DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment a and Grip1

DIOPT Version :9

Sequence 1:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	XP_006514294.1	Gene:	Grip1 / 74053	MGIID:	1921303	Length:	1185	Species:	Mus musculus

Alignment Length:	1217	Identity:	212/1217 - (17%)
Similarity:	367/1217 - (30%)	Gaps:	469/1217 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 KLGNNVNTGNSSATLLLSYGSTSSIANLQQQQQQHAAQYQQYVAQRLHAASSSCLYE--KGSNAS 243
            |.|:.:.:.:....|..::....||.....|:.....:|...|...:..||...|.|  |...||
Mouse   255 KPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEATLLIEYDVSVMDSVATASGPLLVEVAKTPGAS 319

  Fly   244 GGASSNKSSLSLTPNGHLPDYKLVTAMPVVVLDDEHKSNSLPATEASRNSNSSSNMNGSSNSNSL 308
            .|.:...|               |.....|::.|:.||.|:        ::....::...:..|:
Mouse   320 LGVALTTS---------------VCCNKQVIVIDKIKSASI--------ADRCGALHVGDHILSI 361

  Fly   309 DVSNSN--SHSGSSTSLASTTRNVFTWGKRMSRKLDLLKRSDSPAAAHKSHSDLRSLFHSPTHHK 371
            |.::..  :.:.::..||:||..|         ||::|           .|...|.....|.|.|
Mouse   362 DGTSMEYCTLAEATQFLANTTDQV---------KLEIL-----------PHHQTRLALKGPDHVK 406

  Fly   372 SGSGGSSGPSSAKASASPTGGHQNSSGST---------TSTLKKC---KSGPIETIKQRHQQQQQ 424
            ........|..|.|| :..|.|.|...:|         ..|..|.   .|.|.............
Mouse   407 IQRSDRQHPWDAWAS-NQCGVHTNHHHNTYHPDHCRVPALTFPKALPPNSPPAMVPSSSPTSMSA 470

  Fly   425 QQQSVQDVGTGQSQSAQSTPTHQFQAAARPQKALKNFFHRIGSTGMLNHRSHNLLKASEAAQQAT 489
            ...|..::||        .|...:..:.|            |:  |:..|    ||..:.....:
Mouse   471 YSLSSLNMGT--------LPRSLYSTSPR------------GT--MMRRR----LKKKDFKSSLS 509

  Fly   490 PAATTLYRSSSTSQLSSSSYVKCDDPTEGLNLQREQREQRLPRIASLKSSSCDDIAKVSSCLTAS 554
            .|::|:..:.......::..|...||..|..:|.:
Mouse   510 LASSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQ------------------------------ 544

  Fly   555 TSSGSAAGSLGSPP------SSAAAGGGGTANSGQHDPSRRGAFPYAFLRSRLSVLPEENHGNVP 613
             .|..|..:|.|||      :.:.|...|....|....:..|             :|.|:
Mouse   545 -GSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAING-------------IPTED----- 590

  Fly   614 GHLKQQIQRQREQHQQHQRDLLQQEQTSSPLPQRRSPEQAMLNNVSRNDSITSKDWEPLYQRLSS 678
                                              .:.|:|  |.:.|:.|||||
Mouse   591 ----------------------------------STFEEA--NQLLRDSSITSK----------- 608

  Fly   679 CLSSNESGYDSDGGATGARLGNNLSISGGDTESI--ASGTLKRNSLISLSSSEGVGMGMGMSLGL 741
                                 ..|.|.....||:  :|||..    :.|.....|.:|:.:|
Mouse   609 ---------------------VTLEIEFDVAESVIPSSGTFH----VKLPKKHSVELGITIS--- 645

  Fly   742 GAPSTRN-------SSICSAPVSLGGYNYDYETETIR-----RRFRQVKLERKCQEDYIGIV--- 791
             :||:|.       |.|....|:       :.|.|:.     .....::|:....||.:.|:
Mouse   646 -SPSSRKPGDPLVISDIKKGSVA-------HRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQC 702

