DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment a and SLC9A3R1

DIOPT Version :9

Sequence 1:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	NP_004243.1	Gene:	SLC9A3R1 / 9368	HGNCID:	11075	Length:	358	Species:	Homo sapiens

Alignment Length:	184	Identity:	45/184 - (24%)
Similarity:	70/184 - (38%)	Gaps:	49/184 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1134 TNQQQQQQNQQQTHQSLYIKHSPKSVSLFSPNPYVNASSSPASASTSAGAGSSLAPPAAALMHHR 1198
            |::|.|:...|...:.|..:.:|             ..:.|.:|:...|||:...|..|...|
Human    95 TDEQLQKLGVQVREELLRAQEAP-------------GQAEPPAAAEVQGAGNENEPREADKSH-- 144

  Fly  1199 PSLPVAKLTIRDEEMAEVIRASMSEGSGRCTPKTITFFKGPGLKSLGFSIVGGRDSPKGNMGIFV 1263
                        .|..|:            .|:..|..|||  ...||::    .|.|...|.|:
Human   145 ------------PEQREL------------RPRLCTMKKGP--SGYGFNL----HSDKSKPGQFI 179

  Fly  1264 KTVFPSGQAADDGTLQAGDEIVEINGNSVQGMSHAETIGLFKNVREGTIVLKIL 1317
            ::|.|...|...| |:|.|.|||:||..::|..|.:.:..   :|.|....|:|
Human   180 RSVDPDSPAEASG-LRAQDRIVEVNGVCMEGKQHGDVVSA---IRAGGDETKLL 229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492	28/86 (33%)
SLC9A3R1	NP_004243.1	PDZ_signaling	12..91	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	114..192		25/122 (20%)
		PDZ_signaling	152..231	CDD:238492	29/88 (33%)
		EBP50_C	235..358	CDD:312529
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	277..358
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900