQQHQQQHHQAANKLLIIPKP---IESMMPSPPDKQ 1599

  Fly  1317 AL--------------------NAGAGAPGTGGSASNVTV---------SAPSPSPGFLSNGPSI 1352
            .|                    ||.|.|......|..|..         :|.|.|....:|.|.
  Fly  1600 QLQQHQKVLPPQQSPSDMKLHPNAAAAAAVASAQAKLVQTFKANEQNLKNASSWSSLASANSPQ- 1663

  Fly  1353 GTPSNNNNNSSANNNPPSVSSLMQ-------------------------------QPLSNRPGTP 1386
               |:.:::||::...|::.|..|                               |...:...:.
  Fly  1664 ---SHTSSSSSSSKAKPAMDSFQQFRNKAKERDRLKLLEAAEKEKKNQKEAAEKEQQRKHHKSSS 1725

  Fly  1387 PYIPASPV--PATSASGLAASSTPASAAATCASSGSGSNSSSGATAAGASSTSSS---------- 1439
            ..:.::.|  .|..|:..||::....|||..|.:.|.||.|.|:::.||.|||..
  Fly  1726 SSLTSAAVAQAAAIAAATAAAAVTLGAAAAAALASSASNPSGGSSSGGAGSTSQQAITGDRDRDR 1790

  Fly  1440 --------SSAGSGTPLSSVSTPTSATMATSSGGGGGGGGNAGGGSSTTPASNPLLLMSGGTAGG 1496
                    |.:|.|   .|.:...|:..|.|:|.|..|.|.:|||..:.|||      :||...|
  Fly  1791 DRERERERSGSGGG---QSGNGNNSSNSANSNGPGSAGSGGSGGGGGSGPAS------AGGPNSG 1846

  Fly  1497 GTGATTTTSTSSSSRMMSSSSSLSSQMAALEAAARDNDDETPSPSGENTNGSGGSGNAGGMASKG 1561
            |.|..                                          |:| |||.|..||.|..
  Fly  1847 GGGTA------------------------------------------NSN-SGGGGGGGGPALL- 1867

  Fly  1562 KLDSIKQDDDIKKEFMDDSCGGNNDSSQMDCSTGGGKGKNVNNDGTSMIKMEIKTEDGLDGEVKI 1626
                              :.|.|::|.   ..:||....|.|:           :..|:.|
  Fly  1868 ------------------NAGSNSNSG---VGSGGAASSNSNS-----------SVGGIVG---- 1896

  Fly  1627 KTEAMDVDEAGGSTAGEHHGEGGGGSGVGGGKDNINGAHDGGATGGAVD 1675
                     :||..:......||||.|...|         ||...||:|
  Fly  1897 ---------SGGPGSNSQGSSGGGGGGPASG---------GGMGSGAID 1927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nej	NP_001188575.1	ZnF_TAZ	530..600	CDD:214717	15/81 (19%)
		KIX	946..1024	CDD:280354	22/119 (18%)
		Bromo_cbp_like	1705..1812	CDD:99927
		RING_CBP-p300	1824..1906	CDD:276805
		PHD_CBP_p300	1908..1939	CDD:277032
		HAT_KAT11	1970..2283	CDD:285432
		ZZ_CBP	2339..2379	CDD:239077
		ZnF_TAZ	2404..2476	CDD:214717
fs(1)h	NP_001259321.1	Bromo_Brdt_I_like	34..140	CDD:99929	7/23 (30%)
		COG5076	387..>593	CDD:227408	49/250 (20%)
		Bromo_Brdt_II_like	481..581	CDD:99930	20/118 (17%)
		BET	951..1015	CDD:293640	7/63 (11%)
		BRD4_CDT	<2026..2046	CDD:293710
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810