Protein Alignment nej and cbp-1

DIOPT Version :10

• Sequence 1: NP_001188575.1
• Gene: nej / 43856
• FlyBaseID: FBgn0261617
• Length: 3282
• Species: Drosophila melanogaster
• Sequence 2: NP_499160.2
• Gene: cbp-1 / 176380
• WormBaseID: WBGene00000366
• Length: 2017
• Species: Caenorhabditis elegans
• Alignment Length: 3086
• Identity: 896/3086 - (29%)
• Similarity: 1153/3086 - (37%)
• Gaps: 1212/3086 - (39%)

  Fly     6 LDEPPQKRVKMDPTDISYFLE-----ENLPDELVSSNSGWSDQLTGGAGGGNGGGGASGVTTNPT 65
            :||||.|:.:.| :|....|:     |:|  |...::|..:|.....:....|.||.||.|.:|.
 Worm     1 MDEPPSKKSRAD-SDYDSGLDALSALESL--EAFPTSSKDTDVDNNPSTSAGGSGGPSGSTPHPQ 62

  Fly    66 SGPNPGGGPNKPAAQGPGSGTGGVGVGVNVGVGGVVGVGVVPSQ--MNGAGGGNGSGTGGDDGSG 128
            ..|.|....|......||...                    |.|  .|..||.|||
 Worm    63 GTPQPAPSNNGGFNLQPGQSQ--------------------PQQPPQNMGGGVNGS--------- 98

  Fly   129 NGSGAGNRISQMQHQQLQHLLQQQQQGQKGA----MVVPGMQQLGSKS-------PNLQSPNQGG 182
                           .||.||....|....:    ...||.|...::|       ||:.||  ..
 Worm    99 ---------------VLQELLMNPSQTSNNSPRPQAYPPGQQNAFNRSPMMPNGTPNMMSP--PS 146

  Fly   183 MQQVVGTQMGMVNSMPMSISNNGNNGMNAIPGMNTIAQGNLGNMVLTNSVGGGMGGMVNHLKQQP 247
            |.:|.|...|  ...|   ...|...|.  ||...:.||:....::..:.|....||::....
 Worm   147 MGRVPGPSPG--GPQP---PGPGQPQMR--PGQPGMFQGDQQQQMMMGAQGQQFPGMMHRYPY-- 202

  Fly   248 GGGGGGMINSVSVPGGPGAGAGGVGAGGGGAVAANQGMHMQNGPMMGRMVGQQHMLRGPHLMGAS 312
                        ..|||..||.|:..|..|.        .:.||..|:.:|:..|:.|  .|..|
 Worm   203 ------------AQGGPPPGAQGMPQGYPGV--------SRGGPTPGQPMGRGAMMNG--AMPRS 245

  Fly   313 GGAGGPGNGPGGGGPRMQNPNMQMNFRPFAAQLNSLPYGVGQYGGPGGGNNPQQQQQQQQQQLLA 377
            |..      |..|.|.:. ||.|...:|.......:.:  ||||              ||:....
 Worm   246 GPM------PTQGRPGIP-PNQQAMMQPMMTDRQFMQH--GQYG--------------QQRPEFM 287

  Fly   378 QQMAQRGGVVPGMPQGNRPVGTVVPMSTLGGDGSGPAGQLVSGNPQQQQMLAQQQTG-AMGPRPP 441
            ||..:.|| .|.|.||       :.|.:        .||.:.| |.|..|::....| :.||...
 Worm   288 QQYGRPGG-YPMMHQG-------MMMDS--------NGQPIRG-PNQMMMMSNGHPGMSHGPPNG 335

  Fly   442 QPNQLLG---HPGQQQ---QQQQQPGTSQQQQQQQGVGIGGAGVVANAGTVAGVPAVAGGGAGGA 500
            ||.....   |..|||   |.|.|....||||||:                 ...|.|.....||
 Worm   336 QPGPQAAAAQHAAQQQAAAQAQAQAAAQQQQQQQR-----------------EQEAAAAAQRNGA 383

  Fly   501 VQSSGPGG---ANRDVPDDRKRQIQQQLMLLLHAHKCNRRENLN---------PNREVCNVNYCK 553
            .:::.||.   |....|:.|| .|||||:||||||||::||..|         |....|.:.:|.
 Worm   384 GRATTPGSSMLATHQDPEKRK-LIQQQLVLLLHAHKCSQREKENRDFAAKNQPPPHAACTLPHCS 447

