DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nej and BAZ2A

DIOPT Version :9

Sequence 1:	NP_001188575.1	Gene:	nej / 43856	FlyBaseID:	FBgn0261617	Length:	3282	Species:	Drosophila melanogaster
Sequence 2:	XP_011536103.1	Gene:	BAZ2A / 11176	HGNCID:	962	Length:	1912	Species:	Homo sapiens

Alignment Length:	2249	Identity:	382/2249 - (16%)
Similarity:	630/2249 - (28%)	Gaps:	863/2249 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 GGPNKPAAQG----PGSGTG--GVGVGVNVGVGGVVGVGVVPSQMNGAGGGNGSGTGG---DDGS 127
            |.|..|||.|    |.||.|  ..|..:|....|        ..:||....||..|..   ..|.
Human    13 GLPPAPAASGLKPSPSSGEGLYTNGSPMNFPQQG--------KSLNGDVNVNGLSTVSHTTTSGI 69

  Fly   128 GNGSGAGNRISQMQHQQLQH----------------------LLQQQQQGQKGAMVVPGMQQLGS 170
            .|.:...:..|.:.|..:.:                      ||.|...||.....:.|    ||
Human    70 LNSAPHSSSTSHLHHPSVAYDCLWNYSQYPSANPGSNLKDPPLLSQFSGGQYPLNGILG----GS 130

  Fly   171 KSPNLQSPN---QGGMQQ--VVGTQMGMVNSMPMSISNNGNNGMNAIPGMNTIAQGN-------- 222
            :.|:..|.|   :.|.|:  ..|||      .||.::.:.....::.|..|.....|
Human   131 RQPSSPSHNTNLRAGSQEFWANGTQ------SPMGLNFDSQELYDSFPDQNFEVMPNGPPSFFTS 189

  Fly   223 ------LGNMVLT----NSVGGGMGGMVNHLKQQPGGGGGGMINSVSVPGGPGAGAGGVGA---- 273
                  ||:.:.|    ..||.|:         .|.......:.||....|.|.    ||:
Human   190 PQTSPMLGSSIQTFAPSQEVGSGI---------HPDEAAEKEMTSVVAENGTGL----VGSLELE 241

  Fly   274 ---------GGGGAVAANQGMHMQ-----NGPMMGRMVGQQHMLRGPHLMGASGGAGGPGNGPGG 324
                     |..|:|.:.:.:|.:     ..|.:..:....|:   |..:..:
Human   242 EEQPELKMCGYNGSVPSVESLHQEVSVLVPDPTVSCLDDPSHL---PDQLEDT------------ 291

  Fly   325 GGPRMQNPNMQMNFRPFAAQLNSL---PYGVGQYGGPGGGNNPQQQQQQQQQQLLAQQMAQRGGV 386
              |.:...:::    ||    |||   |...|.||             ....:|:        |.
Human   292 --PILSEDSLE----PF----NSLAPEPVSGGLYG-------------IDDTELM--------GA 325

  Fly   387 VPGMPQGNRPV---------GTVVPMSTLGGDG-------SGPAGQLVSG--------------- 420
            ...:|..:.||         ......|.|..|.       :.|....|.|
Human   326 EDKLPLEDSPVISALDCPSLNNATAFSLLADDSQTSTSIFASPTSPPVLGESVLQDNSFDLNNGS 390

  Fly   421 NPQQQQMLAQQQTGAMGPRPPQPNQLLGHPGQQQQQQQQPGTSQQQQQQQGVGIG---------- 475
            :.:|::|  :.|:....|...||     .|.|....|..|.||..........:.
Human   391 DAEQEEM--ETQSSDFPPSLTQP-----APDQSSTIQLHPATSPAVSPTTSPAVSLVVSPAASPE 448

