DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nej and Baz2a

DIOPT Version :9

Sequence 1:	NP_001188575.1	Gene:	nej / 43856	FlyBaseID:	FBgn0261617	Length:	3282	Species:	Drosophila melanogaster
Sequence 2:	XP_011241580.1	Gene:	Baz2a / 116848	MGIID:	2151152	Length:	1888	Species:	Mus musculus

Alignment Length:	2205	Identity:	383/2205 - (17%)
Similarity:	629/2205 - (28%)	Gaps:	797/2205 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 GGPNKPAAQG----PGSGTG--GVGVGVNVGVGGVVGVGVVPSQMNGAGGGNGSGTGG---DDGS 127
            |.|..|||.|    |.||.|  ..|..:|....|        ..:||....||..|..   ..|.
Mouse    11 GLPPAPAASGLKPSPSSGEGLYTNGSPMNFPQQG--------KSLNGDVNVNGLSTVSHTTTSGI 67

  Fly   128 GNGSGAGNRISQMQHQQLQH--LLQQQQQGQKGAMVVPGMQQLGSKSPNLQSPNQGGMQQVVGTQ 190
            .|.:...:..|.:.|..:.:  |....|.....    ||.   ..|.|.|.|...||...:.|..
Mouse    68 LNSAPHSSSTSHLHHPNVAYDCLWNYSQYPSAN----PGN---NLKDPPLLSQFPGGQYPLNGIL 125

  Fly   191 MGMVNSMPMSISNNGN----------NGMNAIPGMNTIAQ------------------------- 220
            .|  |..|.|.|:|.|          ||..:..|:|..:|
Mouse   126 GG--NRQPSSPSHNTNLRAGSQEFWANGTQSPMGLNFDSQELYDSFPDQNFEVMPNGPPSFFTSP 188

  Fly   221 ---GNLGNMVLTNSVGGGMGGMVNHLKQQPGGGGGGMINSVSVPGGPGAGAGGVGA--------- 273
               ..||:.:.|.:....:...::     |.......:.||....|.|.    ||:
Mouse   189 QTSPMLGSSIQTFAPSQDVSSDIH-----PDEAAEKELTSVVAENGTGL----VGSLELEEEQPE 244

  Fly   274 ----GGGGAVAANQGMH------------------------MQNGPMMGR--------------M 296
                |..|:|::.:.:|                        :::.|::..              :
Mouse   245 LKMCGYNGSVSSVESLHQEVSVLVPDPTVSCLDDPSHLPDQLEDTPILSEDSLEPFDSLAAAEPV 309

  Fly   297 VGQQHMLRGPHLMGASGGAGGPGNGPGGGG---PRMQNPN--------MQMNFRPFAA------- 343
            .|..:.:....||||.......|| |....   |.:.|.|        .|.:...|.:
Mouse   310 SGSLYGIDDAELMGAEDKLPLEGN-PVISALDCPALSNANAFSLLADDSQTSASIFVSPTSPPVL 373

  Fly   344 -----QLNSLPYGVGQYGGPGGGNNPQQQQQQQQQQLLAQQMAQRGGVVPGMPQGNRPVG-TVVP 402
                 |.||.        |....::.:|::.:.|.....:.:.:.....|...|.:..|. |..|
Mouse   374 GESVLQDNSF--------GLNSCSDSEQEEIETQSSNFQRPLTEPAPDQPPSTQLHPAVSPTASP 430

  Fly   403 MSTLGGDGS-GPAGQLVSGNPQQQQMLAQQQTGAMGP--RPPQPNQLLGHPGQQQQQQQQPGTSQ 464
            .::|..... .||...|:.:|...::..     |:.|  .|..|...|      :.....|.||.
Mouse   431 AASLTASAEISPAVSPVASSPVPPEVFV-----AVSPASSPALPAISL------EASMTTPVTSP 484

