Protein Alignment nej and Crebbp

DIOPT Version :10

• Sequence 1: NP_001188575.1
• Gene: nej / 43856
• FlyBaseID: FBgn0261617
• Length: 3282
• Species: Drosophila melanogaster
• Sequence 2: XP_006521814.1
• Gene: Crebbp / 12914
• MGIID: 1098280
• Length: 2451
• Species: Mus musculus
• Alignment Length: 3434
• Identity: 1192/3434 - (34%)
• Similarity: 1469/3434 - (42%)
• Gaps: 1136/3434 - (33%)

  Fly     2 MADH-LDEPPQ-KRVKM--------DPTDIS--YFLEENLPDELVSS------NSG--------- 39
            ||:: ||.||. ||.|:        |.||..  :.||.:|||||:.:      |||
Mouse     1 MAENLLDGPPNPKRAKLSSPGFSANDNTDFGSLFDLENDLPDELIPNGELSLLNSGNLVPDAASK 65

  Fly    40 ---WSDQLTGGAGGGNGGGGASGVTTNPTSGPNPGGG---PNKPAAQGPGSGTGGVGVGVNVGVG 98
               .|:.|.||:|                |..|||.|   .:.|..||.|....|.....|:...
Mouse    66 HKQLSELLRGGSG----------------SSINPGIGNVSASSPVQQGLGGQAQGQPNSTNMASL 114

  Fly    99 GVVGVGVVPSQMNGAGGGNGSGTGGDDGSGNGSGAGNRISQMQHQQLQHLLQQQQQGQKGAMVVP 163
            |.:|    .|.:|          .||..:.|                   |.:|.....|. ..|
Mouse   115 GAMG----KSPLN----------QGDSSTPN-------------------LPKQAASTSGP-TPP 145

  Fly   164 GMQQLGSKSPNLQSPNQGGMQQVVGTQMGMVNSMPMSISNNGNNGMNAIPGMNTIAQGNLGNMVL 228
            ..|.|   :|..|.            |:|:|.|.|                             .
Mouse   146 ASQAL---NPQAQK------------QVGLVTSSP-----------------------------A 166

  Fly   229 TNSVGGGMGGMVNHLKQQPGGGGGGMINSVSVPGGPGAGAGGVGAGGGGAVAANQGMHMQNGPMM 293
            |:..|.|:....|..:..|     |::||                        |.|..:.|....
Mouse   167 TSQTGPGICMNANFNQTHP-----GLLNS------------------------NSGHSLMNQAQQ 202

  Fly   294 GRMVGQQHMLRGPHLMGASGGAGGPGNGPGGGGPRMQNPNMQMNFRPFAAQLNSLPYGVGQYGGP 358
            |:          ..:|..|.||.|.|.|.|     |..|...|.....:....:|.....|..|.
Mouse   203 GQ----------AQVMNGSLGAAGRGRGAG-----MPYPAPAMQGATSSVLAETLTQVSPQMAGH 252

  Fly   359 GGGNNPQQQQQQQQQQLLAQQMAQRGGVVP-GMPQGNRPVGTVVPMSTLGGDGSGPAGQLVSGNP 422
            .|.|.                 ||.||:.. ||.....|.|.  |.|..||...|..|.    ||
Mouse   253 AGLNT-----------------AQAGGMTKMGMTGTTSPFGQ--PFSQTGGQQMGATGV----NP 294

  Fly   423 QQQQMLAQQQTGAMGPRPPQPNQLLGHPGQQQQQQQQPGTSQQQQQQQGVGIGGAGVVANAGTVA 487
            |    ||.:|: .:...|..|..:     :.......|..|   |.|..|||
Mouse   295 Q----LASKQS-MVNSLPAFPTDI-----KNTSVTTVPNMS---QLQTSVGI------------- 333

  Fly   488 GVPAVAGGGAGGAVQSSGPGGANRDVPDDRKRQ-IQQQLMLLLHAHKCNRRENLNPNREVCNVNY 551
             ||..|        .::||      ..|..||: |||||:||||||||.|||..|.....|::.:
Mouse   334 -VPTQA--------IATGP------TADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPH 383

  Fly   552 CKAMKSVLAHMGTCKQSKDCTMQHCASSRQILLHYKTCQNSGCVICYPFRQNHSVFQNANVPPGG 616
            |:.||:||.||..|:..|.|.:.||||||||:.|:|.|....|.:|.|.: |.|..:|...
Mouse   384 CRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLK-NASDKRNQQT---- 443

