DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nej and Brd2

DIOPT Version :9

Sequence 1:	NP_001188575.1	Gene:	nej / 43856	FlyBaseID:	FBgn0261617	Length:	3282	Species:	Drosophila melanogaster
Sequence 2:	NP_001191902.1	Gene:	Brd2 / 14312	MGIID:	99495	Length:	798	Species:	Mus musculus

Alignment Length:	796	Identity:	157/796 - (19%)
Similarity:	257/796 - (32%)	Gaps:	270/796 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1673 AVDIKPKTETKPLVPEPLAPNAGDKKKKCQFNPEELRTALLPTLEKLYRQEPESVPFRYPVDPQA 1737
            |:.:.|.....|.|..|..|  |....:.|:    |...::..|.|    ...:.|||.|||...
Mouse    52 ALQLAPANPPPPEVSNPKKP--GRVTNQLQY----LHKVVMKALWK----HQFAWPFRQPVDAVK 106

  Fly  1738 LGIPDYFEIVKKPMDLGTIRTNIQNGKYSDPWEYVDDVWLMFDNAWLYNRKTSRVYRYCTKLSEV 1802
            ||:|||.:|:|:|||:|||:..::|..|....|.:.|...||.|.::||:.|..:......|.::
Mouse   107 LGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKI 171

  Fly  1803 FEAEIDPVMQALGYCCGRKYTFNPQVLCCYGKQLCTIPRD-----AKYYSYQNSLKEY----GVA 1858
            |..::..:.|            ..|.|      :.|||::     ||..:.|.|:...    .|:
Mouse   172 FLQKVASMPQ------------EEQEL------VVTIPKNSHKKGAKLAALQGSITSAHQVPAVS 218

  Fly  1859 SNRYTYCQKCFNDIQGDTVTLGDDPLQSQTQIKKDQFKEMKNDHLELEPFVNCQECGRKQHQI-- 1921
            |..:|              .|...|.:..|.:       :...|    |.|......:..|..
Mouse   219 SVSHT--------------ALYTPPPEIPTTV-------LNIPH----PSVISSPLLKSLHSAGP 258

  Fly  1922 CVLWLDSIWPGGFVCDNCLKKKNSKRKEN----------------------KFNAKRLPTTKLGV 1964
            .:|.:.:..|    .....|||..|||.:                      :..|.|||.
Mouse   259 PLLAVSAAPP----AQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPP----- 314

  Fly  1965 YIETRVNNFLKKKEAGAGEVHIRVVSSSDKCVEVKPGMRRRFVEQGEMMNEFPYRAKALFAFEEV 2029
                      .::|:|.               .:||  .|:.:...:..::...:.|.....:..
Mouse   315 ----------MRRESGR---------------PIKP--PRKDLPDSQQQHQSSKKGKLSEQLKHC 352

  Fly  2030 DGIDVCFFGMHVQEYGSECPAPNTRRVYIAYLDSVHFFRPRQYRTAVYHEILLGYMDYVKQLGYT 2094
            :||        ::|..|        :.:.||  :..|::|........|:    |.|.:|
Mouse   353 NGI--------LKELLS--------KKHAAY--AWPFYKPVDASALGLHD----YHDIIK----- 390

  Fly  2095 MAHIWACPPSEGDDYIFHCHPTDQKIPKPKRLQEWYKKMLDKGMIERII--QDYK------DILK 2151
                               ||.|....|.|.....|:...:.....|::  ..||      |::
Mouse   391 -------------------HPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVV- 435

  Fly  2152 QAMEDKLGSAAELPYF---EGDFWPNVL-------------------EESIKELDQEEEEKRKQA 2194
             ||..||....|..|.   :....|..|                   |||..|...||||:.::.
Mouse   436 -AMARKLQDVFEFRYAKMPDEPLEPGPLPVSTALPPGLTKSSSESSSEESSSESSSEEEEEEEED 499

  Fly  2195 EAAEAAAAAN----------------------LFSIEENEVSGDGKKKGQKKAKKSNKS------ 2231
            |..|.:.:::                      |.::.:..:|...:|:.:|:.||..|:
Mouse   500 EDEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGR 564

  Fly  2232 -------------KAAQRKNSKKSN---------EH----QSGNDLSTKIYATMEKHKEVFFVIR 2270
                         :..|.|.|||:.         .|    .||.. |.|:....:|.........
Mouse   565 IGIDEDDKGPRAPRPPQPKKSKKAGGGGSNATTLSHPGFGTSGGS-SNKLPKKSQKTAPPVLPTG 628

  Fly  2271 LHSAQSAASLAPIQDPDPLLTCDLMD------GRDAFLTLARDKHFEFSSLRRAQ--FSTL--SM 2325
            ..|.:...|.....|....|:.|:..      ||...:..||:.....|:....:  |.||  |.
Mouse   629 YDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPST 693

  Fly  2326 LYELHNQGQDKFVYTC 2341
            |.||     :::|.:|
Mouse   694 LREL-----ERYVLSC 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nej	NP_001188575.1	ZnF_TAZ	530..600	CDD:214717
		KIX	946..1024	CDD:280354
		Bromo_cbp_like	1705..1812	CDD:99927	34/106 (32%)
		RING_CBP-p300	1824..1906	CDD:276805	16/90 (18%)
		PHD_CBP_p300	1908..1939	CDD:277032	4/32 (13%)
		HAT_KAT11	1970..2283	CDD:285432	66/396 (17%)
		ZZ_CBP	2339..2379	CDD:239077	1/3 (33%)
		ZnF_TAZ	2404..2476	CDD:214717
Brd2	NP_001191902.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..72		5/20 (25%)
		Bromo_Brdt_I_like	73..179	CDD:99929	35/113 (31%)
		PHA03247	<215..332	CDD:223021	27/177 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..348		17/116 (15%)
		Bromo_Brdt_II_like	348..449	CDD:99930	27/148 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	454..645		33/191 (17%)
		Nuclear localization signal. /evidence=ECO:0000255	553..557		2/3 (67%)
		BET	639..701	CDD:407211	15/66 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	736..798
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810