DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nej and BRD4

DIOPT Version :9

Sequence 1:	NP_001188575.1	Gene:	nej / 43856	FlyBaseID:	FBgn0261617	Length:	3282	Species:	Drosophila melanogaster
Sequence 2:	NP_001366220.1	Gene:	BRD4 / 23476	HGNCID:	13575	Length:	1362	Species:	Homo sapiens

Alignment Length:	1708	Identity:	318/1708 - (18%)
Similarity:	487/1708 - (28%)	Gaps:	673/1708 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly  1652 SGVGGGKDNINGAHDG------GATGGAVDIKP--KTETKPLVPEPLAPNAGDKKKKCQFNPEEL 1708
            ||.|....|:....||      ..|......:|  ...|.|..||...||    |.|.|.|  :|
Human     5 SGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPN----KPKRQTN--QL 63

  Fly  1709 RTALLPTLEKLYRQEPESVPFRYPVDPQALGIPDYFEIVKKPMDLGTIRTNIQNGKYSDPWEYVD 1773
            :..|...|:.|::.: .:.||:.|||...|.:|||::|:|.|||:|||:..::|..|.:..|.:.
Human    64 QYLLRVVLKTLWKHQ-FAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQ 127

  Fly  1774 DVWLMFDNAWLYNRKTSRVYRYCTKLSEVF----------EAEIDPVMQALGYCCGRKY--TFNP 1826
            |...||.|.::||:....:......|.::|          |.|| .::||.|...|||.  |..|
Human   128 DFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEI-MIVQAKGRGRGRKETGTAKP 191

  Fly  1827 QVLCCYGKQLCTIPRDAKYYSYQNSLKEYGVASNRYTYCQKCFNDIQGDTVTLGDDPLQSQT--- 1888
            .|        .|:|                             |..|..|      |.|:||
Human   192 GV--------STVP-----------------------------NTTQAST------PPQTQTPQP 213

  Fly  1889 -----QIKKDQFKEMKNDHLELEPFVN-----------------------CQECGRKQHQICVLW 1925
                 |.....|..:..|.:...|.:.                       ..:..:....|....
Human   214 NPPPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAAT 278

  Fly  1926 LDSIWPGGFVCDNCLKKKNSKRKENK---------FNAKRLP----TTKLGVYIETRVNNFLKKK 1977
            ...:          ..||..|||.:.         .....||    |||||...|:.......||
Human   279 PQPV----------KTKKGVKRKADTTTPTTIDPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKK 333

  Fly  1978 EAGAGEVH-----IRVVSSSDKCVEVKPGMRRRFVEQGEMMNEFPYRAKALFAFEEVDGIDVCFF 2037
            :....:.|     ...||...||.             ..::.|...:..|.:|:.....:||...
Human   334 DVPDSQQHPAPEKSSKVSEQLKCC-------------SGILKEMFAKKHAAYAWPFYKPVDVEAL 385

  Fly  2038 GMHVQEYGSECPAPNTRRVYIAYLDSVHFFRPRQYRTA-------------VY------HEIL-- 2081
            |:|  :|......|.......:.|::      |:||.|             .|      ||::
Human   386 GLH--DYCDIIKHPMDMSTIKSKLEA------REYRDAQEFGADVRLMFSNCYKYNPPDHEVVAM 442

  Fly  2082 ------LGYMDYVKQLGYTMAHIWA-------------CPPSEGDDYIFHCHPTDQKI-----PK 2122
                  :..|.:.|........:.|             .|||..|........:|...     .:
Human   443 ARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEER 507

  Fly  2123 PKRLQEWYKKMLDKGMIERIIQDYKDILKQAMEDKLGSAAELPYFEGDFWPNVLEESIKELDQEE 2187
            .:||.|..:::                  :|:.::|.:.::         |...:...||.|::|
Human   508 AQRLAELQEQL------------------KAVHEQLAALSQ---------PQQNKPKKKEKDKKE 545

  Fly  2188 EEKRKQAEAAEAAAAANLFSIEENEVSGDGKKKGQKKAKKSNKSKAAQRK------NSKKSNEHQ 2246
            ::|.|.....|         :|||:.| ..|:...||.||:|.|.:...|      .||....::
Human   546 KKKEKHKRKEE---------VEENKKS-KAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYE 600

  Fly  2247 SGNDLSTKIYATMEKHKEVFFVIRLHSAQSAASLAPIQDPDPLLTCDLMDGRDAFLTLARDKHFE 2311
            |..:...|..:..||.:....:.:|...:....:..||..:|.|.....|          :...:
Human   601 SEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPD----------EIEID 655

  Fly  2312 FSSLRRAQFSTLSMLYELHNQGQDKFVYTCNHCKTAVETRYHCTVCDDFDLCIVCKEKVGHQHKM 2376
            |.:|:.      |.|.||     :::|.:|...|...:.                 |||
Human   656 FETLKP------STLREL-----ERYVTSCLRKKRKPQA-----------------EKV------ 686

  Fly  2377 EKLGFDIDDGSALADHKQANPQEARKQSIQRCIQSLAHACQCRDANCRLPSCQKMKLVVQHTKNC 2441
                 |:..||:......::..|:..:|         .:....|:...:....|.|   .|....
Human   687 -----DVIAGSSKMKGFSSSESESSSES---------SSSDSEDSETEMAPKSKKK---GHPGRE 734

  Fly  2442 KRKPNGGCPICKQLIALCCYHAKNCEEQKCPVPFCPNIKHKLKQQQSQQKFQQQQLLRRRVALMS 2506
            ::|.:.             :|.:..::...|||..|....:........:.|||.........|.
Human   735 QKKHHH-------------HHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSMP 786

