DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment a and CYTIP

DIOPT Version :9

Sequence 1:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	NP_004279.3	Gene:	CYTIP / 9595	HGNCID:	9506	Length:	359	Species:	Homo sapiens

Alignment Length:	370	Identity:	76/370 - (20%)
Similarity:	110/370 - (29%)	Gaps:	130/370 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   422 QQQQQQSVQDVGTGQSQSAQSTPTHQFQAAARPQKALKNFFHRIGSTGMLNHRSHNLLKASEAAQ 486
            |.....::.|...|.:.|:.||.|                    ||..|.::|...:|..:.|..
Human     8 QHSSNGNLADFCAGPAYSSYSTLT--------------------GSLTMDDNRRIQMLADTVATL 52

  Fly   487 QATPAATTLYRSSSTSQLSSS-----SYVKCDDPTEGLNLQ--REQREQRLPRIASLKSSSCDD- 543
            ........|.||||.|..|.|     :..|.|:.|.|..:|  |.|.:           ::|..
Human    53 PRGRKQLALTRSSSLSDFSWSQRKLVTVEKQDNETFGFEIQSYRPQNQ-----------NACSSE 106

  Fly   544 ----IAKVSSCLTASTSSGSAAGSLGSPPSSAAAGGGGTANSGQHDPSRRGAFPY---------- 594
                |.|:        ...|.|...|.......|...|.:..|         |.|
Human   107 MFTLICKI--------QEDSPAHCAGLQAGDVLANINGVSTEG---------FTYKQVVDLIRSS 154

  Fly   595 -----------------AFLRSRLSVLPEENHGNVPGHLKQQIQRQREQHQQHQRDL-------- 634
                             ..|.::|.||.:.        |||:....|....|..|.|
Human   155 GNLLTIETLNGTMILKRTELEAKLQVLKQT--------LKQKWVEYRSLQLQEHRLLHGDAANCP 211

  Fly   635 ------LQQEQTSSPLPQRRSPEQAMLNNVSRNDSITSKDWEPLYQRLSSCLSSNESGY------ 687
                  |.:.....|||   .|..|:::....:...:.|.|      |||....:|.||
Human   212 SLENMDLDELSLFGPLP---GPGPALVDRNRLSSESSCKSW------LSSMTMDSEDGYQTCVSE 267

  Fly   688 DSDGGATGARLGNN----LSISGGDTESIASGTLKRNSLISLSSS 728
            ||..||...:...:    :...|.|  .:...:.:||..||.:||
Human   268 DSSRGAFSRQTSTDDECFIPKEGDD--FLRRSSSRRNRSISNTSS 310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492
CYTIP	NP_004279.3	PDZ_signaling	76..161	CDD:238492	18/112 (16%)
CYTIP	NP_004279.3	Interaction with CYTH1	166..188		6/29 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900