DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nej and Brd2

DIOPT Version :9

Sequence 1:	NP_001188575.1	Gene:	nej / 43856	FlyBaseID:	FBgn0261617	Length:	3282	Species:	Drosophila melanogaster
Sequence 2:	NP_997660.1	Gene:	Brd2 / 294276	RGDID:	1303324	Length:	798	Species:	Rattus norvegicus

Alignment Length:	789	Identity:	155/789 - (19%)
Similarity:	250/789 - (31%)	Gaps:	256/789 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1673 AVDIKPKTETKPLVPEPLAPNAGDKKKKCQFNPEELRTALLPTLEKLYRQEPESVPFRYPVDPQA 1737
            |:.:.|.....|.|..|..|  |....:.|:    |...::..|.|    ...:.|||.|||...
  Rat    52 ALQLAPANPPPPEVSNPKKP--GRVTNQLQY----LHKVVMKALWK----HQFAWPFRQPVDAVK 106

  Fly  1738 LGIPDYFEIVKKPMDLGTIRTNIQNGKYSDPWEYVDDVWLMFDNAWLYNRKTSRVYRYCTKLSEV 1802
            ||:|||.:|:|:|||:|||:..::|..|....|.:.|...||.|.::||:.|..:......|.::
  Rat   107 LGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKI 171

  Fly  1803 FEAEIDPVMQALGYCCGRKYTFNPQVLCCYGKQLCTIPRD-----AKYYSYQNSLKEY----GVA 1858
            |..::..:.|            ..|.|      :.|||::     ||..:.|.|:...    .|:
  Rat   172 FLQKVASMPQ------------EEQEL------VVTIPKNSHKKGAKLAALQGSITSAHQVPAVS 218

  Fly  1859 SNRYTYCQKCFNDIQGDTVTLGDDPLQSQTQIKKDQFKEMKNDHLELEPFVNCQECGRKQHQI-- 1921
            |..:|              .|...|.:..|.:       :...|    |.|......:..|..
  Rat   219 SVSHT--------------ALYTPPPEIPTTV-------LNIPH----PSVISSPLLKSLHSAGP 258

  Fly  1922 CVLWLDSIWPGGFVCDNCLKKKNSKRKENKFNAKRLPTTKLGVYIETRVNNFLKKKEAGAGEVHI 1986
            .:|.:.:..|    .....|||..|||.:  .....||..|...........|:.|.|..
  Rat   259 PLLAVSAAPP----AQPLAKKKGVKRKAD--TTTPTPTAILAPGSPASPPGSLEPKAARL----- 312

  Fly  1987 RVVSSSDKCVEVKPGMRR--------------------------RFVEQ----GEMMNEFPYRAK 2021
                         |.|||                          :..||    ..::.|...:..
  Rat   313 -------------PPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKH 364

  Fly  2022 ALFAFEEVDGIDVCFFGMHVQEYGSECPAPNTRRVYIAYLDSVHFFRPRQYRTAVYHEILLGYMD 2086
            |.:|:.....:|....|:|                                   .||:|:...||
  Rat   365 AAYAWPFYKPVDASALGLH-----------------------------------DYHDIIKHPMD 394

  Fly  2087 Y--VKQLGYTMAHIWACPPSEGDDY-------------IFHCH----PTDQKIPKPKRLQE---- 2128
            .  ||:            ..|..||             ..:|:    |....:...::||:
  Rat   395 LSTVKR------------KMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEF 447

  Fly  2129 WYKKMLDK-----------GMIERIIQDYKDILKQAMEDKLGSAAELPYFEGDFWPNVLEESIKE 2182
            .|.||.|:           .:...:.:...:...:....:..|..|....|.|     .||..:.
  Rat   448 RYAKMPDEPLEPGPLPVSTALPPGLAKSSSESSSEESSSESSSEEEEEEDEED-----EEEESES 507

  Fly  2183 LDQEEEEKRKQAEAAEAAAAAN--LFSIEENEVSGDGKKKGQKKAKKSNKS-------------- 2231
            .|.|||...:.||..|...|.:  |.::.:..:|...:|:.:|:.||..|:
  Rat   508 SDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRIGIDEDDK 572

  Fly  2232 -----KAAQRKNSKKSNEHQSGNDLST--------------KIYATMEKHKEVFFVIRLHSAQSA 2277
                 :..|.|.|||:.  ..|::.:|              |:....:|...........|.:..
  Rat   573 GPRAPRPLQPKKSKKAG--GGGSNATTLSHPGFGTSAGSSNKLPKKAQKTAPPVLPTGYDSEEEE 635

  Fly  2278 ASLAPIQDPDPLLTCDLMD------GRDAFLTLARDKHFEFSSLRRAQ--FSTL--SMLYELHNQ 2332
            .|.....|....|:.|:..      ||...:..||:.....|:....:  |.||  |.|.||
  Rat   636 ESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLREL--- 697

  Fly  2333 GQDKFVYTC 2341
              :::|.:|
  Rat   698 --ERYVLSC 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nej	NP_001188575.1	ZnF_TAZ	530..600	CDD:214717
		KIX	946..1024	CDD:280354
		Bromo_cbp_like	1705..1812	CDD:99927	34/106 (32%)
		RING_CBP-p300	1824..1906	CDD:276805	16/90 (18%)
		PHD_CBP_p300	1908..1939	CDD:277032	4/32 (13%)
		HAT_KAT11	1970..2283	CDD:285432	65/411 (16%)
		ZZ_CBP	2339..2379	CDD:239077	1/3 (33%)
		ZnF_TAZ	2404..2476	CDD:214717
Brd2	NP_997660.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..72		5/20 (25%)
		Bromo_Brdt_I_like	73..179	CDD:99929	35/113 (31%)
		PHA03247	<215..332	CDD:223021	28/165 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..348		17/104 (16%)
		Bromo_Brdt_II_like	348..449	CDD:99930	21/147 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..648		33/199 (17%)
		Nuclear localization signal. /evidence=ECO:0000255	553..557		2/3 (67%)
		BET	639..701	CDD:407211	15/66 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	735..798
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910