  Fly   465 QQQQQQGVGIGGAGVVANAGTVAGVPAVAGG---GAGGAVQSSGPGGANRDVPDDRKRQI---QQ 523
            |...:.........|......|:..|.....   ..||||..||.|       |..||:|   ::
Mouse   485 QGSPEPSPAAAFQTVSPARKNVSSAPKARADREETTGGAVAVSGSG-------DVLKRRIATPEE 542

  Fly   524 QLMLLLHAHKCNRRENLNPNR---EVCNVNYC-KAMK---SVLAHMGTCKQSKDCTMQHCASSRQ 581
            ..:.|.|..:...|.....:|   |......| |.||   .|:.::                ||.
Mouse   543 VRLPLQHGWRREVRIKKGSHRWQGETWYYGPCGKRMKQFPEVIKYL----------------SRN 591

  Fly   582 ILLHYKTCQNSGCVICYPFRQNH----------SVFQNANVPPGGGPAGIGGAPPGGGGAGGGAA 636
            ::              :..|:.|          ..|:..:.|.|
Mouse   592 VV--------------HSVRREHFSFSPRMPVGDFFEERDTPEG--------------------- 621

  Fly   637 GAGGNLQQQQQQQQQQQQNQQPNLTGLVVDGKQGQQVAPGGGQNTAIVLPQQQGAGGAPGAPKTP 701
                 ||..|...::.....|      .:.||:|:.......:|..:  |:.:...|.|...|.|
Mouse   622 -----LQWVQLSAEEIPSRIQ------AITGKRGRPRNNEKAKNKEV--PKVKRGRGRPPKIKMP 673

  Fly   702 ADM------------VQQLTQQQQQQQQQVHQQQVQQQELRRFDGMSQQVVAGGMQQQQQQGLPP 754
            ..:            .|::..:..:.:...::::::|:..|   |.||..|.|..:.:::|
Mouse   674 ELLNKTDNRLPKKLETQEILSEDDKAKMTKNKKKMRQKVQR---GESQTPVQGQARNKRKQ---- 731

  Fly   755 VIRIQGAQPAVRVLGPGGPGGPSGPNVLPNDVNSLHQ---------QQQQMLQQQQ--------- 801
                                          |..||.|         ::::|..:|:
Mouse   732 ------------------------------DTKSLKQKDTKKKLKAEKEKMKTKQEKLKEKVKRE 766

  Fly   802 ---------QQGQNRRRGGLA--TMVEQQQQHQQQQQQ------PNPAQ---LGGNIPAP----- 841
                     ::|...|....|  |:..|::..:||:||      ..|.:   |..:.|.|
Mouse   767 KKEKVKAKGKEGPRARPSCRADKTLATQKRLEEQQRQQAILEEMKKPTEDMCLSDHQPLPDFTRI 831

  Fly   842 --LSVNVGGFGNT--------NFGGAAAGGAVGANDKQQLKVAQVHPQSHGVGAGGASAGAGASG 896
              |:::...|.:.        :||...  |.....|...|.|.|                    .
Mouse   832 PGLTLSSRAFSDCLTIVEFLHSFGKVL--GFDLTKDVPSLGVLQ--------------------E 874

  Fly   897 GQVAAGSSV---------LMPADTTGSGNAGNPNQNAGGVAGGAGGGNGGNTGPP--------GD 944
            |.:..|.|:         |:.|.....|.                        ||        |:
Mouse   875 GLLCQGDSLDKVQDLLVRLLKAALHDPGL------------------------PPYCQSLKILGE 915

  Fly   945 NEKD---WRESVTADLRNHLVHKLVQAIFPTS---DPTTMQDKR---------MHNLVS---YAE 991
            ...:   .|::|:..||..|:...|:..|..|   .|...|..:         :|.|.|   ...
Mouse   916 KMSEIPLTRDNVSEILRCFLMAYRVEPSFCDSLRTQPFQAQPPQQKAAILAFLVHELNSSTIIIN 980

