DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nej and Brdt

DIOPT Version :9

Sequence 1:	NP_001188575.1	Gene:	nej / 43856	FlyBaseID:	FBgn0261617	Length:	3282	Species:	Drosophila melanogaster
Sequence 2:	XP_006534791.1	Gene:	Brdt / 114642	MGIID:	1891374	Length:	961	Species:	Mus musculus

Alignment Length:	861	Identity:	167/861 - (19%)
Similarity:	291/861 - (33%)	Gaps:	297/861 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1678 PKT--ETKPL-VP------EPLAPNAGDKKK--KCQFNPEELRTALLPTLEKLYRQE-PESVPFR 1730
            |.|  ||||: :|      :.:.|::..:.|  |.....|:|:.......|.|.::. |.:.||.
Mouse   231 PPTLRETKPVNMPVKENTVKNVLPDSQQQHKVLKTVKVTEQLKHCSEILKEMLAKKHLPYAWPFY 295

  Fly  1731 YPVDPQALGIPDYFEIVKKPMDLGTIRTNIQNGKYSDPWEYVDDVWLMFDNAWLYNRKTSRVYRY 1795
            .|||..|||:.:|:::||.|||||||:..:.|.:|.|.:|:..||.|||.|.:.||.....|...
Mouse   296 NPVDADALGLHNYYDVVKNPMDLGTIKGKMDNQEYKDAYEFAADVRLMFMNCYKYNPPDHEVVAM 360

  Fly  1796 CTKLSEVFE---AEI-DPVMQALGYCCGRKYTFNPQVLCCYGKQLCTIPRDAKYYSYQNSLK-EY 1855
            ...|.:|||   |:| |..::::..|                 .|.|  ..|:..|.::|.: ..
Mouse   361 ARTLQDVFELHFAKIPDEPIESMHAC-----------------HLTT--NSAQALSRESSSEASS 406

  Fly  1856 GVASNRYTYCQKCFNDIQGDTVTLGDDPLQSQTQIKKDQFKEMKNDHLELEPFVNCQECGRKQHQ 1920
            |.||:         .|.:       |:.:|...:::    :::...|.:|:  |..|...||
Mouse   407 GDASS---------EDSE-------DERVQHLAKLQ----EQLNAVHQQLQ--VLSQVPLRK--- 446

  Fly  1921 ICVLWLDSIWPGGFVCDNCLKKKNSKRKENKFNAKRLPTTKLGVYIETRVNNFLKKKEAGAGEVH 1985
                               |||||.|       :||.|..|       :|||
Mouse   447 -------------------LKKKNEK-------SKRAPKRK-------KVNN------------- 465

  Fly  1986 IRVVSSSDKCVEVKPGMRRRFVEQGEMMNEFPYRAKALFAFEEVD-------------GIDVCFF 2037
                  .|:....||...::  ::...:|: |.:.|.|...||.|             .:|:
Mouse   466 ------RDENPRKKPKQMKQ--KEKAKINQ-PKKKKPLLKSEEEDNAKPMNYDEKRQLSLDI--- 518

  Fly  2038 GMHVQEYGSECPAPNTRRVYIAYLDSVHFFRPRQ--YRTAVYHEILLGYMDYVKQLGYTMAHIWA 2100
                    ::.|.....|:       ||..:.|:  .|.:...||   .:|:......|:..:
Mouse   519 --------NKLPGDKLGRI-------VHIIQSREPSLRNSNPDEI---EIDFETLKASTLREL-- 563

  Fly  2101 CPPSEGDDYIFHC------HPTDQKIPKPKRLQEWYKKMLDKGMIERIIQDYKDILKQAMEDKLG 2159
                  :.|:..|      .|..:|:.:.|......||:    .:||.:.|..:
Mouse   564 ------EKYVLACLRKRSLKPQAKKVVRSKEELHSEKKL----ELERRLLDVNN----------- 607

  Fly  2160 SAAELPYFEGDFWPNVLEESIKELDQEEEEKRKQAEA----------------AEAAAAANLFSI 2208
                                  :|:..:.:.::.|:.                .|.|:.:.|...
Mouse   608 ----------------------QLNCRKRQTKRPAKVEKPPPPPPPPPPPPPPPELASGSRLTDS 650

  Fly  2209 EENEVSGDGKKKGQKKAKKSNKSKAAQRKNSKKSNEHQSG--------------NDLSTKIYATM 2259
            ..:..||.|.......:..|:.|..:...:|..|:...|.              |||..|
Mouse   651 SSSSGSGSGSSSSSSGSSSSSSSSGSASSSSDSSSSDSSDSEPEIFPKFTGVKQNDLPPK----- 710

  Fly  2260 EKHKEVFFVIR--------LHSAQSAASLAPIQDPDPLLTCDLMDGRDAFLTLARDKHFEFSSLR 2316
            |..|::...::        |....:|...||.:....:|.|.:.....|....|        |::
Mouse   711 ENIKQIQSSVQDITSAEAPLAQQSTAPCGAPGKHSQQMLGCQVTQHLQATENTA--------SVQ 767

  Fly  2317 RAQFSTLSMLYELHNQGQDK-------FVYTCNHCKTAVETRYHCTVCDDFDLCIVCKEKVGHQH 2374
            ....|...:|      |..|       .|:|.....|.:|...|.....|.        |:.:..
Mouse   768 TQPLSEYVLL------GDCKRVLLGPPVVHTSAESLTVLEPECHAPAQKDI--------KIKNAD 818

  Fly  2375 KMEKLGFDIDDGSALADHKQANPQEARKQSIQRCIQSLAHACQCRDANCRLPSCQKMKLVVQH-- 2437
            ..:.||..:...|.|....:...| .||.:|::.:::...              ::|:..::|
Mouse   819 SWKSLGKPVKASSVLKSSDELFNQ-FRKAAIEKEVKARTQ--------------EQMRKHLEHNA 868

  Fly  2438 -----TKNCKRKPNGG 2448
                 ::..:|:|..|
Mouse   869 KDPKVSQENQREPGSG 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nej	NP_001188575.1	ZnF_TAZ	530..600	CDD:214717
		KIX	946..1024	CDD:280354
		Bromo_cbp_like	1705..1812	CDD:99927	43/111 (39%)
		RING_CBP-p300	1824..1906	CDD:276805	12/82 (15%)
		PHD_CBP_p300	1908..1939	CDD:277032	4/30 (13%)
		HAT_KAT11	1970..2283	CDD:285432	56/371 (15%)
		ZZ_CBP	2339..2379	CDD:239077	6/39 (15%)
		ZnF_TAZ	2404..2476	CDD:214717	6/52 (12%)
Brdt	XP_006534791.1	Bromo_Brdt_I_like	26..132	CDD:99929
		Bromo_Brdt_II_like	271..372	CDD:99930	39/100 (39%)
		BET	505..567	CDD:374956	11/90 (12%)
		BRD4_CDT	919..961	CDD:374989
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900