back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nej and EP300

DIOPT Version :9

Sequence 1:	NP_001188575.1	Gene:	nej / 43856	FlyBaseID:	FBgn0261617	Length:	3282	Species:	Drosophila melanogaster
Sequence 2:	NP_001420.2	Gene:	EP300 / 2033	HGNCID:	3373	Length:	2414	Species:	Homo sapiens

Alignment Length:	3355	Identity:	1172/3355 - (34%)
Similarity:	1453/3355 - (43%)	Gaps:	1138/3355 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 MADHLDE---PPQKRVKM----------DPTDIS--YFLEENLPDELVSSNSGWSDQLTGGAGGG 51
            ||:::.|   |..||.|:          |.||..  :.||.:|||||::|..         .|..
Human     1 MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINSTE---------LGLT 56

  Fly    52 NGGG-----GASGVTTNPTSGP-------NPGGGPNKPAAQGPGSGTGGVGVGVNVGVGGVVGVG 104
            |||.     .:.|:..:..|..       ..|..||                 :|:||||
Human    57 NGGDINQLQTSLGMVQDAASKHKQLSELLRSGSSPN-----------------LNMGVGG----- 99

  Fly   105 VVPSQMNGAGGGNGSGTGGDDGSGNGSGAGNRISQMQHQQLQHLLQQQQQGQKG-----AMVVPG 164
              |.|:                                     :..|.||...|     :||...
Human   100 --PGQV-------------------------------------MASQAQQSSPGLGLINSMVKSP 125

  Fly   165 MQQLGSKSPNL----QSPNQGGMQQVVGTQMGMVNSMPMSISNNGNNGMNAIPGMNTIAQGN--- 222
            |.|.|..|||:    ..||||..|. .|.....||...|.::...|.|||  |||  :|.||
Human   126 MTQAGLTSPNMGMGTSGPNQGPTQS-TGMMNSPVNQPAMGMNTGMNAGMN--PGM--LAAGNGQG 185

  Fly   223 -LGNMVLTNSVGGGMGGMVNHLKQQPGGGGGGMINSVSVPGGPGAGAGGVGAGGGGAVAANQGMH 286
             :.|.|:..|:|.|.|.. |.....||.|..|  |.::.|
Human   186 IMPNQVMNGSIGAGRGRQ-NMQYPNPGMGSAG--NLLTEP------------------------- 222

  Fly   287 MQNG-PMMGRMVGQQHMLRGPHLMGASGGAGGPGNGPGG-GGPRMQNPNMQMNFRPFAAQL---- 345
            :|.| |.||...|    ||||..:..     |..|.|.. |.|..|||..|:.......|:
Human   223 LQQGSPQMGGQTG----LRGPQPLKM-----GMMNNPNPYGSPYTQNPGQQIGASGLGLQIQTKT 278

  Fly   346 ----NSLPYGVGQYGGPGGGNNPQQQQQQQQQQLLAQQMAQRGGVVPGMPQGNRPVGTVVPMSTL 406
                |..|:.:.:...||||                         :|.|
Human   279 VLSNNLSPFAMDKKAVPGGG-------------------------MPNM---------------- 302

  Fly   407 GGDGSGPAGQLVSGNPQQQQMLAQQQTGAMGPRPPQPNQLLGHPGQQQQQQQQPGTSQQQQQQQG 471
               |..||.|:                                        ||||.
Human   303 ---GQQPAPQV----------------------------------------QQPGL--------- 315

  Fly   472 VGIGGAGVVANAGTVAGVPAVAGGGAGGAVQSSGPGGANRDVPDDRKRQIQQQLMLLLHAHKCNR 536
                             |..||.|...|| .::.|         ::::.|||||:||||||||.|
Human   316 -----------------VTPVAQGMGSGA-HTADP---------EKRKLIQQQLVLLLHAHKCQR 353

  Fly   537 RENLNPNREVCNVNYCKAMKSVLAHMGTCKQSKDCTMQHCASSRQILLHYKTCQNSGCVICYPFR 601
            ||..|.....||:.:|:.||:||.||..|:..|.|.:.||||||||:.|:|.|....|.:|.|.:
Human   354 REQANGEVRQCNLPHCRTMKNVLNHMTHCQSGKSCQVAHCASSRQIISHWKNCTRHDCPVCLPLK 418

