DRSC/TRiP Functional Genomics Resources

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Protein Alignment nej and Ep300

DIOPT Version :9

Sequence 1:NP_001188575.1 Gene:nej / 43856 FlyBaseID:FBgn0261617 Length:3282 Species:Drosophila melanogaster
Sequence 2:XP_038936215.1 Gene:Ep300 / 170915 RGDID:620036 Length:2413 Species:Rattus norvegicus


Alignment Length:3365 Identity:1174/3365 - (34%)
Similarity:1425/3365 - (42%) Gaps:1160/3365 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 MADHLDE---PPQKRVKM----------DPTDIS--YFLEENLPDELVSSNSGWSDQLTGGAGGG 51
            ||:::.|   |..||.|:          |.||..  :.||.:|||||::|..         .|..
  Rat     1 MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINSTE---------LGLT 56

  Fly    52 NGGG-----GASGVTTNPTSGP-------NPGGGPNKPAAQGPGSGTGGVGVGVNVGVGGVVGVG 104
            |||.     .:.|:..:..|..       ..|..||                 :|:||||     
  Rat    57 NGGDISQLQTSLGIVQDAASKHKQLSELLRSGSSPN-----------------LNMGVGG----- 99

  Fly   105 VVPSQMNGAGGGNGSGTGGDDGSGNGSGAGNRISQMQHQQLQHLLQQQQQGQKG-----AMVVPG 164
              |.|:                                     :..|.||...|     :||...
  Rat   100 --PGQV-------------------------------------MASQAQQNSPGLSLINSMVKSP 125

  Fly   165 MQQLGSKSPNL----QSPNQGGMQQVVGTQMGMVNSMPMSISNNGNNGMNAIPGMNTIAQGN--- 222
            |.|.|..|||:    ..||||..|...|.....||...|.::...|.|||  |||  :|.||   
  Rat   126 MAQTGLTSPNMGMGSSGPNQGPTQSTAGMMNSPVNQPAMGMNTGMNAGMN--PGM--LAAGNGQG 186

  Fly   223 -LGNMVLTNSVGGGMGGMVNHLKQQPGGGGGGMINSVSVPGGPGAGAGGVGAGGGGAVAANQGMH 286
             :.|.|:..|:|.|.                         |.|.......|.|..|::....   
  Rat   187 IMPNQVMNGSIGAGR-------------------------GRPNMQYPNAGMGNAGSLLTEP--- 223

  Fly   287 MQNG-PMMGRMVGQQHMLRGP--HLMGASGGAGGPGNGPGGGGPRMQNPNMQMNFRPFAAQLNSL 348
            :|.| |.||...|    ||||  |.||                 .|.||.               
  Rat   224 LQQGSPQMGGQPG----LRGPQSHKMG-----------------MMSNPT--------------- 252

  Fly   349 PYGVGQYGGPGGGNNPQQQQQQQQQQLLAQQMAQRGGVVPGMPQGNRPVGTVVPMSTLGGDGSGP 413
            |||           :|..|...||                                 :|..|.|.
  Rat   253 PYG-----------SPYTQNSGQQ---------------------------------IGASGLGL 273

  Fly   414 AGQLVSGNPQQQQMLAQQQTGAMGPRPPQPNQLLGHPGQQQQQQQQPGTSQQQQQQQGVGIGGAG 478
            ..|..:..|......|..:....|             |......|||..|.||.           
  Rat   274 QIQTKTVLPNNLSPFAMDKKAVTG-------------GGMPNMGQQPTPSVQQP----------- 314

  Fly   479 VVANAGTVAGVPAVAGGGAGGAVQSSGPG---GANRDVPDDRKRQIQQQLMLLLHAHKCNRRENL 540
                                |.|....||   ||:...|:.|| .|||||:||||||||.|||..
  Rat   315 --------------------GLVNPVAPGMGSGAHTADPEKRK-LIQQQLVLLLHAHKCQRREQA 358

  Fly   541 NPNREVCNVNYCKAMKSVLAHMGTCKQSKDCTMQHCASSRQILLHYKTCQNSGCVICYPFRQNHS 605
            |.....||:.:|:.||:||.||..|:..|.|.:.||||||||:.|:|.|....|.:|.|.:    
  Rat   359 NGEVRQCNLPHCRTMKNVLNHMTHCQSGKSCQVAHCASSRQIISHWKNCTRHDCPVCLPLK---- 419

  Fly   606 VFQNANVPPGGGPAGIGGAPPGGGGAGGGAAGAGGNLQQQQQQQQQQQQNQQPNLTGLVVDGKQG 670
                                           .||            .::|||..|||        
  Rat   420 -------------------------------NAG------------DKRNQQSILTG-------- 433

