DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment a and MPDZ

DIOPT Version :9

Sequence 1:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	NP_001362342.1	Gene:	MPDZ / 8777	HGNCID:	7208	Length:	2103	Species:	Homo sapiens

Alignment Length:	1551	Identity:	304/1551 - (19%)
Similarity:	478/1551 - (30%)	Gaps:	587/1551 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DTYSTLAAQQQQQQQQQQQHQAEGSNISHSSNSS-SNKSHTPAT-------CSN-------RLNK 60
            |.:.:|.....|...|:|.......:||....|. :...:|||.       |.|       .|..
Human   895 DLHMSLEELYTQNLLQRQDENTPSVDISMGPASGFTINDYTPANAIEQQYECENTIVWTESHLPS 959

  Fly    61 SIVSSTSISSSLPDLHDKSPVMILSCTTLASNG---------------------ATATAAVTATA 104
            .::||..:.|.|||...|....:|..::||.|.                     ..::..:|.:|
Human   960 EVISSAELPSVLPDSAGKGSEYLLEQSSLACNAECVMLQNVSKESFERTINIAKGNSSLGMTVSA 1024

  Fly   105 T----GTAATS---GGSLQQQQQQHLQHQQQQQPLRTATPTCLLSGRQTPSAISVMSLQEATSLH 162
            .    |....|   ||::.:..             |.|...|:||..: .|.|||.:.|....|.
Human  1025 NKDGLGMIVRSIIHGGAISRDG-------------RIAIGDCILSINE-ESTISVTNAQARAMLR 1075

  Fly   163 RQQQQPHQPPTIYVPV----PTKLGNNVNTGNSSATLLLSYGSTSSIANLQQQQQ--------QH 215
            |...........|||.    ..|:.....:|...|..:.|..:...|..|.::::        |:
Human  1076 RHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESELQN 1140

  Fly   216 AAQYQQYVAQRL----HAASSSCLYEKGSNASGGASSN---------KSSLSLTP---NGHL-PD 263
            .|.......:|:    ..:.|..:...|....|...||         |..|..:|   ||.| |.
Human  1141 TAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPG 1205

  Fly   264 YKLVTAMPVVVLDDEHKSNSLPATEASRNSN--------------------------------SS 296
            .::|....:.:.|..|:.    |.||.|.:.                                ||
Human  1206 DRIVEVDGMDLRDASHEQ----AVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSS 1266

  Fly   297 SNMNGSSNSNSLDVSNSNSHS---------------------GS---STSLASTTRNV------- 330
            :|....|...:.|.:.|.|.|                     ||   .:|.:..:::|
Human  1267 TNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFG 1331

  Fly   331 FTWGKRMSRKLDLLKRSDSPAAAHKSHSDL-RSLFHSPTHHK----------SGSGGSSGPSSAK 384
            ::| |.:..:...|..........|.||.| .||..:....:          :|:.|..|.....
Human  1332 YSW-KNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIA 1395

  Fly   385 ASASPTGG-------HQNSSGSTTSTLKKCKSGPIETIKQRHQQQQQQQ-----QSVQDVGTGQS 437
            .......|       |||:     |::.||....::.|..|::....|.     .:|:.: ...|
Human  1396 DELLEINGQILYGRSHQNA-----SSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPL-PSNS 1454

  Fly   438 QSAQSTPT--HQFQAAARPQKALKNFFHRIGSTGMLNHRSHNLLKASE-AAQQATPAATTLYRSS 499
            ::.|:...  |:|...::|:::                .||.:...|: .|.|......|:..|.
Human  1455 ENLQNKELGYHRFSLYSKPRQS----------------SSHLVYLCSQLIAVQLHLTEPTVTTSD 1503

  Fly   500 STSQLSSSSYVKCDDPTEGLNLQREQ--------REQRLPRIASLKS------------------ 538
            :...|||...|      :.|.|.::|        .|..|..:. :||
Human  1504 AAVDLSSFKNV------QHLELPKDQGGLGIAISEEDTLSGVI-IKSLTEHGVAATDGRLKVGDQ 1561

  Fly   539 -SSCDD-------IAKVSSCLTASTSSGSAAGSLGSP-----PSSAAAGGGGTANSGQHDPSRRG 590
             .:.||       |.|..|.|..:..:........:|     ||:|.|..|...||.|
Human  1562 ILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQ------- 1619

  Fly   591 AFPYAFLRSRLSVLPEENHGNVPGHLKQQIQRQREQHQQHQRDLLQQEQTSSPLPQRRSPEQAML 655
                                                              |..:||..|||...:
Human  1620 --------------------------------------------------SLMVPQSGSPEPESI 1634

  Fly   656 NNVSRNDSITSKDWEPLYQRLSSC--LSSNESGYDSDGGATGARLGNNLSISGGDTESIASGTLK 718
            .|.||:.:......:|     ::|  :...|:..:...|.||  ||  |||.||      |.||
Human  1635 RNTSRSSTPAIFASDP-----ATCPIIPGCETTIEISKGRTG--LG--LSIVGG------SDTL- 1683

