DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment a and Pard3

DIOPT Version :9

Sequence 1:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	XP_006531583.1	Gene:	Pard3 / 93742	MGIID:	2135608	Length:	1337	Species:	Mus musculus

Alignment Length:	454	Identity:	104/454 - (22%)
Similarity:	156/454 - (34%)	Gaps:	147/454 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   895 QRTQSTDSLSSMQSLQLQQERIQGHNTEQEQEAQGEDQCDARSMASVSTMPTPMPLMQHRRSSTP 959
            ||..:..|||:...:      :.....:|||:.:|.:: |:..:..|....|.:..|       |
Mouse   214 QRDNARSSLSASHPM------VDRWLEKQEQDEEGTEE-DSSRVEPVGHADTGLENM-------P 264

  Fly   960 RHSLD-----VGAPE-------HELLRRRARSSSGQRSLALTPTPLFASGSSSCSSSPNHRLLDN 1012
            ..|||     |..|.       |.:    ..|:.|.|:|.|....|...|.:...:      |.:
Mouse   265 NFSLDDMVKLVQVPNDGGPLGIHVV----PFSARGGRTLGLLVKRLEKGGKAEQEN------LFH 319

  Fly  1013 END---PANDTDSYTPVYANRAASVCVASSLADDEKWQLLARKRCSEGSALSA---------TPN 1065
            |||   ..||.|     ..||..           |:.|.:.|:      |:.|         ..|
Mouse   320 ENDCIVRINDGD-----LRNRRF-----------EQAQHMFRQ------AMRARVIWFHVVPAAN 362

  Fly  1066 PQQFGQRTHYARNSINLANSHYRSLRFAHSRLSSSRLSLFMQAPPNSLTVGEGVANTPSSTATTT 1130
            .:|:.|.:...:|       :|...||               :|.:.......|||.........
Mouse   363 KEQYEQLSQREKN-------NYSPGRF---------------SPDSHCVANRSVANNAPQALPRA 405

  Fly  1131 TDLTNQQQQQQNQQQTHQSLYIKHSPKSVSLFSPNPYVNASSSPASASTSAGAGSSLAPPAAALM 1195
            ..|:    |...|...|..|  .||                   |.|||...|..:||||:.
Mouse   406 PRLS----QPPEQLDAHPRL--PHS-------------------AHASTKPPAAPALAPPSV--- 442

  Fly  1196 HHRPSLPVAKLTIRDEEMAEVIRASMSEGSGRCTPKT---ITFFKGPGLKSLGFSIVGGRDSPKG 1257
                                   .|.:.||...|.|.   :......|.:.|||||.....:..|
Mouse   443 -----------------------LSTNVGSVYNTKKVGKRLNIQLKKGTEGLGFSITSRDVTIGG 484

  Fly  1258 NMGIFVKTVFPSGQAADDGTLQAGDEIVEINGNSVQGMSHAETIGLFKNVR-EGTIVLKILRRK 1320
            :..|:||.:.|.|.|..||.|:|||.::|:||..:.|.|..|.:.|.::.: |||:.|.:.|::
Mouse   485 SAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLAGKSQEEVVSLLRSTKMEGTVSLLVFRQE 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492	31/90 (34%)
Pard3	XP_006531583.1	DUF3534	2..83	CDD:338230
		PDZ_signaling	272..347	CDD:238492	22/106 (21%)
		PDZ_signaling	465..544	CDD:238492	30/78 (38%)
		PDZ_signaling	588..681	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900