  Fly   554 AMKSVLAHMGTC-----------KQSKDCTMQHCASSRQILLHYKTCQNSGCVICYPFRQNHSVF 607
            .||.||.||.:|           :.:|.|::.||||||||:.|:|.|....|.:|.|.:
 Worm   448 TMKEVLTHMTSCNVGRLCHSDTTQTTKKCSVAHCASSRQIIAHWKNCSREDCPVCKPLK------ 506

  Fly   608 QNANVPPGGGPAGIGGAPPGGGGAGGGAAGAGGNLQQQQQQQQQQQQNQQPNLTGLVVDGKQGQQ 672
                                                   :.|....|...|:|..|
 Worm   507 ---------------------------------------RIQDTPLQFSLPDLANL--------- 523

  Fly   673 VAPGGGQNTAIVLPQQQGAGGAPGAPKTPADMVQQLTQQQQQQQQQVHQQQVQQQELRRFDGMSQ 737
            :...|..|           |.|.|                                    ||:.
 Worm   524 IGVNGNSN-----------GSAEG------------------------------------DGLH- 540

  Fly   738 QVVAGGMQQQQQQGLPPVIRIQGAQPAVRVLGPGGPGGPSGPNVLPNDVNSLHQQQQQMLQQQQQ 802
                                 |...||:|.               .|..|||.:
 Worm   541 ---------------------QFGSPAMRT---------------GNITNSLFE----------- 558

  Fly   803 QGQNRRRGGLATMVEQQQQHQQQQQQPNPAQLGGNIPAPLSVNVGGFGNTNFGGAAAGGAVGAND 867
                                                         ||.
 Worm   559 ---------------------------------------------GFN----------------- 561

  Fly   868 KQQLKVAQVHPQSHGVGAGGASAGAGASGGQVAAGSSVLMPADTTGSGNAGNPNQNA---GGVAG 929
                                                              |||.||.   ||...
 Worm   562 --------------------------------------------------GNPFQNGPNRGGPRP 576

  Fly   930 GAGGGNGGNTGPPG--DNEKDWRESVTADLRNHLVHKLVQAIFPTSDPTTMQDKRMHNLVSYAEK 992
            ..|.|...|..||.  |..|:|...||.|||||||.|||:||||..:...|.|.|:.:|::||.|
 Worm   577 PGGNGEIPNLPPPDMPDCTKEWHHQVTKDLRNHLVGKLVKAIFPEPNQEAMNDNRLKDLIAYARK 641

  Fly   993 VEKDMYEMAKSRSEYYHLLAEKIYKIQKELEEKRLKRKEQ----HQQMLMQQQGVANPVAGGAAG 1053
            |||:|:|.|..|.|||||||||||||||||:||:..|..|    |.|..:..   :|.:|
 Worm   642 VEKEMFESANDREEYYHLLAEKIYKIQKELQEKKNSRLNQGAAAHDQYAIPP---SNELA----- 698

  Fly  1054 GAGSAAGVAGGVVLPQQQQQQQQQQQQQGQQPLQSCIHPSISPMGGVMPPQQLRPQGPPGILGQQ 1118
               ...||.||                      :|.:|...|.| .|.|.||.:|.|
 Worm   699 ---QMLGVEGG----------------------RSDVHSEGSSM-AVAPSQQNQPWG-------- 729

  Fly  1119 TAAGLGVGVGVTNNMVTMRSHSPGGNMLALQQQQRMQFPQQQQQQPPGSGAGKMLVGPPGPSPGG 1183
                                .:|..||              .||.||.           |..|
 Worm   730 --------------------GAPNSNM--------------HQQIPPN-----------GQVP-- 747

  Fly  1184 MVVNPALSPYQTTNVLTSPVPGQQQQQQFINANGGTGANPQLSEIMKQRHIHQQQQQQQQQQQQG 1248
                      |..|..|.|..|
 Worm   748 ----------QVNNSSTFPSSG------------------------------------------- 759

  Fly  1249 MLLPQSPFSNSTPLQQQQQQQQQQQQQQQATSNSFSSPMQQQQQGQQQQQQKPGSVLNNMPPTPT 1313
                     ||||
 Worm   760 ---------NSTP---------------------------------------------------- 763

