DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nej and crebbp

DIOPT Version :9

Sequence 1:	NP_001188575.1	Gene:	nej / 43856	FlyBaseID:	FBgn0261617	Length:	3282	Species:	Drosophila melanogaster
Sequence 2:	NP_001340300.1	Gene:	crebbp / 100101677	XenbaseID:	XB-GENE-6258723	Length:	2431	Species:	Xenopus tropicalis

Alignment Length:	3393	Identity:	1180/3393 - (34%)
Similarity:	1458/3393 - (42%)	Gaps:	1074/3393 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 MADH-LDEPP-QKRVKM---------DPTD-ISYF-LEENLPDELVSSNSGWSDQLTGGAGGGNG 53
            ||:: ||.|| :||.|:         |.|| :|:| ||.:|||||: .|.|....|  |.||..|
Frog     1 MAENLLDGPPNRKRPKLSSPGFSASTDSTDFVSFFDLENDLPDELI-PNGGELSIL--GTGGNLG 62

  Fly    54 GGGASGVTTNPTSGPNPGGGPNKPAAQGPGSGTGGVGVGVNVGVGGVVGVGVVPSQMNGAGGGNG 118
            ...||  .....|....||.    |..|...|.||.|..|..|:
Frog    63 QDAAS--QNKQLSDLLRGGN----AGLGTAMGRGGSGSPVQQGM--------------------- 100

  Fly   119 SGTGGDDGSGNGSGAGNRISQMQHQQLQHLLQQQQQGQKGAMVVP--GMQQLGSKSPNLQSPNQG 181
                |..|..|..|.|| :|.:....|          .:|..|.|  |:.:..:.:|....|...
Frog   101 ----GSQGQQNSPGLGN-LSSLNKSPL----------NQGLSVTPPSGLTKTTTGTPGPSVPASQ 150

  Fly   182 GMQQVVGTQMGMVNSMPMSISNNGNNGMNAIPGMNTIAQGNLGNMVLTNSVGGGMGGMVNHLKQQ 246
            ..:||     .||...|.:        ..|..|:...:..|.|:..|.||..|      :.|..|
Frog   151 AQKQV-----SMVAGSPAA--------PQAPTGICMNSNFNQGHQALLNSNSG------HTLMSQ 196

  Fly   247 PGGGGGGMINSVSVPGGPGAGAGGVGAGGGGAVAANQGMHMQNGPMMGRMVGQQHMLRGPHLMGA 311
            .....|.::|          |:.|||..|.||........||..|  |.::.:. :.:|...|..
Frog   197 AQPAQGQVLN----------GSLGVGNRGRGAALQYNSPAMQTNP--GSVLAET-LTQGATTMPT 248

  Fly   312 SGGAGGPGNGPGGGGPRMQNPNMQMNFRPFAAQLNSLPYGVGQYGGPGGGNNPQQQQQQQQQQLL 376
            ..|.   .....|...:|..|.            |:.|:|             |...|...||:.
Frog   249 HAGM---TTAQTGAMTKMGLPG------------NTSPFG-------------QTFNQATGQQIR 285

  Fly   377 AQQMAQRGGVVPGMPQGNRPVGTVVPMSTLGGDGSGPAGQLVSGNPQQQQMLAQQQTGAMGPRPP 441
            ||      ||.|.:|                            ..|.....|           ||
Frog   286 AQ------GVSPQLP----------------------------AKPAMANSL-----------PP 305

  Fly   442 QPNQLLGHPGQQQQQQQQPGTSQQQQQQQGVGIGGAGVVANAGTVAGVPAVAGGGAGGAVQSSGP 506
            .|:.:...|     ....|..|..|.|.|.|||   |...:.||                   ||
Frog   306 FPSDIKNTP-----VANVPNMSPLQAQVQQVGI---GTTPSMGT-------------------GP 343