  Fly   992 KVEKDMYEMAKSRSEYYHLLAEKIYKIQKELEEKRLKRKEQHQQMLMQQQGVANPVAGGAAGGAG 1056
            :::|.:..::..|.             .|.:.|.||:|.   :..|.::.|....:..||..|.|
Mouse   981 EIDKTLESVSSCRK-------------NKWIVEGRLRRL---KTALAKRTGRPEVMMEGAEDGLG 1029

  Fly  1057 ---------SAAGVAGGVVLPQQQQQQQ-------QQQQQQGQQPL------------------- 1086
                     ..:|:       :::::::       ::.:::|:..:
Mouse  1030 RRRSSRIMEETSGI-------EEEEEEENTTAVHGRRGRKEGEIDVAASSIPELERHIEKLSKRQ 1087

  Fly  1087 ----QSCIHPSISPMGGVMPPQQLRPQGPPGILGQQT----------AAGLGVGVGVTNNMVTMR 1137
                :..:|.|          |.||...    |||..          .||:.|
Mouse  1088 LFFRKKLLHSS----------QMLRAVS----LGQDRYRRHYWVLPYLAGIFV------------ 1126

  Fly  1138 SHSPGGNMLALQQQQRMQFPQQQQQQPPGSGAGKM---LVGPPGPSPGGMVVNPALSPYQTTNVL 1199
            ..|.|..:...:.:|..:...:.....|.|....:   |.|.          |.:.||.::....
Mouse  1127 EGSEGSTVTEDEIKQETESLMEVVTSTPSSARASVKRELTGS----------NASTSPARSRGRP 1181

  Fly  1200 TSPVPGQQQQQQFINANGGTGANPQLSEIMKQRHIHQQQQQQQQQQQQGMLLPQSPFSNSTPLQQ 1264
            ..|.||..|.|..      .....:......|..:|.:.|.|.|...|..|.|.|.|     |:.
Mouse  1182 RKPKPGSLQPQHL------QSTIRECDSEQAQTQVHPEPQPQLQAPTQPHLQPSSGF-----LEP 1235

  Fly  1265 QQQQQQQQQQQQQATSNSFSSPMQQQQQGQQQQQQKPGSVLNNMPPTPTSLEALNAGAGAPGTGG 1329
            :.......|.|...:.::|.|.:        .|.|...|:|::...||.|         :||...
Mouse  1236 EGSPFSLGQSQHDLSQSAFLSWL--------SQTQSHNSLLSSSVLTPDS---------SPGKLD 1283

  Fly  1330 SASNVTVSAPSPSPGFLSNGPSIGTPSNNNNNSSANNNPPSVSSLMQQPLSNRPGTPPYIPA-SP 1393
            ||.:.::..|.|.......||                ..|..:...|.|....|..||.:.. .|
Mouse  1284 SAPSQSLEEPEPDEAQSCPGP----------------QGPWFNFSAQIPCDAAPTPPPAVSEDQP 1332

  Fly  1394 VPATSASGLAASSTPAS---AAATCASSGSGSNSSSGAT---AAGASSTSSSSSAGSGTP----- 1447
            .|:..   |.|||.|.:   ||..|:.....|....|.|   .:|.|...|.|..|.|.|
Mouse  1333 TPSLQ---LLASSKPMNTPGAANPCSPVQLSSTHLPGGTPKRLSGDSEEMSQSPTGLGQPKRRGR 1394

  Fly  1448 -------------LSSVST-PTSATMATSSGGGGGGGGNAGGGSSTTPASNPLLLMSGGTAGGGT 1498
                         |:.::. |....|.            :|......|.:..:||.:....|...
Mouse  1395 PPSKFFKQVEQHYLTQLTAQPIPPEMC------------SGWWWIRDPETLDVLLKALHPRGIRE 1447

  Fly  1499 GA----------------------------------TTTTSTSSSSRMMSSSSSLSSQMAALEAA 1529
            .|                                  ....|.|...:...:..::...:..||..
Mouse  1448 KALHKHLSKHKDFLQEVCLQPLTDPIFEPNELPALEEGVMSWSPKEKTYETDLAVLQWVEELEQR 1512