  Fly   617 GPAGIGGAPPGGGGAGGGAAGAGGNLQQQQQQQQQQQQNQQPNLTGLVVDGKQGQQVAPGGGQNT 681
                |.|:|..|.....|:.|||       ||......|..|              :.|.
Mouse   444 ----ILGSPASGIQNTIGSVGAG-------QQNATSLSNPNP--------------IDPS----- 478

  Fly   682 AIVLPQQQGAGGAPGAPKTPADMVQQLTQQQQQQQQQVHQQQVQQQELRRFDGMSQQVVAGGMQQ 746
                 ..|.|..|.|.|        .:.|.|.|.|.||..||..|
Mouse   479 -----SMQRAYAALGLP--------YMNQPQTQLQPQVPGQQPAQ-------------------- 510

  Fly   747 QQQQGLPPVIRIQGAQPAVRVLGPGGPGGPSGPNVLPNDVNSLHQQQQQMLQQQQQQGQNRRRGG 811
                  ||.                                  |||.:.:
Mouse   511 ------PPA----------------------------------HQQMRTL--------------- 520

  Fly   812 LATMVEQQQQHQQQQQQPNPAQLGGNIPAPLSVNVGGFGNTNFGGAAAGGAVGANDKQQLKVAQV 876
                                ..||.|   |:|:..||.               ..|:|...:.
Mouse   521 --------------------NALGNN---PMSIPAGGI---------------TTDQQPPNLI-- 545

  Fly   877 HPQSHGVGAGGASAGAGASGGQVAAGSSVLMPADTTGSGNAGNPNQNAGGVAGGAGGGNGGNTG- 940
                                      |...:|.    |..|.||..|        .|.|.||.|
Mouse   546 --------------------------SESALPT----SLGATNPLMN--------DGSNSGNIGS 572

  Fly   941 --------PPGDN--EKDWRESVTADLRNHLVHKLVQAIFPTSDPTTMQDKRMHNLVSYAEKVEK 995
                    ||...  .|.|.|.||.|||:|||||||||||||.||..::|:||.|||:||:|||.
Mouse   573 LSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEG 637

  Fly   996 DMYEMAKSRSEYYHLLAEKIYKIQKELEEKRLKRKEQHQQMLMQQQGVANPVAGGAAGGAGSAAG 1060
            ||||.|.||.|||||||||||||||||||||  |...|:|.::..| .|.|.:|........|..
Mouse   638 DMYESANSRDEYYHLLAEKIYKIQKELEEKR--RSRLHKQGILGNQ-PALPASGAQPPVIPPAQS 699

  Fly  1061 VA---GGVVLPQQQQQQQQQQQQQGQQPLQSCIHPSISPM--GGVMPPQQLRPQGPPGILGQQTA 1120
            |.   |.:.||..:.|..|...             |.:||  |.|..||  .|.||
Mouse   700 VRPPNGPLPLPVNRMQVSQGMN-------------SFNPMSLGNVQLPQ--APMGP--------- 740

  Fly  1121 AGLGVGVGVTNNMVTMRSHSPGGNMLALQQQQRMQFPQQQQQQPPGSGAGKMLVGPPGPSPGGMV 1185
                            |:.||..:  ::|.......|                         ||.
Mouse   741 ----------------RAASPMNH--SVQMNSMASVP-------------------------GMA 762

  Fly  1186 VNPALSPYQTTNVLTSPVPGQQQQQQFINANGGTGANPQLSEIMKQRHIHQQQQQQQQQQQQGML 1250
            ::|:..| |..|::                  ||.||    .||            .|...|...
Mouse   763 ISPSRMP-QPPNMM------------------GTHAN----NIM------------AQAPTQNQF 792

  Fly  1251 LPQSPFSNSTPLQQQQQQQQQQQQQQQATSNSFSSPMQQQQQGQQQQQQKPGSVLNNMPPTPTSL 1315
            |||:.|.:|:...........|...|...|                |.|.||:.|    |.|.::
Mouse   793 LPQNQFPSSSGAMSVNSVGMGQPAAQAGVS----------------QGQVPGAAL----PNPLNM 837

  Fly  1316 EALNAGAGAPGTGGSASNVTVSA--PSPSPGFLSNGPSIGTPSNNNNNSSANNNPPSVSSLMQQP 1378
            .|..| :..|     ...||.|.  |:|.|.    ..:.|.||                  :|.|
Mouse   838 LAPQA-SQLP-----CPPVTQSPLHPTPPPA----STAAGMPS------------------LQHP 874