  Fly   476 -GAGVVANAGTVAG---------------------VPAVAGGGAGGAVQSSGPGG-------ANR 511
             ...|...|.||..                     ||..|...:..|...:.|..       ||:
Human   449 ISPEVCPAASTVVSPAVFSVVSPASSAVLPAVSLEVPLTASVTSPKASPVTSPAAAFPTASPANK 513

  Fly   512 DVP-----------------------DDRKRQI---QQQLMLLLHAHKCNRRENLNPNR---EVC 547
            ||.                       |..:|:|   ::..:.|.|..:...|.....:|   |..
Human   514 DVSSFLETTADVEEITGEGLTASGSGDVMRRRIATPEEVRLPLQHGWRREVRIKKGSHRWQGETW 578

  Fly   548 NVNYC-KAMK---SVLAHMGTCKQSKDCTMQHCASSRQILLHYKTCQNSGCVICYPFRQNH---- 604
            ....| |.||   .|:.::                ||.::              :..|:.|
Human   579 YYGPCGKRMKQFPEVIKYL----------------SRNVV--------------HSVRREHFSFS 613

  Fly   605 ------SVFQNANVPPGGGPAGIGGAPPGGGGAGGGAAGAGGNLQQQQQQQQQQQQNQQPNLTGL 663
                  ..|:..:.|.|                          ||..|...::.....|
Human   614 PRMPVGDFFEERDTPEG--------------------------LQWVQLSAEEIPSRIQ------ 646

  Fly   664 VVDGKQGQQVAPGGGQNTAIV----LPQQQGAGGAPGAPKTPADMVQQLTQQQQQQQQQVHQQQV 724
            .:.||:|:.      :||...    :|:.:...|.|  ||  ..:.:.|.:...:..:::..|:.
Human   647 AITGKRGRP------RNTEKAKTKEVPKVKRGRGRP--PK--VKITELLNKTDNRPLKKLEAQET 701

  Fly   725 QQQELRRFDGMSQQVVAGGMQQQQQQGLPPVIRIQGAQPAVRVLGPGGPGGPSGPNVLPNDVNSL 789
            ..:|.:.....|::    .|:|:.|:| .....|||                ...|....:..||
Human   702 LNEEDKAKIAKSKK----KMRQKVQRG-ECQTTIQG----------------QARNKRKQETKSL 745

  Fly   790 HQQQ-QQMLQQQQQQGQNRRR--------------------------------GGLAT---MVEQ 818
            .|:: ::..:.::::|:.::.                                ..|||   :.|:
Human   746 KQKEAKKKSKAEKEKGKTKQEKLKEKVKREKKEKVKMKEKEEVTKAKPACKADKTLATQRRLEER 810

  Fly   819 QQQHQQQQQQPNPAQ---LGGNIPAP-------LSVNVGGFGNT--------NFG---------- 855
            |:|....::...|.:   |..:.|.|       |::..|.|.:.        :||
Human   811 QRQQMILEEMKKPTEDMCLTDHQPLPDFSRVPGLTLPSGAFSDCLTIVEFLHSFGKVLGFDPAKD 875

  Fly   856 ----GAAAGGAVGANDK----QQLKVAQVHPQSHGVGAGGASAGAGASGGQVAAGSSVLMPADT- 911
                |....|.:...|.    |.|.|..:....|..|...........|.:|   |.:.:..|.
Human   876 VPSLGVLQEGLLCQGDSLGEVQDLLVRLLKAALHDPGFPSYCQSLKILGEKV---SEIPLTRDNV 937

  Fly   912 ----------------------TGSGNAGNPNQNAGGVAGGAGGGNGGNTGPPGDNEKDWRESVT 954
                                  |....|..|.|.|..:|
Human   938 SEILRCFLMAYGVEPALCDRLRTQPFQAQPPQQKAAVLA-------------------------- 976