  Fly   719 RNSLISLSSSEGVGMGMGMSLGLGAPSTRNSSICSAPVSLGGYNYDYETETIRRRFRQVKLERKC 783
                                  |||
Human  1684 ----------------------LGA---------------------------------------- 1686

  Fly   784 QEDYIGIVLSPKTVMTNSNEQQYRYLIVELEPYGMAQKDGRLRLGDEIVNVNGKHLRGIQSFAEV 848
                                    .:|.|:...|.|.|||||..||:|:.|||..||
Human  1687 ------------------------IIIHEVYEEGAACKDGRLWAGDQILEVNGIDLR-------- 1719

  Fly   849 QRLLSSFVDNCIDLVIAHDEVTTVTDFYTKIRIDGMSTQRHRLSYV--QRTQSTDSLSSMQSLQL 911
                          ...|||.         |.:...:.||.||:..  :.....:.:....:::|
Human  1720 --------------KATHDEA---------INVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIEL 1761

  Fly   912 QQERIQG---------HNT----------------------EQEQEAQGEDQCDARSMASVSTMP 945
            |::..:|         ::|                      :|.....|||..:|...|..:.:
Human  1762 QKKPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALL- 1825

  Fly   946 TPMPLMQHRRSSTPRHSLDVG----APEHELLRRRARSSSGQRSLALTPTPLFASGSSSCSSSPN 1006
                     :.|....:|:||    .|.|...|....|...:.||:....||  ||||:..|..:
Human  1826 ---------KCSLGTVTLEVGRIKAGPFHSERRPSQSSQVSEGSLSSFTFPL--SGSSTSESLES 1879

  Fly  1007 HRLLDNENDPANDTDSYTPVYANRAASVCVASSLADDEKWQLLARKRCSEGSALSATPNPQQFGQ 1071
            .   ..:|..|::......|...:..:..:..|:|.            ..||.|...|
Human  1880 S---SKKNALASEIQGLRTVEMKKGPTDSLGISIAG------------GVGSPLGDVP------- 1922

  Fly  1072 RTHYARNSINLANSHYRSLRFAHSRLSSSRLSLFMQAPPNSLTVGEGVANTPSSTATTTTDLTNQ 1136
                    |.:|..|...                :.|....|.||:.:.   :...|:|..:|:.
Human  1923 --------IFIAMMHPTG----------------VAAQTQKLRVGDRIV---TICGTSTEGMTHT 1960

  Fly  1137 QQQQQNQQQTHQSLYIKHSPKSVSLFSPNPYVNASSS-----PASASTSAGAGSSLAPPAAALMH 1196
            |                    :|:|..     |||.|     .|....|...|....|.::
Human  1961 Q--------------------AVNLLK-----NASGSIEMQVVAGGDVSVVTGHQQEPASS---- 1996

  Fly  1197 HRPSLPVAKLTIRDEEMAEVIRASMSEGSGRCTPKTITFFKGPGLKSLGFSIVGGRDSPKGNMGI 1261
               ||....||     .:.:.:..:  |..:|  |:||..:||  ..||||||||..||.|::.|
Human  1997 ---SLSFTGLT-----SSSIFQDDL--GPPQC--KSITLERGP--DGLGFSIVGGYGSPHGDLPI 2047

  Fly  1262 FVKTVFPSGQAADDGTLQAGDEIVEINGNSVQGMSHAETIGLFKNVREGTIVLKIL 1317
            :|||||..|.|::||.|:.||:|:.:||.|::|::|.|.:.:.|..: ||:.|.:|
Human  2048 YVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTK-GTVTLMVL 2102

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492	17/89 (19%)
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492	40/86 (47%)
MPDZ	NP_001362342.1	PDZ_signaling	2019..2102	CDD:238492	40/85 (47%)
		L27_2	6..63	CDD:312549
		PDZ_signaling	139..221	CDD:238492
		PDZ_signaling	257..334	CDD:238492
		PDZ	374..463	CDD:214570
		PDZ_signaling	560..629	CDD:238492
		PDZ_signaling	698..784	CDD:238492
		PDZ_signaling	1006..1076	CDD:238492	17/83 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1121..1140		2/18 (11%)
		PDZ_signaling	1149..1240	CDD:238492	20/94 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1278..1324		7/45 (16%)
		PDZ	1347..1433	CDD:214570	18/90 (20%)
		PDZ_signaling	1514..1593	CDD:238492	14/85 (16%)
		MPDZ_u10	1595..1659	CDD:374710	20/125 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1600..1645		17/101 (17%)
		PDZ	1660..1744	CDD:214570	42/211 (20%)
		PDZ_signaling	1758..1836	CDD:238492	12/87 (14%)
		PDZ_signaling	1893..1978	CDD:238492	24/155 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19964
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.000