  Fly  1314 SLEALNAGAGAPGTGGSASNVTVSA---PSPSPGFLSNGPSIGTPSNNNNNSSANNNPPSVSSLM 1375
                 |.||.:          ||||   |...            |.::.|..|.::.||
 Worm   764 -----NIGASS----------TVSAMLQPKTE------------PMDDQNTDSLSSRPP------ 795

  Fly  1376 QQPLSNRPGTPPYIPASPVPATSASGLAASSTPASAAATCASSGSGSNSSSGATAAGASSTSSSS 1440
                                                                 ||.|
 Worm   796 -----------------------------------------------------TAIG-------- 799

  Fly  1441 SAGSGTPLSSVSTPTSATMATSSGGGGGGGGNAGGGSSTTPASNPLLLMSGGTAGGGTGATTTTS 1505
                                            .||.||:|||  |::
 Worm   800 --------------------------------FGGSSSSTPA--PIM------------------ 812

  Fly  1506 TSSSSRMMSSSSSLSSQMAALEAAARDNDDETPSPSGENTNGSGGSGNAGGMASKGKLDSIKQDD 1570
                                                    ||                 .:|:::
 Worm   813 ----------------------------------------NG-----------------IVKKEE 820

  Fly  1571 DIKKEFMDDSCGGNNDSSQMDCSTGGGKGKNVNNDGTSMIKMEIKTEDGLDGEVKIKTEAMDVDE 1635
            |.::.                           :|.....:|   .|:||:
 Worm   821 DPEES---------------------------SNQAPPSVK---DTKDGV--------------- 840

  Fly  1636 AGGSTAGEHHGEGGGGSGVGGGKDNINGAHDGGATGGAVDIKPKTETKPLVPEPLAPNAGDKKKK 1700
                                                  .:.|||.:.....|.|  |...|
 Worm   841 --------------------------------------AESKPKEQQAKREPTP--PPTED---- 861

  Fly  1701 CQFNPEELRTALLPTLEKLYRQEPESVPFRYPVDPQALGIPDYFEIVKKPMDLGTIRTNIQNGKY 1765
            ..|:.|:|...|||..|||.:.| ::.|||.|||.:.|.||||.||:|:||||.|:...:..|:|
 Worm   862 TVFSQEDLIKFLLPVWEKLDKSE-DAAPFRVPVDAKLLNIPDYHEIIKRPMDLETVHKKLYAGQY 925

  Fly  1766 SDPWEYVDDVWLMFDNAWLYNRKTSRVYRYCTKLSEVFEAEIDPVMQALGYCCGRKYTFNPQVLC 1830
            .:..::.||:|||.|||||||||.|:||:|..||||:|.:|:||||:::||||.:|..|.|..|.
 Worm   926 QNAGQFCDDIWLMLDNAWLYNRKNSKVYKYGLKLSEMFVSEMDPVMKSMGYCCAKKLAFTPLSLF 990

  Fly  1831 CYGKQLCTIPRDAKYYSYQNSLKEYGV-ASNRYTYCQKCFNDIQGDTVTLGDDPLQSQTQIKKDQ 1894
            |||..:|||.|:.:|:.::.|..:|.| .:.|||||||||:.:..:.::|.::|........|..
 Worm   991 CYGAAMCTIAREQQYWVFEQSSTQYNVTVTERYTYCQKCFDALPPEGISLSENPNDRNNMAPKTS 1055

  Fly  1895 FKEMKNDHLELEPFVNCQECGRKQHQICVLWLDSIWPGGFVCDNCLKKKNSKRKENKFNAKRLPT 1959
            |.|.||..::.|||..|:.|.||.|:||.|....::|.||:|:.|...|..::.:||:.|.:||.
 Worm  1056 FTEQKNSVIDYEPFERCKYCMRKWHRICALHDKKVYPEGFICECCRTAKKYQKPDNKYLASKLPH 1120

  Fly  1960 TKLGVYIETRVNNFLKKK---EAGAGEVHIRVVSSSDKCVEVKPGMRRRFVEQGEMMNEFPYRAK 2021
            .||..::|.|||.|:||:   ||....|.||.:...||..|||..|::::||..:...:||||.|
 Worm  1121 NKLSTFLEDRVNGFIKKQLQAEAHKYPVIIRTLCVQDKEAEVKAQMKQKYVESNQFPEKFPYRTK 1185