  Fly   671 QQVAPGGGQNTAIVLPQQQGAGGAPGAPKTPADMVQQLTQQQQQQQQQVHQQQVQQQELRRFDGM 735
               ||.|..|     |...|.|                                           
  Rat   434 ---APVGLGN-----PSSLGVG------------------------------------------- 447

  Fly   736 SQQVVAGGMQQQQQQGLPPVIRIQGAQP-----AVRVLGPGGPGGPSGPNVLPNDVNSLHQQQQQ 795
                         ||..|.:..:....|     |...||            ||..||.:..|...
  Rat   448 -------------QQSTPSLSTVSQIDPSSIERAYAALG------------LPYQVNQIPPQPPV 487

  Fly   796 MLQQQQQQGQNRRRGGLATMVEQQQQHQQQQQQPNPAQLGGNIPA-PLSVNVGGFGNTNFGGAAA 859
            ..:.||.|...:...|:.:|                    .|:.| |:.||              
  Rat   488 QAKNQQSQPSGQSPQGMRSM--------------------NNMSASPMGVN-------------- 518

  Fly   860 GGAVGANDKQQLKVAQVHPQSHGVGAGGASAGAGASGGQVAAGSSVLMPADTTGSGNAGNPNQNA 924
             |.||......|..:.:|                         |::          |:.||..|.
  Rat   519 -GGVGVQTPNLLSDSMLH-------------------------STI----------NSQNPMMNE 547

  Fly   925 GGVAGGAG----GGNGGNTGPPGDNEKDWRESVTADLRNHLVHKLVQAIFPTSDPTTMQDKRMHN 985
            .......|    .....:||    ..|.|.|.:|.|||||||||||||||||.||..::|:||.|
  Rat   548 NASVASLGPLPTAAQPSSTG----IRKQWHEDITQDLRNHLVHKLVQAIFPTPDPAALKDRRMEN 608

  Fly   986 LVSYAEKVEKDMYEMAKSRSEYYHLLAEKIYKIQKELEEKRLKRKEQHQQMLMQQQGVANPVAGG 1050
            ||:||.|||.||||.|.:|:||||||||||||||||||||| :.:.|.|.||....|:. ||...
  Rat   609 LVAYARKVEGDMYESANNRAEYYHLLAEKIYKIQKELEEKR-RTRLQKQNMLPSAPGMV-PVPMN 671

  Fly  1051 AAGGAGSAAGVAGGVVLPQQQQQQQQQQQQQGQQPLQSCIHPSISPMGGVMPPQQLRPQGPPGIL 1115
            .|...|                ||.......|..|..|.|..|:        |.|:.|:..|   
  Rat   672 TAPNMG----------------QQPTGMTTNGPLPDPSMIRGSV--------PNQMMPRMTP--- 709

  Fly  1116 GQQTAAGLGVGVGVTNNMVTMRSHSPGGNMLALQQQQRMQFPQQQQQQPPGSGAGKMLVGPPGPS 1180
                                    .||.|          ||.|....|||        :||..||
  Rat   710 ------------------------QPGLN----------QFGQMNIPQPP--------IGPRQPS 732

  Fly  1181 PGGMVVNPALSPYQTTNVLTSPVPGQQQQQQFINANGGTGANPQLSEIMKQRHIHQQQQQQQQQQ 1245
            |        |..:           ||..|...:|...|.|..      |:|.....|...|.|..
  Rat   733 P--------LQHH-----------GQLAQSGSLNPPMGYGPR------MQQTSGQNQFLSQTQFP 772

  Fly  1246 QQGM---LLPQSPFSNSTPLQQQQQQQQQQQQQQQATSNSFSSP-MQQQQQG---------QQQQ 1297
            .|||   .:|.:|.|:..|:         .|.|..::|...:|| |....||         ||..
  Rat   773 SQGMNVTNMPLAPSSSQAPV---------SQAQMSSSSCPVNSPIMPPGSQGSHIHCPTLPQQAH 828

  Fly  1298 QQKPGSVLNNMPP---TPTSLEALNAGAGAPGTGGSASNVTVSAPSPSPGFLSNGPSIGTPSNNN 1359
            |..|..|.:..|.   ||.|:          ||...|: ..:.||.|:|      |::       
  Rat   829 QNSPSPVPSRTPTPHHTPPSI----------GTQQPAA-TAIPAPVPTP------PAM------- 869