  Fly  2507 RTAAPAALQGPAAVSGPTVVSGGVPVVGMSGVAVSQQVIPGQAGILPPGAGGMSPSTVAVPSPVS 2571
            :.||||....|     |..::..|||:        :..:||  .:..| .|..:...:.:|.|
Human   787 QQAAPAMKSSP-----PPFIATQVPVL--------EPQLPG--SVFDP-IGHFTQPILHLPQP-- 833

  Fly  2572 GGAGAGGMGGMTSPHPHQPGIGMKPGGGHSPSPNVLQ---VVKQVQEEAARQQVSHGGGFGKGVP 2633
                      ...||..||       ..||..|::.|   |.......|..||.|........:|
Human   834 ----------ELPPHLPQP-------PEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALP 881

  Fly  2634 MAPPVMNRPMGGAGPNQNVVNQLGGMGVGVGGVGGVGVGGVGGVGVNQLNSGGGNTPGAPISGPG 2698
            ..|.   ||                                                  |...|.
Human   882 PKPA---RP--------------------------------------------------PAVSPA 893

  Fly  2699 MNVNHLMSMDQWGGGGAGGGGANPGGGNPQARYANNTGGMRQPTHVMQTNLIPPQQQQQMMGGLG 2763
            :....|:                     ||.       .|.||..|:..:..||
Human   894 LTQTPLL---------------------PQP-------PMAQPPQVLLEDEEPP----------- 919

  Fly  2764 GPNQLGGGQMPVGGQHGGMGMGMGAPPMAGTVGGVRPSPGAGGGGGSATGGGLNTQQLALIMQKI 2828
                                    |||                         |.:.|:.|.:|::
Human   920 ------------------------APP-------------------------LTSMQMQLYLQQL 935

  Fly  2829 KNNPTNESNQHILAILKQNPQIMAAIIKQRQQSQNNAAAGGGAPGPGGALQQQQAGNGPQNPQQQ 2893
            :.              .|.|..:...:|.:.|..        .|.|           .|.:|..|
Human   936 QK--------------VQPPTPLLPSVKVQSQPP--------PPLP-----------PPPHPSVQ 967

  Fly  2894 QQQQQQQQVMQQQQMQHMMNQQQGGGGPQQMNPNQQQQQQQVNLMQQQQQGGPGGPGSGLPTRMP 2958
            ||.|||.....                |.|..|..|||.|.                   |.|
Human   968 QQLQQQPPPPP----------------PPQPQPPPQQQHQP-------------------PPR-- 995

  Fly  2959 NMPNALGMLQSLPPNMSPGVSTQGGMVPNQNWNKMRYMQMSQYPPPYPQRQRGPHMGGAGPGPGQ 3023
                        |.::.|                |::....|.||| ||.|:.||     |.|||
Human   996 ------------PVHLQP----------------MQFSTHIQQPPP-PQGQQPPH-----PPPGQ 1026

  Fly  3024 QQFPGGGGGAGNFNAGGAGGAGGVVGVGGVPGGAGTV---------PGGDQYSMANAAAASNMLQ 3079
            |..|                        ..|.....|         ...|.||..:...|.:.|.
Human  1027 QPPP------------------------PQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLM 1067

  Fly  3080 QQQGQVGVGVGVGVKPGPGQQQQQMGVGMPPGMQQQQQQQQPLQQQQMMQVAMPNANAQNPSAVV 3144
            ....|:             .|.|.:....||     ||..||.:|:      :..|:...|..:|
Human  1068 IHSPQM-------------SQFQSLTHQSPP-----QQNVQPKKQE------LRAASVVQPQPLV 1108

  Fly  3145 GGPNAQVMGPPTPHSLQQQLMQSARSSPPIRSPQPTPSPRSAPSPRAAPSASPRAQPSPHHV--- 3206
            .....::..|         :::|...||.:| |:|...|.|..:|...|.   |.:..|..|
Human  1109 VVKEEKIHSP---------IIRSEPFSPSLR-PEPPKHPESIKAPVHLPQ---RPEMKPVDVGRP 1160

  Fly  3207 ----MSSHSPAPQGPPHD 3220
                ...::|.|..|..|
Human  1161 VIRPPEQNAPPPGAPDKD 1178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nej	NP_001188575.1	ZnF_TAZ	530..600	CDD:214717
		KIX	946..1024	CDD:280354
		Bromo_cbp_like	1705..1812	CDD:99927	35/116 (30%)
		RING_CBP-p300	1824..1906	CDD:276805	14/89 (16%)
		PHD_CBP_p300	1908..1939	CDD:277032	1/53 (2%)
		HAT_KAT11	1970..2283	CDD:285432	64/368 (17%)
		ZZ_CBP	2339..2379	CDD:239077	5/39 (13%)
		ZnF_TAZ	2404..2476	CDD:214717	10/71 (14%)
BRD4	NP_001366220.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		15/56 (27%)
		Bromo_Brdt_I_like	58..164	CDD:99929	34/108 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..229		20/97 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..352		18/119 (15%)
		Bromo_Brdt_II_like	353..454	CDD:99930	20/121 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	463..615		35/188 (19%)
		NPS region	484..503		3/18 (17%)
		BID region	524..579		19/73 (26%)
		BET	609..673	CDD:407211	15/84 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	674..1100		132/806 (16%)
		PRK03427	<809..>922	CDD:235124	35/250 (14%)
		C-terminal (CTD) region	1047..1362		36/169 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1116..1339		18/76 (24%)
		BRD4_CDT	1319..1362	CDD:407248
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810