  Fly  1530 ARDND-----------DET-----------PSPSGENTNGSGGSGNAGGMASKGKLDSIKQ---- 1568
            ...:|           |.|           .||......|.|..|......:...||....
Mouse  1513 VVLSDLQIRGWTCPTPDSTREDLTYCEHLPDSPEDIPWRGRGREGTVPQRQNNNPLDLAVMRLAV 1577

  Fly  1569 -DDDIKKEFMDDSCGGNND--SSQMDCSTGGGKGKNVNNDGTSMIKMEIKTEDGLDGEVKIKTEA 1630
             :.::::.::.:.....::  ..:...||..|.     .||||   .||..|  :...|::..:.
Mouse  1578 LEQNVERRYLREPLWAAHEVVVEKALLSTPNGA-----PDGTS---TEISYE--ITPRVRVWRQT 1632

  Fly  1631 MDVDEAGGSTA---GEHHGEGGGGSGVG---------GGKDNINGAHDGGATGGAVDI-KPKTET 1682
            ::...:.....   |:..........|.         |..|......||...|..:.. :||.|.
Mouse  1633 LERCRSAAQVCLCMGQLERSIAWEKSVNKVTCLVCRKGDNDEFLLLCDGCDRGCHIYCHRPKMEA 1697

  Fly  1683 KPLVPE--------------------PLAPNAGDKKKK---CQFNPEELRTALLP---------- 1714
               |||                    |..|..|.|:|.   ..|...:.|..:|.
Mouse  1698 ---VPEGDWFCAVCLSQQVEEEYTQRPGFPKRGQKRKSSFPLTFPEGDSRRRMLSRSRDSPAVPR 1759

  Fly  1715 -----------------------TLEKLYRQEPES----VPFRYPVDPQALGIPDYFEIVKKPMD 1752
                                   |..::...|.||    .||..||:|:.  :..|..::|.|||
Mouse  1760 YPEDGLSPPKRRRHSMRSHHSDLTFCEIILMEMESHDAAWPFLEPVNPRL--VSGYRRVIKNPMD 1822

  Fly  1753 LGTIRTNIQNGKYSDPWEYVDDVWLMFDNAWLYNRKTSRVYRYCTKLSEVFEAEIDPVMQ 1812
            ..|:|..:..|.|:...|:..|..|:|||...:|...|.|.:....:...||:..:...|
Mouse  1823 FSTMRERLLRGGYTSSEEFAADALLVFDNCQTFNEDDSEVGKAGHVMRRFFESRWEEFYQ 1882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nej	NP_001188575.1	ZnF_TAZ	530..600	CDD:214717	11/76 (14%)
		KIX	946..1024	CDD:280354	16/95 (17%)
		Bromo_cbp_like	1705..1812	CDD:99927	31/143 (22%)
		RING_CBP-p300	1824..1906	CDD:276805
		PHD_CBP_p300	1908..1939	CDD:277032
		HAT_KAT11	1970..2283	CDD:285432
		ZZ_CBP	2339..2379	CDD:239077
		ZnF_TAZ	2404..2476	CDD:214717
Baz2a	XP_011241580.1	PHA03307	269..>517	CDD:223039	42/267 (16%)
		PRK07003	<408..>534	CDD:235906	30/143 (21%)
		HAT_MBD	542..614	CDD:238691	14/101 (14%)
		DDT	840..902	CDD:214726	13/83 (16%)
		WSD	1101..>1132	CDD:373967	9/46 (20%)
		Atrophin-1	<1151..>1421	CDD:367360	70/326 (21%)
		WSD	<1424..1458	CDD:373967	5/33 (15%)
		PHD_BAZ2A	1663..1709	CDD:277099	11/48 (23%)
		Bromo_BAZ2A_B_like	1781..1877	CDD:99935	29/97 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900