  Fly  1360 NNSSANNNPPSVSSLMQQPLSNRPGTPP------YIPASPVPATSASGLAASSTPASAAATCASS 1418
                    ||.......:|.|.:..|||      ..|:.|||....|    ...|.|..:|.|  
  Rat   870 --------PPGAQPQSLRPPSRQTPTPPTHLPPQVQPSLPVPPADQS----QPQPRSQQSTAA-- 920

  Fly  1419 GSGSNSSSGATAAGASSTSSSSSAGSGTPLSSVSTPTSATMATSSGGGGGGGGNAGGGSSTTPAS 1483
                                           ||.|||:..:..               ...||.|
  Rat   921 -------------------------------SVPTPTAPLLPP---------------QPPTPLS 939

  Fly  1484 NPLLLMSGGTAGGGTGATTTTSTSSSSRMMSSSSSLSSQMAALEAAARDNDDETPSPSGENTNGS 1548
            .|.:.:.|..    :...:|:||..:|:.:....  .||...:|...   |.:.|.|:.      
  Rat   940 QPAVSVEGQV----SNPPSTSSTEVNSQTIPEKQ--PSQEVKMEVKM---DVDQPEPAD------ 989

  Fly  1549 GGSGNAGGMASKGKLDSIKQDDDIKKEFMDDSCGGNNDSSQMDCSTGGGKGKNVNNDGTSMIKME 1613
                              .|.||.|                                       |
  Rat   990 ------------------AQPDDTK---------------------------------------E 997

  Fly  1614 IKTEDGLDGEVKIKTEAMDVDEAGGSTAGEHHGEGGGGSGVGGGKDNINGAHDGGATGGAVDIKP 1678
            .|.|||       |.|..:.:|.|...                 |..:....|          :|
  Rat   998 AKAEDG-------KVEPTETEERGPEL-----------------KTEVKEEED----------QP 1028

  Fly  1679 KTETKPLVPEPLAPNAGDKKKKCQFNPEELRTALLPTLEKLYRQEPESVPFRYPVDPQALGIPDY 1743
            .|......|.|     |..|||. |.|||||.||:||||.||||:|||:|||.|||||.||||||
  Rat  1029 STSAAQSSPAP-----GQSKKKI-FKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDY 1087

  Fly  1744 FEIVKKPMDLGTIRTNIQNGKYSDPWEYVDDVWLMFDNAWLYNRKTSRVYRYCTKLSEVFEAEID 1808
            |:|||.||||.||:..:..|:|.:||:|:||:||||:|||||||||||||:||:|||||||.|||
  Rat  1088 FDIVKSPMDLSTIKRKLDTGQYQEPWQYIDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVFEQEID 1152

  Fly  1809 PVMQALGYCCGRKYTFNPQVLCCYGKQLCTIPRDAKYYSYQNSLKEYGVASNRYTYCQKCFNDIQ 1873
            ||||:||||||||..|:||.|||||||||||||||.|||||          |||.:|:||||:||
  Rat  1153 PVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQ----------NRYHFCEKCFNEIQ 1207

  Fly  1874 GDTVTLGDDPLQSQTQIKKDQFKEMKNDHLELEPFVNCQECGRKQHQICVLWLDSIWPGGFVCDN 1938
            |::|:|||||.|.||.|.|:||.:.|||.|:.|.||.|.|||||.||||||..:.|||.|||||.
  Rat  1208 GESVSLGDDPSQPQTTINKEQFSKRKNDTLDPELFVECTECGRKMHQICVLHHEVIWPSGFVCDG 1272

  Fly  1939 CLKKKNSKRKENKFNAKRLPTTKLGVYIETRVNNFLKKK-EAGAGEVHIRVVSSSDKCVEVKPGM 2002
            ||||....||||||:|||||:|:||.::|.|||:||::: ...:|||.:|||.:|||.|||||||
  Rat  1273 CLKKTARTRKENKFSAKRLPSTRLGTFLENRVNDFLRRQNHPESGEVTVRVVHASDKTVEVKPGM 1337

  Fly  2003 RRRFVEQGEMMNEFPYRAKALFAFEEVDGIDVCFFGMHVQEYGSECPAPNTRRVYIAYLDSVHFF 2067
            :.|||:.|||...||||.||||||||:||:|:||||||||||||:||.||.|||||:||||||||
  Rat  1338 KARFVDSGEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHFF 1402

  Fly  2068 RPRQYRTAVYHEILLGYMDYVKQLGYTMAHIWACPPSEGDDYIFHCHPTDQKIPKPKRLQEWYKK 2132
            ||:..|||||||||:||::|||:||||..|||||||||||||||||||.||||||||||||||||
  Rat  1403 RPKCLRTAVYHEILIGYLEYVKKLGYTTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKK 1467