  Fly   507 GGANRDVPDDRKRQ-IQQQLMLLLHAHKCNRRENLNPNREVCNVNYCKAMKSVLAHMGTCKQSKD 570
                  ..|..||: |||||:||||||||.|||..|.....|::.:|:.||:||.||..|:..|.
Frog   344 ------TADPEKRKLIQQQLVLLLHAHKCQRREQNNGEMRDCSLPHCRTMKNVLNHMTHCQAGKA 402

  Fly   571 CTMQHCASSRQILLHYKTCQNSGCVICYPFRQNHSVFQNANVPPGGGPAGIGGAPPGGGGAGGGA 635
            |.:.||||||||:.|:|.|....|.:|.|.: |.|..:|.|:|.... :|:.. |.|..|||
Frog   403 CQVAHCASSRQIISHWKNCTRHDCPVCLPLK-NASDKRNQNLPVSLS-SGVQN-PIGTAGAG--- 461

  Fly   636 AGAGGNLQQQQQQQQQQQQNQQPNLTGLVVDGKQGQQVAPGGGQN--TAIVLP---QQQGAGGAP 695
                         ||.......||            .:.|...|.  .|:.||   |.|..|
Frog   462 -------------QQSAPSLSSPN------------PIDPSSMQRAYAALGLPYGNQAQSTG--- 498

  Fly   696 GAPKTPADMVQQLTQQQQQQQQQVHQQQVQQQELRRFDGMSQQVVAGGMQQQQQQGLPPVIRIQG 760
                            ||..|.||||   |.:.:....|....:.||||..:||..|
Frog   499 ----------------QQPAQTQVHQ---QIRNMNSLGGNQISLTAGGMAVEQQTNL-------- 536

  Fly   761 AQPAVRVLGPGGPGGPSGPNVLPNDVNSLHQQQQQMLQQQQQQGQNRRRGGLATMVEQQQQHQQQ 825
                  :.....|...:..|.|.||.||     |..:            |.|.||
Frog   537 ------ISEASLPTALASSNSLLNDGNS-----QSTV------------GNLGTM---------- 568

  Fly   826 QQQPNPAQLGGNIPAPLSVNVGGFGNTNFGGAAAGGAVGANDKQQLKVAQVHPQSHGVGAGGASA 890
               |..|
Frog   569 ---PTAA---------------------------------------------------------- 572

  Fly   891 GAGASGGQVAAGSSVLMPADTTGSGNAGNPNQNAGGVAGGAGGGNGGNTGPPGDNEKDWRESVTA 955
                             |..|||.                               .|.|.|.||.
Frog   573 -----------------PPSTTGV-------------------------------RKAWHEHVTQ 589

  Fly   956 DLRNHLVHKLVQAIFPTSDPTTMQDKRMHNLVSYAEKVEKDMYEMAKSRSEYYHLLAEKIYKIQK 1020
            |||||||||||||||||.||..::|:||.|||:||.|||.||||.|.||.|||||||||||||||
Frog   590 DLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANSRDEYYHLLAEKIYKIQK 654

  Fly  1021 ELEEKRLKRKEQHQQMLMQQQGVANPVAGGAAGGAGSAAGVAGGVVLPQQQQQQQQQQQQQGQQP 1085
            ||||||..|        :|:||:                                    ...|.|
Frog   655 ELEEKRRSR--------LQKQGI------------------------------------MSNQPP 675

  Fly  1086 LQSCIHPSISPMGGVMPPQQLRPQGPPGILGQQTAAGLG--VGVGVTNNMVTMRSHSPGGNMLAL 1148
            ||:         .|..||..           .||||.||  ..|..||..::|   |.....:|.
Frog   676 LQA---------PGTQPPTL-----------TQTAAALGQTQPVRPTNGPISM---SMNRMQVAS 717