  Fly   602 QNHSVFQNANVPPGGGPAGIGGAPPGGGGAGGGAAGAGGNLQQQQQQQQQQQQNQQPNLTGLVVD 666
                                               .||            .::||||.|||
Human   419 -----------------------------------NAG------------DKRNQQPILTG---- 432

  Fly   667 GKQGQQVAPGGGQNTAIVLPQQQGAGGAPGAPKTPADMVQQLTQQQQQQQQQVHQQQVQQQELRR 731
                   ||.|..|     |...|.|
Human   433 -------APVGLGN-----PSSLGVG--------------------------------------- 446

  Fly   732 FDGMSQQVVAGGMQQQQQQGLPPVIRI--QGAQPAVRVLGPGGPGGPSGPNVLPNDVNSLHQQQQ 794
                          ||....|..|.:|  ...:.|...||            ||..||
Human   447 --------------QQSAPNLSTVSQIDPSSIERAYAALG------------LPYQVN------- 478

  Fly   795 QMLQQQQQQGQNRRRGGLATMVEQQQQHQQQQQQPNPAQLGGNIPA-PLSVNVGGFGNTNFGGAA 858
            ||..|.|.|.:|             ||:||..|.|...:...|:.| |:.||
Human   479 QMPTQPQVQAKN-------------QQNQQPGQSPQGMRPMSNMSASPMGVN------------- 517

  Fly   859 AGGAVGANDKQQLKVAQVHPQSHGVGAGGASAGAGASGGQVAAGSSV--LMPADTTGSGNAGNPN 921
              |.||......|..:.:|            :...:....::..:||  |.|..|     |..|:
Human   518 --GGVGVQTPSLLSDSMLH------------SAINSQNPMMSENASVPSLGPMPT-----AAQPS 563

  Fly   922 QNAGGVAGGAGGGNGGNTGPPGDNEKDWRESVTADLRNHLVHKLVQAIFPTSDPTTMQDKRMHNL 986
                            .||    ..|.|.|.:|.|||||||||||||||||.||..::|:||.||
Human   564 ----------------TTG----IRKQWHEDITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENL 608

  Fly   987 VSYAEKVEKDMYEMAKSRSEYYHLLAEKIYKIQKELEEKRLKRKEQHQQMLMQQQGVANPVAGGA 1051
            |:||.|||.||||.|.:|:||||||||||||||||||||| :.:.|.|.||....|:. ||:...
Human   609 VAYARKVEGDMYESANNRAEYYHLLAEKIYKIQKELEEKR-RTRLQKQNMLPNAAGMV-PVSMNP 671

  Fly  1052 AGGAGSAAGVAGGVVLPQQQQQQQQQQQQQGQQPLQSCIHPSISPMGGVMPPQQLRPQGPPGILG 1116
            ....|                |.|......|..|..|.|..|:        |.|:.|:..|
Human   672 GPNMG----------------QPQPGMTSNGPLPDPSMIRGSV--------PNQMMPRITP---- 708

  Fly  1117 QQTAAGLGVGVGVTNNMVTMRSHSPGGNMLALQQQQRMQFPQQQQQQPPGSGAGKMLVGPPGPSP 1181
               .:||.                              ||.|....|||
Human   709 ---QSGLN------------------------------QFGQMSMAQPP---------------- 724

  Fly  1182 GGMVVNPALSPYQTTNVLTSPVP--GQQQQQQFINANGGTGANPQLSEIMKQRHIHQQQQQQQQQ 1244
                    :.|.|     |.|:.  ||..|...:|...|.|  |::                ||.
Human   725 --------IVPRQ-----TPPLQHHGQLAQPGALNPPMGYG--PRM----------------QQP 758

  Fly  1245 QQQGMLLPQSPFSN------STPLQQQQQQQQQQQQQQQATSNSFSSPMQQQQQGQQQQQQKPGS 1303
            ..||..|||:.|.:      :.||.....|....|.|..::|...:||:
Human   759 SNQGQFLPQTQFPSQGMNVTNIPLAPSSGQAPVSQAQMSSSSCPVNSPI---------------- 807