  Fly  1379 LSNRPGTPPYIPASPV-PATSASGLAASSTPASAAATCASSGSGSNSSSGATAAGASSTSSSSSA 1442
            .:  ||..|..||:|. |:|..|   :..||.....:..|:....::.:...||.|..|....
Mouse   875 TA--PGMTPPQPAAPTQPSTPVS---SGQTPTPTPGSVPSAAQTQSTPTVQAAAQAQVTPQPQ-- 932

  Fly  1443 GSGTPLS--SVSTPTSATMATSSGGGGGGGGNAGGGSSTTPASNPLLLMSGGTAGGGTGATTTTS 1505
               ||:.  ||:||.|:....:.             ..|.|...||   |...|.......|.:|
Mouse   933 ---TPVQPPSVATPQSSQQQPTP-------------VHTQPPGTPL---SQAAASIDNRVPTPSS 978

  Fly  1506 TSSSSRMMSSSSSLSSQMAALEAAAR-DNDDETPSPSGENTNGSGGSGNAGGMASKGKLDSIKQD 1569
            .:|:.   :||......:..||.... ..||..|.|:                .|||:..|...:
Mouse   979 VTSAE---TSSQQPGPDVPMLEMKTEVQTDDAEPEPT----------------ESKGEPRSEMME 1024

  Fly  1570 DDIKKEFMDDSCGGNNDSSQMDCSTGGGKGKNVNNDGTSMIKMEIKTEDGLDGEVKIKTEAMDVD 1634
            :|::                                |:|.:|.|..|.:.       |:|.|:|:
Mouse  1025 EDLQ--------------------------------GSSQVKEETDTTEQ-------KSEPMEVE 1050

  Fly  1635 EAGGSTAGEHHGEGGGGSGVGGGKDNINGAHDGGATGGAVDIKPKTETKPLVPEPLAPNAGDKKK 1699
            |......            |...::..|.::|..:          ..|.|..|          :|
Mouse  1051 EKKPEVK------------VEAKEEEENSSNDTAS----------QSTSPSQP----------RK 1083

  Fly  1700 KCQFNPEELRTALLPTLEKLYRQEPESVPFRYPVDPQALGIPDYFEIVKKPMDLGTIRTNIQNGK 1764
            |. |.|||||.||:||||.||||:|||:|||.|||||.|||||||:|||.||||.||:..:..|:
Mouse  1084 KI-FKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQ 1147

  Fly  1765 YSDPWEYVDDVWLMFDNAWLYNRKTSRVYRYCTKLSEVFEAEIDPVMQALGYCCGRKYTFNPQVL 1829
            |.:||:|||||||||:|||||||||||||::|:||:||||.|||||||:|||||||||.|:||.|
Mouse  1148 YQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTL 1212

  Fly  1830 CCYGKQLCTIPRDAKYYSYQNSLKEYGVASNRYTYCQKCFNDIQGDTVTLGDDPLQSQTQIKKDQ 1894
            ||||||||||||||.|||||||..:||:.::||.:|:|||.:|||:.|||||||.|.||.|.|||
Mouse  1213 CCYGKQLCTIPRDAAYYSYQNSSPKYGLLADRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQ 1277

  Fly  1895 FKEMKNDHLELEPFVNCQECGRKQHQICVLWLDSIWPGGFVCDNCLKKKNSKRKENKFNAKRLPT 1959
            |::.|||.|:.||||:|:|||||.||||||..|.|||.||||||||||....||||||:||||.|
Mouse  1278 FEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQT 1342

  Fly  1960 TKLGVYIETRVNNFLKKK-EAGAGEVHIRVVSSSDKCVEVKPGMRRRFVEQGEMMNEFPYRAKAL 2023
            |:||.::|.|||.||::: ...||||.:|||:||||.|||||||:.|||:.|||...||||.|||
Mouse  1343 TRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKAL 1407

  Fly  2024 FAFEEVDGIDVCFFGMHVQEYGSECPAPNTRRVYIAYLDSVHFFRPRQYRTAVYHEILLGYMDYV 2088
            |||||:||:||||||||||||||:||.||||||||:||||:||||||..|||||||||:||::||
Mouse  1408 FAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYV 1472

  Fly  2089 KQLGYTMAHIWACPPSEGDDYIFHCHPTDQKIPKPKRLQEWYKKMLDKGMIERIIQDYKDILKQA 2153
            |:|||...|||||||||||||||||||.||||||||||||||||||||...||||.|||||.|||
Mouse  1473 KKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIINDYKDIFKQA 1537