  Fly  1149 QQQQRMQFPQQQQQQPPGSGAGKMLVGPPGPSPGGMVVNPALSPYQTTNVLTSPV----PGQQQQ 1209
            ...|....|. ..|.|         ..|.||    ...:|...|.|..|:.:.|.    |.:..|
Frog   718 GMNQFSSMPIXNVQMP---------TAPMGP----RAASPLNHPTQMNNMGSVPAMAMSPSRMSQ 769

  Fly  1210 -QQFINANGGTGANPQLSEIMKQRHIHQQQQQQQQQQQQGMLLPQSPFSNSTPLQQQQQQQQQQQ 1273
             |..|.|:.|:...|            .|.|.|..||.|   .|.|..:.|..|.|........|
Frog   770 PQSIIGAHAGSLMGP------------TQTQNQFLQQNQ---FPASTGTISVGLGQTGAAAAVSQ 819

  Fly  1274 QQQQAT-----SNSFSSPMQQQQQGQQQQQQKPGSVLNNMPPTPTSLEAL--NAGAGAPGTGGSA 1331
            |.|..|     |||.:  |...|..|..:.....|.|:..||:.|:..|:  :....|| ||.:.
Frog   820 QGQAPTASLPISNSLN--MLGPQTSQLPRPALSQSPLHQTPPSVTASAAVMPSVQHQAP-TGLTP 881

  Fly  1332 SNVTV----SAPSPSPGFLSNGPSIGTPSNNNNNSSANNNPPSVSSLMQQPLSNRPGTPPYIPAS 1392
            ...|.    |.|.|:|| .:..|:.|:..|:..:.|.    |:|.:..|..|:.:|.||  :|..
Frog   882 PKPTAPAQPSTPLPTPG-QTPAPTPGSVPNSMQSQST----PTVQAAAQAQLTPQPPTP--VPIQ 939

  Fly  1393 PVPATSASGLAASSTPASAAATCASSGSGSNSSSGATAAGASSTSSSSSAGSGTPLSSVSTPTSA 1457
            .||....:.|..:|..|.|                                .|||||..:....
Frog   940 SVPTPQPAQLQPTSVHAPA--------------------------------PGTPLSQAAASVD- 971

  Fly  1458 TMATSSGGGGGGGGNAGGGSSTTPASNPLLLMSGGTAGGGTGATTTTSTSSSSRMMSSSSSLSSQ 1522
                              ....||||
Frog   972 ------------------NHVRTPAS--------------------------------------- 979

  Fly  1523 MAALEAAARDNDDETPSPSGENTNGSGGSGNAGGMASKGKLDSIKQDDDIKKEFMDDSCGGNNDS 1587
                 .|:.||.   |:|....|.          :..:||.|.            .::|     .
Frog   980 -----VASTDNQ---PAPDHSMTE----------VKVEGKTDE------------PEAC-----E 1009

  Fly  1588 SQMDCSTGGGKGKNVNNDGTSMIKMEI--KTEDGLDGEVKIKTEAMDVDEAGGSTAGEHHGEGGG 1650
            :|::..|      .|..|.:|.:|..:  .||        ||:|.|:|:|.......|:..|
Frog  1010 NQVEPKT------EVEPDASSQVKEPVCESTE--------IKSEPMEVEEKKTEIKTENKEE--- 1057

  Fly  1651 GSGVGGGKDNINGAHDGGATGGAVDIKPKTETKPLVPEPLAPNAGDKKKKCQFNPEELRTALLPT 1715
                          .:.|.|..::.     .|.|..|          :||. |.|||||.||:||
Frog  1058 --------------EENGGTNSSLQ-----STSPSQP----------RKKI-FKPEELRQALMPT 1092

  Fly  1716 LEKLYRQEPESVPFRYPVDPQALGIPDYFEIVKKPMDLGTIRTNIQNGKYSDPWEYVDDVWLMFD 1780
            ||.||||:|||:|||.|||||.|||||||:|||.||||.||:..:..|:|.:||:|||||||||:
Frog  1093 LEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFN 1157