  Fly  1304 VLNNMPPTPTSLEALNAGAGAPGTGGSASNVTVSAPS-PSPGFLSNGPSIGTPSNNNNNSSANNN 1367
                ||               ||:.||    .:..|. |.|....|.|| ..||   ...:.::.
Human   808 ----MP---------------PGSQGS----HIHCPQLPQPALHQNSPS-PVPS---RTPTPHHT 845

  Fly  1368 PPSVSSLMQQPLSNRPG---TPPYIPASP-----------VPATSASGLAASSTPASAAATCASS 1418
            |||:.: .|.|.:..|.   |||.:|..|           .|....:.|.....|:..||..|..
Human   846 PPSIGA-QQPPATTIPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQVQPSLPAAPSADQ 909

  Fly  1419 GSGSNSSSGATAAGASSTSSSSSAGSGTPLSSVSTPTSATMATSSGGGGGGGGNAGGGSSTTPAS 1483
            ......|..:|||                  ||.|||:..:..               ...||.|
Human   910 PQQQPRSQQSTAA------------------SVPTPTAPLLPP---------------QPATPLS 941

  Fly  1484 NPLLLMSGGTAGGGTGATTTTSTSSSSRMMSSSSSLSSQMAALEAAARDNDDETPSPSGENTNGS 1548
            .|.:.:.|..    :...:|:||..:|:.::...  .||...:||..     |...|...:|
Human   942 QPAVSIEGQV----SNPPSTSSTEVNSQAIAEKQ--PSQEVKMEAKM-----EVDQPEPADT--- 992

  Fly  1549 GGSGNAGGMASKGKLDSIKQDDDIKKEFMDDSCGGNNDSSQMDCSTGGGKGKNVNNDGTSMIKME 1613
                               |.:||            ::|...||                  |||
Human   993 -------------------QPEDI------------SESKVEDC------------------KME 1008

  Fly  1614 -IKTEDGLDGEVKIKTEAMDVDEAGGSTAGEHHGEGGGGSGVGGGKDNINGAHDGGATGGAVDIK 1677
             .:||   :...::|||..:.::                                         :
Human  1009 STETE---ERSTELKTEIKEEED-----------------------------------------Q 1029

  Fly  1678 PKTETKPLVPEPLAPNAGDKKKKCQFNPEELRTALLPTLEKLYRQEPESVPFRYPVDPQALGIPD 1742
            |.|......|.|     |..|||. |.|||||.||:||||.||||:|||:|||.|||||.|||||
Human  1030 PSTSATQSSPAP-----GQSKKKI-FKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPD 1088

  Fly  1743 YFEIVKKPMDLGTIRTNIQNGKYSDPWEYVDDVWLMFDNAWLYNRKTSRVYRYCTKLSEVFEAEI 1807
            ||:|||.||||.||:..:..|:|.:||:||||:||||:|||||||||||||:||:|||||||.||
Human  1089 YFDIVKSPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVFEQEI 1153

  Fly  1808 DPVMQALGYCCGRKYTFNPQVLCCYGKQLCTIPRDAKYYSYQNSLKEYGVASNRYTYCQKCFNDI 1872
            |||||:||||||||..|:||.|||||||||||||||.|||||          |||.:|:||||:|
Human  1154 DPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQ----------NRYHFCEKCFNEI 1208

  Fly  1873 QGDTVTLGDDPLQSQTQIKKDQFKEMKNDHLELEPFVNCQECGRKQHQICVLWLDSIWPGGFVCD 1937
            ||::|:|||||.|.||.|.|:||.:.|||.|:.|.||.|.|||||.||||||..:.|||.|||||
Human  1209 QGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPELFVECTECGRKMHQICVLHHEIIWPAGFVCD 1273

  Fly  1938 NCLKKKNSKRKENKFNAKRLPTTKLGVYIETRVNNFLKKK-EAGAGEVHIRVVSSSDKCVEVKPG 2001
            .||||....||||||:|||||:|:||.::|.|||:||::: ...:|||.:|||.:|||.||||||
Human  1274 GCLKKSARTRKENKFSAKRLPSTRLGTFLENRVNDFLRRQNHPESGEVTVRVVHASDKTVEVKPG 1338