  Fly   955 ADLRNHLVHKLVQAIFPTSDPTTMQDKRMHNLVSYAEKVEKDMYEMAKSRSEYYHLLAEKIYKIQ 1019
                 .|||:|..:....::    .||.:.::.||    .|:.:.:.........:||::..:.:
Human   977 -----FLVHELNGSTLIINE----IDKTLESMSSY----RKNKWIVEGRLRRLKTVLAKRTGRSE 1028

  Fly  1020 KELE--EKRLKRKEQHQQML----MQQQGVANPVAGGAAGGAGSAAGVAGGVV--LPQQQQQQQQ 1076
            .|:|  |:.|.|:...:.|.    |:::.....:| ...|..|...|......  :|:.::|.::
Human  1029 VEMEGPEECLGRRRSSRIMEETSGMEEEEEEESIA-AVPGRRGRRDGEVDATASSIPELERQIEK 1092

  Fly  1077 QQQQQ---------GQQPLQSC------------IHPSISPM------GGVMPPQQLRPQGPPGI 1114
            ..::|         ..|.|::.            :.|.::.:      |.::|.:.::.:
Human  1093 LSKRQLFFRKKLLHSSQMLRAVSLGQDRYRRRYWVLPYLAGIFVEGTEGNLVPEEVIKKE----- 1152

  Fly  1115 LGQQTAAGLGVGVGVTNN--MVTMRSHSPGGNMLALQQQQRMQFPQQQQQQPPGSGAGKMLVGPP 1177
                 ...|.|....:.|  :.:|:....|.|..|               ..|....|:    |.
Human  1153 -----TDSLKVAAHASLNPALFSMKMELAGSNTTA---------------SSPARARGR----PR 1193

  Fly  1178 GPSPGGMVVNPALSPYQTTNVLTSPVPGQQQQQQFINANGGTGANPQLSEIMKQRHIH-----QQ 1237
            ...||.|      .|..    |.|||.||..:|            || :::..:..:|     |.
Human  1194 KTKPGSM------QPRH----LKSPVRGQDSEQ------------PQ-AQLQPEAQLHAPAQPQP 1235

  Fly  1238 QQQQQQQQQQGMLLPQSPFSNSTPLQQQQQQQQQQQ-------QQQQATSNSFSS---------- 1285
            |.|.|.|..:|.|..:     .:||...|.|....|       .|.|:.|:..||
Human  1236 QLQLQLQSHKGFLEQE-----GSPLSLGQSQHDLSQSAFLSWLSQTQSHSSLLSSSVLTPDSSPG 1295

  Fly  1286 -----PMQQQQQGQQQQQQKPGSVLNNMPPTPTSLEALNAGAGAPGTGGSASNVTVS--APSPSP 1343
                 |.|..::.:..:.:.        .|.|.:| ..|..|..|..........||  .|:|||
Human  1296 KLDPAPSQPPEEPEPDEAES--------SPDPQAL-WFNISAQMPCNAAPTPPPAVSEDQPTPSP 1351

  Fly  1344 GFLSNGPSIGTPSNNNNNSSANNNPPSVSSLMQQPLSNRPGTPPYIP------------------ 1390
            ..|::...:..||..|..|....:...::.|..:..:..||..|..|
Human  1352 QQLASSKPMNRPSAANPCSPVQFSSTPLAGLAPKRRAGDPGEMPQSPTGLGQPKRRGRPPSKFFK 1416

  Fly  1391 -----------ASPVPATSASG------------------------------------------L 1402
                       |.|||....||                                          |
Human  1417 QMEQRYLTQLTAQPVPPEMCSGWWWIRDPEMLDAMLKALHPRGIREKALHKHLNKHRDFLQEVCL 1481

  Fly  1403 AASSTPASAAATCASSGSGSNSSS-------------------------------GATAAGASST 1436
            ..|:.|........:...|..|.|                               |.|.....||
Human  1482 RPSADPIFEPRQLPAFQEGIMSWSPKEKTYETDLAVLQWVEELEQRVIMSDLQIRGWTCPSPDST 1546