  Fly  2022 ALFAFEEVDGIDVCFFGMHVQEYGSECPAPNTRRVYIAYLDSVHFFRPRQYRTAVYHEILLGYMD 2086
            |:||||.:||::|||||:|||||||.|||||.||||||||||||||:||:.||.||||:||||:|
 Worm  1186 AVFAFEIIDGVEVCFFGLHVQEYGSACPAPNARRVYIAYLDSVHFFQPRELRTDVYHELLLGYLD 1250

  Fly  2087 YVKQLGYTMAHIWACPPSEGDDYIFHCHPTDQKIPKPKRLQEWYKKMLDKGMIERIIQDYKDILK 2151
            |.|.|||||||||||||||||||||||||.:||||||||||:||||||:||:.|..:.::|||.|
 Worm  1251 YAKMLGYTMAHIWACPPSEGDDYIFHCHPPEQKIPKPKRLQDWYKKMLEKGVQEGSVVEFKDIYK 1315

  Fly  2152 QAMEDKLGSAAELPYFEGDFWPNVLEESIKELDQEEEEKRKQAEAAEAAAAANLFSIEENEVSGD 2216
            ||.:|.|.:..:||||||||||||:|:.|:|...||.:::.:.:..:...|      :.....||
 Worm  1316 QARDDNLTTPTQLPYFEGDFWPNVIEDCIREASNEEAQRKVKEDDDDGEDA------DGGLGGGD 1374

  Fly  2217 GKKKGQKKAKKSNKSKAAQRKNSKKSNEHQSGNDLSTKIYATMEKHKEVFFVIRLHSAQS--AAS 2279
            ..||...|.||:|..|.|  |.:||.....:||:::.|:|:..||||||||.|||.|.|:  |..
 Worm  1375 SGKKKSSKNKKNNLKKNA--KMNKKKAGSITGNEVADKLYSQFEKHKEVFFTIRLVSLQNEPAVL 1437

  Fly  2280 LAPIQDPDPLLTCDLMDGRDAFLTLARDKHFEFSSLRRAQFSTLSMLYELHNQGQDKFVYTCNHC 2344
            ..||.|||.|:..|:|||||.|||.||::|:||||||||::|||.:.|.||........||||.|
 Worm  1438 AKPISDPDGLMQSDMMDGRDTFLTKAREEHWEFSSLRRAKYSTLCLAYSLHETDSKGMEYTCNKC 1502

  Fly  2345 KT-AVETRYHCTVCDDFDLCIVCKEKVGHQHKMEKLGFDIDDGSALADHKQANPQEARKQSIQRC 2408
            .: ||   :||..|||||||..||....|.|:|||:...|..|.| .|.....   .|.:|||||
 Worm  1503 SSPAV---WHCQSCDDFDLCDGCKPTTQHPHEMEKIKSLIGGGEA-GDSAAGG---TRYESIQRC 1560

  Fly  2409 IQSLAHACQCRDANCRLPSCQKMKLVVQHTKNCKRKPNGGCPICKQLIALCCYHAKNCEEQKCPV 2473
            |.||.|||||||||||..||.|||.||||||.||::.||.||:|||||||||||||:|....|.|
 Worm  1561 IASLVHACQCRDANCRRMSCHKMKRVVQHTKMCKKRINGTCPVCKQLIALCCYHAKHCTRDACTV 1625

  Fly  2474 PFCPNIKHKLKQQQSQQKFQQQQLLRRRV-ALMSRT--AAPAALQGPAAVSGPTVVSGGVPVVGM 2535
            |||.||:.||.:|:..|:.:...::|||: .|.|..  |||.          |:.||.|
 Worm  1626 PFCMNIRQKLAEQKRSQQRRADMMMRRRMEGLQSHVGGAAPT----------PSTVSNG------ 1674

  Fly  2536 SGVAVSQQVIPGQAGILPPGAGGMSPSTVAVPSPVSGGAGAGGMGGMTSPHPHQPGIGMKPGGGH 2600
                                    :||....| |||.|                ||..:|.||
 Worm  1675 ------------------------TPSNAPTP-PVSAG----------------PGPAVKGGG-- 1696