  Fly  2002 MRRRFVEQGEMMNEFPYRAKALFAFEEVDGIDVCFFGMHVQEYGSECPAPNTRRVYIAYLDSVHF 2066
            |:.|||:.|||...||||.||||||||:||:|:||||||||||||:||.||.|||||:|||||||
Human  1339 MKARFVDSGEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHF 1403

  Fly  2067 FRPRQYRTAVYHEILLGYMDYVKQLGYTMAHIWACPPSEGDDYIFHCHPTDQKIPKPKRLQEWYK 2131
            |||:..|||||||||:||::|||:||||..|||||||||||||||||||.|||||||||||||||
Human  1404 FRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYK 1468

  Fly  2132 KMLDKGMIERIIQDYKDILKQAMEDKLGSAAELPYFEGDFWPNVLEESIKELDQEEEEKRKQAEA 2196
            |||||.:.|||:.|||||.|||.||:|.||.|||||||||||||||||||||:|||||::::...
Human  1469 KMLDKAVSERIVHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENT 1533

  Fly  2197 AEAAAAANLFSIEENEVS-GDGKKKGQKKAKKSNKSKAA-QRKNSKKSNEHQSGNDLSTKIYATM 2259
                      |.|..:|: ||.|...:|..||::|:|:: .|.|.||.......||||.|:||||
Human  1534 ----------SNESTDVTKGDSKNAKKKNNKKTSKNKSSLSRGNKKKPGMPNVSNDLSQKLYATM 1588

  Fly  2260 EKHKEVFFVIRLHSAQSAASLAPIQDPDPLLTCDLMDGRDAFLTLARDKHFEFSSLRRAQFSTLS 2324
            ||||||||||||.:..:|.||.||.|||||:.||||||||||||||||||.|||||||||:||:.
Human  1589 EKHKEVFFVIRLIAGPAANSLPPIVDPDPLIPCDLMDGRDAFLTLARDKHLEFSSLRRAQWSTMC 1653

  Fly  2325 MLYELHNQGQDKFVYTCNHCKTAVETRYHCTVCDDFDLCIVCKEKVGHQHKMEKLGFDIDDGSAL 2389
            ||.|||.|.||:||||||.||..||||:|||||:|:||||.|.....|.|||||||..:||.|
Human  1654 MLVELHTQSQDRFVYTCNECKHHVETRWHCTVCEDYDLCITCYNTKNHDHKMEKLGLGLDDES-- 1716

  Fly  2390 ADHKQA----NPQEARKQSIQRCIQSLAHACQCRDANCRLPSCQKMKLVVQHTKNCKRKPNGGCP 2450
             :::||    :|.::|:.|||||||||.||||||:|||.||||||||.||||||.||||.|||||
Human  1717 -NNQQAAATQSPGDSRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCP 1780

  Fly  2451 ICKQLIALCCYHAKNCEEQKCPVPFCPNIKHKLKQQQSQQKFQQQQLLRRRVALMSRTAAPAALQ 2515
            ||||||||||||||:|:|.|||||||.|||.||:|||.|.:.||.|:||||:|.|.||......|
Human  1781 ICKQLIALCCYHAKHCQENKCPVPFCLNIKQKLRQQQLQHRLQQAQMLRRRMASMQRTGVVGQQQ 1845

  Fly  2516 G-----PAAVSGPTVVSGGVPVVGMSGVAVSQQVIPGQAGILPPGAGGMSPSTVAVPSPVSGGAG 2575
            |     ||.   ||..:|..|....:....||.. |.....:||    ..|.|.|. .|||.|..
Human  1846 GLPSPTPAT---PTTPTGQQPTTPQTPQPTSQPQ-PTPPNSMPP----YLPRTQAA-GPVSQGKA 1901

  Fly  2576 AGGMGGMTSPHPHQPGIGMKPGGGHSPSPNVLQVVKQVQEEAARQ-QVSHGGGFGKGV------- 2632
            ||.:...|.|...||.:   ||    |.|..:::..|:|..|..| |::|...|.:.:
Human  1902 AGQVTPPTPPQTAQPPL---PG----PPPAAVEMAMQIQRAAETQRQMAHVQIFQRPIQHQMPPM 1959