  Fly  1781 NAWLYNRKTSRVYRYCTKLSEVFEAEIDPVMQALGYCCGRKYTFNPQVLCCYGKQLCTIPRDAKY 1845
            |||||||||||||:|||||:||||.|||||||:||||||||:.|:||.|||||||||||||||.|
Frog  1158 NAWLYNRKTSRVYKYCTKLAEVFEQEIDPVMQSLGYCCGRKFEFSPQTLCCYGKQLCTIPRDAAY 1222

  Fly  1846 YSYQNSLKEYGVASNRYTYCQKCFNDIQGDTVTLGDDPLQSQTQIKKDQFKEMKNDHLELEPFVN 1910
            :|||          |||.:|:|||.:|||:.|||||||.|.||.|.|:||::.|||.|:.||||:
Frog  1223 FSYQ----------NRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKEQFEKKKNDMLDPEPFVD 1277

  Fly  1911 CQECGRKQHQICVLWLDSIWPGGFVCDNCLKKKNSKRKENKFNAKRLPTTKLGVYIETRVNNFLK 1975
            |:|||||.||||||..|.|||.||||||||||....||||||.||||.||:||.::|.|||.||:
Frog  1278 CKECGRKMHQICVLHFDIIWPSGFVCDNCLKKTGRTRKENKFCAKRLQTTRLGNHLEDRVNKFLR 1342

  Fly  1976 KK-EAGAGEVHIRVVSSSDKCVEVKPGMRRRFVEQGEMMNEFPYRAKALFAFEEVDGIDVCFFGM 2039
            :: ...||||.:|||:||||.|||:|||:.:||:.|||...||||.||||||||:||:|||||||
Frog  1343 RQNHPEAGEVSVRVVASSDKIVEVRPGMKSKFVDTGEMPESFPYRTKALFAFEEIDGVDVCFFGM 1407

  Fly  2040 HVQEYGSECPAPNTRRVYIAYLDSVHFFRPRQYRTAVYHEILLGYMDYVKQLGYTMAHIWACPPS 2104
            |||||||:||.||||||||:||||:||||||..|||||||||:||::|||:|||...||||||||
Frog  1408 HVQEYGSDCPMPNTRRVYISYLDSIHFFRPRSLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPS 1472

  Fly  2105 EGDDYIFHCHPTDQKIPKPKRLQEWYKKMLDKGMIERIIQDYKDILKQAMEDKLGSAAELPYFEG 2169
            |||||||||||.||||||||||||||||||||...||||.|||||.|||.||:|.||.|||||||
Frog  1473 EGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELPYFEG 1537

  Fly  2170 DFWPNVLEESIKELDQEEEEKRKQAEAAEAAAAANLFSIEENE-VSGDGKKKGQKKAKKSNKSKA 2233
            ||||||||||||||:|||||::|:...|         :.|..| ..||.|...:|..||:||:|:
Frog  1538 DFWPNVLEESIKELEQEEEERKKEENTA---------ACETTEGCQGDSKNAKKKNNKKTNKNKS 1593

  Fly  2234 A-QRKNSKKSNEHQSGNDLSTKIYATMEKHKEVFFVIRLHSAQSAASLAPIQDPDPLLTCDLMDG 2297
            : .|.|.||::.....||||.|:||||||||||||||..::.....||.||.||||||:||||||
Frog  1594 SMSRANKKKASMPNVCNDLSQKLYATMEKHKEVFFVIHFYAGPVINSLPPIADPDPLLSCDLMDG 1658

  Fly  2298 RDAFLTLARDKHFEFSSLRRAQFSTLSMLYELHNQGQDKFVYTCNHCKTAVETRYHCTVCDDFDL 2362
            ||||||||||||:|||||||:::|||.||.|||.||||:||||||.||..||||:|||||:|:||
Frog  1659 RDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDL 1723