  Fly  2154 MEDKLGSAAELPYFEGDFWPNVLEESIKELDQEEEEKRKQAEAAEAAAAANLFSIEENEVS-GDG 2217
            .||:|.||.|||||||||||||||||||||:|||||::|:    |:.||:     |..|.| ||.
Mouse  1538 NEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKE----ESTAAS-----ETPEGSQGDS 1593

  Fly  2218 KKKGQKKAKKSNKSKAA-QRKNSKKSNEHQSGNDLSTKIYATMEKHKEVFFVIRLHSAQSAASLA 2281
            |...:|..||:||:|:: .|.|.||.:.....||||.|:||||||||||||||.||:....::..
Mouse  1594 KNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVISTQP 1658

  Fly  2282 PIQDPDPLLTCDLMDGRDAFLTLARDKHFEFSSLRRAQFSTLSMLYELHNQGQDKFVYTCNHCKT 2346
            ||.||||||:||||||||||||||||||:|||||||:::|||.||.|||.||||:||||||.||.
Mouse  1659 PIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKH 1723

  Fly  2347 AVETRYHCTVCDDFDLCIVCKEKVGHQHKMEKLGFDIDD-GSALADHKQANPQEARKQSIQRCIQ 2410
            .||||:|||||:|:||||.|.....|.|||.|.|..:|| ||:..:.:..:|||:|:.|||||||
Mouse  1724 HVETRWHCTVCEDYDLCINCYNTKSHTHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQ 1788

  Fly  2411 SLAHACQCRDANCRLPSCQKMKLVVQHTKNCKRKPNGGCPICKQLIALCCYHAKNCEEQKCPVPF 2475
            ||.||||||:|||.||||||||.||||||.||||.|||||:|||||||||||||:|:|.||||||
Mouse  1789 SLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPF 1853

  Fly  2476 CPNIKHKLKQQQSQQKFQQQQLLRRRVALMSRTAAPAALQGPAAVSGPTVVSGGVPVVGMSGVAV 2540
            |.||||||:|||.|.:.||.||:|||:|.|:....|
Mouse  1854 CLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVP----------------------------- 1889

  Fly  2541 SQQVIPGQAGILPPGAGGMSPSTVAVPSPVSGGAGAGGMGGMTSPHPHQPG-IGMKPGG------ 2598
             ||.:|.... .|||.....|||...|.|               |...||. :.|.|.|
Mouse  1890 -QQSLPSPTS-APPGTPTQQPSTPQTPQP---------------PAQPQPSPVNMSPAGFPNVAR 1937

  Fly  2599 ---------------------GHSPSPNVLQVVKQVQEEAARQQVSHGGGFGKGVPMAPPVMNRP 2642
                                 ...|.|..::..:|::.||.:||..:......|:|
Mouse  1938 TQPPTIVSAGKPTNQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRANINNGMP--------- 1993

  Fly  2643 MGGAGPNQNVVNQLGGMGVGVGGVGGVGVGGVGGVGVNQLNSGGGNTPGA-PISGPGMNVNHLMS 2706
                                 .|..|:|..|      :|:...|.|.|.. .:|||.|:   .|.
Mouse  1994 ---------------------PGRAGMGTPG------SQMTPVGLNVPRPNQVSGPVMS---SMP 2028

  Fly  2707 MDQWGGGGAGGGGANPGGGNPQARYANNTGGMRQPTHVMQTNLIPPQQQQQMMGGLGGPNQLGGG 2771
            ..||                .||                      |..|||.|.|:..|......
Mouse  2029 PGQW----------------QQA----------------------PIPQQQPMPGMPRPVMSMQA 2055

  Fly  2772 QMPVGGQHGGMGMGMGAPPMAGTVGGVRP----SPGAGGGGGSATGGGLNTQQLALIMQKIKNNP 2832
            |..|.|           |.|.    .|:|    ||.|                |..:::.:|:..
Mouse  2056 QAAVAG-----------PRMP----NVQPPRSISPSA----------------LQDLLRTLKSPS 2089

  Fly  2833 TNESNQHILAILKQNPQIMAAIIKQRQQSQNNAAAGGGAPGPGGALQQQQAGNGPQNPQQQQQQQ 2897
            :.:..|.:|.|||.|||:|||.|||| .::..|...|..|.||   .|.|.|..||....||...
Mouse  2090 SPQQQQQVLNILKSNPQLMAAFIKQR-TAKYVANQPGMQPQPG---LQSQPGMQPQPGMHQQPSL 2150