  Fly  2133 MLDKGMIERIIQDYKDILKQAMEDKLGSAAELPYFEGDFWPNVLEESIKELDQEEEEKRKQAEAA 2197
            ||||.:.|||:.|||||||||.||:|.||.|||||||||||||||||||||:|||||::::... 
  Rat  1468 MLDKAVSERIVHDYKDILKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENT- 1531

  Fly  2198 EAAAAANLFSIEENEVS-GDGKKKGQKKAKKSNKSKAA-QRKNSKKSNEHQSGNDLSTKIYATME 2260
                     |.|..:|: ||.|...:|..||::|:|:: .|.|.||.......||||.|:|||||
  Rat  1532 ---------SNESTDVTKGDSKNAKKKNNKKTSKNKSSLSRGNKKKPGVPNVSNDLSQKLYATME 1587

  Fly  2261 KHKEVFFVIRLHSAQSAASLAPIQDPDPLLTCDLMDGRDAFLTLARDKHFEFSSLRRAQFSTLSM 2325
            |||||||||||.:..:..||.||.|||||:.||||||||||||||||||.|||||||||:||:.|
  Rat  1588 KHKEVFFVIRLIACPAPNSLPPIVDPDPLIPCDLMDGRDAFLTLARDKHLEFSSLRRAQWSTMCM 1652

  Fly  2326 LYELHNQGQDKFVYTCNHCKTAVETRYHCTVCDDFDLCIVCKEKVGHQHKMEKLGFDIDDGSALA 2390
            |.|||.|.||:||||||.||..||||:|||||:|:||||.|.....|.|||||||..:||.|   
  Rat  1653 LVELHTQSQDRFVYTCNECKHHVETRWHCTVCEDYDLCITCYNTKNHDHKMEKLGLGLDDES--- 1714

  Fly  2391 DHKQA----NPQEARKQSIQRCIQSLAHACQCRDANCRLPSCQKMKLVVQHTKNCKRKPNGGCPI 2451
            :::||    :|.::|:.|||||||||.||||||:|||.||||||||.||||||.||||.||||||
  Rat  1715 NNQQAAATQSPGDSRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPI 1779

  Fly  2452 CKQLIALCCYHAKNCEEQKCPVPFCPNIKHKLKQQQSQQKFQQQQLLRRRVALMSRTAAPAALQG 2516
            |||||||||||||:|:|.|||||||.|||.||:|||.|.:.||.|:||||:|.|.||......||
  Rat  1780 CKQLIALCCYHAKHCQENKCPVPFCLNIKQKLRQQQLQHRLQQAQMLRRRMASMQRTGVAGQQQG 1844

  Fly  2517 -----PAAVSGPTVVSGGVPVVGMSGVAVSQQVIP---GQAGILPPGAGGMSP--STVAVPSPVS 2571
                 ||.   ||..:|..|       |..|...|   .|....||  ..|:|  .......|||
  Rat  1845 LPSPTPAT---PTTPTGQQP-------ATPQTPQPQPTSQPQPTPP--NNMTPYLPRTQTAGPVS 1897

  Fly  2572 GGAGAGGMGGMTSPHPHQPGIGMKPGGGHSPSPNVLQVVKQVQEEAARQ-QVSHGGGFGKGV--- 2632
            .|..||.:...|.|...||.:   ||    |.|..:::..|:|..|..| |::|...|.:.:   
  Rat  1898 QGKAAGQVTPPTPPQTAQPPL---PG----PPPAAVEMAMQIQRAAETQRQMAHVQIFQRPIQHQ 1955

  Fly  2633 --PMAPPVMNRPMGGAGPNQNVVNQLGGMGVGVGGVGGVGVGGVGGVGVNQLNSGGGNTPGAPIS 2695
              ||||..||.|....||                                     ||:.      
  Rat  1956 MAPMAPMGMNPPPMARGP-------------------------------------GGHL------ 1977

  Fly  2696 GPGMNVNHLMSMDQWGGGGAGGGGANPGGGNPQARYANNTGGMRQPTHVMQTNLIPPQQQQQMMG 2760
            .|||                     .|.|...|..:|.  |||.||              |||..
  Rat  1978 DPGM---------------------GPAGMQQQPPWAQ--GGMPQP--------------QQMQS 2005

  Fly  2761 GLGGPNQLGGGQMPVGGQHGGMGMGMGAPPMAGTVGGVRPSPGAGGGGGSATGGGLNTQQ-LALI 2824
            |:..|     ..|.| .|||        .|:     .:.|.||.|..|.|....|..:|| |..:
  Rat  2006 GMPRP-----AMMSV-AQHG--------QPL-----NMAPQPGLGQVGVSPLKPGTVSQQALQNL 2051