  Fly  2363 CIVCKEKVGHQHKMEKLGFDIDDGS-ALADHKQANPQEARKQSIQRCIQSLAHACQCRDANCRLP 2426
            |:.|.....|:|||.|.|..:||.| :..:.:..:|||:|:.|||||||||.||||||:|||.||
Frog  1724 CVNCYNAKSHEHKMVKWGLGLDDESNSQGEAQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLP 1788

  Fly  2427 SCQKMKLVVQHTKNCKRKPNGGCPICKQLIALCCYHAKNCEEQKCPVPFCPNIKHKLKQQQSQQK 2491
            ||||||.||||||.||||.|||||:|||||||||||||:|:|.|||||||.|||.||:|||.|.:
Frog  1789 SCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKQKLRQQQIQHR 1853

  Fly  2492 FQQQQLLRRRVALMSRTAAPAALQGPAAVSGPTVVSGGVPVVGMSGVAVSQQV-IPGQAGILPPG 2555
            .||.||:|||:|.|:..|.|     ..::..||..:.|.|....|.....|.. .|....|..||
Frog  1854 LQQAQLMRRRMATMNTRAVP-----QQSLPSPTSATPGTPTQQPSTPQTPQPAPQPSPVSIASPG 1913

  Fly  2556 AGGMSPSTVAVPSPVSGGAGAGGMGGMTSP----HPHQPGIGMKPGGGHSPSPNVLQVVKQVQEE 2616
                .||......|     .....|..|:|    .|.||.:        .|.|..:...:|::.|
Frog  1914 ----FPSVQRTQPP-----NVASQGKPTNPVPPVPPSQPTV--------QPPPAAVAAARQIELE 1961

  Fly  2617 AARQQVSHGGGFGKGVPMAPPVMNRPMGGAGPNQNVVNQLGGMGVGVGGVGGVGVGGVGGVGVNQ 2681
            |.:||:.......:|:..|.|.|..|..|:      ||.:..|.:.|...|.:|...:
Frog  1962 AQQQQLYRVTSIAEGINSARPGMVNPSVGS------VNPMQQMAMNVPRPGPIGAPPI------- 2013

  Fly  2682 LNSGGGNTPGAPISGPGMNVNHLMSMDQWGGGGAGGGGANPGGGNPQARYANNTGGMRQPTHVMQ 2746
               ..|..||                 ||           |....||
Frog  2014 ---MAGMQPG-----------------QW-----------PAAQLPQ------------------ 2029

  Fly  2747 TNLIPPQQQQQMMGGLGGPNQLGGGQMPVGGQHGGMGMGMGAPPMAGTVGGVRPSPGAGGGGGSA 2811
                .||.||.:...:   .|:...|..|.|....     |.||....  .:.|:|.|
Frog  2030 ----QPQMQQSIQRPV---MQMATAQQAVAGPRLA-----GVPPQQAR--NIAPAPNA------- 2073

  Fly  2812 TGGGLNTQQLALIMQKIKNNPTNESNQHILAILKQNPQIMAAIIKQRQQSQNNAAAGGGAPGPGG 2876
                     |..:::.:|:..:.:..|.:|.|||.||.:|||.||||.                .
Frog  2074 ---------LQDLLRTLKSPSSPQQQQQVLNILKSNPHLMAAFIKQRT----------------A 2113

  Fly  2877 ALQQQQAGNGPQNPQQQQQQQQQQQVMQQQQMQHM-----------MNQQQGGGGPQ-------- 2922
            .....|.|..||...|||||.||..:..|..:|:|           :.|||.|..||
Frog  2114 KYVANQPGMQPQQAPQQQQQPQQPGMHPQAGLQNMSPMPVGVPRAAVPQQQPGMAPQGQGIGLMN 2178

  Fly  2923 --------QMNPN-----------QQQQQQQVNLMQQQQQGGPGGPGSGLPTRMPNMPNALGMLQ 2968
                    .:||.           |||||||    |||||...|..| |||        |.|..|
Frog  2179 TAHNTNLANINPQYREMYRRQQLLQQQQQQQ----QQQQQSAAGMAG-GLP--------AHGQFQ 2230