  Fly  2898 QQQQVMQ--------------------QQQMQHMMNQQQGGGGPQQMNPN-------------QQ 2929
            |....||                    |.|..::||.   |..|...|.|             .|
Mouse  2151 QNLNAMQAGVPRPGVPPPQPAMGGLNPQGQALNIMNP---GHNPNMTNMNPQYREMVRRQLLQHQ 2212

  Fly  2930 QQQQQVNLMQQQQQGGPGGPGSGLPTRMPNMPNALGMLQSLPPNMSPGVSTQGGMVPNQNWNKMR 2994
            |||||....|||||.                                ..|..|||..:
Mouse  2213 QQQQQQQQQQQQQQN--------------------------------SASLAGGMAGH------- 2238

  Fly  2995 YMQMSQYPPPYPQRQRGPHMGGAGPGPGQQQ----FPGGGGGAGNFNAGGAGGAGGVVGVGGVPG 3055
                ||:     |:.:||  ||..|...||:    .|..|...|...|     ..|.:|..|.||
Mouse  2239 ----SQF-----QQPQGP--GGYAPAMQQQRMQQHLPIQGSSMGQMAA-----PMGQLGQMGQPG 2287

  Fly  3056 -GAGTVPGGDQYSMANAAAASNMLQQQQGQVGVGVGVGVKPGPGQQQQQMGVGMPPGMQQQQQQQ 3119
             ||.:.|...|      |....:||||                 |.:||:|   .||      |.
Mouse  2288 LGADSTPNIQQ------ALQQRILQQQ-----------------QMKQQIG---SPG------QP 2320

  Fly  3120 QPLQQQQMMQVAMPNANAQNPSAVVGGPNAQVMGPPTPHSLQQQLMQSARSSPPIRSPQP-TPSP 3183
            .|:..||.|....|.|             :.:.|.....||..|:    ||..|::||:| :..|
Mouse  2321 NPMSPQQHMLSGQPQA-------------SHLPGQQIATSLSNQV----RSPAPVQSPRPQSQPP 2368

  Fly  3184 RSAPSPRAAPSASPRAQPSPHHVMSSHSPAPQ-GPPHDGMHNHGMHHQSPLPGVPQDVGVGVGVG 3247
            .|:||||..|      |||||||      :|| |.||.|:                        .
Mouse  2369 HSSPSPRIQP------QPSPHHV------SPQTGSPHPGL------------------------A 2397

  Fly  3248 VGVGVNVNVGNVGVGNAGGALPD-------------------ASDQLTKFVERL 3282
            |.:..:::.|::|.......||.                   ..|.|.||||.|
Mouse  2398 VTMASSMDQGHLGNPEQSAMLPQLNTPNRSALSSELSLVGDTTGDTLEKFVEGL 2451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nej	NP_001188575.1	zf-TAZ	530..597	CDD:460457	32/66 (48%)
		KIX	944..1024	CDD:366953	58/81 (72%)
		Bromo_cbp_like	1705..1812	CDD:99927	80/106 (75%)
		RING_CBP-p300	1824..1906	CDD:276805	55/81 (68%)
		PHD_CBP_p300	1908..1939	CDD:277032	23/30 (77%)
		HAT_KAT11	1970..2284	CDD:400497	217/316 (69%)
		ZZ_CBP	2339..2379	CDD:239077	25/39 (64%)
		zf-TAZ	2405..2473	CDD:460457	57/67 (85%)
		NCBD_CREBBP-p300_like	2820..2862	CDD:411021	17/41 (41%)
		PLN02983	<3147..>3218	CDD:215533	27/72 (38%)
Crebbp	XP_006521814.1	zf-TAZ	362..429	CDD:460457	32/66 (48%)
		KIX	586..666	CDD:366953	58/79 (73%)
		PHA03247	<687..1037	CDD:223021	114/576 (20%)
		COG5076	942..>1194	CDD:227408	123/358 (34%)
		Bromo_cbp_like	1088..1195	CDD:99927	80/106 (75%)
		RING_CBP-p300	1207..1289	CDD:276805	55/81 (68%)
		PHD_CBP_p300	1291..1322	CDD:277032	23/30 (77%)
		HAT_KAT11	1353..1660	CDD:400497	216/315 (69%)
		ZZ_CBP	1716..1756	CDD:239077	25/39 (64%)
		zf-TAZ	1783..1851	CDD:460457	57/67 (85%)
		Med15	1971..>2361	CDD:312941	144/608 (24%)
		Creb_binding	2024..2125	CDD:462659	41/173 (24%)