  Fly  2601 SPSPNVLQVVKQVQEEAARQQVSHGGGFGKGVPMAPPVMNRPMGGAGPNQNVVNQLGGM-GVGVG 2664
                     |.|||.:  :.|.||.||.|      |..|.:||          |..||| |:|:|
 Worm  1697 ---------VGQVQMQ--QHQGSHVGGSG------PAGMGQPM----------NSFGGMPGMGLG 1734

  Fly  2665 GVGGVGVGGVGGVGVNQLNSGGGNTPGAPISGPGMNVNHLMSMDQWGGGGAGGGGANPG------ 2723
                               ....|.||.|...|.||.|....|.  .|.|.|..|| ||
 Worm  1735 -------------------PNAQNGPGLPGMNPQMNANQSRYMP--NGPGLGQSGA-PGQQQQPM 1777

  Fly  2724 --GGNPQARYANNTGGMRQPTHVMQTNLIPPQQQQQMMG--GLGGPNQLGGGQMPVGGQHGGM-G 2783
              .|.|..| ....|||.           |.||.||..|  ||..|          ||:.||: |
 Worm  1778 YSSGMPMQR-PGGLGGMN-----------PQQQPQQQQGHPGLQNP----------GGRPGGVHG 1820

  Fly  2784 MGMGAPPMAGTVGGVRPSPGAGGGGGSATGGGLNTQQLALIMQ---------------------- 2826
            ||...|        ||                 |.|.:.:.||
 Worm  1821 MGQNQP--------VR-----------------NNQDMVMNMQMQNQHQQPPPFDSTLQPQIMKI 1860

  Fly  2827 --KIKNNPTNESNQHILAILKQNPQIMAAIIKQR------------------------------- 2858
              ::|...|.|..:.:.:.||:.|.:..|.::.|
 Worm  1861 NSRLKAAKTEEERETVFSDLKKTPHLFHAWLRMRENQNLVPNRMQGYSQMSMGSSNLQNLQQQQL 1925

  Fly  2859 QQSQNNAAAGGGAPGPGGALQQQQAGNG---PQNPQQQQQQQQQQQVMQQQQMQHMMNQQQGGGG 2920
            ||.|..|..|||...||....|.:|.:|   ..||..|||..||||...||:      ||..||.
 Worm  1926 QQQQAGAMRGGGGFAPGQNNSQPRAPSGQFASMNPSMQQQYPQQQQGWPQQR------QQNPGGM 1984

  Fly  2921 PQQMNP-NQQQQQQQVNLMQQQQQGGPGGPG 2950
            .|..|| ||.|.:|.:.:|.||||..|...|
 Worm  1985 QQNANPYNQFQNRQNMMMMPQQQQPHPSNAG 2015

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nej	NP_001188575.1	zf-TAZ	530..597	CDD:460457	32/86 (37%)
		KIX	944..1024	CDD:366953	50/79 (63%)
		Bromo_cbp_like	1705..1812	CDD:99927	57/106 (54%)
		RING_CBP-p300	1824..1906	CDD:276805	30/82 (37%)
		PHD_CBP_p300	1908..1939	CDD:277032	13/30 (43%)
		HAT_KAT11	1970..2284	CDD:400497	178/318 (56%)
		ZZ_CBP	2339..2379	CDD:239077	22/40 (55%)
		zf-TAZ	2405..2473	CDD:460457	50/67 (75%)
		NCBD_CREBBP-p300_like	2820..2862	CDD:411021	12/96 (13%)
		PLN02983	<3147..>3218	CDD:215533
cbp-1	NP_499160.2	Med15	<193..>338	CDD:312941	51/208 (25%)
		zf-TAZ	415..502	CDD:460457	32/86 (37%)
		KIX	593..673	CDD:366953	50/79 (63%)
		Bromo_cbp_like	866..972	CDD:99927	57/106 (54%)
		RING_CBP-p300	970..1009	CDD:399179	18/38 (47%)
		PHD_CBP_p300	1069..1100	CDD:277032	13/30 (43%)
		HAT_KAT11	1131..>1346	CDD:413203	142/214 (66%)
		ZZ_CBP	1497..1535	CDD:239077	22/40 (55%)
		ZnF_TAZ	1551..1629	CDD:214717	55/80 (69%)
		Med15	1629..>2015	CDD:312941	144/546 (26%)