  Fly  2969 SLPPNMSPGVSTQGGMVPNQNWNKMRYMQMSQYPPPYP-QRQRGPHMGGAGPGPGQQQFPGGGGG 3032
                      ..||.                 ||.|.. |:||            .||.....||
Frog  2231 ----------QPQGA-----------------YPQPQALQQQR------------MQQHLSIQGG 2256

  Fly  3033 AGNFNAGGAGGAGGVVGVGGVPGGAGTVPGGDQYSMANAAAASNMLQQQQGQVGVGVGVGVKPGP 3097
            .                :|.:|            .||                        :||.
Frog  2257 T----------------MGQIP------------QMA------------------------QPGL 2269

  Fly  3098 GQQQQQMGVGMPPGMQQQQQQQQPLQQQQMMQVAMPNANAQNPS--AVVGGPNAQVMGPPTPHSL 3160
            |.:..|..:        ||...|.:|||...|:|...||..:|.  .:.|.|.:..:  ||...:
Frog  2270 GNEGSQASL--------QQALHQRIQQQIKQQIASGQANPMSPQQHLLTGQPPSAHL--PTGQQI 2324

  Fly  3161 QQQLMQSARSSPPIRSPQP-TPSPRSAPSPRAAPSASPRAQPSPHHVMSSHSPAPQ-GPPHDGMH 3223
            ...|....||..|::||:| :..|.|:||||..|      |||||||      :|| |.||.|:
Frog  2325 ATALSNQVRSPAPVQSPRPQSQPPHSSPSPRVQP------QPSPHHV------SPQTGSPHPGL- 2376

  Fly  3224 NHGMHHQSPLPGVPQDVGVGVGVGVGVGVNVNVGNVGVGNAGGALPD------------------ 3270
                                   ...:|.:::.|::|.......||.
Frog  2377 -----------------------AASMGNSLDQGHLGNPEQSAMLPQLNPPNRSALTNDLSLVGD 2418

  Fly  3271 -ASDQLTKFVERL 3282
             :.|.|.||||.|
Frog  2419 TSGDTLEKFVEGL 2431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nej	NP_001188575.1	ZnF_TAZ	530..600	CDD:214717	33/69 (48%)
		KIX	946..1024	CDD:280354	59/77 (77%)
		Bromo_cbp_like	1705..1812	CDD:99927	82/106 (77%)
		RING_CBP-p300	1824..1906	CDD:276805	50/81 (62%)
		PHD_CBP_p300	1908..1939	CDD:277032	23/30 (77%)
		HAT_KAT11	1970..2283	CDD:285432	211/315 (67%)
		ZZ_CBP	2339..2379	CDD:239077	24/39 (62%)
		ZnF_TAZ	2404..2476	CDD:214717	61/71 (86%)
crebbp	NP_001340300.1	zf-TAZ	362..429	CDD:307990	32/66 (48%)
		KIX	578..658	CDD:280354	60/110 (55%)
		Atrophin-1	<605..977	CDD:331285	145/527 (28%)
		Bromo_cbp_like	1082..1189	CDD:99927	82/106 (77%)
		RING_CBP-p300	1201..1273	CDD:276805	50/81 (62%)
		PHD_CBP_p300	1275..1306	CDD:277032	23/30 (77%)
		HAT_KAT11	1337..1645	CDD:311917	212/316 (67%)
		ZZ_CBP	1700..1740	CDD:239077	24/39 (62%)
		zf-TAZ	1767..1835	CDD:307990	57/67 (85%)
		Creb_binding	2039..2118	CDD:312539	26/120 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	430	1.000	Domainoid score	I588
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1418	1.000	Inparanoid score	I125
OMA	1	1.010	-	-		QHG47779
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001062
OrthoInspector	1	1.000	-	-		otm48572
Panther	1	1.100	-	-	O	PTHR13808
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X719
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.070