  Fly   792 -----LSPKTVMTNSNEQQYRYLI---VELEPY--------------------------GMAQKD 822
                 |..:....||:||:....|   |||:.|                          |:|::.
Mouse   703 EDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITISGTEEPFDPIIISSLTKGGLAERT 767

  Fly   823 GRLRLGDEIVNVNGKHLRGIQSFAEVQRLLSSFVDNCIDLVIAHDEVTTVTDFYTKIRIDGMSTQ 887
            |.:.:||.|:.:|...|:| :..:|...||.          :|.:.||      .||:
Mouse   768 GAIHIGDRILAINSSSLKG-KPLSEAIHLLQ----------MAGETVT------LKIK------- 808

  Fly   888 RHRLSYVQRTQSTDSLSSMQSLQLQQERIQGHNTEQEQEAQGEDQCDARSMASVSTMPTPMPLMQ 952
                                                       .|.||:|.:|    |...|:
Mouse   809 -------------------------------------------KQTDAQSASS----PKKFPI-- 824

  Fly   953 HRRSSTPRHSLDVGAPEHELLRRRARSSSGQRSLALTPTPLFASGSSSCSSSPNHRLLDNENDPA 1017
                  |.||.|:|..|.:                  |:|:                    ..|.
Mouse   825 ------PGHSGDLGDGEED------------------PSPI--------------------QKPG 845

  Fly  1018 NDTDSYTPVYANRAASVCVASSLADDEKWQLLARKRCSEGSALSATPNPQQFG-QRTHYARNSIN 1081
            ..:|:|.....:..::|         :.|         :||.:.|:     :| |.:.:..:..|
Mouse   846 KLSDAYPSTVPSVDSAV---------DSW---------DGSGIDAS-----YGSQGSTFQTSGYN 887

  Fly  1082 LANSHYRSLRFAHSRLSSSRLSLFMQAPPNSLTVGE-GVANTPSSTATTT-----TDLTNQQQQQ 1140
            .....:||        ...|.||.....|.|.|..: |::|.....:|.:     :|..:.:|::
Mouse   888 YNTYDWRS--------PKQRTSLSPVPKPRSQTYPDVGLSNEDWDRSTASGFVGASDSADAEQEE 944

  Fly  1141 QNQQQTHQSLYI-----------KHSPKSVSL--------FSPNPYVNASSSPASASTSAGAGSS 1186
            ....|..:.|..           :.:.:.|||        ......::.:.....|.:..|..:|
Mouse   945 NFWSQALEDLETCGQSGILRELEEKADRRVSLRNMTLLATIMSGSTMSLNHEAPMARSQLGRQAS 1009

  Fly  1187 LAPPAAALMHHRP-----SLP--VAKLTIRDEEMAEVIRASMSEGSGRCTP---KTITFFKGPGL 1241
            ....:::..|:..     :||  |.:.::...:|.:.|:..||.     ||   ..:|.:|..|:
Mouse  1010 FQERSSSRPHYSQTTRSNTLPSDVGRKSVTLRKMKQEIKEIMSP-----TPVELHKVTLYKDSGM 1069

  Fly  1242 KSLGFSIVGGRDSPKGNMGIFVKTVFPSGQAADDGTLQAGDEIVEIN 1288
            :..|||:..|    ....|::||.:.|:| ..|.|.|:..|.::::|
Mouse  1070 EDFGFSVADG----LLEKGVYVKNIRPAG-PGDVGGLKPYDRLLQVN 1111

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492	26/126 (21%)
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492	18/62 (29%)
Grip1	XP_006514294.1	PDZ_signaling	110..190	CDD:238492
		PDZ_signaling	209..292	CDD:238492	6/36 (17%)
		PDZ_signaling	307..390	CDD:238492	22/114 (19%)
		PDZ_signaling	526..614	CDD:238492	27/204 (13%)
		PDZ_signaling	627..711	CDD:238492	18/98 (18%)
		PDZ_signaling	727..808	CDD:238492	20/97 (21%)
		PDZ_signaling	1058..1138	CDD:238492	17/59 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900