  Fly  1437 SSSSSAGSGTPLSSVSTPTSATMATSSGGGGGGGGNAGGGSSTTPASNPLLLMSG---------- 1491
            ...         .:.....|.:....:..|.|..|.|....:|.|....::.::.
Human  1547 RED---------LAYCEHLSDSQEDITWRGRGREGLAPQRKTTNPLDLAVMRLAALEQNVERRYL 1602

  Fly  1492 -----------------GTAGGG-TGATTTTSTSSSSRMMSSSSSLSSQMAALEAAARDNDDETP 1538
                             .|..|. .|.||..|..|.||....:..:......||..
Human  1603 REPLWPTHEVVLEKALLSTPNGAPEGTTTEISPLSPSRSYEITPRIRVWRQTLERC--------- 1658

  Fly  1539 SPSGENTNGSGGSGNAGGMASKGKLD-SIKQDDDIKKEFMDDSC----GGNNDSSQMDCSTGGGK 1598
                        ...|......|:|: ||..:..:.|.    :|    .|:||...:.|. |..:
Human  1659 ------------RSAAQVCLCLGQLERSIAWEKSVNKV----TCLVCRKGDNDEFLLLCD-GCDR 1706

  Fly  1599 GKNVNNDGTSMIKMEIKTE----------DGLDGEVKIKTEAMDVDEAGGSTAGEHHGEGGGGSG 1653
            |.::.   ....|||...|          ..::||.        ..:.|....|:....|
Human  1707 GCHIY---CHRPKMEAVPEGDWFCTVCLAQQVEGEF--------TQKPGFPKRGQKRKSG----- 1755

  Fly  1654 VGGGKDNINGAHDGGATGGAVDIKPKTETKPLVPEPLAPNAGDKKKKCQFNPEELRTALLP---- 1714
                 .::|.:...|           ...:.|:....:|.||.:..:...:|.:.|...:.
Human  1756 -----YSLNFSEGDG-----------RRRRVLLRGRESPAAGPRYSEEGLSPSKRRRLSMRNHHS 1804

  Fly  1715 --TLEKLYRQEPES----VPFRYPVDPQALGIPDYFEIVKKPMDLGTIRTNIQNGKYSDPWEYVD 1773
              |..::...|.||    .||..||:|:.  :..|..|:|.|||..|:|..:..|.|:...|:..
Human  1805 DLTFCEIILMEMESHDAAWPFLEPVNPRL--VSGYRRIIKNPMDFSTMRERLLRGGYTSSEEFAA 1867

  Fly  1774 DVWLMFDNAWLYNRKTSRVYRYCTKLSEVFEAEIDPVMQ 1812
            |..|:|||...:|...|.|.:....:...||:..:...|
Human  1868 DALLVFDNCQTFNEDDSEVGKAGHIMRRFFESRWEEFYQ 1906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nej	NP_001188575.1	ZnF_TAZ	530..600	CDD:214717	11/76 (14%)
		KIX	946..1024	CDD:280354	13/79 (16%)
		Bromo_cbp_like	1705..1812	CDD:99927	32/116 (28%)
		RING_CBP-p300	1824..1906	CDD:276805
		PHD_CBP_p300	1908..1939	CDD:277032
		HAT_KAT11	1970..2283	CDD:285432
		ZZ_CBP	2339..2379	CDD:239077
		ZnF_TAZ	2404..2476	CDD:214717
BAZ2A	XP_011536103.1	HAT_MBD	551..623	CDD:238691	14/101 (14%)
		DDT	848..913	CDD:214726	11/64 (17%)
		WHIM3	1439..1477	CDD:292248	0/37 (0%)
		PHD_BAZ2A	1685..1731	CDD:277099	11/49 (22%)
		Bromo_BAZ2A_B_like	1805..1901	CDD:99935	30/97 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900