  Fly  2633 -PMAPPVMNRPMGGAGPNQNVVNQLGGMGVGVGGVGGVGVGGVGGVGVNQLNSGGGNTPGAPISG 2696
             ||||..||.|....||:.::                                           .
Human  1960 TPMAPMGMNPPPMTRGPSGHL-------------------------------------------E 1981

  Fly  2697 PGMNVNHLMSMDQWGGGGAGGGGANPGGGNPQARYANNTGGMRQPTHVMQTNLIPPQQQQQMMGG 2761
            |||....:.....|                       :.||:.||              ||:..|
Human  1982 PGMGPTGMQQQPPW-----------------------SQGGLPQP--------------QQLQSG 2009

  Fly  2762 LGGPNQLGGGQMPVGGQHGGMGMGMGAPPMAGTVGGVRPSPGAGGGGGSATGGGLNTQQ-LALIM 2825
            :..|     ..|.| .|||        .|:     .:.|.||.|..|.|....|..:|| |..::
Human  2010 MPRP-----AMMSV-AQHG--------QPL-----NMAPQPGLGQVGISPLKPGTVSQQALQNLL 2055

  Fly  2826 QKIKNNPTNESNQHILAILKQNPQIMAAIIKQR--QQSQNNAAAGGGAPGPGGALQQQQAGNGP- 2887
            :.:::..:....|.:|:||..|||::||.||||  :.:.:|.....|.||    :.|.|.|..|
Human  2056 RTLRSPSSPLQQQQVLSILHANPQLLAAFIKQRAAKYANSNPQPIPGQPG----MPQGQPGLQPP 2116

  Fly  2888 ---------QNPQQQQQQQQQQQV----MQQQQMQHMMNQQQGGGGP--QQMNPNQQQQQQQV-- 2935
                     .||..|.....|..|    :.|||.|..:....||..|  ||||.|......|.
Human  2117 TMPGQQGVHSNPAMQNMNPMQAGVQRAGLPQQQPQQQLQPPMGGMSPQAQQMNMNHNTMPSQFRD 2181

  Fly  2936 -----NLMQQQQQGGPGGPGSGLPTRMPNMPNALGMLQSLPPNMSPGVSTQGGMVPNQNWNKMRY 2995
                 .:||||||.| .|||.|                       ||::         |.|:.:.
Human  2182 ILRRQQMMQQQQQQG-AGPGIG-----------------------PGMA---------NHNQFQQ 2213

  Fly  2996 MQMSQYPPPYPQRQRGPHMGGAGPGPGQQQFPGGGGGAGNFNAGGAGGAGGVVGVGGVPGGAGTV 3060
            .|...|||...||.: .||         ||...|..|.                :|.:|...|..
Human  2214 PQGVGYPPQQQQRMQ-HHM---------QQMQQGNMGQ----------------IGQLPQALGAE 2252

  Fly  3061 PGGDQYSMANAAAASNMLQQQQGQVGVGVGVGVKPGPGQQQQQMGVGMPPGMQQQQQQQQPLQQQ 3125
            .|      |:..|....|.|||      :|..|:|.|...||.|
Human  2253 AG------ASLQAYQQRLLQQQ------MGSPVQPNPMSPQQHM--------------------- 2284

  Fly  3126 QMMQVAMPNANAQNPSAVVGGPNAQVMGPPTPHSLQQQLMQSARSSPPIRSPQPTPSPR------ 3184
                  :|| .||:|         .:.|...|:||..|          :|||||.||||
Human  2285 ------LPN-QAQSP---------HLQGQQIPNSLSNQ----------VRSPQPVPSPRPQSQPP 2323

  Fly  3185 -SAPSPRAAPSASPRAQPSPHHVMSSHSPAPQ-GPPHDGM 3222
             |:||||..|      |||||||      :|| ..||.|:
Human  2324 HSSPSPRMQP------QPSPHHV------SPQTSSPHPGL 2351

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.