  Fly  2825 MQKIKNNPTNESNQHILAILKQNPQIMAAIIKQRQQSQNNAAAGGGAPGPGGALQQQQAGNGPQN 2889
            ::.:::..:....|.:|:||..|||::||.||||.....|:                       |
  Rat  2052 LRTLRSPSSPLQQQQVLSILHANPQLLAAFIKQRAAKYANS-----------------------N 2093

  Fly  2890 PQQQQQQQQQQQVMQQQQMQHMMNQQQGGGGPQQMNPNQQQQQQQVNLMQQQQQGGPGGPGSGLP 2954
            ||..                                                    ||.||    
  Rat  2094 PQPL----------------------------------------------------PGQPG---- 2102

  Fly  2955 TRMPNMPNALGMLQSLPPNMSPGVSTQGGMVPN---QNWNKMRY-MQMSQYPPPYPQRQRGPHMG 3015
                 ||.....||  ||.| ||   |.|:..|   ||.|.|:. :|.:..|...||:|..|.||
  Rat  2103 -----MPQGQPGLQ--PPTM-PG---QQGVHSNPALQNMNPMQAGVQRAGLPQQQPQQQLQPPMG 2156

  Fly  3016 GAGPGPGQQQFPGGGGGAGNFNAGGAGGAGGVVGVGGVPGGAGTVPGGDQYSMANAAAASNMLQQ 3080
            |..|...|...        |.|                     |:|     |.........|:||
  Rat  2157 GMSPQAQQMNM--------NHN---------------------TMP-----SQFRDILRRQMMQQ 2187

  Fly  3081 QQGQVGVGVGVGVKPG---PGQQQQQMGVGMPPGMQQQQQQQQPLQQQQMMQVAMPNANAQNPSA 3142
            |      |.|.|:.||   ..|.||..|:|.||..|||||||:.....|.||........|.|.|
  Rat  2188 Q------GAGPGIGPGMANHNQFQQPQGIGYPPQQQQQQQQQRMQHHMQQMQQGNMGQMGQLPQA 2246

  Fly  3143 VVGGPNA-----------QVMG---PPTPHSLQQQLMQSARSSP-------------PIRSPQPT 3180
            :.....|           |.||   .|.|.|.||.::.:...||             .:|||||.
  Rat  2247 LGAEAGASLQAYQQRLLQQQMGSPAQPNPMSPQQHMLPNQAQSPHLQGQQIPNSLSNQVRSPQPV 2311

  Fly  3181 PSPR-------SAPSPRAAPSASPRAQPSPHHVMSSHSPAPQ-GPPHDGM 3222
            ||||       |:||||..|      |||||||      :|| ..||.|:
  Rat  2312 PSPRPQSQPPHSSPSPRMQP------QPSPHHV------SPQTSSPHPGL 2349

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nejNP_001188575.1 ZnF_TAZ 530..600 CDD:214717 34/69 (49%)
KIX 946..1024 CDD:280354 57/77 (74%)
Bromo_cbp_like 1705..1812 CDD:99927 80/106 (75%)
RING_CBP-p300 1824..1906 CDD:276805 51/81 (63%)
PHD_CBP_p300 1908..1939 CDD:277032 22/30 (73%)
HAT_KAT11 1970..2283 CDD:285432 210/315 (67%)
ZZ_CBP 2339..2379 CDD:239077 26/39 (67%)
ZnF_TAZ 2404..2476 CDD:214717 62/71 (87%)
Ep300XP_038936215.1 Med15 80..>323 CDD:312941 90/459 (20%)
zf-TAZ 348..415 CDD:396624 33/66 (50%)
KIX 567..647 CDD:366953 58/83 (70%)
Med15 <654..>857 CDD:312941 73/317 (23%)
Bromo_cbp_like 1049..1156 CDD:99927 80/106 (75%)
RING_CBP-p300 1168..1240 CDD:276805 51/81 (63%)
PHD_p300 1241..1275 CDD:277116 23/33 (70%)
HAT_KAT11 1304..1610 CDD:400497 210/315 (67%)
ZZ_CBP 1666..1706 CDD:239077 26/39 (67%)
zf-TAZ 1733..1801 CDD:396624 58/67 (87%)
Med15 1956..>2335 CDD:312941 154/613 (25%)
Creb_binding 1989..2093 CDD:401102 42/161 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 128 1.000 Domainoid score I5187
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001062
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_101987
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.900

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