Protein Alignment a and lnx2

DIOPT Version :10

• Sequence 1: NP_524641.1
• Gene: a / 43852
• FlyBaseID: FBgn0000008
• Length: 1329
• Species: Drosophila melanogaster
• Sequence 2: NP_001072606.1
• Gene: lnx2 / 780062
• XenbaseID: XB-GENE-877144
• Length: 685
• Species: Xenopus tropicalis
• Alignment Length: 762
• Identity: 156/762 - (20%)
• Similarity: 244/762 - (32%)
• Gaps: 263/762 - (34%)

  Fly   617 KQQIQR-QREQH-------QQHQRDLLQQEQTSSPLPQRRSPEQAMLNNVSRNDSITSKDWEPLY 673
            |:.:|| ..|.|       ..|:|:||.|.:.|          :..:.....|.|:......|:
 Frog   119 KETMQRCDMEAHLKNRCPGASHRRELLNQHRAS----------KLQIEIEGENGSVLIDHQGPV- 172

  Fly   674 QRLSSCLSSNESGYDSDGGATGARLGNNLSISGGDTESIASGTLKRNSLISLSSSEGVGMGMGMS 738
                    |.||.....|.|...|   |:      |.|:....::.:
 Frog   173 --------SPESDKTRSGSALPER---NV------TPSVMPAWMEEH------------------ 202

  Fly   739 LGLGAPSTRNSSICSA---PVSLGGYNYDYETETIRRRFRQVKLERKCQEDYIGIVLSPKTVMTN 800
             |...|:...|::..|   |.||.  ..:..|..|.|....::|.       |.||...:|.:.|
 Frog   203 -GFDNPAFEESTVADATHPPPSLP--EGEITTIEIHRSNPYIELG-------ISIVGGNETPLIN 257

  Fly   801 SNEQQYRYLIVELEPYGMAQKDGRLRLGDEIVNVNGKHLRGI-QSFAEVQRLLSSFVDNCIDLVI 864
                   .:|.|:...|:..:||||..||:|:.||...:..: .::|   |.:.|.....:.|.:
 Frog   258 -------VVIQEIYRDGVIARDGRLLAGDQILQVNNFDISNVSHNYA---RWVLSQPCTVLHLTV 312

  Fly   865 ---------AH---------DEVTTVTDFYTKIRIDGMSTQRHRLSYVQRTQST-----DSLSSM 906
                     ||         ||     .|:..:...| |.::..:..|:||..:     |.|..
 Frog   313 LRERRFGSRAHGHGDGGSQRDE-----SFHITLNKRG-SNEQLGIKLVRRTDESGVFILDLLEG- 370

  Fly   907 QSLQLQQERIQGHNTEQEQEAQGEDQCDARSMASVSTMPTPMPLMQHRRSSTPRHSLDVGAPEHE 971
             .|..|..|:  |:.::.....|.|                   ::|            |.||
 Frog   371 -GLAAQDGRL--HSNDRVLAINGLD-------------------LKH------------GTPE-- 399

  Fly   972 LLRRRARSSSGQRSLALTPTPLFASGSSSCSSSPNHRLLD-NENDPANDTDSYTPVY-----ANR 1030
             |..:....||:| :.||.       |......|.:...| ..|.|.:.|..   ||     |::
 Frog   400 -LAAQIIQGSGER-VNLTV-------SRPGKHQPGNITRDLGMNQPHHHTQQ---VYHHRPSAHK 452

  Fly  1031 AASVCVASSLADDEKWQLLARKRCSEGSALSATPNPQQ-FGQRTHYARNSINLANSHYRSLRFAH 1094
            ..:.||                :|.| ..::....||: .|......|.|
 Frog   453 DLAQCV----------------KCQE-KHITVKKEPQESLGMTVAGGRGS--------------- 485

  Fly  1095 SRLSSSRLSLFMQA--PPNSLTVGEGVANTPSSTATTTTDLTNQQQQQQNQQQTHQSLYIKHSPK 1157
               .|..|.:|:.:  |...|.....:.......:....|||
 Frog   486 ---KSGELPIFVTSVQPHGCLARDSRIKRGDVLLSINGIDLT----------------------- 524

  Fly  1158 SVSLFSPNPYVNASSSPASASTSAGAGSSLAPPAAALMHHRPSLPVAKLTIRDEE---MAEVIRA 1219
                       |.|.|.|.|...|.|.||:.           ||...::.:.:|:   ..|:...
 Frog   525 -----------NLSHSEAVAMLKASATSSVV-----------SLKAIEVEVIEEQTPGKEEMSTV 567

  Fly  1220 SMSEGSGRCTPKTITFFKGP--------------GLKSLGFSIVGGRDSPKGNMGIFVKTVFPSG 1270
            |.:|.....:|..:.:...|              .|.|.|||||||.:....|...|:||:....
 Frog   568 SENEYDASWSPSWVMWLGLPSCLHSCHDVVLRRSSLGSWGFSIVGGYEENHTNQPFFIKTIVLGT 632

  Fly  1271 QAADDGTLQAGDEIVEINGNSVQGMSHAETIGLFKNVREGTIVLKIL 1317
            .|..||.|:.||.|:.:||.|..||||:..:.:.|..| ..:.|.::
 Frog   633 PAYYDGRLKCGDMIIAVNGLSTVGMSHSALVPMLKEQR-NKVTLSVI 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_524641.1	PDZ_canonical	<815..868	CDD:483948	16/71 (23%)
		PDZ3_PDZD2-PDZ1_hPro-IL-16-like	1231..1316	CDD:467240	31/98 (32%)
lnx2	NP_001072606.1	mRING-HC-C3HC3D_LNX2	43..87	CDD:319694
		PDZ1_LNX1_2-like	227..315	CDD:467165	25/104 (24%)
		PDZ2_LNX1_2-like	336..418	CDD:467166	24/128 (19%)
		PDZ3_LNX1_2-like	463..550	CDD:467167	24/149 (16%)
		PDZ4_LNX1_2-like	594..682	CDD:467168	30/86 (35%)